Wenwei Qian
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View article: Femoral head diameter varies widely in hips with developmental dysplasia and predicts acetabular component size in total hip arthroplasty
Femoral head diameter varies widely in hips with developmental dysplasia and predicts acetabular component size in total hip arthroplasty Open
Aims The aim of this study was to explore the relationship between the femoral head diameter (FHD) and the degree of subluxation in developmental dysplasia of the hip (DDH) patients, and develop a machine-learning model for predicting acet…
View article: Optimized Lipid Nanoparticle-Mediated mRNA Co-Delivery of SOX5/SOX9 Enables Synergistic Senescence Reversal for Osteoarthritis Therapy
Optimized Lipid Nanoparticle-Mediated mRNA Co-Delivery of SOX5/SOX9 Enables Synergistic Senescence Reversal for Osteoarthritis Therapy Open
This work provides an advanced, synergistic mRNA therapeutic approach employing optimized LNPs to alleviate chondrocyte senescence and stimulate cartilage regeneration, representing a promising strategy for OA intervention.
View article: Investigating the Impact of Circulating MicroRNAs on Knee and Hip Osteoarthritis: Causal Links, Biological Mechanisms, and Drug Interactions
Investigating the Impact of Circulating MicroRNAs on Knee and Hip Osteoarthritis: Causal Links, Biological Mechanisms, and Drug Interactions Open
Osteoarthritis (OA), particularly in the knee and hip, poses a significant global health challenge due to limited therapeutic options. To elucidate the molecular mechanisms of OA and identify potential biomarkers and therapeutic targets, w…
View article: Macrophage Polarization in the Osteoarthritis Pathogenesis and Treatment
Macrophage Polarization in the Osteoarthritis Pathogenesis and Treatment Open
Osteoarthritis (OA) is a prevalent degenerative disorder that severely impacts quality of life due to pain and disability. Although the pathophysiology of OA remains incompletely understood, recent research highlights the role of synovial …
View article: Gender, <scp>BMI</scp>, and Age‐Related Variations in Lower Limb Alignment Parameters and <scp>CPAK</scp> Phenotypes in Chinese Patients with Knee Osteoarthritis
Gender, <span>BMI</span>, and Age‐Related Variations in Lower Limb Alignment Parameters and <span>CPAK</span> Phenotypes in Chinese Patients with Knee Osteoarthritis Open
Objectives Research on the distribution of and the variation in coronal plane alignment of the knee (CPAK) in the Chinese osteoarthritis population is limited. We aimed to establish the CPAK classification based on the characteristics of l…
View article: Incidence of and risk factors for preoperative deep vein thrombosis in elderly patients with end-stage osteoarthritis following total knee arthroplasty: a retrospective cohort study
Incidence of and risk factors for preoperative deep vein thrombosis in elderly patients with end-stage osteoarthritis following total knee arthroplasty: a retrospective cohort study Open
View article: The role and current research status of resveratrol in the treatment of osteoarthritis and its mechanisms: a narrative review
The role and current research status of resveratrol in the treatment of osteoarthritis and its mechanisms: a narrative review Open
Osteoarthritis (OA) is a chronic degenerative disease caused by various factors such as aging, obesity, trauma, and genetics. It is a challenging condition faced by orthopedic doctors in clinical practice and places a heavy burden on patie…
View article: Comparison of the safety and efficacy of three superficial skin closure methods for multi-layer wound closure in total knee arthroplasty: a multicenter, prospective, randomized controlled trial
Comparison of the safety and efficacy of three superficial skin closure methods for multi-layer wound closure in total knee arthroplasty: a multicenter, prospective, randomized controlled trial Open
Background Good wound healing is critical to infection prophylaxis and satisfactory rehabilitation in Total Knee Arthroplasty (TKA). Currently, two techniques, i.e., barbed continuous subcuticular suture without skin adhesive or combined u…
View article: The Effect of the Morphology of the Femur and Acetabulum in Dysplastic Hips on the Selection of Arthroplasty Femoral Implants: A Computer Tomography‐Based Study
The Effect of the Morphology of the Femur and Acetabulum in Dysplastic Hips on the Selection of Arthroplasty Femoral Implants: A Computer Tomography‐Based Study Open
Objectives Due to the technical challenges associated with femoral reconstruction in total hip arthroplasty for patients with developmental dysplasia of the hip (DDH), the exact indications for using femoral modular stems, despite their sa…
View article: Bone marrow mesenchymal stem cells in treatment of peripheral nerve injury
Bone marrow mesenchymal stem cells in treatment of peripheral nerve injury Open
Peripheral nerve injury (PNI) is a common neurological disorder and complete functional recovery is difficult to achieve. In recent years, bone marrow mesenchymal stem cells (BMSCs) have emerged as ideal seed cells for PNI treatment due to…
View article: Assessment of body composition-related imaging parameters indicative of sarcopenia in Chinese patients with Crohn’s disease: correlation with disease severity and biologic efficacy
Assessment of body composition-related imaging parameters indicative of sarcopenia in Chinese patients with Crohn’s disease: correlation with disease severity and biologic efficacy Open
SMI may indicate CD severity, while MFI and MA could predict biologic response. Integrating multiple body composition parameters enhances treatment outcome evaluation, suggesting their potential utility in CD assessment.
