Wes Lee
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View article: Associations Between Maternal Sociodemographics and Hospital Mortality in Newborns With Prenatally Diagnosed Hypoplastic Left Heart Syndrome
Associations Between Maternal Sociodemographics and Hospital Mortality in Newborns With Prenatally Diagnosed Hypoplastic Left Heart Syndrome Open
ace and ethnicity, socioeconomic status (SES), and geography have been associated with differential outcomes in congenital heart disease death.In patients with hypoplastic left heart syndrome (HLHS), lower SES has been associated with incr…
View article: Insight into Radical Initiation, Solvent Effects, and Biphenyl Production in Iron–Bisphosphine Cross-Couplings
Insight into Radical Initiation, Solvent Effects, and Biphenyl Production in Iron–Bisphosphine Cross-Couplings Open
Iron-bisphosphines have attracted broad interest as highly effective and versatile catalytic systems for two- and three-component cross-coupling strategies. While recent mechanistic studies have defined the role of organoiron(II)-bisphosph…
View article: General and Practical Route to Diverse 1-(Difluoro)alkyl-3-aryl Bicyclo[1.1.1]pentanes Enabled by an Fe-Catalyzed Multicomponent Radical Cross-Coupling Reaction
General and Practical Route to Diverse 1-(Difluoro)alkyl-3-aryl Bicyclo[1.1.1]pentanes Enabled by an Fe-Catalyzed Multicomponent Radical Cross-Coupling Reaction Open
Bicyclo[1.1.1]pentanes (BCPs) are of great interest to the agrochemical, materials, and pharmaceutical industries. In particular, synthetic methods to access 1,3-dicarbosubsituted BCP-aryls have recently been developed, but most protocols …
View article: General and Practical Route to Diverse 1,3-(Difluoro)alkyl bicyclo[1.1.1]-Aryl Pentanes Enabled by an Fe-Catalyzed Multicomponent Radical Coupling
General and Practical Route to Diverse 1,3-(Difluoro)alkyl bicyclo[1.1.1]-Aryl Pentanes Enabled by an Fe-Catalyzed Multicomponent Radical Coupling Open
Bicyclo[1.1.1]pentanes (BCPs) are of great interest to the agrochemical, materials, and pharmaceutical industries. In particular, synthetic methods to access 1,3-dicarbosubsituted BCP-aryls have recently been developed but most protocols r…
View article: General method for iron-catalyzed multicomponent radical cascades–cross-couplings
General method for iron-catalyzed multicomponent radical cascades–cross-couplings Open
Iron links a trio Iron holds particular appeal as a catalytic metal—it is safe and abundant, as well as a mainstay of enzymatic reactivity. Nonetheless, in synthetic construction of carbon-carbon bonds, modern chemists have largely had to …
View article: MECHANISTIC STUDY AND THE DESIGN OF IRON-CATALYZED MULTI-COMPONENT CROSS-COUPLING REACTION
MECHANISTIC STUDY AND THE DESIGN OF IRON-CATALYZED MULTI-COMPONENT CROSS-COUPLING REACTION Open
Cross-coupling reactions (CCRs) are one of the most versatile methods for the formation of C-C bonds. Traditionally, palladium and nickel are broadly used as the catalyst in this type of transformation. However, due to the low cost, low to…
View article: Fe-Catalyzed Conjunctive Cross-Couplings of Unactivated Alkenes with Grignard Reagents
Fe-Catalyzed Conjunctive Cross-Couplings of Unactivated Alkenes with Grignard Reagents Open
The first iron-catalyzed three-component cross-coupling of unactivated olefins with alkyl halides and Grignard reagents is reported. The reaction operates under fast turnover frequency and tolerates a diverse range of sp2-hybridized nucleo…
View article: Fe-Catalyzed Conjunctive Cross-Couplings of Unactivated Alkenes with Grignard Reagents
Fe-Catalyzed Conjunctive Cross-Couplings of Unactivated Alkenes with Grignard Reagents Open
The first iron-catalyzed three-component cross-coupling of unactivated olefins with alkyl halides and Grignard reagents is reported. The reaction operates under fast turnover frequency and tolerates a diverse range of sp2-hybridized nucleo…
View article: Fe-Catalyzed Conjunctive Cross-Couplings of Unactivated Alkenes with Grignard Reagents
Fe-Catalyzed Conjunctive Cross-Couplings of Unactivated Alkenes with Grignard Reagents Open
The first iron-catalyzed three-component cross-coupling of unactivated olefins with alkyl halides and Grignard reagents is reported. The reaction operates under fast turnover frequency and tolerates a diverse range of sp2-hybridized nucleo…
View article: Fe-catalyzed three-component dicarbofunctionalization of unactivated alkenes with alkyl halides and Grignard reagents
Fe-catalyzed three-component dicarbofunctionalization of unactivated alkenes with alkyl halides and Grignard reagents Open
A highly selective iron-catalyzed three-component dicarbofunctionalization of unactivated alkenes with alkyl halides and sp 2 -hybridized Grignard reagents is reported.
