Feng Wang
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View article: A neural circuit for female-specific defensive homeostasis in risk assessment
A neural circuit for female-specific defensive homeostasis in risk assessment Open
SUMMARY Risk assessment in defensive behavior is an adaptive mechanism shaped by natural selection, enabling individuals to evaluate potential threats and thereby maintain defensive homeostasis. Although risk assessment is essential for su…
View article: Interstitial pneumonia triggered by H1N1 influenza A virus as the initial presentation of chronic myeloid leukemia
Interstitial pneumonia triggered by H1N1 influenza A virus as the initial presentation of chronic myeloid leukemia Open
View article: Charging Station Siting and Capacity Determination Based on a Generalized Least-Cost Model of Traffic Distribution
Charging Station Siting and Capacity Determination Based on a Generalized Least-Cost Model of Traffic Distribution Open
With the popularization of electric vehicles and the continuous expansion of the electric vehicle market, the construction and management of charging facilities for electric vehicles have become important issues in research and practice. I…
View article: Environmental risk factors, protective factors and lifestyles for lung cancer: an umbrella review
Environmental risk factors, protective factors and lifestyles for lung cancer: an umbrella review Open
Background Lung cancer remains a leading cause of cancer-related mortality worldwide, with environmental exposures and lifestyle factors playing a crucial role in its etiology. This umbrella review aims to systematically assess and classif…
View article: Prediction of apolipoprotein A-I and high-density lipoprotein cholesterol in the neurological impairment and relapse of neuromyelitis optica spectrum disorder
Prediction of apolipoprotein A-I and high-density lipoprotein cholesterol in the neurological impairment and relapse of neuromyelitis optica spectrum disorder Open
Background and purpose Neuromyelitis Optica Spectrum Disorder (NMOSD) is a rare inflammatory demyelinating disorder of the central nervous system, frequently resulting in irreversible neurological deficits such as blindness and paralysis. …
View article: The clinical efficacy and mechanism of gamma frequency electroacupuncture stimulation on the rehabilitation of upper limb motor function in stroke patients: study protocol of a randomized clinical trial
The clinical efficacy and mechanism of gamma frequency electroacupuncture stimulation on the rehabilitation of upper limb motor function in stroke patients: study protocol of a randomized clinical trial Open
Background The field of neuroscience has discovered that gamma oscillations (30–100 Hz) in the brain play a key role in neuroplasticity, information conduction and neuroprotective mechanisms. Electroacupuncture stimulation (ES) is a modern…
View article: Hierarchical behavioral analysis framework as a platform for standardized quantitative identification of behaviors
Hierarchical behavioral analysis framework as a platform for standardized quantitative identification of behaviors Open
View article: KDM1A-Driven RNF81 Downregulation Promotes Gastric Cancer Progression via KLF4 Destabilization
KDM1A-Driven RNF81 Downregulation Promotes Gastric Cancer Progression via KLF4 Destabilization Open
Gastric cancer (GC) is a leading cause of cancer-related deaths worldwide, especially in East Asia, with a low 5-year survival rate due to late-stage diagnosis. Identifying molecular mechanisms that regulate GC progression is critical for …
View article: Identification and Verification of the Driver Genes for the Formation and Development of Intracranial Aneurysms
Identification and Verification of the Driver Genes for the Formation and Development of Intracranial Aneurysms Open
STX17-mediated changes in the smooth muscle cell phenotype are new driver genes for IA formation and progression, providing a new approach for the early screening, diagnosis, and treatment of IA.
