Wesley K. Thompson
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View article: Neuroticism heterogeneity through item-level associations in resting-state functional connectivity
Neuroticism heterogeneity through item-level associations in resting-state functional connectivity Open
Neuroticism is characterized by emotional instability and increased susceptibility to stress-related disorders. While traditionally treated as a unitary construct, growing evidence suggests that neuroticism is heterogeneous in both its gen…
View article: Retaining infants and young children who experience transitions in care in longitudinal studies of child health and development: Considerations from the HEALthy Brain and Child Development study
Retaining infants and young children who experience transitions in care in longitudinal studies of child health and development: Considerations from the HEALthy Brain and Child Development study Open
A transition in care (TIC) is a significant change in the primary adults who provide care for a child, involving a move to informal or formal non‐parental care, including kinship and foster care. In this paper, we address three issues: (1)…
View article: Vulnerability to memory decline in aging revealed by a mega-analysis of structural brain change
Vulnerability to memory decline in aging revealed by a mega-analysis of structural brain change Open
Brain atrophy is a key factor behind episodic memory loss in aging, but the nature and ubiquity of this relationship remains poorly understood. This study leverages 13 longitudinal datasets, including 3737 cognitively healthy adults (10,34…
View article: Population-representative inference for primary and secondary outcomes in extended case-cohort designs
Population-representative inference for primary and secondary outcomes in extended case-cohort designs Open
Background The case-cohort design is useful for obtaining population-representative inference with smaller samples, but the performance when dealing with secondary outcomes and extended follow-up remains unclear. We compare the case-cohort…
View article: Prevalence of Biochemically-Verified Substance Use in Healthy Adolescents Across the United States: Hair Toxicology Results in the ABCD Study
Prevalence of Biochemically-Verified Substance Use in Healthy Adolescents Across the United States: Hair Toxicology Results in the ABCD Study Open
Objective To determine correspondence between self-reported substance use and biochemical verification through hair samples and to estimate U.S. prevalence of adolescent substance use. Methods Data came from the nationwide Adolescent Brain…
View article: Examining relationships between the Danish Composite Deprivation Index and risk of developing schizophrenia: A national multilevel analysis
Examining relationships between the Danish Composite Deprivation Index and risk of developing schizophrenia: A national multilevel analysis Open
This novel population-based multilevel analysis has evidenced the independent associations of neighborhood-level deprivation indicators on schizophrenia risk elevation. Replication is needed in other populations to inform the refinement of…
View article: Longitudinal impacts of family conflict and school environment on youth mental health: An ABCD study
Longitudinal impacts of family conflict and school environment on youth mental health: An ABCD study Open
Background: Adolescence is a critical period for social and emotional development during which these dynamics start to shift, placing them at an increased risk for poor mental health outcomes. Bioecological theory posits that various level…
View article: Integrating multilevel, multidomain and multimodal neuroimaging factors to predict early alcohol exposure trajectories using explainable AI
Integrating multilevel, multidomain and multimodal neuroimaging factors to predict early alcohol exposure trajectories using explainable AI Open
Various multilevel, multidomain factors at the individual-, family-, and environmental-level, and changes in neurobiology have been associated with the likelihood of developing alcohol use disorder (AUD) or binge drinking later in life. Pr…
View article: Prediction of generalized anxiety disorder treatment outcomes with neurobehavioral responses to approach-avoidance conflict: a randomized clinical trial
Prediction of generalized anxiety disorder treatment outcomes with neurobehavioral responses to approach-avoidance conflict: a randomized clinical trial Open
Treatments for generalized anxiety disorder (GAD) often aim to address maladaptive approach-avoidance behavior patterns. Approach-avoidance conflict (AAC) offers a potential framework for identifying treatment outcome predictors and inform…
View article: A ayesian egularized and nnotation- formed ntegrative nalysis of ognition (BRAINIAC)
A ayesian egularized and nnotation- formed ntegrative nalysis of ognition (BRAINIAC) Open
We present the novel Bayesian Regularized and Annotation-Informed Integrative Analysis of Cognition (BRAINIAC) model. BRAINIAC allows for estimation of total variance explained by all features for a given cognitive phenotype, as well as a …
View article: FEMA-Long: Modeling unstructured covariances for discovery of time-dependent effects in large-scale longitudinal datasets
FEMA-Long: Modeling unstructured covariances for discovery of time-dependent effects in large-scale longitudinal datasets Open
Linear mixed-effects (LME) models are commonly used for analyzing longitudinal data. However, most applications of LME models rely on random intercepts or simple, e.g., stationary, covariance. Here, we extend the Fast and Efficient Mixed-E…
View article: Encoding of pretrained large language models mirrors the genetic architectures of human psychological traits.
