Wenyi Zheng
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View article: CAP1-Mediated m6A Modification of RRM2 Suppresses Tumor-Associated M2 Macrophage Polarization and Colorectal Cancer Growth
CAP1-Mediated m6A Modification of RRM2 Suppresses Tumor-Associated M2 Macrophage Polarization and Colorectal Cancer Growth Open
Colorectal cancer (CRC) progression is critically regulated by dynamic interactions between tumor cells and tumor-associated macrophages (TAMs), which shape the immuno-suppressive tumor microenvironment. In this study, we identify CAP1 as …
View article: Systemic Inflammation Modulates Clearance and drives Extra-Hepatic Distribution of Extracellular Vesicles
Systemic Inflammation Modulates Clearance and drives Extra-Hepatic Distribution of Extracellular Vesicles Open
Extracellular vesicles (EVs) are promising vehicles for targeted therapeutic delivery, capable of encapsulating and transporting biomolecules to specific cells and tissues. Given that inflammation is central to many acute and chronic disea…
View article: Screening scaffold proteins for improved functional delivery of luminal proteins using engineered extracellular vesicles
Screening scaffold proteins for improved functional delivery of luminal proteins using engineered extracellular vesicles Open
The potential for engineered extracellular vesicles (EVs) to efficiently deliver biotherapeutics is still largely untapped. One of the key structures in determining cargo loading and subsequent functional delivery efficiency of engineered …
View article: Mechanisms underlying seizures and hypothermia during busulphan administration
Mechanisms underlying seizures and hypothermia during busulphan administration Open
Busulphan (Bu) is used as a part of the conditioning regimen prior to HSCT. Neurotoxicity is one of Bu major adverse-effects. We investigated the kinetics of busulphan and its metabolites (tetrahydothiophene, tetrahydrothiophene-1-oxide, s…
View article: Engineering of extracellular vesicles for efficient intracellular delivery of multimodal therapeutics including genome editors
Engineering of extracellular vesicles for efficient intracellular delivery of multimodal therapeutics including genome editors Open
View article: A novel antioxidant N-acetylcysteine Amide Alleviates Cyclophosphamide-induced Endothelial Damage
A novel antioxidant N-acetylcysteine Amide Alleviates Cyclophosphamide-induced Endothelial Damage Open
The alkylating agent cyclophosphamide (Cy) is one of the important corner stones in cancer treatment. Cy is used also as a part of conditioning regimens prior to hematopoietic cell transplantation and as a prophylactic treatment post trans…
View article: Gas Vesicle-Assisted Ultrasound Imaging for Effective Anti-Tumour CAR-T Cell Immunotherapy Efficacy in Mice Model
Gas Vesicle-Assisted Ultrasound Imaging for Effective Anti-Tumour CAR-T Cell Immunotherapy Efficacy in Mice Model Open
This study presents an efficient method for in vivo tracking of CAR-T cells and offers new insights for predicting the efficacy of CAR-T cell immunotherapy.