View article: Hierarchical behavioral analysis framework as a platform for standardized quantitative identification of behaviors
Hierarchical behavioral analysis framework as a platform for standardized quantitative identification of behaviors Open
Behavior is composed of modules that operate based on inherent logic. Understanding behavior and its neural mechanisms is facilitated by clear structural behavioral analysis. Here, we developed a hierarchical behavioral analysis framework …
View article: Metrnl/C‐KIT Axis Attenuates Early Brain Injury Following Subarachnoid Hemorrhage by Inhibiting Neuronal Ferroptosis
Metrnl/C‐KIT Axis Attenuates Early Brain Injury Following Subarachnoid Hemorrhage by Inhibiting Neuronal Ferroptosis Open
Background and Purpose Ferroptosis is a distinct form of cell death characterized by iron‐dependent lipid peroxidation and plays a crucial role in the early brain injury (EBI) following subarachnoid hemorrhage (SAH). As a newly discovered …
View article: Environmental Risk Factors, Protective Factors and Lifestyles for Lung Cancer: An Umbrella Review
Environmental Risk Factors, Protective Factors and Lifestyles for Lung Cancer: An Umbrella Review Open
View article: iTRAQ proteomic analysis of the anterior insula in morphine‐induced conditioned place preference rats with high‐frequency deep brain stimulation intervention
iTRAQ proteomic analysis of the anterior insula in morphine‐induced conditioned place preference rats with high‐frequency deep brain stimulation intervention Open
Morphine dependence or addiction is a serious global public health and social problem, and traditional treatments are very limited. Deep brain stimulation (DBS) has emerged as a new potential treatment for drug addiction. Repeated use of m…
View article: Mapping the Behavioral Signatures of Shank3b Mice in Both Sexes
Mapping the Behavioral Signatures of Shank3b Mice in Both Sexes Open
Autism spectrum disorders (ASD) are characterized by social and repetitive abnormalities. Although the ASD mouse model with Shank3b mutations is widely used in ASD research, the behavioral phenotype of this model has not been fully elucida…
View article: Sex-Dimorphic Kidney-Brain Connectivity Map of Mice
Sex-Dimorphic Kidney-Brain Connectivity Map of Mice Open
View article: Network pharmacology to explore the mechanism of traditional Chinese medicine in the treatment of ground glass nodules
Network pharmacology to explore the mechanism of traditional Chinese medicine in the treatment of ground glass nodules Open
Chinese herbal formulas containing quercetin could be a potential treatment for GGNs, targeting C-reactive protein (CRP), tumor necrosis factor (TNF), interferon gamma (IFN-γ), intercellular adhesion molecule 1 (ICA…
View article: Whole-brain connections of glutamatergic neurons in the mouse lateral habenula in both sexes
Whole-brain connections of glutamatergic neurons in the mouse lateral habenula in both sexes Open
Background The lateral habenula (LHb) is an epithalamus nucleus that is evolutionarily conserved and involved in various physiological functions, such as encoding value signals, integrating emotional information, and regulating related beh…
View article: Development and Validation of Androgen-induced Hair Loss and Anagen Induction Mouse Models for Pharmacological Evaluation of Anti-Androgenic Agents
Development and Validation of Androgen-induced Hair Loss and Anagen Induction Mouse Models for Pharmacological Evaluation of Anti-Androgenic Agents Open
Background and objectives: Androgen-induced hair loss and anagen induction mouse models are commonly used in Androgenetic alopecia (AGA) studies. This paper aims to verify the feasibility of these models for evaluating the androgen recepto…
View article: Scoring system related to retrograde percutaneous coronary intervention for coronary chronic total occlusion
Scoring system related to retrograde percutaneous coronary intervention for coronary chronic total occlusion Open
The retrograde approach is a principal procedure used in coronary chronic total occlusion percutaneous coronary intervention. However, the retrograde approach presents more challenges compared with the antegrade approach, as it is associat…
View article: An LQT2-related mutation in the voltage-sensing domain is involved in switching the gating polarity of hERG
An LQT2-related mutation in the voltage-sensing domain is involved in switching the gating polarity of hERG Open
