Wenting Zhong
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View article: Accurate Cobb Angle Estimation via SVD-Based Curve Detection and Vertebral Wedging Quantification
Accurate Cobb Angle Estimation via SVD-Based Curve Detection and Vertebral Wedging Quantification Open
Adolescent idiopathic scoliosis (AIS) is a common spinal deformity affecting approximately 2.2% of boys and 4.8% of girls worldwide. The Cobb angle serves as the gold standard for AIS severity assessment, yet traditional manual measurement…
View article: Delving into the pinnacle: an in-depth analysis of the top 100 most cited articles on cardio-oncology
Delving into the pinnacle: an in-depth analysis of the top 100 most cited articles on cardio-oncology Open
View article: Response to two Janus kinase inhibitors in a boy with SAVI during 2-year follow-up: case report and literature review
Response to two Janus kinase inhibitors in a boy with SAVI during 2-year follow-up: case report and literature review Open
STING-associated vasculopathy with onset in infancy (SAVI) represents an identified rare type I interferonopathy, triggered by gain-of-function mutations in the STING1 gene. It is characterized by early-onset systemic inflammation, cutaneo…
View article: Application and prospects of genetic engineering in CAR-NK cell therapy
Application and prospects of genetic engineering in CAR-NK cell therapy Open
With the rapid advancement of genetic engineering technologies, CAR-NK cell therapy, as an emerging immunotherapeutic approach, has demonstrated significant potential. CAR-NK cells recognize and eliminate tumor cells through chimeric antig…
View article: Targeting Mesothelin Enhances Personalized Neoantigen Vaccine Induced Antitumor Immune Response in Orthotopic Pancreatic Cancer Mouse Models
Targeting Mesothelin Enhances Personalized Neoantigen Vaccine Induced Antitumor Immune Response in Orthotopic Pancreatic Cancer Mouse Models Open
The immunosuppressive microenvironment in pancreatic cancer, characterized by low tumor‐specific T cells and excessive fibrosis, limits the effectiveness of immunotherapy. Here, three datasets and multi‐immunofluorescence staining of tissu…
View article: Development and validation of a multivariable nomogram predictive of hepatitis B e antigen seroconversion after pregnancy in hepatitis B virus-infected mothers
Development and validation of a multivariable nomogram predictive of hepatitis B e antigen seroconversion after pregnancy in hepatitis B virus-infected mothers Open
Background and aims Current guidelines are controversial regarding the continuation of nucleos(t)ide analogues (NAs) therapy after delivery in Hepatitis B virus (HBV)-infected pregnant women. The postpartum period may be an opportune momen…
View article: A high functional cure rate was induced by pegylated interferon alpha-2b treatment in postpartum hepatitis B e antigen-negative women with chronic hepatitis B virus infection: an exploratory study
A high functional cure rate was induced by pegylated interferon alpha-2b treatment in postpartum hepatitis B e antigen-negative women with chronic hepatitis B virus infection: an exploratory study Open
Background and aims Limited data have been reported on achieving functional cure using pegylated interferon (Peg-IFN) alpha-2b treatment for postpartum hepatitis B e antigen (HBeAg)-negative women with chronic hepatitis B virus (HBV) infec…
View article: Advances in Extraction Protocols, Degradation Methods, and Bioactivities of Proanthocyanidins
Advances in Extraction Protocols, Degradation Methods, and Bioactivities of Proanthocyanidins Open
Proanthocyanidins, natural polyphenolic compounds abundantly present in plants, exhibit diverse bioactivities, including antioxidative, anti-inflammatory, and antibacterial effects. These bioactivities are intricately linked to the degree …
View article: Valproic acid increases CAR T cell cytotoxicity against acute myeloid leukemia
Valproic acid increases CAR T cell cytotoxicity against acute myeloid leukemia Open
The treatment of B cell malignancies has dramatically changed with the introduction of immunotherapy, especially chimeric antigen receptor T (CAR-T) cell therapy. However, only limited efficacy is observed in acute myeloid leukaemia (AML).…
