Wesley D. Frey
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View article: RNA-binding motif protein 10 inactivates c-Myc by partnering with ribosomal proteins uL18 and uL5
RNA-binding motif protein 10 inactivates c-Myc by partnering with ribosomal proteins uL18 and uL5 Open
RNA-binding motif protein 10 (RBM10) is a frequently mutated tumor suppressor in lung adenocarcinoma (LUAD). Yet, it remains unknown whether cancer-derived mutant RBM10 compromises its tumor suppression function and, if so, the molecular i…
View article: Phosphoinositide species and filamentous actin formation mediate engulfment by senescent tumor cells
Phosphoinositide species and filamentous actin formation mediate engulfment by senescent tumor cells Open
Cancer cells survive chemotherapy and cause lethal relapse by entering a senescent state that facilitates expression of many phagocytosis/macrophage-related genes that engender a novel cannibalism phenotype. We used biosensors and live-cel…
View article: Mouse model and human patient data reveal critical roles for Pten and p53 in suppressing POLE mutant tumor development
Mouse model and human patient data reveal critical roles for Pten and p53 in suppressing POLE mutant tumor development Open
Mutations in the exonuclease domain of POLE are associated with tumors harboring very high mutation burdens. The mechanisms linking this significant mutation accumulation and tumor development remain poorly understood. Pole+/P286R;Trp53+/–…
View article: Mouse model and human patient data suggest critical roles for Pten and p53 in suppressing POLE mutant tumor development
Mouse model and human patient data suggest critical roles for Pten and p53 in suppressing POLE mutant tumor development Open
Mutations in the exonuclease domain of POLE are associated with tumors harboring very high mutation burdens. The mechanisms linking this significant mutation accumulation and tumor development remain poorly understood. Pole +/P286R ; Trp53…
View article: Preparation and Characterization of Thin Arsenic Targets for Stacked-Target Experiments
Preparation and Characterization of Thin Arsenic Targets for Stacked-Target Experiments Open
Thin, uniform arsenic targets suitable for high-fidelity cross section measurements in stacked-target experiments were prepared by electrodeposition of arsenic on titanium backings from aqueous solutions. Electrolytic cells were constructe…
View article: Allele-specific enhancer interaction at the Peg3 imprinted domain
Allele-specific enhancer interaction at the Peg3 imprinted domain Open
The parental allele specificity of mammalian imprinted genes has been evolutionarily well conserved, although its functional constraints and associated mechanisms are not fully understood. In the current study, we generated a mouse mutant …
View article: Chemotherapy-induced senescent cancer cells engulf other cells to enhance their survival
Chemotherapy-induced senescent cancer cells engulf other cells to enhance their survival Open
In chemotherapy-treated breast cancer, wild-type p53 preferentially induces senescence over apoptosis, resulting in a persisting cell population constituting residual disease that drives relapse and poor patient survival via the senescence…
View article: Pregnancy reprograms the enhancer landscape of mammary epithelial cells and alters the response to cMYC-driven oncogenesis
Pregnancy reprograms the enhancer landscape of mammary epithelial cells and alters the response to cMYC-driven oncogenesis Open
Pregnancy leaves a series of cellular and molecular modifications on mammary epithelial cells (MECs). Pregnancy is also known for decreasing the predisposition of rodent and human MECs to oncogenesis. Here, in order to understand the molec…
View article: Breast cancer survival predicted by TP53 mutation status differs markedly depending on treatment
Breast cancer survival predicted by TP53 mutation status differs markedly depending on treatment Open
The poor survival of chemotherapy-treated patients with TP53 wild-type tumors may be improved by strategies to eliminate senescent cells, including the addition of hormone therapy when appropriate.
View article: Oxytocin receptor is regulated by Peg3
Oxytocin receptor is regulated by Peg3 Open
Mouse Peg3 encodes a DNA-binding protein involved in the milk letdown process. In the current study, we tested whether PEG3 controls the expression of the oxytocin receptor gene. According to the results, PEG3 directly binds to a genomic r…
View article: Allele and dosage specificity of the Peg3 imprinted domain
Allele and dosage specificity of the Peg3 imprinted domain Open
The biological impetus for gene dosage and allele specificity of mammalian imprinted genes is not fully understood. To address this, we generated and analyzed four sets of mice from a single breeding scheme with varying allelic expression …
View article: Additional file 5: of Breast cancer survival predicted by TP53 mutation status differs markedly depending on treatment
Additional file 5: of Breast cancer survival predicted by TP53 mutation status differs markedly depending on treatment Open
Table S3. Statistical analyses for Fig. 3. (XLSX 21 kb)
View article: BPTF Maintains Chromatin Accessibility and the Self-Renewal Capacity of Mammary Gland Stem Cells
BPTF Maintains Chromatin Accessibility and the Self-Renewal Capacity of Mammary Gland Stem Cells Open
Chromatin remodeling is a key requirement for transcriptional control of cellular differentiation. However, the factors that alter chromatin architecture in mammary stem cells (MaSCs) are poorly understood. Here, we show that BPTF, the lar…
View article: Tissue-Specific Contributions of Paternally Expressed Gene 3 in Lactation and Maternal Care of Mus musculus
Tissue-Specific Contributions of Paternally Expressed Gene 3 in Lactation and Maternal Care of Mus musculus Open
© 2015 Frey, Kim.This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in anymedium, provided the original author and source a…
View article: Antisense Regulation and Tissue-specific Roles of Peg3 in Lactation and Maternal Care
Antisense Regulation and Tissue-specific Roles of Peg3 in Lactation and Maternal Care Open
Genomic imprinting is characterized by the restrictive expression of a gene from one of the two inherited parental alleles. Many of these genes have been implicated in neonatal growth and mammalian reproduction. The two studies discussed i…