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View article: lncRNA IGFL2-AS1 mediates NSCLC chemoresistance via YBX1-induced HSPA1A/RAP1 activation
lncRNA IGFL2-AS1 mediates NSCLC chemoresistance via YBX1-induced HSPA1A/RAP1 activation Open
View article: Cucurbitacin B suppresses glioblastoma via the STAT3/ROS/endoplasmic reticulum stress pathway
Cucurbitacin B suppresses glioblastoma via the STAT3/ROS/endoplasmic reticulum stress pathway Open
Cucurbitacin B (CuB), the tetracyclic triterpenoid compound belonging to cucurbitaceae family, demonstrates significant anticancer properties across various tumor types. However, its efficacy against glioblastoma (GBM), particularly in ove…
View article: Risk Factor Analysis of Transient Ischemic Attack for Moyamoya Disease After a First Combined Revascularization Surgery
Risk Factor Analysis of Transient Ischemic Attack for Moyamoya Disease After a First Combined Revascularization Surgery Open
Patients who experienced TIA had a relatively high risk of progressing to stroke, which was associated with preoperative SBP-ARV and MAP-ARV.
View article: Whole-genome resequencing unveils the phylogeographic coevolution of Oncomelania hupensis with Yangtze River dynamics in China
Whole-genome resequencing unveils the phylogeographic coevolution of Oncomelania hupensis with Yangtze River dynamics in China Open
The freshwater snail Oncomelania hupensis is the only intermediate host of Schistosoma japonicum and is currently mainly distributed in the middle and lower reaches of the Yangtze River in China. To explore the evolutionary history and ada…
View article: Global Trend and Cross-country Inequalities in the Burden of Colorectal Cancer Among Adults Aged 65 Years and Older, 1990–2021: A Systematic Analysis of the Global Burden of Disease Study 2021
Global Trend and Cross-country Inequalities in the Burden of Colorectal Cancer Among Adults Aged 65 Years and Older, 1990–2021: A Systematic Analysis of the Global Burden of Disease Study 2021 Open
Background Colorectal cancer (CRC) is one of the leading causes of death among the elderly worldwide. Due to population aging, the burden of CRC among older adults is continuously increasing. However, the epidemiological characteristics, s…
View article: Carotid Endarterectomy Ameliorates Cognitive Impairment in Clinical and Experimental Unilateral Carotid Artery Stenosis
Carotid Endarterectomy Ameliorates Cognitive Impairment in Clinical and Experimental Unilateral Carotid Artery Stenosis Open
Background Carotid endarterectomy (CEA) is widely used to treat carotid artery stenosis (CAS). However, the effects of CEA on unilateral CAS‐induced cognitive impairment and the underlying mechanism remain poorly understood. Methods and Re…
View article: Trend and forecast analysis of the changing disease burden of tuberculosis in China, 1990–2021
Trend and forecast analysis of the changing disease burden of tuberculosis in China, 1990–2021 Open
Tuberculosis (TB) remains a significant public health concern in China. Using data from the Global Burden of Disease (GBD) study 2021, we analyzed trends in age-standardized incidence rate (ASIR), prevalence rate (ASPR), mortality rate (AS…
View article: D-Limonene Reduces Body Mass Index in Metabolism-Associated Fatty Liver Disease: A Randomized, Double-Blind Placebo-Controlled Trial
D-Limonene Reduces Body Mass Index in Metabolism-Associated Fatty Liver Disease: A Randomized, Double-Blind Placebo-Controlled Trial Open
View article: Tislelizumab Plus Lenvatinib as the First-Line Therapy in Patients with Advanced Fumarate Hydratase-Deficient Renal Cell Carcinoma: A Single-Arm, Single-Centre, Phase 2 Trial and Metabolic Biomarker Analysis
Tislelizumab Plus Lenvatinib as the First-Line Therapy in Patients with Advanced Fumarate Hydratase-Deficient Renal Cell Carcinoma: A Single-Arm, Single-Centre, Phase 2 Trial and Metabolic Biomarker Analysis Open
View article: Harnessing Nature: Oil Body Membrane as Intelligent Self-Assembled Amphiphilic Micelle Nano Aggregate
Harnessing Nature: Oil Body Membrane as Intelligent Self-Assembled Amphiphilic Micelle Nano Aggregate Open
View article: Epidemiological survey of 32,786 culture-positive dermatophytosis cases in Hangzhou from 2018 to 2023
Epidemiological survey of 32,786 culture-positive dermatophytosis cases in Hangzhou from 2018 to 2023 Open
