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View article: WWOX promotes apoptosis and inhibits autophagy in paclitaxel‑treated ovarian carcinoma cells
WWOX promotes apoptosis and inhibits autophagy in paclitaxel‑treated ovarian carcinoma cells Open
Although paclitaxel (PTX) is a first‑line chemotherapeutic agent for the treatment of epithelial ovarian cancer (EOC), its clinical use is restricted by chemoresistance. Autophagy is believed to promote drug resistance, and WW domain‑conta…
View article: COMP-08. COMPREHENSIVE RNA ANALYSIS OF CEREBROSPINAL FLUID FROM LEPTOMENINGEAL METASTASES
COMP-08. COMPREHENSIVE RNA ANALYSIS OF CEREBROSPINAL FLUID FROM LEPTOMENINGEAL METASTASES Open
Leptomeningeal metastases (LM), a diffuse form of brain metastases is rare and fatal progression of non-small cell lung cancer (NSCLC). In LM, metastatic cancer cells spread and resign on the brain meninges, the cerebrospinal fluid (CSF), …
View article: Alignment-free filtering for cfNA fusion fragments
Alignment-free filtering for cfNA fusion fragments Open
Motivation Cell-free nucleic acid (cfNA) sequencing data require improvements to existing fusion detection methods along multiple axes: high depth of sequencing, low allele fractions, short fragment lengths and specialized barcodes, such a…
View article: Noninvasive blood tests for fetal development predict gestational age and preterm delivery
Noninvasive blood tests for fetal development predict gestational age and preterm delivery Open
Toward more predictable birthdays Low-cost methods for monitoring fetal development could improve prenatal care, especially in low-resource settings. By measuring the levels of certain placental RNA transcripts in maternal blood, Ngo et al…
View article: Recurrently Mutated Genes Differ between Leptomeningeal and Solid Lung Cancer Brain Metastases
Recurrently Mutated Genes Differ between Leptomeningeal and Solid Lung Cancer Brain Metastases Open
Purpose Brain metastases from non-small cell lung cancer (NSCLC) engraft and grow either within the brain (solid) or diffusely on its surface (leptomeningeal disease; LMD). Routine clinical diagnostics have low sensitivity and provide no i…
View article: A Noninvasive Molecular Clock for Fetal Development Predicts Gestational Age and Preterm Delivery
A Noninvasive Molecular Clock for Fetal Development Predicts Gestational Age and Preterm Delivery Open
We performed a high time-resolution, longitudinal study of normal pregnancy development by measuring cell-free RNA (cfRNA) in blood from women during each week of pregnancy. Analysis of tissue-specific transcripts in these samples enabled …
View article: Simultaneously Monitoring Immune Response and Microbial Infections during Pregnancy through Plasma cfRNA Sequencing
Simultaneously Monitoring Immune Response and Microbial Infections during Pregnancy through Plasma cfRNA Sequencing Open
BACKGROUND Plasma cell-free RNA (cfRNA) encompasses a broad spectrum of RNA species that can be derived from both human cells and microbes. Because cfRNA is fragmented and of low concentration, it has been challenging to profile its transc…
View article: Numerous uncharacterized and highly divergent microbes which colonize humans are revealed by circulating cell-free DNA
Numerous uncharacterized and highly divergent microbes which colonize humans are revealed by circulating cell-free DNA Open
Significance Through massive shotgun sequencing of circulating cell-free DNA from the blood of more than 1,000 independent samples, we identified hundreds of new bacteria and viruses which represent previously unidentified members of the h…
View article: Humans are colonized by many uncharacterized and highly divergent microbes
Humans are colonized by many uncharacterized and highly divergent microbes Open
Blood circulates throughout the entire body and contains molecules drawn from virtually every tissue, including the microbes and viruses which colonize the body. Through massive shotgun sequencing of circulating cell-free DNA from the bloo…
View article: BMET-15TUMOR CELL FREE DNA IN CEREBRAL SPINAL FLUID REFLECTS TREATMENT RESPONSE IN LEPTOMENINGEAL METASTASIS
BMET-15TUMOR CELL FREE DNA IN CEREBRAL SPINAL FLUID REFLECTS TREATMENT RESPONSE IN LEPTOMENINGEAL METASTASIS Open
Cerebral Spinal Fluid (CSF) from brain tumor patients contains tumor cell free DNA (cfDNA), which may provide a non-invasive and routinely accessible method to obtain tumor genomic information.This "liquid biopsy" method would prove consid…
View article: Brain Tumor Mutations Detected in Cerebral Spinal Fluid
Brain Tumor Mutations Detected in Cerebral Spinal Fluid Open
BACKGROUND Detecting tumor-derived cell-free DNA (cfDNA) in the blood of brain tumor patients is challenging, presumably owing to the blood–brain barrier. Cerebral spinal fluid (CSF) may serve as an alternative “liquid biopsy” of brain tum…