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View article: <i>NOTCH1</i> Mutation and Survival Analysis of Tislelizumab in Advanced or Metastatic Esophageal Squamous Cell Carcinoma: A Biomarker Analysis From the Randomized, Phase III, RATIONALE-302 Trial
<i>NOTCH1</i> Mutation and Survival Analysis of Tislelizumab in Advanced or Metastatic Esophageal Squamous Cell Carcinoma: A Biomarker Analysis From the Randomized, Phase III, RATIONALE-302 Trial Open
PURPOSE Although multiple agents targeting PD-1 have been approved as second-line treatment for esophageal squamous cell carcinoma (ESCC), only a fraction of patients derive long-term survival. Hence, reliable predictive biomarkers are urg…
View article: Supplementary Figure S7 from Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth
Supplementary Figure S7 from Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth Open
Figure S7: Tumor cell-initiated autocrine signaling drives IL-33 upregulation in pancreatic fibroblasts.
View article: Data from Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth
Data from Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth Open
Pancreatic cancer is characterized by an extensive fibroinflammatory microenvironment. During carcinogenesis, normal stromal cells are converted to cytokine-high cancer-associated fibroblasts (CAF). The mechanisms underlying this conversio…
View article: Supplementary Table S2 from Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth
Supplementary Table S2 from Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth Open
Table S2. Primer sequences used in qRT-PCR
View article: Supplementary Figure S1 from Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth
Supplementary Figure S1 from Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth Open
Figure S1: IL-33+ stromal cells are abundant in human and mouse PDA.
View article: Supplementary Figure S4 from Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth
Supplementary Figure S4 from Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth Open
Figure S4: Loss of stromal IL-33 alters the ST2+ immune cell secretome, resulting in a shift in CAF differentiation.
View article: Supplementary Figure S6 from Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth
Supplementary Figure S6 from Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth Open
Figure S6: Expression of fibroblast IL-33 is extrinsically induced by epithelial KrasG12D and requires JAK1/2-STAT3 activation throughout tumorigenesis.
View article: Supplementary Figure S3 from Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth
Supplementary Figure S3 from Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth Open
Figure S3: Pancreatic fibroblasts secrete IL-33 in response to oxidative stress.
View article: Supplementary Figure S5 from Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth
Supplementary Figure S5 from Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth Open
Figure S5: Inactivation of stromal IL-33 enables cytotoxic T cell activity.
View article: Supplementary Table S1 from Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth
Supplementary Table S1 from Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth Open
Table S1. Single cell RNA sequencing datasets.
View article: Supplementary Figure S2 from Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth
Supplementary Figure S2 from Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth Open
Figure S2: Stromal IL-33 promotes PDA growth.
View article: Supplementary Figures Part 1 from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions.
Supplementary Figures Part 1 from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions. Open
Supplementary Figures 1-10 and associated legends
View article: Supplementary Figures Part 1 from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions.
Supplementary Figures Part 1 from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions. Open
Supplementary Figures 1-10 and associated legends
View article: Supplementary Tables from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions.
Supplementary Tables from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions. Open
Supplemental Table 1: Demographics and clinical data for donor Gife of Life Samples Supplemental Table 2: Putative Ligand-Receptor pairs comparing all cell types from single cell sequencing of tumor samples compared to healthy samples. Sup…
View article: Supplementary Figures Part 1 from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions.
Supplementary Figures Part 1 from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions. Open
Supplementary Figures 1-10 and associated legends
View article: Supplementary Figures Part 1 from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions.
Supplementary Figures Part 1 from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions. Open
Supplementary Figures 1-10 and associated legends
View article: Data from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions.
Data from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions. Open
The adult healthy human pancreas has been poorly studied given lack of indication to obtain tissue from the pancreas in the absence of disease and rapid postmortem degradation. We obtained pancreata from brain dead donors thus avoiding any…
View article: Supplementary Tables from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions.
Supplementary Tables from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions. Open
Supplemental Table 1: Demographics and clinical data for donor Gife of Life Samples Supplemental Table 2: Putative Ligand-Receptor pairs comparing all cell types from single cell sequencing of tumor samples compared to healthy samples. Sup…
View article: Data from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions.