View article: Oxidation of 8-thioguanosine gives redox-responsive hydrogels and reveals intermediates in a desulfurization pathway
Oxidation of 8-thioguanosine gives redox-responsive hydrogels and reveals intermediates in a desulfurization pathway Open
Oxidation of 8-thioguanosine gives a disulfide that forms redox-responsive hydrogels and is an intermediate in oxidative desulfurization of 8-thioG.
View article: Intra- and intermolecular Fe-catalyzed dicarbofunctionalization of vinyl cyclopropanes
Intra- and intermolecular Fe-catalyzed dicarbofunctionalization of vinyl cyclopropanes Open
Design and implementation of the first (asymmetric) Fe-catalyzed intra- and intermolecular difunctionalization of vinyl cyclopropanes (VCPs) with alkyl halides and aryl Grignard reagents has been realized via a mechanistically driven appro…
View article: Design and Development of Fe-Catalyzed Intra- and Intermolecular Carbofunctionalization of Vinyl Cyclopropanes
Design and Development of Fe-Catalyzed Intra- and Intermolecular Carbofunctionalization of Vinyl Cyclopropanes Open
Design and implementation of the first (asymmetric) Fe-catalyzed intra- and intermolecular difunctionalization of vinyl cyclopropanes (VCPs) with alkyl halides and aryl Grignard reagents has been realized via a mechanistically driven appro…
View article: Design and Development of Fe-Catalyzed Intra- and Intermolecular Carbofunctionalization of Vinyl Cyclopropanes
Design and Development of Fe-Catalyzed Intra- and Intermolecular Carbofunctionalization of Vinyl Cyclopropanes Open
Design and implementation of the first (asymmetric) Fe-catalyzed intra- and intermolecular difunctionalization of vinyl cyclopropanes (VCPs) with alkyl halides and aryl Grignard reagents has been realized via a mechanistically driven appro…
View article: Templating and Catalyzing [2+2] Photocycloaddition in Solution Using a Dynamic G‐Quadruplex
Templating and Catalyzing [2+2] Photocycloaddition in Solution Using a Dynamic G‐Quadruplex Open
We describe a templating/covalent capture strategy that enables photochemical formation of 8 cyclobutanes in one noncovalent assembly. This process was characterized by experiment and quantum mechanical/molecular mechanics (ONIOM) calculat…
View article: Templating and Catalyzing [2+2] Photocycloaddition in Solution Using a Dynamic G‐Quadruplex
Templating and Catalyzing [2+2] Photocycloaddition in Solution Using a Dynamic G‐Quadruplex Open
We describe a templating/covalent capture strategy that enables photochemical formation of 8 cyclobutanes in one noncovalent assembly. This process was characterized by experiment and quantum mechanical/molecular mechanics (ONIOM) calculat…
View article: CCDC 1869119: Experimental Crystal Structure Determination
CCDC 1869119: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: You Have Become a Graphic Novel in My Dreams
You Have Become a Graphic Novel in My Dreams Open
Storyboarded in dazzling scenesso I can't go back, only to the dazzling scenes.