Wesley Kimble
YOU?
Author Swipe
View article: CTIM-09. PHASE II RUN-IN STUDY OF DARATUMUMAB IN COMBINATION WITH RADIATION THERAPY AND TEMOZOLOMIDE IN NEWLY DIAGNOSED GLIOBLASTOMA
CTIM-09. PHASE II RUN-IN STUDY OF DARATUMUMAB IN COMBINATION WITH RADIATION THERAPY AND TEMOZOLOMIDE IN NEWLY DIAGNOSED GLIOBLASTOMA Open
BACKGROUND Daratumumab, a CD38-targeted monoclonal antibody, has shown preclinical activity in glioblastoma (GBM). Given the expression of CD38 on GBM cells, daratumumab’s mechanisms, potentially mirroring multiple myeloma, may include dir…
View article: Association of substance use with stroke in heart failure by community socioeconomic distress
Association of substance use with stroke in heart failure by community socioeconomic distress Open
Substance use is linked to higher stroke risk among HF patients, especially in socioeconomically distressed communities. Addressing both clinical and structural factors is essential for effective stroke prevention in this population.
View article: Characterizing Long COVID: Deep Phenotype of a Complex Condition
Characterizing Long COVID: Deep Phenotype of a Complex Condition Open
View article: Leveraging a global, federated, real-world data network to optimize investigator-initiated pediatric clinical trials: the TriNetX Pediatric Collaboratory Network
Leveraging a global, federated, real-world data network to optimize investigator-initiated pediatric clinical trials: the TriNetX Pediatric Collaboratory Network Open
Objective Clinical research networks facilitate collaborative research, but data sharing remains a common barrier. Materials and Methods The TriNetX platform provides real-time access to electronic health record (EHR)-derived, anonymized d…
View article: Enhanced SARS-CoV-2 case prediction using public health data and machine learning models
Enhanced SARS-CoV-2 case prediction using public health data and machine learning models Open
Objectives The goal of this study is to propose and test a scalable framework for machine learning (ML) algorithms to predict near-term severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cases by incorporating and evaluating the …
View article: Poverty and population health – The need for A Paradigm shift to capture the working poor and better inform public health planning
Poverty and population health – The need for A Paradigm shift to capture the working poor and better inform public health planning Open
View article: Assessing the effects of therapeutic combinations on SARS-CoV-2 infected patient outcomes: A big data approach
Assessing the effects of therapeutic combinations on SARS-CoV-2 infected patient outcomes: A big data approach Open
Background The COVID-19 pandemic has demonstrated the need for efficient and comprehensive, simultaneous assessment of multiple combined novel therapies for viral infection across the range of illness severity. Randomized Controlled Trials…
View article: Issue Information
Issue Information Open
View article: If you build it, will they come? Is test site availability a root cause of geographic disparities in COVID-19 testing?
If you build it, will they come? Is test site availability a root cause of geographic disparities in COVID-19 testing? Open
The study findings could be used to guide the delivery of testing facilities in resource-constrained states.