BACKGROUND: With the rapid development of the economy and changes in lifestyle in recent years, the epidemiological pattern of dermatophytosis has changed. We analyzed the epidemiological features of dermatophytosis in a hospital in Hangzh…
View article: Harnessing TME depicted by histological images to improve cancer prognosis through a deep learning system
Harnessing TME depicted by histological images to improve cancer prognosis through a deep learning system Open
View article: Alternations of Blood Pressure Following Surgical or Drug Therapy for Prolactinomas
Alternations of Blood Pressure Following Surgical or Drug Therapy for Prolactinomas Open
Several subtypes of pituitary neuroendocrine tumors (PitNETs), such as acromegaly and Cushing’s disease, can result in hypertension. However, whether prolactinoma is associated with this complication remains unknown. Moreover, the effect o…
View article: Global Trends and Geographic Disparities of Gastrointestinal Cancers in Adolescents and Young Adults: A Systematic Analysis for the Global Burden of Disease Study 2021
Global Trends and Geographic Disparities of Gastrointestinal Cancers in Adolescents and Young Adults: A Systematic Analysis for the Global Burden of Disease Study 2021 Open
View article: Assessing the association between the circulating levels of inflammatory cytokines and the risk of tuberculosis: A bidirectional two-sample mendelian randomization study
Assessing the association between the circulating levels of inflammatory cytokines and the risk of tuberculosis: A bidirectional two-sample mendelian randomization study Open
The study has illuminated the causal link between inflammatory cytokines and TB, thereby enhancing our comprehension of the potential mechanisms underlying TB pathogenesis. This discovery offers promising avenues for the identification of …
View article: Impact factors of Blastocystis hominis infection in persons living with human immunodeficiency virus: a large-scale, multi-center observational study from China
Impact factors of Blastocystis hominis infection in persons living with human immunodeficiency virus: a large-scale, multi-center observational study from China Open
View article: Predicting Gene Spatial Expression and Cancer Prognosis: An Integrated Graph and Image Deep Learning Approach Based on HE Slides
Predicting Gene Spatial Expression and Cancer Prognosis: An Integrated Graph and Image Deep Learning Approach Based on HE Slides Open
Interpreting the tumor microenvironment (TME) heterogeneity within solid tumors presents a cornerstone for precise disease diagnosis and prognosis. However, while spatial transcriptomics offers a wealth of data, ranging from gene expressio…
View article: Surface EMG analysis of weakness distribution in upper limb muscles post-stroke
Surface EMG analysis of weakness distribution in upper limb muscles post-stroke Open
Weakness is a common symptom after a stroke. This study aims to depict weakness distribution among forearm muscles given that joints in the upper limb are usually driven by a group of muscles. Multi-channel electromyography (EMG) was appli…
View article: Sandwich Mixed Randomisation: A Pragmatic Allocation Scheme to Prevent Guessing and Imbalance and a Call for the Abandonment of Permuted Block Randomisation in Clinical Trials
Sandwich Mixed Randomisation: A Pragmatic Allocation Scheme to Prevent Guessing and Imbalance and a Call for the Abandonment of Permuted Block Randomisation in Clinical Trials Open
View article: A high-efficiency differential expression method for cancer heterogeneity using large-scale single-cell RNA-sequencing data
A high-efficiency differential expression method for cancer heterogeneity using large-scale single-cell RNA-sequencing data Open
Colorectal cancer is a highly heterogeneous disease. Tumor heterogeneity limits the efficacy of cancer treatment. Single-cell RNA-sequencing technology (scRNA-seq) is a powerful tool for studying cancer heterogeneity at cellular resolution…
View article: Chromoblastomycosis: A case series from Eastern China
Chromoblastomycosis: A case series from Eastern China Open
Chromoblastomycosis (CBM) is a chronic fungal infection of the cutaneous and subcutaneous tissues caused by brown pigmented fungi. Fonsecaea monophora is one of the most common pathogens of CBM in China. Most formal cases have been reporte…
View article: Panoramic quality assessment tool for investigator initiated trials
Panoramic quality assessment tool for investigator initiated trials Open