Data from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions. Open
The adult healthy human pancreas has been poorly studied given lack of indication to obtain tissue from the pancreas in the absence of disease and rapid postmortem degradation. We obtained pancreata from brain dead donors thus avoiding any…
View article: Supplementary Tables from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions.
Supplementary Tables from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions. Open
Supplemental Table 1: Demographics and clinical data for donor Gife of Life Samples Supplemental Table 2: Putative Ligand-Receptor pairs comparing all cell types from single cell sequencing of tumor samples compared to healthy samples. Sup…
View article: Supplementary Figures Part 2 from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions.
Supplementary Figures Part 2 from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions. Open
Supplementary Figures 11-14 and associated legends.
View article: Supplementary Tables from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions.
Supplementary Tables from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions. Open
Supplemental Table 1: Demographics and clinical data for donor Gife of Life Samples Supplemental Table 2: Putative Ligand-Receptor pairs comparing all cell types from single cell sequencing of tumor samples compared to healthy samples. Sup…
View article: Supplementary Figures Part 2 from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions.
Supplementary Figures Part 2 from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions. Open
Supplementary Figures 11-14 and associated legends.
View article: Supplementary Figures Part 2 from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions.
Supplementary Figures Part 2 from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions. Open
Supplementary Figures 11-14 and associated legends.
View article: Supplementary Figures Part 2 from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions.
Supplementary Figures Part 2 from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions. Open
Supplementary Figures 11-14 and associated legends.
View article: The Relationship Between Benefit Finding and Quality of Life in Patients with Chronic Obstructive Pulmonary Disease: The Mediating Effects of Self-Management
The Relationship Between Benefit Finding and Quality of Life in Patients with Chronic Obstructive Pulmonary Disease: The Mediating Effects of Self-Management Open
The QOL of patients with COPD needs to be improved, especially in terms of physical aspects. Helping COPD patients obtain better BF not only helps them improve their PCS and MCS directly but also indirectly through enhancing self-managemen…
View article: Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth
Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth Open
Pancreatic cancer is characterized by an extensive fibroinflammatory microenvironment. During carcinogenesis, normal stromal cells are converted to cytokine-high cancer-associated fibroblasts (CAF). The mechanisms underlying this conversio…
View article: Supplementary Fig 6 from KRT17<sup>high</sup>/CXCL8<sup>+</sup> Tumor Cells Display Both Classical and Basal Features and Regulate Myeloid Infiltration in the Pancreatic Cancer Microenvironment
Supplementary Fig 6 from KRT17<sup>high</sup>/CXCL8<sup>+</sup> Tumor Cells Display Both Classical and Basal Features and Regulate Myeloid Infiltration in the Pancreatic Cancer Microenvironment Open
CXCL8 is expressed in a unique subpopulation of tumor epithelial cells and in tumor infiltrating granulocytes.
View article: Supplementary Table 4 from KRT17<sup>high</sup>/CXCL8<sup>+</sup> Tumor Cells Display Both Classical and Basal Features and Regulate Myeloid Infiltration in the Pancreatic Cancer Microenvironment
Supplementary Table 4 from KRT17<sup>high</sup>/CXCL8<sup>+</sup> Tumor Cells Display Both Classical and Basal Features and Regulate Myeloid Infiltration in the Pancreatic Cancer Microenvironment Open
TCGA Timer 2.0 Analysis
View article: Supplementary Fig 12 from KRT17<sup>high</sup>/CXCL8<sup>+</sup> Tumor Cells Display Both Classical and Basal Features and Regulate Myeloid Infiltration in the Pancreatic Cancer Microenvironment
Supplementary Fig 12 from KRT17<sup>high</sup>/CXCL8<sup>+</sup> Tumor Cells Display Both Classical and Basal Features and Regulate Myeloid Infiltration in the Pancreatic Cancer Microenvironment Open
CXCL8 levels in patient plasma correlate with abundance of KRT17high; CXCL8+ cancer cells in neoadjuvant-treated patients.