Wenzhe Ma
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View article: Targeting Ferroptosis in Nasopharyngeal Carcinoma: Mechanisms of Therapy Resistance and Therapeutic Opportunities
Targeting Ferroptosis in Nasopharyngeal Carcinoma: Mechanisms of Therapy Resistance and Therapeutic Opportunities Open
Nasopharyngeal carcinoma (NPC), an Epstein‐Barr virus (EBV)‐driven malignancy with geographic prevalence in Asia, faces therapeutic challenges due to acquired resistance. Ferroptosis—an iron‐dependent cell death pathway driven by lipid per…
View article: Candy box technique with sutures and Nice knot
Candy box technique with sutures and Nice knot Open
Aims Our study explores the candy box (CB) technique with sutures and Nice knot as a novel treatment for inferior pole patellar fractures, potentially superior to traditional wire fixation. Methods CT data from five adult knee joints were …
View article: The protein kinase SmSnRK2.7 mediates abscisic acid-regulated tanshinone biosynthesis under drought stress in Salvia miltiorrhiza
The protein kinase SmSnRK2.7 mediates abscisic acid-regulated tanshinone biosynthesis under drought stress in Salvia miltiorrhiza Open
View article: Paracrine signaling in cancer-associated fibroblasts: central regulators of the tumor immune microenvironment
Paracrine signaling in cancer-associated fibroblasts: central regulators of the tumor immune microenvironment Open
View article: Metabolic pathways and male fertility: exploring the role of Sertoli cells in energy homeostasis and spermatogenesis
Metabolic pathways and male fertility: exploring the role of Sertoli cells in energy homeostasis and spermatogenesis Open
Globalization has driven a surge in noncommunicable diseases, including metabolic disorders, which are major global health challenges. These disorders, fueled by high-calorie diets, sedentary lifestyles, and gut microbiota imbalances, disr…
View article: Xanthocillin X Dimethyl Ether Exhibits Anti-Proliferative Effect on Triple-Negative Breast Cancer by Depletion of Mitochondrial Heme
Xanthocillin X Dimethyl Ether Exhibits Anti-Proliferative Effect on Triple-Negative Breast Cancer by Depletion of Mitochondrial Heme Open
Triple-negative breast cancer (TNBC) presents a significant therapeutic challenge due to the absence of specific targeted treatments. In this study, we explored the therapeutic potential of xanthocillin X dimethyl ether (XanDME), a natural…
View article: Kaixuan Qibi granules attenuate myocardial fibrosis through BRD4 blockade regulated by the NF-κB/NLRP3 signaling pathway
Kaixuan Qibi granules attenuate myocardial fibrosis through BRD4 blockade regulated by the NF-κB/NLRP3 signaling pathway Open
View article: Correction: Yinzhihuang injection induces apoptosis and suppresses tumor growth in acute myeloid leukemia cells
Correction: Yinzhihuang injection induces apoptosis and suppresses tumor growth in acute myeloid leukemia cells Open
[This corrects the article DOI: 10.1371/journal.pone.0289697.].
View article: Paleoenvironmental and Vegetational Controls on Tar Yield in the Jurassic Xishanyao Formation Coals of Southern Junggar Basin, China
Paleoenvironmental and Vegetational Controls on Tar Yield in the Jurassic Xishanyao Formation Coals of Southern Junggar Basin, China Open
View article: A chalcone derivative SBD-2 exerts anticancer effects in human colorectal cancer cells
A chalcone derivative SBD-2 exerts anticancer effects in human colorectal cancer cells Open
Background In this study, the potential anticancer activity and mechanism of action of SBD-2, a chalcone isolated from Shuteria involucrata , was investigated in colorectal cancer (CRC) cells. Results SBD-2 inhibited the proliferation of C…
View article: Prospective comparison of 68Ga-DOTA-ibandronate and bone scans for detecting bone metastases in breast cancer
Prospective comparison of 68Ga-DOTA-ibandronate and bone scans for detecting bone metastases in breast cancer Open
Introduction 68 Ga labeled DOTA-Ibandronate ( 68 Ga-DOTA-IBA) positron emission tomography/computed tomography (PET/CT), is a novel bone-targeting imaging tracer and promising diagnostic method for bone metastases detection. Therefore, thi…
View article: A bibliometric analysis based on hotspots and frontier trends of positron emission tomography/computed tomography utility in bone and soft tissue sarcoma
A bibliometric analysis based on hotspots and frontier trends of positron emission tomography/computed tomography utility in bone and soft tissue sarcoma Open
Purpose This study aimed to analyze articles on the diagnosis and treatment of bone and soft tissue sarcoma using positron emission tomography (PET)/computed tomography (CT) published in the last 13 years. The objective was to conduct a bi…
View article: Lactic acid: a narrative review of a promoter of the liver cancer microenvironment
Lactic acid: a narrative review of a promoter of the liver cancer microenvironment Open
Lactate may be key to developing novel approaches in the future treatment of liver cancer. Related research on the combination of classic therapies and molecular targeted drugs may provide innovative medicines that more selectively regulat…
View article: Lovastatin-Induced Mitochondrial Oxidative Stress Leads to the Release of mtDNA to Promote Apoptosis by Activating cGAS-STING Pathway in Human Colorectal Cancer Cells
Lovastatin-Induced Mitochondrial Oxidative Stress Leads to the Release of mtDNA to Promote Apoptosis by Activating cGAS-STING Pathway in Human Colorectal Cancer Cells Open
Statins are 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase inhibitors widely used in the treatment of hyperlipidemia. The inhibition of HMG-CoA reductase in the mevalonate pathway leads to the suppression of cell proliferation a…