Objectives Quality can be a challenge for Investigator initiated trials (IITs) since these trials are scarcely overseen by a sponsor or monitoring team. Therefore, quality assessment for departments managing clinical research grants progra…
View article: <scp>D</scp>‐Limonene for regulating metabolism‐associated fatty liver disease (MAFLD) and analysis of the TCM constitution: A protocol for an exploratory, randomized, double‐blind, placebo‐controlled trial (DL‐MAFLD‐TCM)
<span>D</span>‐Limonene for regulating metabolism‐associated fatty liver disease (MAFLD) and analysis of the TCM constitution: A protocol for an exploratory, randomized, double‐blind, placebo‐controlled trial (DL‐MAFLD‐TCM) Open
The protocol describes the first study evaluating the treatment of metabolism‐associated fatty liver disease (MAFLD). MAFLD, formerly known as nonalcoholic fatty liver disease, was renamed by an internationally renowned liver disease exper…
View article: The prevalence of adult tinea capitis: a 10-year retrospective study in Hangzhou, eastern China, between 2012 and 2021
The prevalence of adult tinea capitis: a 10-year retrospective study in Hangzhou, eastern China, between 2012 and 2021 Open
Introduction: Tinea capitis (TC) is a disease caused by dermatophytes on the scalp and hair. This disease mainly infects pre-school children, although there has been a gradual increase in the number of adults infected with TC over recent y…
View article: Construction and Confirmatory Factor Analysis of Panoramic Quality Assessment Tool for Investigator-Initiated Trials
Construction and Confirmatory Factor Analysis of Panoramic Quality Assessment Tool for Investigator-Initiated Trials Open
Introduction. Investigator initiated trials (IITs) are laid on the optimization and improvement of already existing therapies or treatment approaches and attempts to answer problems faced by clinicians in their daily practice. However, the…
View article: Telitacicept Following Plasma Exchange in the Treatment of Subjects With Recurrent NMOSD: Study Protocol for a Single-Center, Single-Arm, Open-Label Study
Telitacicept Following Plasma Exchange in the Treatment of Subjects With Recurrent NMOSD: Study Protocol for a Single-Center, Single-Arm, Open-Label Study Open
Background: Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune demyelinating disease that recurrently relapses and leads to severe disability. The available choices for disease prevention are few or intolerable. Previous studi…
View article: BCCIPβ facilitates p53 ubiquitination via binding with E6 protein in high-risk HPV positive head and neck squamous cell carcinoma
BCCIPβ facilitates p53 ubiquitination via binding with E6 protein in high-risk HPV positive head and neck squamous cell carcinoma Open
BRCA2 And CDKN1A Interacting Protein (BCCIP) is initially identified as a tumor suppressor. Some recent studies confirmed its p53 binding capability. In this study, we explored the regulatory effect of BCCIPβ on p53 stability in HPV-positi…
View article: MicroRNA Biomarker <i>hsa-miR-195-5p</i> for Detecting the Risk of Lung Cancer
MicroRNA Biomarker <i>hsa-miR-195-5p</i> for Detecting the Risk of Lung Cancer Open
Background . Lung cancer is one of the leading diagnosed cancers worldwide, and microRNAs could be used as biomarkers to diagnose lung cancer. hsa-miR-195 has been demonstrated to affect the prognosis of NSCLC (non-small-cell lung cancer) …
View article: Neuroprotective Effects of Lindleyin on Hydrogen Peroxide‐Induced Cell Injury and MPTP‐Induced Parkinson’s Disease in C57BL/6 Mice
Neuroprotective Effects of Lindleyin on Hydrogen Peroxide‐Induced Cell Injury and MPTP‐Induced Parkinson’s Disease in C57BL/6 Mice Open
Oxidative stress (OS) is a crucial factor influencing the development of Parkinson’s disease (PD). Here we first reported that Lindleyin ( Lin ), one of the major components of rhubarb, possessed neuroprotective effects against H 2 O 2 ‐in…
View article: Safety of combining vascular endothelial growth factor receptor tyrosine-kinase inhibitors with chemotherapy in patients with advanced non–small-cell lung cancer
Safety of combining vascular endothelial growth factor receptor tyrosine-kinase inhibitors with chemotherapy in patients with advanced non–small-cell lung cancer Open
Background: Vascular endothelial growth factor receptor-tyrosine kinase inhibitors (VEGFR-TKIs) have been developed for targeted therapies in non–small-cell lung cancer (NSCLC); moreover, some drug-related toxic reactions among cancer pati…