View article: The efficacy and safety of first-line monotherapies in primary therapy of invasive aspergillosis: a systematic review
The efficacy and safety of first-line monotherapies in primary therapy of invasive aspergillosis: a systematic review Open
Objective Several antifungals are available for the treatment of patients with invasive aspergillosis (IA). This study aims to evaluate the relative efficacy and safety of the first-line monotherapies in primary therapy of IA through netwo…
View article: Association between ALK Tyrosine Kinase Inhibitor and the Risk of Interstitial Lung Disease and Pneumonitis in Non-Small Cell Lung Cancer Patients: A Systematic Review
Association between ALK Tyrosine Kinase Inhibitor and the Risk of Interstitial Lung Disease and Pneumonitis in Non-Small Cell Lung Cancer Patients: A Systematic Review Open
View article: Behaviour of Bamboo Scrimber Sheathing-to-Framing Screwed Connections
Behaviour of Bamboo Scrimber Sheathing-to-Framing Screwed Connections Open
View article: Surface display of proximity labeling enzymes on extracellular vesicles for surfaceome and target cell mapping
Surface display of proximity labeling enzymes on extracellular vesicles for surfaceome and target cell mapping Open
Extracellular vesicles (EV) surface proteins have important extracellular functions and determine cellular tropism; however, characterizing the EV surfaceome remains challenging with available methods. EV-mediated intercellular communicati…
View article: Antibody-displaying extracellular vesicles for targeted cancer therapy
Antibody-displaying extracellular vesicles for targeted cancer therapy Open
View article: The methodological quality of systematic reviews regarding the Core Outcome Set (COS) development
The methodological quality of systematic reviews regarding the Core Outcome Set (COS) development Open
Background The Core Outcome Measures in Effectiveness Trials (COMET) working group proposed core outcome sets (COS) to address the heterogeneity in outcome measures in clinical studies. According to the recommendations of COMET, performing…
View article: Engineering of extracellular vesicles for efficient intracellular delivery of multimodal therapeutics including genome editors
Engineering of extracellular vesicles for efficient intracellular delivery of multimodal therapeutics including genome editors Open
Intracellular delivery of protein and RNA therapeutics represents a major challenge. Here, we developed highly potent engineered extracellular vesicles (EVs) by incorporating essential bio-inspired attributes required for effective deliver…
View article: Identification of scaffold proteins for improved endogenous engineering of extracellular vesicles
Identification of scaffold proteins for improved endogenous engineering of extracellular vesicles Open
Extracellular vesicles (EVs) are gaining ground as next-generation drug delivery modalities. Genetic fusion of the protein of interest to a scaffold protein with high EV-sorting ability represents a robust cargo loading strategy. To addres…
View article: Cutaneous squamous cell carcinoma-derived extracellular vesicles exert an oncogenic role by activating cancer-associated fibroblasts
Cutaneous squamous cell carcinoma-derived extracellular vesicles exert an oncogenic role by activating cancer-associated fibroblasts Open
Cutaneous squamous cell carcinoma (cSCC) is a fast-increasing cancer with metastatic potential. Extracellular vesicles (EVs) are small membrane-bound vesicles that play important roles in intercellular communication, particularly in the tu…
View article: EV-mediated promotion of myogenic differentiation is dependent on dose, collection medium, and isolation method
EV-mediated promotion of myogenic differentiation is dependent on dose, collection medium, and isolation method Open
View article: Association between Antibiotic Exposure and the Risk of Rash in Children with Infectious Mononucleosis: a Multicenter, Retrospective Cohort Study
Association between Antibiotic Exposure and the Risk of Rash in Children with Infectious Mononucleosis: a Multicenter, Retrospective Cohort Study Open
Present evidence suggests that the administration of antibiotics, particularly aminopenicillins, may increase the risk of rash in children with infectious mononucleosis (IM). This retrospective, multicenter cohort study of children with IM…
View article: Identification of Novel Scaffold Proteins for Improved Endogenous Engineering of Extracellular Vesicles
Identification of Novel Scaffold Proteins for Improved Endogenous Engineering of Extracellular Vesicles Open
Extracellular vesicles (EVs) are gaining ground as next-generation drug delivery modalities. Genetic fusion of the protein of interest to a scaffold protein with high EV-sorting ability represents a robust cargo loading strategy. To addres…
View article: Multimodal engineering of extracellular vesicles for efficient intracellular protein delivery
Multimodal engineering of extracellular vesicles for efficient intracellular protein delivery Open