View article: SFPQ promotes the proliferation, migration and invasion of hepatocellular carcinoma cells and is associated with poor prognosis
SFPQ promotes the proliferation, migration and invasion of hepatocellular carcinoma cells and is associated with poor prognosis Open
Liver cancer is a prevalent type of tumor worldwide. CRISPR-Cas9 technology can be utilized to identify therapeutic targets for novel therapeutic approaches. In this study, our goal was to identify key genes related to the survival of hepa…
View article: Cardiovascular involvement in Epstein–Barr virus infection
Cardiovascular involvement in Epstein–Barr virus infection Open
Cardiovascular involvement is an uncommon but severe complication of Epstein–Barr virus (EBV) infection caused by direct damage and immune injury. Recently, it has drawn increasing attention due to its dismal prognosis. It can manifest in …
View article: High DAPK1 Expression Promotes Tumor Metastasis of Gastric Cancer
High DAPK1 Expression Promotes Tumor Metastasis of Gastric Cancer Open
Gastric cancer (GC) is a common upper gastrointestinal tumor. Death-associated protein kinase (DAPK1) was found to participate in the development of various malignant tumors. However, there are few reports on DAPK1 in gastric cancer. In th…
View article: Emerging trends in sacubitril/valsartan research: A bibliometric analysis of the years 1995–2021
Emerging trends in sacubitril/valsartan research: A bibliometric analysis of the years 1995–2021 Open
Background: Sacubitril/valsartan has been approved for the treatment of heart failure (HF) patients with reduced ejection fraction; since then, it gradually became a new star drug in the therapy of HF. Nevertheless, the effectiveness of sa…
View article: Elevated expression of LIF predicts a poor prognosis and promotes cell migration and invasion of clear cell renal cell carcinoma
Elevated expression of LIF predicts a poor prognosis and promotes cell migration and invasion of clear cell renal cell carcinoma Open
Background Renal cell carcinoma (RCC) is the seventh most common cancer in humans, of which clear cell renal cell carcinoma (ccRCC) accounts for the majority. Recently, although there have been significant breakthroughs in the treatment of…
View article: Identification of UBE2I as a Novel Biomarker in ccRCC Based on a Large-Scale CRISPR-Cas9 Screening Database and Immunohistochemistry
Identification of UBE2I as a Novel Biomarker in ccRCC Based on a Large-Scale CRISPR-Cas9 Screening Database and Immunohistochemistry Open
Background: The genome-wide CRISPR-cas9 dropout screening has emerged as an outstanding approach for characterization of driver genes of tumor growth. The present study aims to investigate core genes related to clear cell renal cell carcin…
View article: The Expression and Prognostic Value of SUMO1-Activating Enzyme Subunit 1 and Its Potential Mechanism in Triple-Negative Breast Cancer
The Expression and Prognostic Value of SUMO1-Activating Enzyme Subunit 1 and Its Potential Mechanism in Triple-Negative Breast Cancer Open
Background: Triple-negative breast cancer (TNBC) is the most invasive and metastatic subtype of breast cancer. SUMO1-activating enzyme subunit 1 (SAE1), an E1-activating enzyme, is indispensable for protein SUMOylation. SAE1 has been found…
View article: Regulatory Non-coding RNAs for Death Associated Protein Kinase Family
Regulatory Non-coding RNAs for Death Associated Protein Kinase Family Open
The death associated protein kinases (DAPKs) are a family of calcium dependent serine/threonine kinases initially identified in the regulation of apoptosis. Previous studies showed that DAPK family members, including DAPK1, DAPK2 and DAPK3…
View article: A smooth brown snake-skin like hemispherical bulge in the stomach
A smooth brown snake-skin like hemispherical bulge in the stomach Open
A 47-year-old Chinese female was admitted for epigastric discomfort and the gastric endoscopy showed an approximately 3 cm hemispherical mucosal bulge, with a smooth brown snake-skin like surface, on the anterior wall of the lower gastric …