Werner Held
YOU?
Author Swipe
View article: Emergence and fate of stem cell–like<i>Tcf7</i><sup>+</sup>CD8<sup>+</sup>T cells during a primary immune response to viral infection
Emergence and fate of stem cell–like<i>Tcf7</i><sup>+</sup>CD8<sup>+</sup>T cells during a primary immune response to viral infection Open
In response to infection, naïve CD8 + T (T N ) cells yield a large pool of short-lived terminal effector (T TE ) cells that eliminate infected host cells. In parallel, a minor population of stem cell–like central memory (T CM ) cells forms…
View article: Induction of mitophagy reverts age-associated decline of the hematopoietic and immune systems
Induction of mitophagy reverts age-associated decline of the hematopoietic and immune systems Open
Aging compromises hematopoietic and immune system functions, making elderly individuals especially susceptible to hematopoietic failure, infections and tumor development and thus representing an important medical target for a broad range o…
View article: The alarmin interleukin-33 promotes the expansion and preserves the stemness of Tcf-1+ CD8+ T cells in chronic viral infection
The alarmin interleukin-33 promotes the expansion and preserves the stemness of Tcf-1+ CD8+ T cells in chronic viral infection Open
Raw data underlying the publication
The alarmin interleukin-33 promotes the expansion and preserves the stemness of Tcf-1+ CD8+ T cells in chronic viral infection Open
T cell factor 1 (Tcf-1) expressing CD8+ T cells exhibit stem-like self-renewing capacity, rendering them key for immune defense against chronic viral infection and cancer. Yet, the signals that promote the formation and maintenance of thes…
View article: P1400: BOOSTING MITOCHONDRIAL RECYCLING REJUVENATES HEMATOPOIETIC AND IMMUNE SYSTEMS
P1400: BOOSTING MITOCHONDRIAL RECYCLING REJUVENATES HEMATOPOIETIC AND IMMUNE SYSTEMS Open
Background: Hematopoietic stem cells (HSCs) generate all blood lineages and ensure the correct homeostasis between myeloid and lymphoid lineages during the entire life of an organism. However, HSCs decrease their regenerative potential and…
NFAT5 induction by the tumor microenvironment enforces CD8 T cell exhaustion Open
Persistent exposure to antigen during chronic infection or cancer renders T cells dysfunctional. The molecular mechanisms regulating this state of exhaustion are thought to be common in infection and cancer, despite obvious differences in …
PD-1+ Tcf1+ CD8+ T cells from established chronic infection can form memory while retaining a stable imprint of persistent antigen exposure Open
(Cell Reports 36, 109672-1–109672-14.e1–e4; September 7, 2021) In the originally published version of this article, the title contained a typo, where “stable imprint” was inadvertently changed to one word during the production process. The…
Unanticipated Difficult Airway Management in a Trauma Partient with Severe Ankylosing Spondylitis Open
Ankylosing Spondylitis is a debilitating chronic arthropathy that affects multiple joints. Anaesthesiologists face significant challenges when dealing with the airway implications of this disease, especially when it is unanticipated that a…
PD-1+ Tcf1+ CD8+ T cells from established chronic infection can form memory while retaining a stable imprint of persistent antigen exposure Open
Virus-specific PD1+ Tcf1+ memory-like CD8+ T cells (TMLs) maintain the CD8+ T cell response during chronic viral infection. However, the fate of these cells following cessation of persistent antigen exposure has been unclear. Here, we find…
Deciphering the transcriptomic landscape of tumor-infiltrating CD8 lymphocytes in B16 melanoma tumors with single-cell RNA-Seq Open
Recent studies have proposed that tumor-specific tumor-infiltrating CD8(+) T lymphocytes (CD8 TIL) can be classified into two main groups: “exhausted” TILs, characterized by high expression of the inhibitory receptors PD-1 and TIM-3 and la…
Intratumoral CD8 <sup>+</sup> T cells with stem cell–like properties: Implications for cancer immunotherapy Open
Intratumoral PD-1 + TCF1 + CD8 + T cells with stem cell–like properties mediate cellular expansion and tumor control in response to immunotherapy.
The human CD8 T stem cell-like memory phenotype appears in the acute phase in Yellow Fever virus vaccination Open
Long-term memory is a fundamental feature of cytotoxic CD8 T cell immunity. Yet when do memory cells arise, especially in humans, is poorly documented, the pathways of effector / memory cell differentiation being largely debated. Based on …
Deciphering the transcriptomic landscape of tumor-infiltrating CD8 lymphocytes in B16 melanoma tumors with single-cell RNA-Seq Open
Recent studies have proposed that tumor-specific tumor-infiltrating CD8 + T lymphocytes (CD8 TIL) can be classified into two main groups: “exhausted” TILs, characterized by high expression of the inhibitory receptors PD-1 and TIM-3 and lac…