Wenxiang Cao
YOU?
Author Swipe
View article: Kinetic mechanism of ENPP1 ATPase: Implications for aberrant calcification disorders and enzyme replacement therapy
Kinetic mechanism of ENPP1 ATPase: Implications for aberrant calcification disorders and enzyme replacement therapy Open
View article: Bending stiffness of Toxoplasma gondii actin filaments
Bending stiffness of Toxoplasma gondii actin filaments Open
View article: High-resolution yeast actin structures indicate the molecular mechanism of actin filament stiffening by cations
High-resolution yeast actin structures indicate the molecular mechanism of actin filament stiffening by cations Open
View article: Publisher Correction: Cryo-EM structures reveal how phosphate release from Arp3 weakens actin filament branches formed by Arp2/3 complex
Publisher Correction: Cryo-EM structures reveal how phosphate release from Arp3 weakens actin filament branches formed by Arp2/3 complex Open
View article: Cryo-EM structures reveal how phosphate release from Arp3 weakens actin filament branches formed by Arp2/3 complex
Cryo-EM structures reveal how phosphate release from Arp3 weakens actin filament branches formed by Arp2/3 complex Open
View article: Abstract 1424 Distinct functional constraints driving conservation of the cofilin N-terminal regulatory tail
Abstract 1424 Distinct functional constraints driving conservation of the cofilin N-terminal regulatory tail Open
Cofilin family proteins have essential roles in remodeling the cytoskeleton through filamentous actin depolymerization and severing. The short unstructured N-terminal region of cofilin is critical for actin binding and harbors the major si…
View article: Distinct functional constraints driving conservation of the cofilin N-terminal regulatory tail
Distinct functional constraints driving conservation of the cofilin N-terminal regulatory tail Open
Cofilin family proteins have essential roles in remodeling the cytoskeleton through filamentous actin depolymerization and severing. The short, unstructured N-terminal region of cofilin is critical for actin binding and harbors the major s…
View article: Cofilin-mediated actin filament network flexibility facilitates 2D to 3D actomyosin shape change
Cofilin-mediated actin filament network flexibility facilitates 2D to 3D actomyosin shape change Open
The organization of actin filaments (F-actin) into crosslinked networks determines the transmission of mechanical stresses within the cytoskeleton and subsequent changes in cell and tissue shape. Principally mediated by proteins such as α-…
View article: Investigation into the Influence of Stress Conditions on the Permeability Characteristics of Weakly Cemented Sandstone
Investigation into the Influence of Stress Conditions on the Permeability Characteristics of Weakly Cemented Sandstone Open
This study, conducted in the geological context of the Yixin coalfield, systematically performed indoor mechanical tests to analyze the impact of different stress conditions on the permeability of weakly cemented sandstone. The results wer…
View article: Cooperative ligand binding to a double-stranded Ising lattice—Application to cofilin binding to actin filaments
Cooperative ligand binding to a double-stranded Ising lattice—Application to cofilin binding to actin filaments Open
Cooperative ligand binding to linear polymers is fundamental in many scientific disciplines, particularly biological and chemical physics and engineering. Such ligand binding interactions have been widely modeled using infinite one-dimensi…
View article: Friction patterns guide actin network contraction
Friction patterns guide actin network contraction Open
The shape of cells is the outcome of the balance of inner forces produced by the actomyosin network and the resistive forces produced by cell adhesion to their environment. The specific contributions of contractile, anchoring and friction …
View article: Distinct functional constraints driving conservation of the cofilin N-terminal regulatory tail
Distinct functional constraints driving conservation of the cofilin N-terminal regulatory tail Open
Summary Cofilin family proteins have essential roles in remodeling the cytoskeleton through filamentous actin depolymerization and severing. The short unstructured N-terminal region of cofilin is critical for actin binding and harbors the …
View article: Finetuning ERK activity enables most somatic cells to reprogram into pluripotency
Finetuning ERK activity enables most somatic cells to reprogram into pluripotency Open
Somatic cell reprogramming is a stochastic process typically resulting in only a small fraction of cells successfully converting into induced pluripotent stem cells (iPSCs). The molecular and cellular basis underlying this stochasticity re…
View article: Twist response of actin filaments
Twist response of actin filaments Open
Actin cytoskeleton force generation, sensing, and adaptation are dictated by the bending and twisting mechanics of filaments. Here, we use magnetic tweezers and microfluidics to twist and pull individual actin filaments and evaluate their …
View article: Novel 3d Superhydrophobic Lightweight Foam Concrete Designed Via In-Situ Foaming and Self-Assembled Silicone Microfilms
Novel 3d Superhydrophobic Lightweight Foam Concrete Designed Via In-Situ Foaming and Self-Assembled Silicone Microfilms Open
View article: Flagella-like beating of actin bundles driven by self-organized myosin waves
Flagella-like beating of actin bundles driven by self-organized myosin waves Open
View article: Similarity Simulation on the Movement Characteristics of Surrounding Rock and Floor Stress Distribution for Large-Dip Coal Seam