View article: Development and Validation of an Artificial Intelligence Preoperative Planning and Patient-Specific Instrumentation System for Total Knee Arthroplasty
Development and Validation of an Artificial Intelligence Preoperative Planning and Patient-Specific Instrumentation System for Total Knee Arthroplasty Open
Background: Accurate preoperative planning for total knee arthroplasty (TKA) is crucial. Computed tomography (CT)-based preoperative planning offers more comprehensive information and can also be used to design patient-specific instrumenta…
View article: PUFAs add fuel to Crohn’s disease-associated AIEC-induced enteritis by exacerbating intestinal epithelial lipid peroxidation
PUFAs add fuel to Crohn’s disease-associated AIEC-induced enteritis by exacerbating intestinal epithelial lipid peroxidation Open
Polyunsaturated fatty acids (PUFAs) have been shown to exacerbate Crohn's disease (CD) by promoting lipid peroxidation (LPO) of intestinal epithelial cells (IECs). Dysbiosis of the gut microbiota may play a crucial role in this process. CD…
View article: Correction to: Hypoxic ASCs-derived Exosomes Attenuate Colitis by Regulating Macrophage Polarization via miR-216a-5p/HMGB1 Axis
Correction to: Hypoxic ASCs-derived Exosomes Attenuate Colitis by Regulating Macrophage Polarization via miR-216a-5p/HMGB1 Axis Open
View article: Crohn’s disease-associated AIEC inhibiting intestinal epithelial cell-derived exosomal let-7b expression regulates macrophage polarization to exacerbate intestinal fibrosis
Crohn’s disease-associated AIEC inhibiting intestinal epithelial cell-derived exosomal let-7b expression regulates macrophage polarization to exacerbate intestinal fibrosis Open
The interaction between adherent-invasive Escherichia coli (AIEC) and intestinal macrophages is implicated in the pathogenesis of Crohn's disease (CD). However, its role in intestinal fibrogenesis and the underlying molecular mechan…
View article: Comparison of risk of complication between neuraxial anaesthesia and general anaesthesia for hip fracture surgery: a systematic review and meta-analysis
Comparison of risk of complication between neuraxial anaesthesia and general anaesthesia for hip fracture surgery: a systematic review and meta-analysis Open
Background: Controversy remains over the choice of anaesthetic technique for patients undergoing surgery for hip fracture. Aim: The aim was to compare the risk of complication of neuraxial anaesthesia with that of general anaesthesia in pa…
View article: Total Hip Arthroplasty in the Nonparalytic Limb of Residual Poliomyelitis Patients: A Propensity Score Matched Study
Total Hip Arthroplasty in the Nonparalytic Limb of Residual Poliomyelitis Patients: A Propensity Score Matched Study Open
Objective Poliomyelitis is a rare neuromuscular disease that can cause hip osteoarthritis on the contralateral side due to an abnormal mechanical weight‐bearing state, making some residual poliomyelitis patients candidates for total hip ar…
View article: Long-Term clinical results of patellofemoral arthroplasty for isolated patellofemoral osteoarthritis
Long-Term clinical results of patellofemoral arthroplasty for isolated patellofemoral osteoarthritis Open
Objectives The aim of this study was to explore the clinical outcomes and long-term survival of patellofemoral arthroplasty in treatment of isolated patellofemoral osteoarthritis. Methods We retrospectively studied a total of 46 type Y-L-Q…
View article: Total Knee Arthroplasty in Patients with Primary Sjögren’s Syndrome: A Retrospective Case-Control Study Matched Patients without Rheumatic Diseases
Total Knee Arthroplasty in Patients with Primary Sjögren’s Syndrome: A Retrospective Case-Control Study Matched Patients without Rheumatic Diseases Open
Background: The number of patients with primary Sjögren’s syndrome (pSS) who require total knee arthroplasty (TKA) is expected to increase, and there are few studies describing their outcomes. This research was focused on the evaluation of…
View article: Computer Navigation Assisted Restricted Kinematic Alignment Improves Short‐Term Outcomes in Total Knee Arthroplasty: An Ambispective Cohort Study
Computer Navigation Assisted Restricted Kinematic Alignment Improves Short‐Term Outcomes in Total Knee Arthroplasty: An Ambispective Cohort Study Open
Objectives Mechanical alignment (MA)‐total knee arthroplasty (TKA) has been challenged due to the excessive soft tissue release and the evidence of the clinical outcomes of computer assisted navigation is still limited. The aim of this amb…
