Wenxia Yao
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View article: Comprehensive profiling of host- and virus-derived circular RNAs during vesicular stomatitis virus infection
Comprehensive profiling of host- and virus-derived circular RNAs during vesicular stomatitis virus infection Open
Circular RNA (circRNA) is a new member of noncoding RNA family, which has garnered increasing attention, particularly in the context of viral infections. Vesicular stomatitis virus (VSV) is a negative-sense RNA virus that threatens animal …
View article: Antigen presentation-related protein APOL3 promotes anti-tumor T cell immunity and suppresses melanoma cell growth in mice
Antigen presentation-related protein APOL3 promotes anti-tumor T cell immunity and suppresses melanoma cell growth in mice Open
Melanoma is a malignant tumor with limited treatment option in advanced stages. Apolipoprotein L3 (APOL3), a protein implicated in immune regulation, has recently emerged as a potential player in tumor immunity. This research aims to explo…
View article: Genome-wide identification of potato Trihelix gene family and its response to different abiotic stresses
Genome-wide identification of potato Trihelix gene family and its response to different abiotic stresses Open
The Trihelix transcription factor family, characterized by its unique triple-helix structure (helix-loop-helix-loop-helix), plays a significant role in plant growth, development, and responses to various abiotic stresses. Potato (Solanum t…
View article: Optimization of composite microbial agents containing plant inter-root growth-promoting bacteria and verification using mini Chinese cabbage (Brassica rapa L. ssp. Pekinensis)
Optimization of composite microbial agents containing plant inter-root growth-promoting bacteria and verification using mini Chinese cabbage (Brassica rapa L. ssp. Pekinensis) Open
Microbial agent research has developed from single strain to multi-strain complex studies, and Plant growth promoting rhizobacteria (PGPR) has emerged as a hot topic in relation to biofertilizers. Soil environmental degradation problems, s…
View article: Intratracheal instillation of respiratory syncytial virus is superior to intranasal inoculation as a model method in mice and can induce infiltration of important immune cells
Intratracheal instillation of respiratory syncytial virus is superior to intranasal inoculation as a model method in mice and can induce infiltration of important immune cells Open
Respiratory syncytial virus (RSV) causes a substantial global disease burden, particularly in children and older adults. Despite the availability of three vaccines and two prophylactic monoclonal antibodies, there remains an urgent unmet n…
View article: Genome-Wide Identification and Analysis of WD40 Family and Its Expression in F. vesca at Different Coloring Stages
Genome-Wide Identification and Analysis of WD40 Family and Its Expression in F. vesca at Different Coloring Stages Open
WD40 proteins play important roles in the synthesis and regulation of anthocyanin, the regulation of plant morphology and development, and the response to various abiotic stresses. However, the role of WD40 in Fragaria vesca (F. vesca) has…
View article: Comprehensive landscape of m6A regulator-related gene patterns and tumor microenvironment infiltration characterization in gastric cancer
Comprehensive landscape of m6A regulator-related gene patterns and tumor microenvironment infiltration characterization in gastric cancer Open
The epigenetic regulation of N6-methyladenosine (m 6 A) has attracted considerable interest in tumor research, but the potential roles of m 6 A regulator-related genes, remain largely unknown within the context of gastric cancer (GC) and t…
View article: Kallistatin enhances the phagocytic function of macrophages by decreasing the expression of CD24 in gastric cancer cells via the HIF-1α signaling pathway
Kallistatin enhances the phagocytic function of macrophages by decreasing the expression of CD24 in gastric cancer cells via the HIF-1α signaling pathway Open
Gastric cancer, the most frequently diagnosed type of primary cancers, is associated with a high mortality rate, and imposes a significant burden on patients and society. Recent studies have found that the kallikrein-binding protein kallis…
View article: Cobalt Chloride Promotes Osteogenesis of Rat Bone Marrow Mesenchymal Stem Cells In Vitro and In Vivo
Cobalt Chloride Promotes Osteogenesis of Rat Bone Marrow Mesenchymal Stem Cells In Vitro and In Vivo Open
This work aimed to investigate the effect of low-concentration cobalt chloride on the in vitro and in vivo proliferation of rat bone mesenchymal stem cells, the expression of hypoxia-inducing fraction-1 alpha and the related osteogenic gen…