View article: Transcriptome sequencing and metabolome analysis reveal the molecular mechanism of Salvia miltiorrhiza in response to drought stress
Transcriptome sequencing and metabolome analysis reveal the molecular mechanism of Salvia miltiorrhiza in response to drought stress Open
View article: Single‐cell profiling reveals the metastasis‐associated immune signature of hepatocellular carcinoma
Single‐cell profiling reveals the metastasis‐associated immune signature of hepatocellular carcinoma Open
Aim Metastasis is the leading cause of mortality in hepatocellular carcinoma (HCC). The metastasis‐associated immune signature in HCC is worth exploring. Methods Bioinformatic analysis was conducted based on the single‐cell transcriptome d…
View article: Phloretic acid requires the insulin/IGF-1 pathway and autophagy to enhance stress resistance and extend the lifespan of Caenorhabditis elegans
Phloretic acid requires the insulin/IGF-1 pathway and autophagy to enhance stress resistance and extend the lifespan of Caenorhabditis elegans Open
Objective: In humans, aging is associated with increased susceptibility to most age-related diseases. Phloretic acid (PA), a naturally occurring compound found in Ginkgo biloba and Asparagus, exhibits has potential as an anti-aging agent a…
View article: Clinical efficacy of probiotics in the treatment of alcoholic liver disease: a systematic review and meta-analysis
Clinical efficacy of probiotics in the treatment of alcoholic liver disease: a systematic review and meta-analysis Open
Objective Alcoholic liver disease (ALD) is a liver damage disease caused by long-term heavy drinking. Currently, there is no targeted pharmaceutical intervention available for the treatment of this disease. To address this, this paper eval…
View article: Tension band high-strength suture combined with absorbable cannulated screws for treating transverse patellar fractures: finite element analysis and clinical study
Tension band high-strength suture combined with absorbable cannulated screws for treating transverse patellar fractures: finite element analysis and clinical study Open
Objective: Few reports exist on the treatment of transverse patellar fractures (TPFs) using absorbable cannulated screws and high-strength sutures, and most screws and sutures lack good biomechanics and clinical trials. Therefore, this stu…
View article: Melatonin derivative 6a as a PARP-1 inhibitor for the treatment of Parkinson’s disease
Melatonin derivative 6a as a PARP-1 inhibitor for the treatment of Parkinson’s disease Open
Both continuous oxidative stress and poly (ADP-ribose) polymerase 1 (PARP-1) activation occur in neurodegenerative diseases such as Parkinson’s disease. PARP-1 inhibition can reverse mitochondrial damage and has a neuroprotective effect. I…
View article: Effect, main targets and molecular mechanisms of glycyrrhiza-derived flavonoids on malignant tumor in comprehensive cancer treatment
Effect, main targets and molecular mechanisms of glycyrrhiza-derived flavonoids on malignant tumor in comprehensive cancer treatment Open
Glycyrrhiza flavonoids (GF) are essential antitumor components of Glycyrrhiza uralensis, Glycyrrhiza glabra, and Glycyrrhiza inflata roots and tubers, with antioxidant, anti-inflammatory, antibacterial, immune-enhancing amongst other prope…
View article: Involucrasin B Inhibits the Proliferation of Caco-2 Cells by Regulating the TGFβ/SMAD2-3-4 Pathway
Involucrasin B Inhibits the Proliferation of Caco-2 Cells by Regulating the TGFβ/SMAD2-3-4 Pathway Open
(1) Background: Colorectal cancer (CRC) is the third most common malignant tumor worldwide and the second most common cause of cancer death. However, effective anti-CRC drugs are still lacking in clinical settings. This article investigate…
View article: Effectiveness of teriparatide in in improving healing rates and bone-turnover markers of osteoporotic hip fracture: a meta-analysis
Effectiveness of teriparatide in in improving healing rates and bone-turnover markers of osteoporotic hip fracture: a meta-analysis Open
Objective: To evaluate the effect of subcutaneous teriparatide therapy on fracture healing rate and change in bone mass density in osteoporotic hip fractures. Method: The meta-analysis was done from September to December 2022, and comprise…
View article: Four Sulfur-Containing Compounds with Anti-Colon Cancer Effect from Marine-Derived Fungus Aspergillus Terreus
Four Sulfur-Containing Compounds with Anti-Colon Cancer Effect from Marine-Derived Fungus Aspergillus Terreus Open
View article: Degradation of amyloid beta species by multi-copper oxidases
Degradation of amyloid beta species by multi-copper oxidases Open
Reduction of the production of amyloid beta (Aβ) species has been intensively investigated as potential therapeutic approaches for Alzheimer’s disease (AD). However, the degradation of Aβ species, another potential beneficial approach, has…
View article: A phosphate-sensing organelle regulates phosphate and tissue homeostasis
A phosphate-sensing organelle regulates phosphate and tissue homeostasis Open
View article: Anticancer effect of involucrasin A on colorectal cancer cells by modulating the Akt/MDM2/p53 pathway
Anticancer effect of involucrasin A on colorectal cancer cells by modulating the Akt/MDM2/p53 pathway Open
Colorectal cancer (CRC) is the second leading cause of cancer mortality worldwide; however, there is still a lack of effective clinical anti-CRC agents. Naturally-occurring compounds have been considered a potentially valuable source of ne…
View article: CCDC 2221026: Experimental Crystal Structure Determination
CCDC 2221026: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2220768: Experimental Crystal Structure Determination
CCDC 2220768: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2220776: Experimental Crystal Structure Determination
CCDC 2220776: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …