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View article: Neurofunctional Reversibility in Psoriasis Vulgaris After IL-17A Inhibition: A Resting-State fMRI and Neurocognitive Analysis
Neurofunctional Reversibility in Psoriasis Vulgaris After IL-17A Inhibition: A Resting-State fMRI and Neurocognitive Analysis Open
Psoriasis is associated with brain dysfunction and neuropsychiatric symptoms. IL-17A antibody therapy improves skin symptoms, restores brain function, and alleviates neuropsychiatric issues vs untreated patients, supporting multidimensiona…
View article: Upper Extremity Muscle Recovery Profiles with Functional Electrical Stimulation Therapy in Chronic Spinal Cord Injury
Upper Extremity Muscle Recovery Profiles with Functional Electrical Stimulation Therapy in Chronic Spinal Cord Injury Open
Background Spinal cord injuries (SCI) can affect muscle control, often resulting in significant functional impairments. Damage to sensorimotor pathways in the spinal cord can lead to muscle weakness, which may gradually recover during the …
View article: Application of Tianji Orthopedic Robot-Assisted Screw Placement versus Traditional Free-Hand Screw Placement in Upper Cervical Fractures
Application of Tianji Orthopedic Robot-Assisted Screw Placement versus Traditional Free-Hand Screw Placement in Upper Cervical Fractures Open
View article: <i>APOE</i> ε4–associated downregulation of the IL‐7/IL‐7R pathway in effector memory T cells: Implications for Alzheimer's disease
<i>APOE</i> ε4–associated downregulation of the IL‐7/IL‐7R pathway in effector memory T cells: Implications for Alzheimer's disease Open
INTRODUCTION The apolipoprotein E ( APOE ) ε4 allele exerts a significant influence on peripheral inflammation and neuroinflammation, yet the underlying mechanisms remain elusive. METHODS The present study enrolled 54 patients diagnosed wi…
View article: Mendelian Randomization Analysis Reveals Causal Factors behind Alzheimer's Disease Risk: Evidence, Opportunities, and Challenges
Mendelian Randomization Analysis Reveals Causal Factors behind Alzheimer's Disease Risk: Evidence, Opportunities, and Challenges Open
Alzheimer's disease and its comorbidities pose a heavy disease burden globally, and its treatment remains a major challenge. Identifying the protective and risk factors for Alzheimer's disease, as well as its possible underlying molecular …
View article: HOI-02 induces apoptosis and G2-M arrest in esophageal cancer mediated by ROS
HOI-02 induces apoptosis and G2-M arrest in esophageal cancer mediated by ROS Open
Reactive oxygen species (ROS) are chemically reactive molecules that perform essential functions in living organisms. Accumulating evidence suggests that many types of cancer cells exhibit elevated levels of ROS. Conversely, generation of …
View article: Cyclin-dependent kinase 2 (CDK2) is a key mediator for EGF-induced cell transformation mediated through the ELK4/c-Fos signaling pathway
Cyclin-dependent kinase 2 (CDK2) is a key mediator for EGF-induced cell transformation mediated through the ELK4/c-Fos signaling pathway Open