Wenyan Yu
YOU?
Author Swipe
View article: Fucoidan attenuated diabetic kidney disease through liver-kidney crosstalk based on CXCL1
Fucoidan attenuated diabetic kidney disease through liver-kidney crosstalk based on CXCL1 Open
View article: Supplementation of aged garlic extract attenuates age-associated memory impairment and cognitive decline: Involvement of molecular pathways in the cortex and hippocampus
Supplementation of aged garlic extract attenuates age-associated memory impairment and cognitive decline: Involvement of molecular pathways in the cortex and hippocampus Open
The aging of the human population is associated with increases in comorbidities, including functional impairment and cognitive decline. With decreasing numbers of neurons and declining synaptic plasticity, the aging brain exhibits less per…
View article: Norwegian scabies coinfected with disseminated Talaromyces marneffei – a dual challenge in HIV immunodeficiency: A case report
Norwegian scabies coinfected with disseminated Talaromyces marneffei – a dual challenge in HIV immunodeficiency: A case report Open
Rationale: Norwegian scabies (crusted scabies) is an extreme manifestation of Sarcoptes scabiei infestation, primarily affecting immunocompromised populations such as HIV-positive individuals. This condition is characterized by a severe mi…
View article: Effects of albumin-bound paclitaxel combined with Sophora subprostrate polysaccharide on inflammatory factors and immune function in breast cancer rats
Effects of albumin-bound paclitaxel combined with Sophora subprostrate polysaccharide on inflammatory factors and immune function in breast cancer rats Open
Albumin-bound paclitaxel combined with Sophora subprostrate polysaccharide can reduce the local inflammation level, promote the proportion of CDB + T cells and NK cells and cell killing function, reduce the proportion of MDSC and immunosup…
View article: Mitochondrial reactive oxygen species promote cancer metastasis and tumor microenvironment immunosuppression through gasdermin D
Mitochondrial reactive oxygen species promote cancer metastasis and tumor microenvironment immunosuppression through gasdermin D Open
View article: A Multifunctional Enzyme Cascade Catalytic Nanoplatform for Effective Synergistic Therapy of Rheumatoid Arthritis
A Multifunctional Enzyme Cascade Catalytic Nanoplatform for Effective Synergistic Therapy of Rheumatoid Arthritis Open
Insufficient oxygen supply and elevated levels of reactive oxygen species (ROS) in rheumatoid arthritis (RA) joints synergistically exacerbate inflammation and accelerate disease progression. In this study, a hybrid nanoassembly composed o…
View article: Long non-coding RNAs promote colorectal cancer development through other epigenetic modifications
Long non-coding RNAs promote colorectal cancer development through other epigenetic modifications Open
Colorectal cancer is one of the most prevalent malignant tumors worldwide, and it has one of the highest rates of mortality and morbidity. Its emergence and progression are intricately linked to various genetic and epigenetic factors influ…
View article: ITGB1 Alleviates High Glucose-Induced Myocardial Cell Injury by Inhibiting Endoplasmic Reticulum Stress and Cell Apoptosis
ITGB1 Alleviates High Glucose-Induced Myocardial Cell Injury by Inhibiting Endoplasmic Reticulum Stress and Cell Apoptosis Open
Diabetic cardiopathy is a common clinical complication of diabetes and is one of the main causes of mortality in type 2 diabetes mellitus patients. In this study, we examined the effect and mechanism of integrin β1 (ITGB1) on high glucose-…
View article: Autophagy regulates apoptosis of colorectal cancer cells based on signaling pathways
Autophagy regulates apoptosis of colorectal cancer cells based on signaling pathways Open
View article: Discovery of aurovertin B as a potent metastasis inhibitor against triple-negative breast cancer: Elucidating the complex role of the ATF3-DUSP1 axis
Discovery of aurovertin B as a potent metastasis inhibitor against triple-negative breast cancer: Elucidating the complex role of the ATF3-DUSP1 axis Open
Triple-negative breast cancer (TNBC) is characterized by high mortality rates primarily due to its propensity for metastasis. Addressing this challenge necessitates the development of effective antimetastatic therapies. This study aimed to…
