Wesley Freppel
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View article: A storm is born: immune activation and pathogenesis in arthritogenic alphavirus infections
A storm is born: immune activation and pathogenesis in arthritogenic alphavirus infections Open
Arthritogenic alphaviruses, including chikungunya (CHIKV), Ross River, and Mayaro viruses, are emerging global viruses responsible for causing arthralgia and chronic arthritis. Following mosquito-borne transmission, they quickly initiate i…
View article: Seroprevalence of Antibodies Against Legionella Species in Northeastern Australian Blood Donors, 2016 and 2023
Seroprevalence of Antibodies Against Legionella Species in Northeastern Australian Blood Donors, 2016 and 2023 Open
Background In 2021–2022, Queensland, Australia observed an increase in Legionnaire's disease cases, predominantly due to Legionella longbeachae. This study assessed seroprevalence at time points 2016 and 2023, representing before and after…
View article: Twelfth scientific biennial meeting of the Australasian Virology Society: AVS12 2024
Twelfth scientific biennial meeting of the Australasian Virology Society: AVS12 2024 Open
The Australasian Virology Society (AVS) holds premier biennial virology meetings that foster multidisciplinary research and collaboration and promote equity and inclusion of early-career researchers. The 12th AVS meeting (AVS12), convened …
View article: Dengue virus and Zika virus alter endoplasmic reticulum-mitochondria contact sites to regulate respiration and apoptosis
Dengue virus and Zika virus alter endoplasmic reticulum-mitochondria contact sites to regulate respiration and apoptosis Open
View article: Pathogenicity and virulence of chikungunya virus
Pathogenicity and virulence of chikungunya virus Open
Chikungunya virus (CHIKV) is a mosquito-transmitted, RNA virus that causes an often-severe musculoskeletal illness characterized by fever, joint pain, and a range of debilitating symptoms. The virus has re-emerged as a global health threat…
View article: Synoviocytes assist in modulating the effect of Ross River virus infection in micromass-cultured primary human chondrocytes
Synoviocytes assist in modulating the effect of Ross River virus infection in micromass-cultured primary human chondrocytes Open
Graphical abstract A schematic representation of the study methodology. Human micromass-cultured chondrocytes were either directly infected with RRV or secondarily through co-culture with RRV-infected FLS. Micromass chondrocytes were analy…
View article: Extracellular matrix signals promotes actin-dependent mitochondrial elongation and activity
Extracellular matrix signals promotes actin-dependent mitochondrial elongation and activity Open
Mitochondria are crucial metabolic organelles that are regulated by both intracellular and extracellular cues. The extracellular matrix (ECM) is a key component of the cellular environment that controls cellular behavior and metabolic acti…
View article: Extracellular Matrix Signals Promote Actin-Dependent Mitochondrial Elongation and Activity
Extracellular Matrix Signals Promote Actin-Dependent Mitochondrial Elongation and Activity Open
View article: Flaviviruses alter endoplasmic reticulum-mitochondria contacts to regulate respiration and apoptosis
Flaviviruses alter endoplasmic reticulum-mitochondria contacts to regulate respiration and apoptosis Open
With no therapeutics available, there is an urgent need to better understand the pathogenesis of flaviviruses which constitute a threat to public health worldwide. During infection, dengue virus (DENV) and Zika virus (ZIKV), two flavivirus…
View article: The Biogenesis of Dengue Virus Replication Organelles Requires the ATPase Activity of Valosin-Containing Protein
The Biogenesis of Dengue Virus Replication Organelles Requires the ATPase Activity of Valosin-Containing Protein Open
The dengue virus (DENV) causes the most prevalent arthropod-borne viral disease worldwide. While its incidence is increasing in many countries, there is no approved antiviral therapy currently available. In infected cells, the DENV induces…
View article: Validation of saliva sampling as an alternative to oro-nasopharyngeal swab for detection of SARS-CoV-2 using unextracted rRT-PCR with the Allplex 2019-nCoV assay
Validation of saliva sampling as an alternative to oro-nasopharyngeal swab for detection of SARS-CoV-2 using unextracted rRT-PCR with the Allplex 2019-nCoV assay Open
Introduction. The current severe acute respiratory syndrome-associated coronavirus-2 (SARS-CoV-2) pandemic has stressed the global supply chain for specialized equipment, including flocked swabs. Hypothesis. Saliva could be a potential alt…
View article: Efficient SARS-CoV-2 detection in unextracted oro-nasopharyngeal specimens by rRT-PCR with the Seegene Allplex™ 2019-nCoV assay
Efficient SARS-CoV-2 detection in unextracted oro-nasopharyngeal specimens by rRT-PCR with the Seegene Allplex™ 2019-nCoV assay Open
View article: Efficient SARS-CoV-2 detection in unextracted oro-nasopharyngeal specimens by rRT-PCR with the Seegene AllplexTM 2019-nCoV assay
Efficient SARS-CoV-2 detection in unextracted oro-nasopharyngeal specimens by rRT-PCR with the Seegene AllplexTM 2019-nCoV assay Open
The fight against the COVID-19 pandemic has created an urgent need to detect and isolate infected people. The challenge for clinical laboratories has been finding a high throughput, cheap, and efficient testing method in the context of ext…
View article: The Interplay between Dengue Virus and the Human Innate Immune System: A Game of Hide and Seek
The Interplay between Dengue Virus and the Human Innate Immune System: A Game of Hide and Seek Open
With 40% of the world population at risk, infections with dengue virus (DENV) constitute a serious threat to public health. While there is no antiviral therapy available against this potentially lethal disease, the efficacy of the only app…
View article: Structure, composition, and roles of the Toxoplasma gondii oocyst and sporocyst walls
Structure, composition, and roles of the Toxoplasma gondii oocyst and sporocyst walls Open
View article: The Multiples Fates of the Flavivirus RNA Genome During Pathogenesis
The Multiples Fates of the Flavivirus RNA Genome During Pathogenesis Open
The Flavivirus genus comprises many viruses (including dengue, Zika, West Nile and yellow fever viruses) which constitute important public health concerns worldwide. For several of these pathogens, neither antivirals nor vaccines ar…
View article: La mitochondrie: au coeur de la réplication des virus Zika et de la dengue
La mitochondrie: au coeur de la réplication des virus Zika et de la dengue Open
pour son rôle de fournisseur d’énergie au sein de la cellule mais également dans son rôle dans l’immunité contre les virus. Pourtant, peut-elle être détournée par certains virus dans leur propre intérêt?
View article: Production, Titration and Imaging of Zika Virus in Mammalian Cells
Production, Titration and Imaging of Zika Virus in Mammalian Cells Open
Since the outbreak of Zika virus (ZIKV) in Latin America and the US in 2016, this flavivirus has emerged as a major threat for public health. Indeed, it is now clear that ZIKV is vertically transmitted from the infected mother to the fetus…
View article: Macrophages facilitate the excystation and differentiation of Toxoplasma gondii sporozoites into tachyzoites following oocyst internalisation
Macrophages facilitate the excystation and differentiation of Toxoplasma gondii sporozoites into tachyzoites following oocyst internalisation Open