Wenying Qiu
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View article: The China Brain Multi-omics Atlas Project (CBMAP)
The China Brain Multi-omics Atlas Project (CBMAP) Open
The China Brain Multi-omics Atlas Project (CBMAP) aims to generate a comprehensive molecular reference map of over 1000 human brains (Phase I), spanning a broad age range and multiple regions in China, to address the underrepresentation of…
View article: Epigenetic Rewiring Connects Aging to Alzheimer’s Pathology in the Human Prefrontal Cortex
Epigenetic Rewiring Connects Aging to Alzheimer’s Pathology in the Human Prefrontal Cortex Open
The epigenetic mechanisms that connect aging to neurodegeneration remain incompletely understood, particularly in non-European populations. To address this gap, we constructed a comprehensive DNA methylation atlas of the human prefrontal c…
View article: Highly efficient gene editing of Feline herpesvirus 1 using CRISPR/Cas9 combined with FACS
Highly efficient gene editing of Feline herpesvirus 1 using CRISPR/Cas9 combined with FACS Open
Feline herpesvirus 1 ( FHV-1 ) is a major causative agent of feline viral rhinotracheitis and ocular lesions. Due to its large DNA genome, the construction of recombinant FHV-1 viruses presents considerable challenges for conventional meth…
View article: Distinct composition of different types of Abeta plaques in the pathogenesis of Alzheimer’s disease and the role of neutrophil-derived myeloperoxidase
Distinct composition of different types of Abeta plaques in the pathogenesis of Alzheimer’s disease and the role of neutrophil-derived myeloperoxidase Open
Alzheimer’s disease (AD) is an age-related neurodegenerative disorder. Different types of Aβ plaques are likely to play distinct roles in the brains of patients with AD. In this study, through the combination of pathological techniques and…
View article: Compliance-to-Code: Enhancing Financial Compliance Checking via Code Generation
Compliance-to-Code: Enhancing Financial Compliance Checking via Code Generation Open
Nowadays, regulatory compliance has become a cornerstone of corporate governance, ensuring adherence to systematic legal frameworks. At its core, financial regulations often comprise highly intricate provisions, layered logical structures,…
View article: PRMT3‐Mediated H4R3me2a Promotes Primary Age‐Related Tauopathy by Driving Tau Hyperphosphorylation in Neuron
PRMT3‐Mediated H4R3me2a Promotes Primary Age‐Related Tauopathy by Driving Tau Hyperphosphorylation in Neuron Open
Primary age‐related tauopathy (PART) and Alzheimer's disease (AD) both exhibit 3R/4R hyperphosphorylated tau‐positive neurofibrillary tangles (NFTs) within the hippocampal–entorhinal system. Notably, PART patients show a higher degree of t…
View article: The China Brain Multi-omics Atlas Project (CBMAP)
The China Brain Multi-omics Atlas Project (CBMAP) Open
The China Brain Multi-omics Atlas Project (CBMAP) aims to generate a comprehensive molecular reference map of over 1,000 human brains (Phase I), spanning a broad age range and multiple regions in China, to address the underrepresentation o…
View article: Prevalence of cerebral amyloid angiopathy and its correlation with Alzheimer's disease and cognition in an autopsy‐confirmed cohort from China
Prevalence of cerebral amyloid angiopathy and its correlation with Alzheimer's disease and cognition in an autopsy‐confirmed cohort from China Open
BACKGROUND We aimed to investigate the prevalence of cerebral amyloid angiopathy (CAA) and its correlations with Alzheimer's disease (AD) and cognitive impairment in an autopsy‐confirmed cohort donated to a human brain bank in Beijing, Chi…
View article: Structural changes in cerebral microvasculature induced by ferroptosis contribute to blood–brain barrier disruption in Alzheimer's disease: an autopsy study
Structural changes in cerebral microvasculature induced by ferroptosis contribute to blood–brain barrier disruption in Alzheimer's disease: an autopsy study Open
INTRODUCTION Cerebrovascular lesions are associated with cognitive impairment. However, the impact of AD neuropathological changes (ADNC) on cerebral microvasculature is not completely understood. METHODS Twelve decedents with ADNC and 15 …
View article: Neuropathological comorbidity, genetics and cognition in a Chinese community-based autopsy cohort
Neuropathological comorbidity, genetics and cognition in a Chinese community-based autopsy cohort Open
