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View article: Noninvasive Evaluation of Trop2 Expression Using <sup>64</sup> Cu-NOTA-Trodelvy-F(ab’) <sub>2</sub> in Gastric and Pancreatic Cancer
Noninvasive Evaluation of Trop2 Expression Using <sup>64</sup> Cu-NOTA-Trodelvy-F(ab’) <sub>2</sub> in Gastric and Pancreatic Cancer Open
This study aimed to develop and evaluate a 64Cu-labeled NOTA-conjugated F(ab')2 fragment of Trodelvy for ImmunoPET imaging of Trop2 expression in gastric and pancreatic cancer models. Trodelvy was enzymatically digested using IdeS protease…
View article: PSMA PET‐directed radiotherapy for prostate cancer: From precision planning to future innovations
PSMA PET‐directed radiotherapy for prostate cancer: From precision planning to future innovations Open
Positron emission tomography (PET), particularly with prostate‐specific membrane antigen (PSMA) tracers, has revolutionized the clinical management of prostate cancer (PCa). This review highlights the pivotal role of PET molecular imaging …
View article: [<sup>64</sup>Cu]Cu-NOTA-EV-F(ab′)<sub>2</sub> Enables Same-Day Immuno-PET Imaging of Nectin-4 in Triple-Negative Breast and Urothelial Bladder Cancers
[<sup>64</sup>Cu]Cu-NOTA-EV-F(ab′)<sub>2</sub> Enables Same-Day Immuno-PET Imaging of Nectin-4 in Triple-Negative Breast and Urothelial Bladder Cancers Open
Our study aimed to develop and evaluate [64Cu]Cu-NOTA-EV-F(ab')2 for immuno-PET imaging of nectin-4 expression in triple-negative breast cancer (TNBC) and urothelial bladder cancer (UBC) models, with the goal of achieving rapid, specific t…
View article: ALMformer: a modified Transformer based on Adaptive frequency enhanced attention, large kernel convolution, and multi-scale implementation for bearing fault diagnosis
ALMformer: a modified Transformer based on Adaptive frequency enhanced attention, large kernel convolution, and multi-scale implementation for bearing fault diagnosis Open
Bearing fault diagnosis has attracted increasing attention due to its critical role in monitoring the health of rotating machinery. Data-driven models based on deep learning (DL) have demonstrated powerful capabilities in feature extractio…
View article: Rapid and specific immunoPET imaging of Nectin-4 in gastric cancer and non-small cell lung cancer using [64Cu]Cu-NOTA-EV-F(ab’)2
Rapid and specific immunoPET imaging of Nectin-4 in gastric cancer and non-small cell lung cancer using [64Cu]Cu-NOTA-EV-F(ab’)2 Open
Purpose This study aimed to develop and evaluate [ 64 Cu]Cu-NOTA-EV-F(ab’) 2 as a rapid and specific immunoPET imaging probe targeting Nectin-4 in gastric cancer (GC) and non-small cell lung cancer (NSCLC). Materials and methods F(ab’) 2 f…
View article: Radiolabeled Nanogels: From Multimodality Imaging to Combination Therapy of Cancer
Radiolabeled Nanogels: From Multimodality Imaging to Combination Therapy of Cancer Open
Advancements in nanotechnology over the past few decades have offered tremendous possibilities toward cancer theranostics. Radiolabeled nanogels (NGs) represent a promising nanoplatform in this direction, offering a multifunctional toolset…
View article: In situ radiochemical doping of functionalized inorganic nanoplatforms for theranostic applications: a paradigm shift in nanooncology
In situ radiochemical doping of functionalized inorganic nanoplatforms for theranostic applications: a paradigm shift in nanooncology Open
In situ radiochemical doping presents a transformative approach for synthesizing radiolabeled inorganic nanoparticles (NPs) for cancer theranostics. Traditional radiolabeling techniques rely on bifunctional chelators, which often require h…
View article: A human pose estimation network based on YOLOv8 framework with efficient multi-scale receptive field and expanded feature pyramid network
A human pose estimation network based on YOLOv8 framework with efficient multi-scale receptive field and expanded feature pyramid network Open
Deep neural networks are used to accurately detect, estimate, and predict human body poses in images or videos through deep learning-based human pose estimation. However, traditional multi-person pose estimation methods face challenges due…
View article: Conformal Retinal Image Sensor Based on Electrochemically Exfoliated MoS2 Nanosheets
Conformal Retinal Image Sensor Based on Electrochemically Exfoliated MoS2 Nanosheets Open
Retina-like photoimaging devices with features such as a wide-field-of-view and high spatial resolution have wide application prospects in retinal prosthetics and remote sensing. However, the fabrication of flexible and conformal surfaces …