Encoding of pretrained large language models mirrors the genetic architectures of human psychological traits. Open
Recent advances in large language models (LLMs) have prompted a frenzy in utilizing them as universal translators for biomedical terms. However, the black box nature of LLMs has forced researchers to rely on artificially designed benchmark…
View article: Integrating Multilevel, Multidomain and Multimodal Neuroimaging Factors to Predict Early Alcohol Exposure Trajectories Using Explainable AI
Integrating Multilevel, Multidomain and Multimodal Neuroimaging Factors to Predict Early Alcohol Exposure Trajectories Using Explainable AI Open
Alcohol consumption tends to increase from childhood to adolescence, and risk factors at the individual, family, and environmental level (multilevel, multidomain factors), as well as changes in brain structure and function, have been assoc…
View article: Building Community Through Data: The value of a Researcher Driven Open Science Ecosystem
Building Community Through Data: The value of a Researcher Driven Open Science Ecosystem Open
Exponential scientific data growth presents challenges and opportunities for addressing complex public health issues like the opioid epidemic and chronic pain management. Despite the vast amount of research conducted globally, many dataset…
View article: Analysis of exonic deletions in a large population study provides novel insights into NRXN1 pathology
Analysis of exonic deletions in a large population study provides novel insights into NRXN1 pathology Open
The NRXN1 locus is a hotspot for non-recurrent copy number variants and exon-disrupting NRXN1 deletions have been associated with increased risk of neurodevelopmental disorders in case-control studies. However, corresponding population-bas…
View article: The longitudinal association between reward processing and symptoms of video game addiction in the Adolescent Brain Cognitive Development Study
The longitudinal association between reward processing and symptoms of video game addiction in the Adolescent Brain Cognitive Development Study Open
Background and aims Video games are a common form of entertainment in adolescents, which may result in gaming habits characterized by impairment to reward-related decision-making. The aim of the current study was to investigate the relatio…
View article: Geographic variation of recorded neurodevelopmental disorders in children and adults
Geographic variation of recorded neurodevelopmental disorders in children and adults Open
INTRODUCTION. While diagnosis rates of autism spectrum disorders (ASD) and attention deficit hyperactivity disorder (ADHD) vary within countries at a large-scale municipal level, small neighbourhood geographic variation remains understudie…
View article: Hemochromatosis neural archetype reveals iron disruption in motor circuits
Hemochromatosis neural archetype reveals iron disruption in motor circuits Open
Our understanding of brain iron regulation and its disruption in disease is limited. Excess iron affects motor circuitry, contributing to Parkinson’s disease (PD) risk. The molecular mechanisms regulating central iron levels, beyond a few …
View article: Assortative mating across nine psychiatric disorders is consistent and persistent over cultures and generations
Assortative mating across nine psychiatric disorders is consistent and persistent over cultures and generations Open
Emerging evidence has shown that assortative mating (AM) is a key factor that shapes the landscape of complex human traits. It can increase the overall prevalence of disorders, influence occurrences of comorbidities, and bias estimation of…
View article: Advancing high quality longitudinal data collection: Implications for the HEALthy Brain and Child Development (HBCD) Study design and recruitment
Advancing high quality longitudinal data collection: Implications for the HEALthy Brain and Child Development (HBCD) Study design and recruitment Open
The HEALthy Brain and Child Development (HBCD) Study, a multi-site prospective longitudinal cohort study, will examine human brain, cognitive, behavioral, social, and emotional development beginning prenatally and planned through early chi…
View article: Estimating the total variance explained by whole-brain imaging for zero-inflated outcomes
Estimating the total variance explained by whole-brain imaging for zero-inflated outcomes Open
There is a dearth of statistical models that adequately capture the total signal attributed to whole-brain imaging features. The total signal is often widely distributed across the brain, with individual imaging features exhibiting small e…
View article: Genetic Correlates of Treatment-Resistant Depression: Insights from Polygenic Scores Across Cognitive, Temperamental, and Sleep Traits in the All of US cohort
Genetic Correlates of Treatment-Resistant Depression: Insights from Polygenic Scores Across Cognitive, Temperamental, and Sleep Traits in the All of US cohort Open
Background Treatment-resistant depression (TRD) is a major challenge in mental health, affecting a significant number of patients and leading to considerable economic and social burdens. The etiological factors contributing to TRD are comp…
View article: Population-Based Risk of Psychiatric Disorders Associated With Recurrent Copy Number Variants
Population-Based Risk of Psychiatric Disorders Associated With Recurrent Copy Number Variants Open
Importance Recurrent copy number variants (rCNVs) have been associated with increased risk of psychiatric disorders in case-control studies, but their population-level impact is unknown. Objective To provide unbiased population-based estim…
View article: Missing data approaches for longitudinal neuroimaging research: Examples from the Adolescent Brain and Cognitive Development (ABCD) Study
Missing data approaches for longitudinal neuroimaging research: Examples from the Adolescent Brain and Cognitive Development (ABCD) Study Open
This paper addresses the challenges of managing missing values within expansive longitudinal neu-roimaging datasets, using the specific example of data derived from the Adolescent Brain and Cog-nitive Development (ABCD ® ) study. The conve…