Wenting Zhou
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View article: Bioinformatics-Based Analysis of the Screening and Evaluation of Potential Targets of FTY720 for the Treatment of Non-Small Cell Lung Cancer
Bioinformatics-Based Analysis of the Screening and Evaluation of Potential Targets of FTY720 for the Treatment of Non-Small Cell Lung Cancer Open
Background: A range of cancer cells are significantly inhibited by FTY720. It is unknown, nevertheless, how FTY720 influences the onset of non-small cell lung cancer (NSCLC). Using bioinformatics techniques, we analyzed and the possible mo…
View article: A visualized machine learning model using noninvasive parameters to differentiate men with and without prostatic carcinoma before biopsy
A visualized machine learning model using noninvasive parameters to differentiate men with and without prostatic carcinoma before biopsy Open
This study aimed to create a visualized extreme gradient boosting (XGBOOST) model to distinguish prostatic carcinoma (PCA) from non-PCA using noninvasive prebiopsy parameters before biopsy. This was a cross-sectional study of 310 Chinese m…
View article: Drugging the 'undruggable' KRAS: breakthroughs, challenges, and opportunities in pancreatic cancer.
Drugging the 'undruggable' KRAS: breakthroughs, challenges, and opportunities in pancreatic cancer. Open
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a poor prognosis that is driven primarily by oncogenic KRAS mutations present in > 90% of cases. KRAS mutations, particularly the G12D mutation which dominates in PDA…
View article: Isolation and Bioactive Characterization of Berberis kaschgarica Rupr-Derived Exosome-Like Nanovesicles: Exploring Therapeutic Potential in Atherosclerosis Pathogenesis
Isolation and Bioactive Characterization of Berberis kaschgarica Rupr-Derived Exosome-Like Nanovesicles: Exploring Therapeutic Potential in Atherosclerosis Pathogenesis Open
Berberis kaschgarica Rupr.-derived exosome-like nanovesicles (BELNs), a type of plant-derived extracellular vesicle, consist of proteins, lipids, and nucleic acids. In this research, we employed differential centrifugation and ultracentrif…
View article: Advances in Plant-Derived Extracellular Vesicle Extraction Methods and Pharmacological Effects
Advances in Plant-Derived Extracellular Vesicle Extraction Methods and Pharmacological Effects Open
Extracellular vesicles (EVs) are those with a double-membrane structure that contains proteins, lipids, nucleic acids, and other biologically active substances that play an important role in cell–cell and cell–environment communication. Th…
View article: Shared Genomic Features Between Lung Adenocarcinoma and Type 2 Diabetes: A Bioinformatics Study
Shared Genomic Features Between Lung Adenocarcinoma and Type 2 Diabetes: A Bioinformatics Study Open
Background: Lung adenocarcinoma (LUAD) is a common histopathological variant of non-small cell lung cancer. Individuals with type 2 diabetes (T2DM) face an elevated risk of developing LUAD. We examined the common genomic characteristics be…
View article: Maculopathy after long-term use of fondaparinux, a heparin mimetic and heparanase inhibitor
Maculopathy after long-term use of fondaparinux, a heparin mimetic and heparanase inhibitor Open
View article: Elucidating the multi-target pharmacological mechanism of Xiaoyandina for the treatment of hepatitis C virus based on bioinformatics and cyberpharmacology studies
Elucidating the multi-target pharmacological mechanism of Xiaoyandina for the treatment of hepatitis C virus based on bioinformatics and cyberpharmacology studies Open
An estimated 170 million people worldwide suffer from chronic hepatitis C virus (HCV) infection, which is the main reason for liver transplantation in numerous nations. Traditional Chinese medicine is also frequently employed in medicine t…
View article: Bioinformatics Analysis of the Anti-Inflammatory Mechanism and Potential Therapeutic Efficacy of Kezimuke granules in Treating Urinary Tract Infections by Inhibiting NLRP3 Inflammasome Activation
Bioinformatics Analysis of the Anti-Inflammatory Mechanism and Potential Therapeutic Efficacy of Kezimuke granules in Treating Urinary Tract Infections by Inhibiting NLRP3 Inflammasome Activation Open
Kezimuke granules (KZMK), derived from traditional Kazakh folk medicine, exhibit a variety of pharmacological properties. Long-term clinical studies have demonstrated their efficacy in clearing heat, detoxifying, promoting qi circulation, …
