Wenyan Xu
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View article: Correlation study on the risk of cardiovascular adverse events in diabetic foot patients based on machine learning - a retrospective cohort study
Correlation study on the risk of cardiovascular adverse events in diabetic foot patients based on machine learning - a retrospective cohort study Open
Introduction Diabetic Foot (DF), as a serious complication of diabetes, is closely related to major adverse cardiovascular events (MACE) and mortality. However, research on predictive models for the MACE risk in DF patients is not sufficie…
View article: Main pancreatic duct exposure, repair, or reconstruction during minimally invasive pancreatic enucleation: a long-term metabolic outcome from a prospective cohort study (CSPAC-MIEN-1)
Main pancreatic duct exposure, repair, or reconstruction during minimally invasive pancreatic enucleation: a long-term metabolic outcome from a prospective cohort study (CSPAC-MIEN-1) Open
Background: While minimally invasive enucleation (MIEN) is known for its excellent long-term metabolic outcomes and comparable quality of life (QoL) to that of the general population, previous reports have rarely included exposure, repair,…
View article: The ACSS2-PPARD-BCAT1 axis synchronously regulates branched-chain amino acid metabolism and development in pancreatic cancer
The ACSS2-PPARD-BCAT1 axis synchronously regulates branched-chain amino acid metabolism and development in pancreatic cancer Open
The characteristics of the tumor microenvironment (TME) of pancreatic cancer include an abundant stroma, hypoxia, insufficient blood supply and high degree of immunosuppression. Therefore, overcoming the TME conditions to reach a hypermeta…
View article: Distinctive grade based on Ki67 index and immune microenvironment of metastatic pancreatic neuroendocrine tumors responding to capecitabine plus temozolomide
Distinctive grade based on Ki67 index and immune microenvironment of metastatic pancreatic neuroendocrine tumors responding to capecitabine plus temozolomide Open
View article: Laparoscopic versus open pancreatoduodenectomy following neoadjuvant chemotherapy for borderline resectable pancreatic ductal adenocarcinoma: protocol of a multicenter, open-label randomized clinical trial (CSPAC-5)
Laparoscopic versus open pancreatoduodenectomy following neoadjuvant chemotherapy for borderline resectable pancreatic ductal adenocarcinoma: protocol of a multicenter, open-label randomized clinical trial (CSPAC-5) Open
Background Surgery remains the only effective potential curative method for pancreatic ductal adenocarcinoma (PDAC). For borderline resectable PDAC, neoadjuvant chemotherapy (NACT) can reduce tumor volume, decrease the rate of pathologic l…
View article: Feasibility of laparoscopic versus open pancreatoduodenectomy following neoadjuvant chemotherapy for borderline resectable pancreatic cancer: a retrospective cohort study
Feasibility of laparoscopic versus open pancreatoduodenectomy following neoadjuvant chemotherapy for borderline resectable pancreatic cancer: a retrospective cohort study Open
Background There is no evidence supporting the feasibility of laparoscopic pancreaticoduodenectomy (LPD) compared to open pancreatoduodenectomy (OPD) following neoadjuvant chemotherapy (NACT) for pancreatic ductal adenocarcinoma (PDAC). Me…
View article: Minimally invasive enucleation of pancreatic tumors: The main pancreatic duct is no longer a restricted area
Minimally invasive enucleation of pancreatic tumors: The main pancreatic duct is no longer a restricted area Open
View article: The effect of PD-1/PD-L1 signaling axis on the interaction between CD19+B cells and CD4+T cells in peripheral blood of patients with systemic lupus erythematosus
The effect of PD-1/PD-L1 signaling axis on the interaction between CD19+B cells and CD4+T cells in peripheral blood of patients with systemic lupus erythematosus Open
Background The defect of B cell self-tolerance and the continuous antigen presentation by T cells (TCs) mediated by autoreactive B cells (BCs) play a key role in the occurrence and development of systemic lupus erythematosus (SLE). PD-1/PD…
View article: Application of split pancreatic duct stent in laparoscopic pancreaticoduodenectomy
Application of split pancreatic duct stent in laparoscopic pancreaticoduodenectomy Open
Laparoscopic pancreaticoduodenectomy (LPD) is a classic surgical method for diseases, such as tumors at the lower end of the common bile duct, pancreatic head, and benign and malignant tumors of the duodenum. Postoperative pancreatic fistu…
View article: The effect of PD-1/PD-L1 signaling axis on the interaction between CD19+B cells and CD4+T cells in peripheral blood of patients with systemic Lupus erythematosus
The effect of PD-1/PD-L1 signaling axis on the interaction between CD19+B cells and CD4+T cells in peripheral blood of patients with systemic Lupus erythematosus Open
Background The defect of B cell self-tolerance and the continuous antigen presentation by T cells (TCs) mediated by autoreactive B cells (BCs) play a key role in the occurrence and development of systemic lupus erythematosus (SLE). PD-1/PD…
View article: Laparoscopic enucleation of the pancreatic head tumor
Laparoscopic enucleation of the pancreatic head tumor Open
View article: Mitochondrial HSC70-1 Regulates Polar Auxin Transport through ROS Homeostasis in Arabidopsis Roots
Mitochondrial HSC70-1 Regulates Polar Auxin Transport through ROS Homeostasis in Arabidopsis Roots Open
Arabidopsis mitochondrial-localized heat shock protein 70-1 (mtHSC70-1) modulates vegetative growth by assisting mitochondrial complex IV assembly and maintaining reactive oxygen species (ROS) homeostasis. In addition, mtHSC70-1 affects em…
View article: Application of split pancreatic drainage tube in laparoscopic pancreaticoduodenectomy
Application of split pancreatic drainage tube in laparoscopic pancreaticoduodenectomy Open
Background Laparoscopic pancreaticoduodenectomy (LPD) is a classic surgical method for diseases, such as tumors at the lower end of the common bile duct, pancreatic head, and benign and malignant tumors of the duodenum. Postoperative pancr…
View article: Value of lymphadenectomy in patients with surgically resected pancreatic neuroendocrine tumors
Value of lymphadenectomy in patients with surgically resected pancreatic neuroendocrine tumors Open
Background Although some factors that predict the prognosis in pancreatic neuroendocrine tumor (pNET) have been confirmed, the predictive value of lymph node metastasis (LNM) in the prognosis of pNETs remains conflicting and it is not clea…
View article: Value Of Lymphadenectomy In Patients With Surgically Resected Grade 1 Pancreatic Neuroendocrine Tumors
Value Of Lymphadenectomy In Patients With Surgically Resected Grade 1 Pancreatic Neuroendocrine Tumors Open
Background: Although some factors that predict the prognosis in pancreatic neuroendocrine tumor (pNET) have been confirmed, the predictive value of lymph node metastasis (LNM) in the prognosis of pNETs remains conflicting and it is not cle…
View article: Pevonedistat Suppresses Pancreatic Cancer Growth via Inactivation of the Neddylation Pathway
Pevonedistat Suppresses Pancreatic Cancer Growth via Inactivation of the Neddylation Pathway Open
Background The neddylation pathway is aberrantly overactivated in multiple human cancers and has been indicated as an effective target for anticancer therapy in clinical trials. We aimed to study whether the neddylation pathway is upregula…
View article: ALDOA inhibits cell cycle arrest induced by DNA damage via the ATM-PLK1 pathway in pancreatic cancer cells
ALDOA inhibits cell cycle arrest induced by DNA damage via the ATM-PLK1 pathway in pancreatic cancer cells Open
View article: MTAP Deficiency–Induced Metabolic Reprogramming Creates a Vulnerability to Cotargeting <i>De Novo</i> Purine Synthesis and Glycolysis in Pancreatic Cancer
MTAP Deficiency–Induced Metabolic Reprogramming Creates a Vulnerability to Cotargeting <i>De Novo</i> Purine Synthesis and Glycolysis in Pancreatic Cancer Open
Methylthioadenosine phosphorylase (MTAP) is a key enzyme associated with the salvage of methionine and adenine that is deficient in 20% to 30% of pancreatic cancer. Our previous study revealed that MTAP deficiency indicates a poor prognosi…
View article: Polymerase chain reaction-based assays facilitate the breeding and study of mouse models of Klinefelter syndrome
Polymerase chain reaction-based assays facilitate the breeding and study of mouse models of Klinefelter syndrome Open
Klinefelter syndrome (KS) is one of the most frequent genetic abnormalities and the leading genetic cause of nonobstructive azoospermia. The breeding and study of KS mouse models are essential to advancing our knowledge of the underlying p…
View article: Low dose of homoharringtonine and cytarabine-based priming induction regimens for patients with <i>de novo</i> acute myeloid leukemia and high-risk myelodysplastic syndrome aged over 70 years
Low dose of homoharringtonine and cytarabine-based priming induction regimens for patients with <i>de novo</i> acute myeloid leukemia and high-risk myelodysplastic syndrome aged over 70 years Open
Our study provides a hint of the efficacy of low dose of HHT and cytarabine-based priming induction regimens for patients aged over 70 years with de novo AML and high-risk MDS should be further studied.
