Explanipedia

Airflow: A double-edged sword in shaping white tea quality Open

Jinyuan Wang, David C. Lin, Jiao Feng, Shuping Ye, W. H. Tian , et al. · 2025

A construction of heterogeneous transfer learning model based on associative fusion of image feature data Open

W. H. Tian, I‐Ming Chen, Zhong Shu, Tian Xu · 2025

Multi-Condition Guided Diffusion Network for Multimodal Emotion Recognition in Conversation Open

W. H. Tian, Xianying Huang, Shihao Zou · 2025

Ground-Based Hyperspectral Imaging Detection Method for Methane Escape from Coal Fire Sources Open

Yanqiu Liu, Kai Qin, Fei Cao, Xiaoxing Zhong, W. H. Tian , et al. · 2025

Different smoking processes with the special fuel rods: Impart a smoky aroma to Souchong black tea Open

W. H. Tian, Jiao Feng, Jinyuan Wang, Hongzheng Lin, Qianlian Chen , et al. · 2024

132P An open-label, prospective phase II study of cadonilimab in combination with neoadjuvant chemotherapy for patients diagnosed with advanced ovarian cancer (AK104-IIT-003) Open

Jie Tang, W. H. Tian, Shujie Huang, Jianguo Yang, H. J. Yang · 2024

Autophagy Deficiency Induced by SAT1 Potentiates Tumor Progression in Triple‐Negative Breast Cancer Open

W. H. Tian, Lewei Zhu, Yongzhou Luo, Yuhui Tang, Qingjian Tan , et al. · 2024

Aggressive triple‐negative breast cancer (TNBC) still lacks approved targeted therapies, requiring more exploration of its underlying mechanisms. Previous studies have suggested a potential role of SAT1 (Spermidine/Spermine N1‐acetyltransf…

RNA modification gene WDR4 facilitates tumor progression and immunotherapy resistance in breast cancer Open

Yongzhou Luo, W. H. Tian, Da Kang, Linyu Wu, Hailin Tang , et al. · 2024

Research on Visualization of Digital Ground Model Based on Satellite Image Open

Yuxin Huang, Ting Xu, Meng Sun, W. H. Tian, Yipeng Li · 2024

3D printing technology has the advantages of high precision, low cost and environmental protection, and can provide a new and reliable technology for visual expression. This paper takes Qinghai Lake as the research object, uses remote sens…

PIWI-interacting RNA-YBX1 inhibits proliferation and metastasis by the MAPK signaling pathway via YBX1 in triple-negative breast cancer Open

Linyu Wu, Shanshan Huang, W. H. Tian, Peng Liu, Yi Xie , et al. · 2024

Breast cancer is the second leading cause of death in women worldwide, with triple-negative breast cancer (TNBC) having the worst prognosis. Although there are numerous studies on TNBC, there is no effective treatment for it, and it is sti…

Different Smoking Process with the Special Fuel Rods: Imparts a Smoky Aroma to Souchong Black Tea Open

W. H. Tian, Jiao Feng, Jinyuan Wang, Hongzheng Lin, Qianlian Chen , et al. · 2024

AURKAIP1 actuates tumor progression through stabilizing DDX5 in triple negative breast cancer Open

W. H. Tian, Yuhui Tang, Yongzhou Luo, Jindong Xie, Shaoquan Zheng , et al. · 2023

Aurora-A kinase interacting protein 1 (AURKAIP1) has been proved to take an intermediary role in cancer by functioning as a negative regulator of Aurora-A kinase. However, it remains unclear whether and how AURKAIP1 itself would directly e…

Dissecting the role of cancer‐associated fibroblast‐derived biglycan as a potential therapeutic target in immunotherapy resistance: A tumor bulk and single‐cell transcriptomic study Open

Shaoquan Zheng, Jie‐Ying Liang, Yuhui Tang, Jindong Xie, Yutian Zou , et al. · 2023

Introduction Cancer‐associated fibroblasts (CAFs) are correlated with the immunotherapy response. However, the culprits that link CAFs to immunotherapy resistance are still rarely investigated in real‐world studies. Objectives This study a…

Advances in artificial intelligence to predict cancer immunotherapy efficacy Open

Jindong Xie, Xiyuan Luo, Xinpei Deng, Yuhui Tang, W. H. Tian , et al. · 2023

Tumor immunotherapy, particularly the use of immune checkpoint inhibitors, has yielded impressive clinical benefits. Therefore, it is critical to accurately screen individuals for immunotherapy sensitivity and forecast its efficacy. With t…

Dissection of FOXO1-Induced LYPLAL1-DT Impeding Triple-Negative Breast Cancer Progression via Mediating hnRNPK/β-Catenin Complex Open

Yuhui Tang, W. H. Tian, Shaoquan Zheng, Yutian Zou, Jindong Xie , et al. · 2023

Triple-negative breast cancer (TNBC) is considered as the most hazardous subtype of breast cancer owing to its accelerated progression, enormous metastatic potential, and refractoriness to standard treatments. Long noncoding RNAs (lncRNAs)…

Novel Implication of the Basement Membrane for Breast Cancer Outcome and Immune Infiltration Open

W. H. Tian, Yongzhou Luo, Yuhui Tang, Yanan Kong, Linyu Wu , et al. · 2023

Therapeutic failure in breast cancer patients is largely attributed to postoperative advancement and therapy resistance. Nevertheless, an efficacious prognostic signature for recognizing this population is lacking. The basement membrane (B…