View article: Nectin4‐targeted molecular imaging in solid tumors: Current status and future perspectives
Nectin4‐targeted molecular imaging in solid tumors: Current status and future perspectives Open
Nectin cell adhesion molecule 4 (Nectin4), a Ca 2+ ‐independent immunoglobulin‐like cell adhesion molecule, plays a role in both physiological and pathological processes. Nectin4 is physiologically expressed at minimal levels in most norma…
View article: Development and Preclinical Evaluation of [<sup>64</sup>Cu]Cu-NOTA-ABDB6: A CD70 and Albumin Dual-Binding Tracer with Improved Pharmacokinetics
Development and Preclinical Evaluation of [<sup>64</sup>Cu]Cu-NOTA-ABDB6: A CD70 and Albumin Dual-Binding Tracer with Improved Pharmacokinetics Open
CD70 is an emerging biomarker for both solid tumors and hematologic malignancies, highlighting the urgent need for a molecular imaging tracer capable of visualizing CD70 with favorable pharmacokinetics. Methods: ABDB6 was prepared by fusin…
View article: Biomineralized Nanocomposite‐Integrated Microneedle Patch for Combined Brachytherapy and Photothermal Therapy in Postoperative Melanoma Recurrence and Infectious Wound Healing
Biomineralized Nanocomposite‐Integrated Microneedle Patch for Combined Brachytherapy and Photothermal Therapy in Postoperative Melanoma Recurrence and Infectious Wound Healing Open
In the surgical management of malignant melanoma, incomplete tumor resection and large‐area cutaneous defects are major contributors to high locoregional recurrence and uncontrolled wound infections, resulting in poor prognosis and prolong…
View article: Voices of Nanomedicine: Blueprint Guidelines for Collaboration in Addressing Global Unmet Medical Needs
Voices of Nanomedicine: Blueprint Guidelines for Collaboration in Addressing Global Unmet Medical Needs Open
The "Voices" under this Perspective underline the importance of interdisciplinary collaboration and partnerships across several disciplines, such as medical science and technology, medicine, bioengineering, and computational approaches, in…
View article: [89Zr]Zr-DFO-Trodelvy immunoPET for noninvasive Trop2 imaging in bladder cancer
[89Zr]Zr-DFO-Trodelvy immunoPET for noninvasive Trop2 imaging in bladder cancer Open
[89Zr]Zr-DFO-Trodelvy enables precise immunoPET imaging of bladder cancer models with high Trop2 expression, demonstrating specific and sustained tumor accumulation. These findings highlight the potential of this imaging approach for the n…
View article: A fault diagnosis method for rolling bearing based on gram matrix and multiscale convolutional neural network
A fault diagnosis method for rolling bearing based on gram matrix and multiscale convolutional neural network Open
The safety and reliability of rotating machinery hinge significantly on the proper functioning of rolling bearings. In the last few years, there have been significant advances in the algorithms for intelligent fault diagnosis of bearings. …
View article: Immuno-PET Imaging of CD93 Expression with <sup>64</sup>Cu-Radiolabeled NOTA-mCD93 ([<sup>64</sup>Cu]Cu-NOTA-mCD93) and Insulin-Like Growth Factor Binding Protein 7 ([<sup>64</sup>Cu]Cu-NOTA-IGFBP7)
Immuno-PET Imaging of CD93 Expression with <sup>64</sup>Cu-Radiolabeled NOTA-mCD93 ([<sup>64</sup>Cu]Cu-NOTA-mCD93) and Insulin-Like Growth Factor Binding Protein 7 ([<sup>64</sup>Cu]Cu-NOTA-IGFBP7) Open
CD93 is overexpressed in multiple solid tumor types, serving as a novel target for antiangiogenic therapy. The goal of this study was to develop a 64Cu-based positron emission tomography (PET) tracer for noninvasive imaging of CD93 express…
View article: Trop2-Targeted Molecular Imaging in Solid Tumors: Current Advances and Future Outlook
Trop2-Targeted Molecular Imaging in Solid Tumors: Current Advances and Future Outlook Open
Trophoblast cell surface antigen 2 (Trop2), a transmembrane glycoprotein, plays a dual role in physiological and pathological processes. In healthy tissues, Trop2 facilitates development and orchestrates intracellular calcium signaling. Ho…
View article: Figure S4 from Expression and therapeutic targeting of Trop-2 in treatment resistant prostate cancer
Figure S4 from Expression and therapeutic targeting of Trop-2 in treatment resistant prostate cancer Open
Figure S4. Biodistribution Study
View article: Figure S2 from Expression and therapeutic targeting of Trop-2 in treatment resistant prostate cancer
Figure S2 from Expression and therapeutic targeting of Trop-2 in treatment resistant prostate cancer Open
Figure S2. Capture Efficiency of Trop-2 Expressing Cell Lines.