Explanipedia

Siglec-15 antibody–GM-CSF chimera suppresses tumor progression via reprogramming tumor-associated macrophages Open

Zemeng Ma, Xiaoyao Hao, Shuang Qu, Quanli Zhang, Jiajing Luo , et al. · 2025

Background Sialic acid-binding immunoglobulin-like lectin (Siglec)-15-expressing tumor-associated macrophages (TAMs) drive immunosuppression in the tumor microenvironment (TME), promoting CD8 + T cell exhaustion and limiting immunotherapy …

Co-LLaVA: Efficient Remote Sensing Visual Question Answering via Model Collaboration Open

Fan Liu, Wenwen Dai, Chuanyi Zhang, Jiale Zhu, Lin Yao , et al. · 2025

Large vision language models (LVLMs) are built upon large language models (LLMs) and incorporate non-textual modalities; they can perform various multimodal tasks. Applying LVLMs in remote sensing (RS) visual question answering (VQA) tasks…

Retinoic Acid Regulates Allergic Inflammation via Limiting Mast Cell Activation Open

Wenxin Zhang, Wenwen Dai, Yinghong Xie, Xingyang Chen, Peng Zhang , et al. · 2025

BackgroundAllergic diseases have become one of the major public health problems to be addressed in the world today. As a tissue resident cell, mast cells are crucial in the pathogenesis of allergic diseases. Vitamin A is an important fat‐s…

1425 BSI-118, a novel anti-B7H7 antibody antagonizing B7H7-KIR3DL3 signaling pathway without affecting B7H7-TMIGD2 stimulatory signaling pathway Open

Hui Wang, Wenwen Dai, Jinyu Liu, Hongyan Li, Xiaodong Liu , et al. · 2024

1423 BSI-120, a fully human anti-MICA/B antibody with enhanced Fc receptor function, prevents MICA/B shedding and reinforces anti-tumor immunity Open

Wenwen Dai, Jinyu Liu, Hongyan Li, Xiaodong Liu, Shukai Xia , et al. · 2024

1424 BSI-115, a novel anti-Vγ9Vδ2 agonist monoclonal antibody, promotes Vγ9Vδ2 T cell activity against tumor cells Open

Hongyan Li, Wenwen Dai, Jinyu Liu, Xiaodong Liu, Shukai Xia , et al. · 2024

Few-shot adaptation of multi-modal foundation models: a survey Open

Fan Liu, Tianshu Zhang, Wenwen Dai, Chuanyi Zhang, Wenwen Cai , et al. · 2024

Multi-modal (vision-language) models, such as CLIP, are replacing traditional supervised pre-training models (e.g., ImageNet-based pre-training) as the new generation of visual foundation models. These models with robust and aligned semant…

Influence mechanism of emulsion collector on the flotation effect of coal gasification fine slag Open

Panpan Fan, Wenwen Dai, Xiaoting Fan, Lianping Dong, Jiancheng Wang , et al. · 2024

Coal gasification slag (CGS) presents significant challenge to the green and low-carbon development of the coal gasification industry due to its limited utilization restriction. In this study, cationic surfactant DTAB was used with kerosen…

Few-shot Adaptation of Multi-modal Foundation Models: A Survey Open

Fan Liu, Tianshu Zhang, Wenwen Dai, Wenwen Cai, Xiaocong Zhou , et al. · 2024

Multi-modal (vision-language) models, such as CLIP, are replacing traditional supervised pre-training models (e.g., ImageNet-based pre-training) as the new generation of visual foundation models. These models with robust and aligned semant…

Siglec-15 Antibody-GM-CSF Chimera Suppresses Tumor Progression via Reprogramming Tumor-Associated Macrophages Open

Zemeng Ma, Xiaoyao Hao, Shuang Qu, Quanli Zhang, Jiajing Luo , et al. · 2024

Few-Shot Image Classification via Mutual Distillation Open

T Zhang, Wenwen Dai, Zhiyu Chen, Sai Yang, Fan Liu , et al. · 2023

Due to their compelling performance and appealing simplicity, metric-based meta-learning approaches are gaining increasing attention for addressing the challenges of few-shot image classification. However, many similar methods employ intri…

1176 BSI-510, a novel bispecific molecule combining an anti-Siglec-15 antibody with cytokine GM-CSF for enhanced antitumor efficacy Open

Zemeng Ma, Xiaoyao Hao, Xiaodong Liu, Hongyan Li, Wenwen Dai , et al. · 2023

Background Siglec-15 has increased expression levels not only in solid tumors but also in tumor associated macrophages. It is an immune suppressive molecule that inhibits T cell activity in the tumor microenvironment (TME). Siglec-15 block…

1151 Antibody-drug conjugates targeting CLDN18.2 for the treatment of solid tumors Open

Xiaoyao Hao, Jinyu Liu, Xiaodong Liu, Hongyan Li, Jun Li , et al. · 2023

Background CLDN18.2 protein, an isoform of Claudin 18, is a member of the tight junction proteins with four transmembrane regions and two extracellular loops. It is limited expressed in gastric mucosa in normal healthy tissues, but is high…

Few-shot Adaptation of Multi-modal Foundation Models: A Survey Open

Fan Liu, Tianshu Zhang, Wenwen Dai, Wenwen Cai, Xiaocong Zhou , et al. · 2023

Multi-modal models, such as CLIP, are replacing traditional supervised pre-training models (e.g., ImageNet-based pre-training) as the new generation of foundational visual models. These multi-modal models with robust and aligned semantic r…

Amelioration effects of the soybean lecithin–gallic acid complex on iron-overload-induced oxidative stress and liver damage in C57BL/6J mice Open

Caihong Wu, Wenxin Zhang, Feifei Yan, Wenwen Dai, Fang Fang , et al. · 2022

These findings encourage the use of SL-GAC to treat liver injury induced by iron-overloaded. Further in vivo and in vitro studies are needed to validate its potential in clinical medicine.

The difference of gut microbiome in different biliary diseases in infant before operation and the changes after operation Open

Xinhe Sun, Yaoyao Cai, Wenwen Dai, Weiwei Jiang, Weibing Tang · 2022

Background Evidence supports an association between cholestatic liver disease and changes in microbiome composition. Nevertheless, the identification of this special type of biliary atresia from non-biliary atresia cholestasis is still a m…

K5BW12O40 Induces the Apoptosis of A549 Cells by Regulating Caspase-3 Open

Liping Liu, Shanshan Liu, Renli Liu, Wenwen Dai, Chaojie Wei , et al. · 2022

Objective. The purpose of the study is to explore the effect of K5BW12O40, a polyoxometalate (POM), on the apoptosis of A549 cells and its underlying mechanism and to analyze the potential therapeutic effect of K5BW12O40 in non-small-cell …

Let AI Perform Better Next Time—A Systematic Review of Medical Imaging-Based Automated Diagnosis of COVID-19: 2020–2022 Open

Fan Liu, Delong Chen, Xiaocong Zhou, Wenwen Dai, Feng Xu · 2022

The pandemic of COVID-19 has caused millions of infections, which has led to a great loss all over the world, socially and economically. Due to the false-negative rate and the time-consuming characteristic of the Reverse Transcription Poly…

Association between the Phytochemical Index and Overweight/Obesity: A Meta-Analysis Open

Chaojie Wei, Liping Liu, Renli Liu, Wenwen Dai, Weiwei Cui , et al. · 2022

Some studies suggest that a higher phytochemical index (PI) is associated with a lower risk of overweight/obesity. This meta-analysis is performed to summarize published studies on the relationship of PI and the risk of overweight/obesity.…

The difference of gut microbiome in different biliary diseases in infant before operation and the changes after operation Open

Xinhe Sun, Yaoyao Cai, Wenwen Dai, Weiwei Jiang, Weibing Tang · 2022

Background Evidence supports an association between cholestatic liver disease and changes in microbiome composition. Nevertheless, the identification of this special type of biliary atresia from non-biliary atresia cholestasis is still a m…