View article: FBW7-NRA41-SCD1 axis synchronously regulates apoptosis and ferroptosis in pancreatic cancer cells
FBW7-NRA41-SCD1 axis synchronously regulates apoptosis and ferroptosis in pancreatic cancer cells Open
View article: SETD8 potentiates constitutive ERK1/2 activation via epigenetically silencing DUSP10 expression in pancreatic cancer
SETD8 potentiates constitutive ERK1/2 activation via epigenetically silencing DUSP10 expression in pancreatic cancer Open
Constitutive ERK1/2 activation has been frequently observed in pancreatic adenocarcinoma (PDAC). How ERK1/2 activation status been potentiated and maintained by epigenetic mechanisms has seldom been discussed in PDAC. In this study, we fir…
View article: Case Report of a Patient with Hemophagocytic Lymphohistiocytosis in Small Cell Lung Cancer
Case Report of a Patient with Hemophagocytic Lymphohistiocytosis in Small Cell Lung Cancer Open
Background Hemophagocytic lymphohistiocytosis (HLH) is a rare and almost universally fatal disease in adults. Due to lack of recognition, under-diagnosis or delayed diagnosis, malignancy related HLH has a poor outcome in adults.Case Presen…
View article: Function and regulation of F‑box/WD repeat‑containing protein 7 (Review)
Function and regulation of F‑box/WD repeat‑containing protein 7 (Review) Open
The ubiquitin-proteasome system is an important post-translational modification system involved in numerous biological processes, such as cell cycle regulation, gene transcription, signal transduction, apoptosis, differentiation and develo…
View article: Pin1 promotes pancreatic cancer progression and metastasis by activation of NF‐κB‐IL‐18 feedback loop
Pin1 promotes pancreatic cancer progression and metastasis by activation of NF‐κB‐IL‐18 feedback loop Open
Objectives Accumulated evidence suggests that Pin1 contributes to oncogenesis of diverse cancers. However, the underlying mechanism of oncogenic function of Pin1 in PDAC requires further exploration . Materials and Methods IHC was performe…
View article: Ferroptosis: Final destination for cancer?
Ferroptosis: Final destination for cancer? Open
Ferroptosis is a recently defined, non‐apoptotic, regulated cell death (RCD) process that comprises abnormal metabolism of cellular lipid oxides catalysed by iron ions or iron‐containing enzymes. In this process, a variety of inducers dest…
View article: Abrogation of ARF6 promotes RSL3-induced ferroptosis and mitigates gemcitabine resistance in pancreatic cancer cells.
Abrogation of ARF6 promotes RSL3-induced ferroptosis and mitigates gemcitabine resistance in pancreatic cancer cells. Open
ADP Ribosylation Factor 6 (ARF6) is a part of the RAS superfamily and regulates vesicular trafficking, remodeling of membrane lipids, and signaling pathways. Our previous study has found that ARF6, functioned as a downstream of Kras/ERK si…
View article: The impact of lymphadenectomy on prognosis and survival of clinically apparent early-stage malignant ovarian germ cell tumors
The impact of lymphadenectomy on prognosis and survival of clinically apparent early-stage malignant ovarian germ cell tumors Open
Objective To determine the impact of lymphadenectomy (LND) on survival of clinically apparent early-stage malignant ovarian germ cell tumors (MOGCTs). Methods We retrospectively analyzed the survival of patients who were diagnosed with the…
View article: ABO Blood Group and the Risk of Pancreatic Neoplasms in Chinese Han Population
ABO Blood Group and the Risk of Pancreatic Neoplasms in Chinese Han Population Open
To the Editor: Pancreatic cancer is one of the most aggressive cancers.1 Accumulating epidemiological studies suggested a link between human blood group antigens and carcinogenesis or progression of various human tumors including pancreati…
View article: Research on Relationships between Sexual Identity, Adverse Childhood Experiences and Non-Suicidal Self-Injury among Rural High School Students in Less Developed Areas of China
Research on Relationships between Sexual Identity, Adverse Childhood Experiences and Non-Suicidal Self-Injury among Rural High School Students in Less Developed Areas of China Open
Purpose: The objective of this study was to examine the influence of sexual identity and adverse childhood experiences (ACEs) on non-suicidal self-injury (NSSI) among rural high school students in less developed areas of China. Methods: Be…