The Single‐Cell Landscape of Intratumoral Heterogeneity and The Immunosuppressive Microenvironment in Liver and Brain Metastases of Breast Cancer Open

Yutian Zou, Feng Ye, Yanan Kong, Xiaoqian Hu, Xinpei Deng , et al. · 2022

Distant metastasis remains the major cause of morbidity for breast cancer. Individuals with liver or brain metastasis have an extremely poor prognosis and low response rates to anti‐PD‐1/L1 immune checkpoint therapy compared to those with …

The Pan-Cancer Multi-Omics Landscape of FOXO Family Relevant to Clinical Outcome and Drug Resistance Open

Jindong Xie, Junsheng Zhang, W. H. Tian, Yutian Zou, Yuhui Tang , et al. · 2022

The forkhead box O (FOXO) transcription factors (TFs) family are frequently mutated, deleted, or amplified in various human cancers, making them attractive candidates for therapy. However, their roles in pan-cancer remain unclear. Here, we…

Prognosis stratification in breast cancer and characterization of immunosuppressive microenvironment through a pyrimidine metabolism-related signature Open

Yongzhou Luo, W. H. Tian, Xiuqing Lu, Chao Zhang, Jindong Xie , et al. · 2022

Pyrimidine metabolism is a hallmark of cancer and will soon become an essential part of cancer therapy. In the tumor microenvironment, cells reprogram pyrimidine metabolism intrinsically and extracellularly, thereby promoting tumorigenesis…

Turning up a new pattern: Identification of cancer-associated fibroblast-related clusters in TNBC Open

Jindong Xie, Shaoquan Zheng, Yutian Zou, Yuhui Tang, W. H. Tian , et al. · 2022

Growing evidence indicates a connection between cancer-associated fibroblasts (CAFs) and tumor microenvironment (TME) remodeling and tumor progression. Nevertheless, how patterns of CAFs impact TME and immunotherapy responsiveness in tripl…

Integrative Analysis of KCNK Genes and Establishment of a Specific Prognostic Signature for Breast Cancer Open

Yutian Zou, Jindong Xie, W. H. Tian, Linyu Wu, Yi Xie , et al. · 2022

Two-pore domains potassium channel subunits, encoded by KCNK genes, play vital roles in breast cancer progression. However, the characteristics of most KCNK genes in breast cancer has yet to be clarified. In this study, we comprehensively …

N6-methyladenosine regulated FGFR4 attenuates ferroptotic cell death in recalcitrant HER2-positive breast cancer Open

Yutian Zou, Shaoquan Zheng, Xinhua Xie, Feng Ye, Xiaoqian Hu , et al. · 2022

Establishment of a Cell Necroptosis Index to Predict Prognosis and Drug Sensitivity for Patients With Triple-Negative Breast Cancer Open

Jindong Xie, W. H. Tian, Yuhui Tang, Yutian Zou, Shaoquan Zheng , et al. · 2022

Background: Necroptosis has been an alternatively identified mechanism of programmed cancer cell death, which plays a significant role in cancer. However, research about necroptosis-related long noncoding RNAs (lncRNAs) in cancer are still…

Prognosis and Dissection of Immunosuppressive Microenvironment in Breast Cancer Based on Fatty Acid Metabolism-Related Signature Open

Yuhui Tang, W. H. Tian, Jindong Xie, Yutian Zou, Zehao Wang , et al. · 2022

Fatty acid metabolism has been deciphered to augment tumorigenesis and disease progression in addition to therapy resistance via strengthened lipid synthesis, storage, and catabolism. Breast cancer is strongly associated with the biologica…

The Impact of Preoperative Radiomics Signature on the Survival of Breast Cancer Patients With Residual Tumors After NAC Open

Ling Zhang, Xinhua Jiang, Xiaoming Xie, Yaopan Wu, Shaoquan Zheng , et al. · 2021

Background Residual cancer cells remaining after chemotherapy may have more aggressive behavior that promotes recurrence or metastasis, and which patients would benefit from subsequent additional treatment is controversial. The purpose of …

Prenatal diagnosis and molecular cytogenetic characterization of two hereditary chromosomal duplications with favorable outcomes Open

Y. J. Wu, Changjun Yu, W. H. Tian, Zihang Xu · 2020

The objective of this study was to report two cases of hereditary chromosomal duplications with favorable outcomes. In both cases, conventional karyotyping showed a normal karyotype. However, chromosomal microarray analysis on uncultured a…

Breast-Conserving Therapy Versus Mastectomy in Young Breast Cancer Patients Concerning Molecular Subtypes: A SEER Population-Based Study Open

Ping Yu, Hailin Tang, Yutian Zou, Peng Liu, W. H. Tian , et al. · 2020

Breast-conserving therapy was once a contraindication in young breast cancer patients (aged ≤40 years). Emerging studies suggest that breast-conserving therapy and mastectomy could achieve similar prognosis in this population. However, the…

Nomogram predicted overall survival of patients with neuroendocrine carcinoma of the breast Open

W. H. Tian, Xinhua Xie, Yanan Kong, Peng Liu, Weige Tan , et al. · 2020

Background For primary neuroendocrine carcinoma of breast was a very rare subtype in breast cancers, its prognosis was still controversial and there was no independent standard for its treatment. The purpose of our retrospective study was …

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