View article: Genetic insights and therapeutic avenues: unraveling the role of polyunsaturated fatty acids as mediators between hypothyroidism and Von Willebrand disease through Mendelian randomization
Genetic insights and therapeutic avenues: unraveling the role of polyunsaturated fatty acids as mediators between hypothyroidism and Von Willebrand disease through Mendelian randomization Open
Background Previous observational studies have shown that Hypothyroidism is associated with Von Willebrand Disease (VWD), but the causal relationship has not been confirmed because of conflicting findings and confounding by mixing factors.…
View article: How Urban Road Characteristics Affect Urban Carbon Emissions: Empirical Evidence in China
How Urban Road Characteristics Affect Urban Carbon Emissions: Empirical Evidence in China Open
View article: Challenges and Countermeasures of Marine Ecological and Environmental Governance in the Guangdong-Hong Kong-Macao Greater Bay Area - Based on the Perspective of Multi-Level Governance
Challenges and Countermeasures of Marine Ecological and Environmental Governance in the Guangdong-Hong Kong-Macao Greater Bay Area - Based on the Perspective of Multi-Level Governance Open
View article: Challenges and Countermeasures of Marine Ecological and Environmental Governance in the Guangdong-Hong Kong-Macao Greater Bay Area - Based on the Perspective of Multi-Level Governance
Challenges and Countermeasures of Marine Ecological and Environmental Governance in the Guangdong-Hong Kong-Macao Greater Bay Area - Based on the Perspective of Multi-Level Governance Open
View article: Challenges and Countermeasures of Marine Ecological and Environmental Governance in Guangdong, Hong Kong and Macao Greater Bay Area --Based on the Perspective of Multi-Level Governance
Challenges and Countermeasures of Marine Ecological and Environmental Governance in Guangdong, Hong Kong and Macao Greater Bay Area --Based on the Perspective of Multi-Level Governance Open
View article: A thermostatically controlled loads regulation method based on hybrid communication and cloud–edge–end collaboration
A thermostatically controlled loads regulation method based on hybrid communication and cloud–edge–end collaboration Open
View article: Screening of Hub Genes and Therapeutic Drugs in Cervical Cancer Using Integrated Bioinformatics Analysis
Screening of Hub Genes and Therapeutic Drugs in Cervical Cancer Using Integrated Bioinformatics Analysis Open
Objective: Cervical cancer (CC) is one of the most common female malignancies globally. The current study aimed to identify novel hub genes associated with traditional Chinese herbs and investigate their underlying mechanisms using …
View article: Optimization of Ultrasound Extraction of Total Anthocyanin From <i>Berberis kaschgarica</i> Rupr. by Response Surface Methodology and Its Antihypertensive Effect
Optimization of Ultrasound Extraction of Total Anthocyanin From <i>Berberis kaschgarica</i> Rupr. by Response Surface Methodology and Its Antihypertensive Effect Open
Berberis kaschgarica Rupr. is a berry fruit shrub found in the north‐western region of China, locally its fruit is consumed as a tea ingredient a part of the daily diet, for treatment of different diseases like eczema, and for cardiovascul…
View article: Searching for Hub Genes of Quince–Basil Co-Administration Against Atherosclerosis Using Bioinformatics Analysis and Experimental Validation
Searching for Hub Genes of Quince–Basil Co-Administration Against Atherosclerosis Using Bioinformatics Analysis and Experimental Validation Open
Background: Atherosclerosis (AS) has one of the highest rates of morbidity and death globally. Cydonia oblonga Mill. (quince, COM) and Ocimum basilicum L. (basil, OB) are Uyghur medicines that are often used for anti-inflammatory, anti-tum…
View article: Global, regional, and national burden of HIV-negative tuberculosis, 1990–2021: findings from the Global Burden of Disease Study 2021
Global, regional, and national burden of HIV-negative tuberculosis, 1990–2021: findings from the Global Burden of Disease Study 2021 Open
View article: Global, regional, and national burden of HIV-negative tuberculosis, 1990–2021: Findings from the Global Burden of Disease 2021 Study
Global, regional, and national burden of HIV-negative tuberculosis, 1990–2021: Findings from the Global Burden of Disease 2021 Study Open
Background Tuberculosis (TB) is an infectious disease primarily caused by the inhalation of Mycobacterium tuberculosis(Mtb). Its widespread transmission, lengthy treatment duration, significant side effects, and high mortality rate severel…