View article: Persistence and Protective Potential of SARS-CoV-2 Antibody Levels After COVID-19 Vaccination in a West Virginia Nursing Home Cohort
Persistence and Protective Potential of SARS-CoV-2 Antibody Levels After COVID-19 Vaccination in a West Virginia Nursing Home Cohort Open
In this cross-sectional study, anti-RBD IgG levels decreased after vaccination or infection. Higher antibody responses were found in individuals who received a third (booster) vaccination. Although lower antibody levels were associated wit…
View article: An ordinal severity scale for COVID-19 retrospective studies using Electronic Health Record data
An ordinal severity scale for COVID-19 retrospective studies using Electronic Health Record data Open
Objectives Although the World Health Organization (WHO) Clinical Progression Scale for COVID-19 is useful in prospective clinical trials, it cannot be effectively used with retrospective Electronic Health Record (EHR) datasets. Modifying t…
View article: Higher hospitalization and mortality rates among SARS‐CoV‐2‐infected persons in rural America
Higher hospitalization and mortality rates among SARS‐CoV‐2‐infected persons in rural America Open
Purpose Rural communities are among the most underserved and resource‐scarce populations in the United States. However, there are limited data on COVID‐19 outcomes in rural America. This study aims to compare hospitalization rates and inpa…
View article: Substance Abuse and Rural Appalachian Pediatric Trauma in West Virginia
Substance Abuse and Rural Appalachian Pediatric Trauma in West Virginia Open
Introduction. Rural Appalachia is endemic to issues such as substance abuse, poverty, and lack of community support, all of which negatively influence health outcomes. The incidence of pediatric trauma as it relates to substance abuse is o…
View article: Corrigendum to ’ Coronavirus testing disparities associated with community level deprivation, racial inequalities, and food insecurity in West Virginia’
Corrigendum to ’ Coronavirus testing disparities associated with community level deprivation, racial inequalities, and food insecurity in West Virginia’ Open
View article: HEALTH DISPARITIES INVOLVING HOSPITALIZATIONS AMONG COVID-19 VACCINATED CARDIOVASCULAR DISEASE PATIENTS INFECTED BY SARS-COV-2
HEALTH DISPARITIES INVOLVING HOSPITALIZATIONS AMONG COVID-19 VACCINATED CARDIOVASCULAR DISEASE PATIENTS INFECTED BY SARS-COV-2 Open
View article: Characterizing Long COVID: Deep Phenotype of a Complex Condition
Characterizing Long COVID: Deep Phenotype of a Complex Condition Open
View article: Predicting increases in COVID-19 incidence to identify locations for targeted testing in West Virginia: A machine learning enhanced approach
Predicting increases in COVID-19 incidence to identify locations for targeted testing in West Virginia: A machine learning enhanced approach Open
During the COVID-19 pandemic, West Virginia developed an aggressive SARS-CoV-2 testing strategy which included utilizing pop-up mobile testing in locations anticipated to have near-term increases in SARS-CoV-2 infections. This study descri…
View article: 447. An Ordinal Scale Assessing SARS-CoV-2 Infected Patient Outcomes Using Electronic Health Records
447. An Ordinal Scale Assessing SARS-CoV-2 Infected Patient Outcomes Using Electronic Health Records Open
Background A major challenge to identifying effective treatments for COVID-19 has been the conflicting results offered by small, often underpowered clinical trials. The World Health Organization (WHO) Ordinal Scale (OS) has been used to me…
View article: Predicting increases in COVID-19 incidence to identify locations for targeted testing in West Virginia: A machine learning enhanced approach
Predicting increases in COVID-19 incidence to identify locations for targeted testing in West Virginia: A machine learning enhanced approach Open
During the COVID-19 pandemic, West Virginia developed an aggressive SARS-CoV-2 testing strategy which included utilizing pop-up mobile testing in locations anticipated to have near-term increases in SARS-CXoV-2 infections. In this study, w…
View article: Clinical and demographic factors associated with stimulant use disorder in a rural heart failure population
Clinical and demographic factors associated with stimulant use disorder in a rural heart failure population Open
View article: Characterizing Long COVID: Deep Phenotype of a Complex Condition
Characterizing Long COVID: Deep Phenotype of a Complex Condition Open
Importance Since late 2019, the novel coronavirus SARS-CoV-2 has given rise to a global pandemic and introduced many health challenges with economic, social, and political consequences. In addition to a complex acute presentation that can …
View article: Clinical Characteristics and Outcomes of COVID-19 in West Virginia
Clinical Characteristics and Outcomes of COVID-19 in West Virginia Open
This study examines the clinical characteristics, outcomes and types of management in SARS-CoV-2 infected patients, in the hospitals affiliated with West Virginia University. We included patients from West Virginia with SARS-CoV-2 infectio…
View article: Coronavirus testing disparities associated with community level deprivation, racial inequalities, and food insecurity in West Virginia
Coronavirus testing disparities associated with community level deprivation, racial inequalities, and food insecurity in West Virginia Open
View article: High prevalence of co-occurring substance use in individuals with opioid use disorder
High prevalence of co-occurring substance use in individuals with opioid use disorder Open