Neurodegenerative comorbidities are common and critical, yet data specific to the Chinese population remains limited. In this study, we aimed to investigate the prevalence and associations of neuropathological changes and comorbidities and…
View article: Glucose‐induced LINC01419 reprograms the glycolytic pathway by recruiting YBX1 to enhance PDK1 mRNA stability in hepatocellular carcinoma
Glucose‐induced LINC01419 reprograms the glycolytic pathway by recruiting YBX1 to enhance PDK1 mRNA stability in hepatocellular carcinoma Open
Metabolic reprogramming provides the necessary energy for the development of malignant tumours and is emerging as a novel tumour treatment strategy. However, the widespread expression of metabolic enzymes in diverse cell types makes the de…
View article: GNG5 is a novel regulator of Aβ42 production in Alzheimer’s disease
GNG5 is a novel regulator of Aβ42 production in Alzheimer’s disease Open
View article: Cross-ancestry analysis of brain QTLs enhances interpretation of schizophrenia genome-wide association studies
Cross-ancestry analysis of brain QTLs enhances interpretation of schizophrenia genome-wide association studies Open
View article: TLR2/NF-κB signaling in macrophage/microglia mediated COVID-pain induced by SARS-CoV-2 envelope protein
TLR2/NF-κB signaling in macrophage/microglia mediated COVID-pain induced by SARS-CoV-2 envelope protein Open
Pain has become a major symptom of long COVID-19 without effective therapy. Apart from viral infection pathological process, SARS-CoV-2 membranal proteins (envelope [S2E], spike [S2S] and membrane [S2M]) also present pro-inflammatory featu…
View article: Brain eQTLs of European, African American, and Asian ancestry improve interpretation of schizophrenia GWAS
Brain eQTLs of European, African American, and Asian ancestry improve interpretation of schizophrenia GWAS Open
Research on brain expression quantitative trait loci (eQTLs) has illuminated the genetic underpinnings of schizophrenia (SCZ). Yet, the majority of these studies have been centered on European populations, leading to a constrained understa…
View article: Reduced neurogenesis in human hippocampus with Alzheimer's disease
Reduced neurogenesis in human hippocampus with Alzheimer's disease Open
Adult hippocampal neurogenesis (AHN), essential for the plasticity of hippocampal structure and function, may be disrupted in Alzheimer‘s disease (AD). However, the relationship between the changes in AHN and AD‐related pathology in humans…
View article: Integrative Transcriptomic Analyses of Hippocampal–Entorhinal System Subfields Identify Key Regulators in Alzheimer's Disease
Integrative Transcriptomic Analyses of Hippocampal–Entorhinal System Subfields Identify Key Regulators in Alzheimer's Disease Open
The hippocampal–entorhinal system supports cognitive function and is selectively vulnerable to Alzheimer's disease (AD). Little is known about global transcriptomic changes in the hippocampal–entorhinal subfields during AD. Herein, large‐s…
View article: Research on the Integration of Wireless Sensor Networks Based on IoT Technology
Research on the Integration of Wireless Sensor Networks Based on IoT Technology Open
Wireless Sensor Network (WSN) is a wireless network formed by a group of sensors with wireless transceiver capabilities, connected in a multi-hop autonomous manner. It has several advantages: low traffic, greater stability, longer wireless…
View article: The Brain Aging National Cohort-PUMC: study design and baseline characteristics
The Brain Aging National Cohort-PUMC: study design and baseline characteristics Open
Objectives: To describe the study design and baseline characteristics of the Brain Aging National Cohort (BANC)-Peking Union Medical College (PUMC), a study aiming to identify risk and protective factors that contribute to brain aging and …
View article: Standardized Operational Protocol of Human Brain Banking for Amyotrophic Lateral Sclerosis
Standardized Operational Protocol of Human Brain Banking for Amyotrophic Lateral Sclerosis Open
Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease for which there is currently no reliable treatment. Existing clinical diagnostic methods include neurophysiological examination, neuroimaging, and genetic testi…
View article: Study on the transparent dFC-Tesos microscopic imaging method for large tissues in human brain
Study on the transparent dFC-Tesos microscopic imaging method for large tissues in human brain Open