View article: Obesity paradox among patients undergoing total knee arthroplasty: a retrospective cohort study
Obesity paradox among patients undergoing total knee arthroplasty: a retrospective cohort study Open
Background Obesity has been recognized as the risk factor for postoperative complication for surgical patients. However, recent studies have showed protective effect of obesity in surgical and non-surgical patients. Our study is to examine…
View article: Goals, challenges and strategies for wound and bleeding management in total knee arthroplasty: A modified Delphi method
Goals, challenges and strategies for wound and bleeding management in total knee arthroplasty: A modified Delphi method Open
Background Surgical techniques related to soft tissue management play critical roles in optimizing surgical outcomes and patient satisfaction in total knee arthroplasty (TKA). Despite the importance of wound closure and bleeding management…
View article: Primary Sjögren’s syndrome is not associated with poor outcomes after total hip arthroplasty: a retrospective case–control study with a matched cohort of osteoarthritis patients
Primary Sjögren’s syndrome is not associated with poor outcomes after total hip arthroplasty: a retrospective case–control study with a matched cohort of osteoarthritis patients Open
View article: Effect of alendronate sodium plus vitamin D3 tablets on knee joint structure and osteoarthritis pain: a multi-center, randomized, double-blind, placebo-controlled study protocol
Effect of alendronate sodium plus vitamin D3 tablets on knee joint structure and osteoarthritis pain: a multi-center, randomized, double-blind, placebo-controlled study protocol Open
View article: Validation of <scp>CT</scp>‐Based Three‐Dimensional Preoperative Planning in Comparison with Acetate Templating for Primary Total Hip Arthroplasty
Validation of <span>CT</span>‐Based Three‐Dimensional Preoperative Planning in Comparison with Acetate Templating for Primary Total Hip Arthroplasty Open
Objective This study aims to compare the accuracy of CT‐based preoperative planning with that of acetate templating in predicting implant size, neck length, and neck cut length, and to evaluate the reproducibility of the two methods. Metho…
View article: The Effect of a Local Injection of Flurbiprofen Ester Microspheres on Systemic Inflammatory Model Rats With a Closed Femoral Shaft Fracture
The Effect of a Local Injection of Flurbiprofen Ester Microspheres on Systemic Inflammatory Model Rats With a Closed Femoral Shaft Fracture Open
Background: Periarticular injections with a combination of local anesthetics, non-steroidal anti-inflammatory analgesics (NSAIDs), and epinephrine are becoming increasingly popular in the perioperative analgesia of artificial joint replace…
View article: Development and Validation of an Artificial Intelligence Preoperative Planning System for Total Hip Arthroplasty
Development and Validation of an Artificial Intelligence Preoperative Planning System for Total Hip Arthroplasty Open
Background Accurate preoperative planning is essential for successful total hip arthroplasty (THA). However, the requirements of time, manpower, and complex workflow for accurate planning have limited its application. This study aims to de…
View article: Surgical treatment of femoroacetabular impingement in a patient with Stickler syndrome: a case report
Surgical treatment of femoroacetabular impingement in a patient with Stickler syndrome: a case report Open
Stickler syndrome is a multisystem connective tissue disorder caused by mutations in collagen genes that can present with craniofacial, ocular, audial, or skeletal abnormalities. Here, we report on a male patient with a COL2A1 misse…
View article: Possible Risk Factors for Severe Complications Occurring after Primary Total Knee Arthroplasty
Possible Risk Factors for Severe Complications Occurring after Primary Total Knee Arthroplasty Open
Objective Total knee arthroplasty is one of the most common orthopedic surgeries. Readmission due to severe complications after total knee arthroplasty is a grave concern to surgeons. In this study, we evaluated the risk factors for severe…
View article: Degree of coronal alignment correction can’t predict knee function in total knee replacement
Degree of coronal alignment correction can’t predict knee function in total knee replacement Open