View article: Evaluation of the Efficacy of OSU-2S in the Treatment of Non-Small-Cell Lung Cancer and Screening of Potential Targets of Action
Evaluation of the Efficacy of OSU-2S in the Treatment of Non-Small-Cell Lung Cancer and Screening of Potential Targets of Action Open
(1) Background: OSU-2S is a derivative of FTY720 and exhibits significant inhibitory effects on various cancer cells. There is currently no research on the mechanism of the impact of OSU-2S on NSCLC development. We analysed and validated t…
View article: Musashi-2 potentiates colorectal cancer immune infiltration by regulating the post-translational modifications of HMGB1 to promote DCs maturation and migration
Musashi-2 potentiates colorectal cancer immune infiltration by regulating the post-translational modifications of HMGB1 to promote DCs maturation and migration Open
Post-translational modifications (PTMs) of the non-histone protein high-mobility group protein B1 (HMGB1) are involved in modulating inflammation and immune responses. Recent studies have implicated that the RNA-binding protein (RBP) Musas…
View article: Antitumor effects of a novel photosensitizer-mediated photodynamic therapy and its influence on the cell transcriptome
Antitumor effects of a novel photosensitizer-mediated photodynamic therapy and its influence on the cell transcriptome Open
Photodynamic therapy (PDT) is a promising cancer treatment. This study investigated the antitumor effects and mechanisms of a novel photosensitizer meso-5-[ρ-diethylene triamine pentaacetic acid-aminophenyl]-10,15,20-triphenyl-porphyrin (D…
View article: Musashi-2 Deficiency Triggers Colorectal Cancer Ferroptosis by Downregulating the MAPK Signaling Cascade to Inhibit HSPB1 Phosphorylation
Musashi-2 Deficiency Triggers Colorectal Cancer Ferroptosis by Downregulating the MAPK Signaling Cascade to Inhibit HSPB1 Phosphorylation Open
View article: Investigation of target genes and potential mechanisms related to compound Xiao-ai-fei honey ointment based on network pharmacology and bioinformatics analysis
Investigation of target genes and potential mechanisms related to compound Xiao-ai-fei honey ointment based on network pharmacology and bioinformatics analysis Open
Background: Compound Xiao-ai-fei honey ointment (CXHO) is an anticancer preparation with a long history in Uyghur folk medicine in China and has been used for the treatment of gastric cancer (GC) in Xinjiang, China. Nevertheless, the mecha…
View article: Exploring the hub genes and mechanisms of Daphne altaica treating esophageal squamous cell carcinoma based on network pharmacology and bioinformatics analysis
Exploring the hub genes and mechanisms of Daphne altaica treating esophageal squamous cell carcinoma based on network pharmacology and bioinformatics analysis Open
View article: Exploring the hub genes and mechanisms of Daphne altaica. treating esophageal squamous cell carcinoma based on Network Pharmacology and Bioinformatics Analysis
Exploring the hub genes and mechanisms of Daphne altaica. treating esophageal squamous cell carcinoma based on Network Pharmacology and Bioinformatics Analysis Open
Purpose Esophageal squamous cell carcinoma (ESCC), is a frequent digestive tract malignant carcinoma with a high fatality rate. Daphne altaica. ( D. altaica ), a medicinal plant that is frequently employed in Kazakh traditional medicine, a…
View article: Surveillance of SARS-CoV-2 at the Huanan Seafood Market
Surveillance of SARS-CoV-2 at the Huanan Seafood Market Open
View article: Total Flavone Content of Cydonia oblonga Miller Inhibits Proliferation and Migration of Renal Carcinoma Cells by Inhibiting the S1PR2/FAK Pathway
Total Flavone Content of Cydonia oblonga Miller Inhibits Proliferation and Migration of Renal Carcinoma Cells by Inhibiting the S1PR2/FAK Pathway Open
Cydonia oblonga Miller (C. oblonga) is known for its beneficial properties for health since ancient times. C. oblonga has also been shown to possess antihemolytic, antidiabetic, and antilipoperoxidation, as well as lipid-lowering propertie…
View article: Quince extract resists atherosclerosis in rats by down-regulating the EGFR/PI3K/Akt/GSK-3β pathway
Quince extract resists atherosclerosis in rats by down-regulating the EGFR/PI3K/Akt/GSK-3β pathway Open
We identified the effective components and the underlying mechanisms of Quince (Cydonia oblonga Mill, COM) extract against atherosclerosis. The effective components of COM extract were identified with UHPLC-Q-TOF-MS/MS. Network pharmacolog…