Similarity Simulation on the Movement Characteristics of Surrounding Rock and Floor Stress Distribution for Large-Dip Coal Seam Open
The question of how to mine safely in close multi coal seams is the main concern for coal operators, in particular for large-dip coal seams with complex geological and mechanical conditions. This paper presents a detailed similarity simula…
View article: The nucleoporin Gle1 activates DEAD-box protein 5 (Dbp5) by promoting ATP binding and accelerating rate limiting phosphate release
The nucleoporin Gle1 activates DEAD-box protein 5 (Dbp5) by promoting ATP binding and accelerating rate limiting phosphate release Open
The DEAD-box protein Dbp5 is essential for RNA export, which involves regulation by the nucleoporins Gle1 and Nup159 at the cytoplasmic face of the nuclear pore complex (NPC). Mechanistic understanding of how these nucleoporins regulate RN…
View article: Structural basis of fast- and slow-severing actin–cofilactin boundaries
Structural basis of fast- and slow-severing actin–cofilactin boundaries Open
Members of the ADF/cofilin family of regulatory proteins bind actin filaments cooperatively, locally change actin subunit conformation and orientation, and sever filaments at "boundaries" between bare and cofilin-occupied segments. A clust…
View article: Preparation of Anhydrite from Phosphogypsum: Influence of Phosphorus and Fluorine Impurities on the Performances
Preparation of Anhydrite from Phosphogypsum: Influence of Phosphorus and Fluorine Impurities on the Performances Open
View article: Improving the Pharmacodynamics and In Vivo Activity of ENPP1‐Fc Through Protein and Glycosylation Engineering
Improving the Pharmacodynamics and In Vivo Activity of ENPP1‐Fc Through Protein and Glycosylation Engineering Open
Enzyme replacement with ectonucleotide pyrophosphatase phospodiesterase‐1 (ENPP1) eliminates mortality in a murine model of the lethal calcification disorder generalized arterial calcification of infancy. We used protein engineering, glyca…
View article: Force and phosphate release from Arp2/3 complex promote dissociation of actin filament branches
Force and phosphate release from Arp2/3 complex promote dissociation of actin filament branches Open
Significance Arp2/3 complex is an ATPase that binds to the side of a preexisting actin filament and nucleates an actin filament branch. Growing branched networks experience variable resistance and respond by adapting growth speed, power, a…
View article: Directional allosteric regulation of protein filament length
Directional allosteric regulation of protein filament length Open
Cofilin and ADF are cytoskeleton remodeling proteins that cooperatively bind and fragment actin filaments. Bound cofilin molecules do not directly interact with each other, indicating that cooperative binding of cofilin is mediated by the …
View article: Structures of cofilin-induced structural changes reveal local and asymmetric perturbations of actin filaments
Structures of cofilin-induced structural changes reveal local and asymmetric perturbations of actin filaments Open
Members of the cofilin/ADF family of proteins sever actin filaments, increasing the number of filament ends available for polymerization or depolymerization. Cofilin binds actin filaments with positive cooperativity, forming clusters of co…
View article: Isolated S3D-cofilin bound to an actin filament
Isolated S3D-cofilin bound to an actin filament Open
Members of the cofilin/ADF family of proteins sever actin filaments, increasing the number of filament ends available for polymerization or depolymerization. Cofilin binds actin filaments with positive cooperativity, forming clusters of co…
View article: Severed Actin and Microtubules with Motors Walking All Over Them: Cryo-EM Studies of Seriously Perturbed Helical Assemblies
Severed Actin and Microtubules with Motors Walking All Over Them: Cryo-EM Studies of Seriously Perturbed Helical Assemblies Open
Journal Article Severed Actin and Microtubules with Motors Walking All Over Them: Cryo-EM Studies of Seriously Perturbed Helical Assemblies Get access Garrett Debs, Garrett Debs Department of Molecular Biophysics and Biochemistry, Yale Uni…
View article: Active cargo positioning in antiparallel transport networks
Active cargo positioning in antiparallel transport networks Open
Significance Cellular functions rely on small groups of molecular motors to transport their cargoes throughout the cell along polar filaments of the cytoskeleton. Cytoskeletal filaments self-assemble into dense networks comprising intersec…
View article: Active cargo positioning in antiparallel transport networks
Active cargo positioning in antiparallel transport networks Open
Cytoskeletal filaments assemble into dense parallel, antiparallel or disordered networks, providing a complex environment for active cargo transport and positioning by molecular motors. The interplay between the network architecture and in…
View article: The actin filament twist changes abruptly at boundaries between bare and cofilin-decorated segments
The actin filament twist changes abruptly at boundaries between bare and cofilin-decorated segments Open
Cofilin/ADF proteins are actin-remodeling proteins, essential for actin disassembly in various cellular processes, including cell division, intracellular transport, and motility. Cofilins bind actin filaments cooperatively and sever them p…
View article: Cofilin Induces a Local Change in the Twist of Actin Filaments
Cofilin Induces a Local Change in the Twist of Actin Filaments Open