Background Cyclic Nucleotide-Binding Domain (CNBD)-family channels display distinct voltage-sensing properties despite sharing sequence and structural similarity. For example, the human Ether-a-go-go Related Gene (hERG) channel and the Hyp…
View article: Hierarchical Behavioral Analysis Framework (HBAF) as a Platform for Standardized Quantitative Identification of Behaviors
Hierarchical Behavioral Analysis Framework (HBAF) as a Platform for Standardized Quantitative Identification of Behaviors Open
View article: Effectiveness and safeties of hemocoagulase and tranexamic acid to reduce perioperative blood loss in intertrochanteric fracture PFNA fixation
Effectiveness and safeties of hemocoagulase and tranexamic acid to reduce perioperative blood loss in intertrochanteric fracture PFNA fixation Open
This study evaluated the efficacy of hemocoagulase and tranexamic acid (TXA) in minimizing perioperative blood loss in perioperative period of proximal femoral nail antirotation (PFNA) repair. 99 patients having intertrochanteric fracture …
View article: Cellular and Molecular Connections Between Bone Fracture Healing and Exosomes
Cellular and Molecular Connections Between Bone Fracture Healing and Exosomes Open
Fracture healing is a multifaceted process that requires various phases and intercellular interactions. In recent years, investigations have been conducted to assess the feasibility of utilizing exosomes, small extracellular vesicles (EVs)…
View article: Whole-brain connections of glutamatergic neurons in the lateral habenula in both sexes
Whole-brain connections of glutamatergic neurons in the lateral habenula in both sexes Open
Background The lateral habenula (LHb) is an evolution-conserved epithalamic nucleus that plays a role in multiple physiological functions, such as encoding value signals, integrating emotional information, and regulating related behaviors.…
View article: Inulin Inhibits the Inflammatory Response through Modulating Enteric Glial Cell Function in Type 2 Diabetic Mellitus Mice by Reshaping Intestinal Flora
Inulin Inhibits the Inflammatory Response through Modulating Enteric Glial Cell Function in Type 2 Diabetic Mellitus Mice by Reshaping Intestinal Flora Open
Inulin, a commonly used dietary fiber supplement, is capable of modulating the gut microbiome. Chronic inflammation resulting from metabolic abnormalities and gut flora dysfunction plays a significant role in the development of type 2 diab…
View article: Hsa_circ_0005397 could promote hepatocellular carcinoma progression and metastasis through EIF4A3
Hsa_circ_0005397 could promote hepatocellular carcinoma progression and metastasis through EIF4A3 Open
Purpose The purpose was to explore the expression and potential mechanism of hsa_circ_0005397 in hepatocellular carcinoma metabolism. Methods The quantitative real-time PCR (qPCR) was used to measure the expression of hsa_circ_0005397 and …
View article: 487. CAMRELIZUMAB COMBINED WITH CHEMOTHERAPY OR APATINIB AS NEOADJUVANT THERAPY FOR LOCALLY ADVANCED ESOPHAGEAL SQUAMOUS CELL CARCINOMA: A PHASE 2 TRIAL
487. CAMRELIZUMAB COMBINED WITH CHEMOTHERAPY OR APATINIB AS NEOADJUVANT THERAPY FOR LOCALLY ADVANCED ESOPHAGEAL SQUAMOUS CELL CARCINOMA: A PHASE 2 TRIAL Open
Background Increasing evidences prove the encouraging efficacy of neoadjuvant immunochemotherapy for esophageal squamous cell carcinoma (ESCC). However, the safety of chemotherapy is still unsatisfactory. Previous studies have confirmed th…
View article: Physcion increases the sensitivity of hepatocellular carcinoma to sorafenib through miRNA-370/PIM1 axis-regulated glycolysis
Physcion increases the sensitivity of hepatocellular carcinoma to sorafenib through miRNA-370/PIM1 axis-regulated glycolysis Open
Colitis-associated colorectal cancer (CAC) is defined as a specific cluster of colorectal cancers that develop as a result of prolonged colitis in patients with inflammatory bowel disease (IBD). Patients with IBD, including ulcerative coli…
View article: Altered effective connectivity of the default mode network in juvenile myoclonic epilepsy
Altered effective connectivity of the default mode network in juvenile myoclonic epilepsy Open
View article: Morusin shows potent antitumor activity for melanoma through apoptosis induction and proliferation inhibition
Morusin shows potent antitumor activity for melanoma through apoptosis induction and proliferation inhibition Open
Background The discovery of new anti-melanoma drugs with low side effect is urgently required in the clinic. Recent studies showed that morusin, a flavonoid compound isolated from the root bark of Morus Alba, has the potential to treat mul…