View article: Exosomal microRNAs associated with tuberculosis among people living with human immunodeficiency virus
Exosomal microRNAs associated with tuberculosis among people living with human immunodeficiency virus Open
View article: Exosomal MicroRNAs Associated with Tuberculosis Among People Living with Human Immunodeficiency Virus
Exosomal MicroRNAs Associated with Tuberculosis Among People Living with Human Immunodeficiency Virus Open
View article: The Role of Tumor Stem Cells in Colorectal Cancer Drug Resistance
The Role of Tumor Stem Cells in Colorectal Cancer Drug Resistance Open
Background: Colorectal cancer is a major cause of mortality among the prevalent malignant tumors of the gastrointestinal tract. Although chemotherapy is a standard treatment for colorectal cancer, its efficacy is limited by chemoresistance…
View article: Unveiling the hidden clues: Döhle body-like inclusions as morphological markers for MYH9-related disorders: A case report
Unveiling the hidden clues: Döhle body-like inclusions as morphological markers for MYH9-related disorders: A case report Open
Rationale: This study aimed to address the diagnostic challenges associated with MYH9-related disorders (MYH9-RDs) and highlight the importance of recognizing Döhle body-like inclusions as crucial diagnostic markers for this condition. Pat…
View article: P1074: PROGNOSIS ANALYSIS AND A NEW RISK MODEL FOR RELAPSED AND REFRACTORY HODGKIN LYMPHOMA PATIENTS TREATED BY ANTI-PD-1: A REAL-WORLD MULTICENTER RETROSPECTIVE STUDY OF PATIENTS IN CHINA
P1074: PROGNOSIS ANALYSIS AND A NEW RISK MODEL FOR RELAPSED AND REFRACTORY HODGKIN LYMPHOMA PATIENTS TREATED BY ANTI-PD-1: A REAL-WORLD MULTICENTER RETROSPECTIVE STUDY OF PATIENTS IN CHINA Open
Topic: 17. Hodgkin lymphoma - Clinical Background: Although the promising benefit of PD-1 inhibitors for relapsed/refractory Hodgkin’s lymphoma (R/R HL) has been shown by several large clinical trials, there remains a paucity of studies de…
View article: Integrative bioinformatics approaches to establish potential prognostic immune-related genes signature and drugs in the non-small cell lung cancer microenvironment
Integrative bioinformatics approaches to establish potential prognostic immune-related genes signature and drugs in the non-small cell lung cancer microenvironment Open
Introduction: Research has revealed that the tumor microenvironment (TME) is associated with the progression of malignancy. The combination of meaningful prognostic biomarkers related to the TME is expected to be a reliable direction for i…
View article: Are Librarians Ready for Space Transformation? A Systematic Review of Spatial Literacy for Librarians
Are Librarians Ready for Space Transformation? A Systematic Review of Spatial Literacy for Librarians Open
To achieve transformation, libraries must undertake a profound and rapid reconfiguration of space. The spatial literacy competencies of librarians are directly related to the construction and service level of library spaces. This paper cla…
View article: Multisensory reading promotion in academic libraries
Multisensory reading promotion in academic libraries Open
To confront college students’ new reading patterns and the continuous decline in academic library borrowing rates, we conducted empirical research on promoting multisensory reading as a way to attract students’ attention, and to stimulate …
View article: The activation of SIRT1 by resveratrol reduces breast cancer metastasis to lung through inhibiting neutrophil extracellular traps
The activation of SIRT1 by resveratrol reduces breast cancer metastasis to lung through inhibiting neutrophil extracellular traps Open
Neutrophil extracellular traps (NETs) play a crucial role in breast cancer metastasis. However, the therapeutic target of NETs in breast cancer metastasis is still unknown. Using a natural metabolite library and single-cell sequencing data…
View article: <scp>FBP1</scp> induced by β‐elemene enhances the sensitivity of gefitinib in lung cancer
<span>FBP1</span> induced by β‐elemene enhances the sensitivity of gefitinib in lung cancer Open
Background β‐elemene is known to play a critical role in tumorigenesis as well as tyrosine kinase inhibitor (TKI) resistance in lung cancer. However, the biological function and molecular mechanism remain largely unknown. Methods In this s…
View article: Transcription factor FoxM1 promotes cyst growth in PKD1 mutant ADPKD
Transcription factor FoxM1 promotes cyst growth in PKD1 mutant ADPKD Open