View article: Low Dose Sophora flavescens Polysaccharide Promote the Migration and Osteogenic Differentiation of Dental Pulp Stem Cells and Up-Regulate the Expression of Osteogenic Genes
Low Dose Sophora flavescens Polysaccharide Promote the Migration and Osteogenic Differentiation of Dental Pulp Stem Cells and Up-Regulate the Expression of Osteogenic Genes Open
This work aimed to investigate the effect of Sophora flavescens polysaccharide on proliferation and osteogenic differentiation of dental pulp stem cells. The dental pulp stem cells were isolated from rat dental crown tissue and the surface…
View article: oxLDL promotes EMS-induced angiogenesis by up-regulating VEGF-A expression and secretion of endometrial cells
oxLDL promotes EMS-induced angiogenesis by up-regulating VEGF-A expression and secretion of endometrial cells Open
Background Endometriosis (EMS) is a "tumor-like" gynecological disease with distant metastasis, and studies have shown that EMS can carry out distant metastasis through vascular vessels, but the driving factor and its mechanism is not clea…
View article: Icaritin-loaded PLGA nanoparticles activate immunogenic cell death and facilitate tumor recruitment in mice with gastric cancer
Icaritin-loaded PLGA nanoparticles activate immunogenic cell death and facilitate tumor recruitment in mice with gastric cancer Open
This study aimed to explore the anti-tumor effect of icaritin loading poly (lactic-co-glycolic acid) nanoparticles (refer to PLGA@Icaritin NPs) on gastric cancer (GC) cells. Transmission Electron Microscope (TEM), size distribution, zeta p…
View article: Circular RNA hsa_circ_0110389 promotes gastric cancer progression through upregulating SORT1 via sponging miR-127-5p and miR-136-5p
Circular RNA hsa_circ_0110389 promotes gastric cancer progression through upregulating SORT1 via sponging miR-127-5p and miR-136-5p Open
Increasing studies have found that circular RNAs (circRNAs) are aberrantly expressed and play important roles in the occurrence and development of human cancers. However, the function of circRNAs on environmental carcinogen-induced gastric…
View article: Identification of circRNA–miRNA–mRNA networks contributes to explore underlying pathogenesis and therapy strategy of gastric cancer
Identification of circRNA–miRNA–mRNA networks contributes to explore underlying pathogenesis and therapy strategy of gastric cancer Open
Background Circular RNAs (circRNAs) are a new class of noncoding RNAs that have gained increased attention in human tumor research. However, the identification and function of circRNAs are largely unknown in the context of gastric cancer (…
View article: Resveratrol-modified mesoporous silica nanoparticle for tumor-targeted therapy of gastric cancer
Resveratrol-modified mesoporous silica nanoparticle for tumor-targeted therapy of gastric cancer Open
Resveratrol (Res) has been shown to exhibit anti-cancer properties in gastric cancer. However, its clinical application is limited by its poor pharmacokinetics, stability, and low solubility. Hence, this study aimed to explore and verify a…
View article: Circular RNA hsa_circ_0001829 Promotes Gastric Cancer Progression through miR-155-5p/SMAD2 Axis
Circular RNA hsa_circ_0001829 Promotes Gastric Cancer Progression through miR-155-5p/SMAD2 Axis Open
Background: Accumulating evidences have shown that circular RNAs (circRNAs) play important roles in regulating the pathogenesis of cancer. However, the role of circRNAs in gastric cancer (GC) remains largely unclear. Methods: In this study…
View article: Expression profiles of genes associated with inflammatory responses and oxidative stress in lung after heat stroke
Expression profiles of genes associated with inflammatory responses and oxidative stress in lung after heat stroke Open
Background: Heat stroke (HS) is a physically dysfunctional illness caused by hyperthermia. Lung, as the important place for gas-exchange and heat-dissipation organ, is often first to be injured. Lung injury caused by HS impairs the ventila…
View article: p62 promotes proliferation, apoptosis‑resistance and invasion of prostate cancer cells through the Keap1/Nrf2/ARE axis
p62 promotes proliferation, apoptosis‑resistance and invasion of prostate cancer cells through the Keap1/Nrf2/ARE axis Open
Prostate cancer poses a public health threat to hundreds of people around the world. p62 has been identified as a tumor suppressor, however, the mechanism by which p62 promotes prostate cancer remains poorly understood. The present study a…
View article: Wnt5a Promotes Cortical Neuron Survival by Inhibiting Cell-Cycle Activation
Wnt5a Promotes Cortical Neuron Survival by Inhibiting Cell-Cycle Activation Open
β-Amyloid protein (Aβ) is thought to cause neuronal loss in Alzheimer's disease (AD). Aβ treatment promotes the re-activation of a mitotic cycle and induces rapid apoptotic death of neurons. However, the signaling pathways mediating cell-c…