Experimental study of supercontinuum generation in step-index highly nonlinear fibers Open

Weiqing Gao, Lei Zhang, Haiwen Chen, LI Jing-ya, Yuxi Jiang , et al. · 2021

In this work, supercontinuum (SC) generation in three kinds of step-index highly nonlinear fibers (HNLFs) are experimentally investigated. The generated SC spectra are compared with each other by changing the numbers and wavelengths of the…

Antiviral Efficacy of Flavonoids against Enterovirus 71 Infection in Vitro and in Newborn Mice Open

Wenwen Dai, Jinpeng Bi, Fang Li, Shuai Wang, Xinyu Huang , et al. · 2019

Enterovirus 71 (EV71) infection is known to cause hand, foot, and mouth disease (HFMD), which is associated with neurological complications; however, there is currently no effective treatment for this infection. Flavonoids are a large grou…

Exosomes Released from Rabies Virus-Infected Cells May be Involved in the Infection Process Open

Jingyu Wang, Fan Wu, Chuntian Liu, Wenwen Dai, Yawei Teng , et al. · 2019

Antiviral Effects of ABMA against Herpes Simplex Virus Type 2 In Vitro and In Vivo Open

Wenwen Dai, Yu Wu, Jinpeng Bi, Shuai Wang, Fang Li , et al. · 2018

Herpes simplex virus type 2 (HSV-2) is the causative pathogen of genital herpes and is closely associated with the occurrence of cervical cancer and human immunodeficiency virus (HIV) infection. The absence of an effective vaccine and the …

Prognostic Role of Long Noncoding RNA BANCR in Solid Tumors: A Meta-Analysis Open

Jun Zhao, Yali Qi, Jiahao Hu, Wenwen Dai, Yifei Chen · 2017

Accumulating studies have reported that long noncoding RNA BRAF-activated nonprotein coding RNA plays vital role in various cancers. However, the prognostic values of BRAF-activated nonprotein coding RNA in solid tumors remain controversia…

Additional file 5: of Transcriptome analysis reveals dynamic changes in coxsackievirus A16 infected HEK 293T cells Open

Jun Jin, Rujiao Li, Chunlai Jiang, Ruosi Zhang, Xiaomeng Ge , et al. · 2017

Differently expressed target genes between CVA16-infected and CVA16-non-infected cell samples. (XLS 403 kb)

Synthesis and characterization of boron-doped ordered mesoporous carbon by evaporation induced self-assembly under HCl conditions Open

Yan Zhang, Wenwen Dai, Yujian Liu, Bing’e Ma · 2017

With double-layer hydrogen bonding and electrostatic Coulomb forces acting as the driving force, the obtained B-OMC has the well-ordered mesoporous structure, highest surface area (689.85 m² g⁻¹) and boron content (1.…

Additional file 2: of Transcriptome analysis reveals dynamic changes in coxsackievirus A16 infected HEK 293T cells Open

Jun Jin, Rujiao Li, Chunlai Jiang, Ruosi Zhang, Xiaomeng Ge , et al. · 2017

Differently expressed genes between CVA16-infected and CVA16-non-infected cell samples. (XLS 584 kb)

Transcriptome analysis reveals dynamic changes in coxsackievirus A16 infected HEK 293T cells Open

Jun Jin, Rujiao Li, Chunlai Jiang, Ruosi Zhang, Xiaomeng Ge , et al. · 2017

The present study elucidated the changes in 293T cells upon CVA16 infection at transcriptome level, containing highly up-regulated SCARB2 and genes in ECM-receptor interaction and circadian rhythm pathways, and key miRNAs in gene expressio…

Additional file 4: of Transcriptome analysis reveals dynamic changes in coxsackievirus A16 infected HEK 293T cells Open

Jun Jin, Rujiao Li, Chunlai Jiang, Ruosi Zhang, Xiaomeng Ge , et al. · 2017

Differently expressed miRNA between CVA16-infected and CVA16-non-infected cell samples. (XLS 38 kb)

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