Objective: Human brain has features with high fat, high density, difficulty in deep and even labeling, and strong background fluorescence, which made it uneasy to get high-resolution imaging. To solve the above problems, this study success…
View article: Arteriolosclerosis differs from venular collagenosis in relation to cerebrovascular parenchymal damages: an autopsy-based study
Arteriolosclerosis differs from venular collagenosis in relation to cerebrovascular parenchymal damages: an autopsy-based study Open
Background and purpose Cerebrovascular parenchymal damage is prevalent in ageing brains; however, its vascular aetiology has not been fully elucidated. In addition to the underlying role of sclerotic arterioles, the correlation between col…
View article: Standardized Operational Protocol for the China Human Brain Bank Consortium
Standardized Operational Protocol for the China Human Brain Bank Consortium Open
The study of post-mortem human brains is fundamental to the discovery and diagnosis of most neurological diseases and an in-depth understanding of brain structure, function and disorders. Human brain banks use a standardized protocol to co…
View article: Focal-type, but not Diffuse-type, Amyloid Beta Plaques are Correlated with Alzheimer’s Neuropathology, Cognitive Dysfunction, and Neuroinflammation in the Human Hippocampus
Focal-type, but not Diffuse-type, Amyloid Beta Plaques are Correlated with Alzheimer’s Neuropathology, Cognitive Dysfunction, and Neuroinflammation in the Human Hippocampus Open
Amyloid beta (Aβ) plaques are one of the hallmarks of Alzheimer’s disease (AD). However, currently available anti-amyloid therapies fail to show effectiveness in the treatment of AD in humans. It has been found that there are different typ…
View article: Histopathological Analysis of Cerebral Microvasculature Pathology with Alzheimer’s Disease Neuropathological Changes: An Autopsy Study
Histopathological Analysis of Cerebral Microvasculature Pathology with Alzheimer’s Disease Neuropathological Changes: An Autopsy Study Open
Background: Cerebrovascular lesions are associated with cognitive impairment. However, the implication of Alzheimer’s disease (AD) neuropathological changes (ADNC) on cerebral microvasculature is not completely understood. This study aimed…
View article: Transcriptome dynamics of hippocampal neurogenesis in macaques across the lifespan and aged humans
Transcriptome dynamics of hippocampal neurogenesis in macaques across the lifespan and aged humans Open
View article: Transcriptome dynamics of hippocampal neurogenesis in macaques across the lifespan and aged humans
Transcriptome dynamics of hippocampal neurogenesis in macaques across the lifespan and aged humans Open
Whether adult hippocampal neurogenesis (AHN) persists in adult and aged humans remains extensive debates1-8. Here, to provide a better understanding of AHN of primates, droplet-based single nucleus RNA sequencing (snRNA-seq) is used to inv…
View article: A Global Multiregional Proteomic Map of the Human Cerebral Cortex
A Global Multiregional Proteomic Map of the Human Cerebral Cortex Open
The Brodmann area (BA)-based map is one of the most widely used cortical maps for studies of human brain functions and in clinical practice; however, the molecular architecture of BAs remains unknown. The present study provided a global mu…
View article: Immunoreactivity and a new staining method of monocarboxylate transporter 1 located in endothelial cells of cerebral vessels of human brain in distinguishing cerebral venules from arterioles
Immunoreactivity and a new staining method of monocarboxylate transporter 1 located in endothelial cells of cerebral vessels of human brain in distinguishing cerebral venules from arterioles Open
Distinguishing brain venules from arterioles with arteriolosclerosis is less reliable using traditional staining methods. We aimed to immunohistochemically assess the monocarboxylate transporter 1 (MCT1), a specific marker of venous endoth…
View article: The Altered Anatomical Distribution of ACE2 in the Brain With Alzheimer’s Disease Pathology
The Altered Anatomical Distribution of ACE2 in the Brain With Alzheimer’s Disease Pathology Open
The whole world is suffering from the coronavirus disease 2019 (COVID-19) pandemic, induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) through angiotensin-converting enzyme 2 (ACE2). Neurological manifestations in COVI…