Extracellular vesicles (EVs) are promising tools to transfer macromolecular therapeutic molecules to recipient cells, however, efficient functional intracellular protein delivery by EVs remains challenging. Here, we have developed novel an…
View article: Surface display of functional moieties on extracellular vesicles using lipid anchors
Surface display of functional moieties on extracellular vesicles using lipid anchors Open
Extracellular vesicles (EVs) are efficient natural vehicles for intercellular communication and are under extensive investigation for the delivery of diverse therapeutics including small molecule drugs, nucleic acids, and proteins. To unde…
View article: Cell‐specific targeting of extracellular vesicles through engineering the glycocalyx
Cell‐specific targeting of extracellular vesicles through engineering the glycocalyx Open
Extracellular vesicles (EVs) are promising carriers for the delivery of a variety of chemical and biological drugs. However, their efficacy is limited by the lack of cellular specificity. Available methods to improve the tissue specificity…
View article: Identification of storage conditions stabilizing extracellular vesicles preparations
Identification of storage conditions stabilizing extracellular vesicles preparations Open
Extracellular vesicles (EVs) play a key role in many physiological and pathophysiological processes and hold great potential for therapeutic and diagnostic use. Despite significant advances within the last decade, the key issue of EV stora…
View article: Extracellular vesicles engineered to bind albumin demonstrate extended circulation time and lymph node accumulation in mouse models
Extracellular vesicles engineered to bind albumin demonstrate extended circulation time and lymph node accumulation in mouse models Open
Extracellular vesicles (EVs) have shown promise as potential therapeutics for the treatment of various diseases. However, their rapid clearance after administration could be a limitation in certain therapeutic settings. To solve this, an e…
View article: Influence of short term storage conditions, concentration methods and excipients on extracellular vesicle recovery and function
Influence of short term storage conditions, concentration methods and excipients on extracellular vesicle recovery and function Open
Extracellular vesicles (EVs) are phospholipid bilayer enclosed vesicles which play an important role in intercellular communication. To date, many studies have focused on therapeutic application of EVs. However, to progress EV applications…
View article: Growth Media Conditions Influence the Secretion Route and Release Levels of Engineered Extracellular Vesicles
Growth Media Conditions Influence the Secretion Route and Release Levels of Engineered Extracellular Vesicles Open
Extracellular vesicles (EVs) are nanosized cell‐derived vesicles produced by all cells, which provide a route of intercellular communication by transmitting biological cargo. While EVs offer promise as therapeutic agents, the molecular mec…
View article: The Efficacy and Safety of Revefenacin for the Treatment of Chronic Obstructive Pulmonary Disease: A Systematic Review
The Efficacy and Safety of Revefenacin for the Treatment of Chronic Obstructive Pulmonary Disease: A Systematic Review Open
Background Revefenacin (REV) is a novel once-daily long-acting muscarinic antagonist (LAMA) in the treatment of moderate to very severe chronic obstructive pulmonary disease (COPD). This systematic review incorporating a dose-response meta…
View article: Tumor elastography and its association with cell-free tumor DNA in the plasma of breast tumor patients: a pilot study
Tumor elastography and its association with cell-free tumor DNA in the plasma of breast tumor patients: a pilot study Open
These results have established proof of principle that WGS analysis of ctDNA could complement current UE approaches to assess tumor stiffness changes for the early diagnosis and prognostic assessment of breast cancer.
View article: Functional Nanocarriers for Drug Delivery by Surface Engineering of Polymeric Nanoparticle Post-Polymerization-Induced Self-Assembly
Functional Nanocarriers for Drug Delivery by Surface Engineering of Polymeric Nanoparticle Post-Polymerization-Induced Self-Assembly Open
Engineered polymeric nanoparticles (NPs) have been comprehensively explored as potential platforms for diagnosis and targeted therapy for several diseases including cancer. Herein, we designed functional poly(acrylic acid)-b-poly(butyl acr…
View article: Multimodal Imaging of Pancreatic Ductal Adenocarcinoma Using Multifunctional Nanoparticles as Contrast Agents
Multimodal Imaging of Pancreatic Ductal Adenocarcinoma Using Multifunctional Nanoparticles as Contrast Agents Open
Late diagnosis and refractory behavior toward current treatment protocols make pancreatic ductal adenocarcinoma (PDAC) one of the most difficult cancer forms to treat. The imaging-based approach plays an important role to identify potentia…