Autosomal dominant polycystic kidney disease (ADPKD) is driven by mutations in the PKD1 and PKD2 genes, and it is characterized by renal cyst formation, inflammation and fibrosis. Forkhead box protein M1 (FoxM1), a transcription factor of …
View article: Identification of pyroptosis-related gene signature for predicting prognosis of patients with pancreatic cancer using bioinformatics
Identification of pyroptosis-related gene signature for predicting prognosis of patients with pancreatic cancer using bioinformatics Open
Pancreatic cancer, a common digestive system malignancy, is dubbed the “king of cancers”. The role of pyrophosis-related genes (PRGs) in pancreatic cancer prognosis is yet unknown. In pancreatic cancer and normal tissue, we discovered 9 PR…
View article: X-box Binding Protein 1 is a Potential Immunotherapy Target in Ovarian Cancer
X-box Binding Protein 1 is a Potential Immunotherapy Target in Ovarian Cancer Open
The allure of potentially dramatic and durable responses to immunotherapy has driven the study of several immune checkpoint inhibitor (ICI) agents in ovarian cancer. However, the results of ICI therapy in ovarian cancer have been rather di…
View article: Protective Effects of Ferulic Acid on Deoxynivalenol-Induced Toxicity in IPEC-J2 Cells
Protective Effects of Ferulic Acid on Deoxynivalenol-Induced Toxicity in IPEC-J2 Cells Open
Deoxynivalenol (DON), a mycotoxin that contaminates crops such as wheat and corn, can cause severe acute or chronic injury when ingested by animals or humans. This study investigated the protective effect of ferulic acid (FA), a polyphenol…
View article: Lipid raft involvement in signal transduction in cancer cell survival, cell death and metastasis
Lipid raft involvement in signal transduction in cancer cell survival, cell death and metastasis Open
Lipid rafts are cholesterol‐ and sphingolipid‐enriched specialized membrane domains within the plasma membrane. Lipid rafts regulate the density and activity of signal receptors by compartmentalizing them, promoting signalling cascades tha…
View article: Progress in the Application of Immune Checkpoint Inhibitor-Based Immunotherapy for Targeting Different Types of Colorectal Cancer
Progress in the Application of Immune Checkpoint Inhibitor-Based Immunotherapy for Targeting Different Types of Colorectal Cancer Open
Colorectal cancer (CRC), a common malignant disease, has the second highest mortality rate among all cancer types. Due to the diversity and heterogeneity of CRC, few effective treatment strategies have been developed in recent years, excep…
View article: Circle RNA PLEC Acts as a Sponge of Microrna-198 to Promote Gastric&nbsp;Carcinoma Cell Resistance to Paclitaxel and Tumorigenesis
Circle RNA PLEC Acts as a Sponge of Microrna-198 to Promote Gastric Carcinoma Cell Resistance to Paclitaxel and Tumorigenesis Open
Gastric carcinoma (GC) is one of the most frequent type of malignancy all over the world. The resistance of Paclitaxel (PTX) has become the obstacle of the prognosis of GC, and the underlying mechanism of is not clear. Previous study showe…
View article: <p>Loxoprofen Sodium Alleviates Oxidative Stress and Apoptosis Induced by Angiotensin II in Human Umbilical Vein Endothelial Cells (HUVECs)</p>
Loxoprofen Sodium Alleviates Oxidative Stress and Apoptosis Induced by Angiotensin II in Human Umbilical Vein Endothelial Cells (HUVECs) Open
Loxoprofen sodium might alleviate the high ROS levels and apoptosis induced by angiotensin II in HUVECs.
View article: Postnatal leptin surge is critical for the transient induction of the developmental beige adipocytes in mice
Postnatal leptin surge is critical for the transient induction of the developmental beige adipocytes in mice Open
Beige adipocytes have become a promising therapeutic target to combat obesity. Our senior author Dr. B. Xue previously discovered a transient but significant induction of beige adipocytes in mice during early postnatal development, which p…
View article: The Lung Adenocarcinoma Microenvironment Mining and Its Prognostic Merit
The Lung Adenocarcinoma Microenvironment Mining and Its Prognostic Merit Open
Background: As a common pathological type of lung cancer, lung adenocarcinoma (LUAD) is mainly treated by surgery, chemotherapy, targeted therapy and radiotherapy. Although a relatively mature treatment system has been established, there a…