Wesley Tung
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View article: BCMA Deficiency as a Novel Cause of Common Variable Immunodeficiency
BCMA Deficiency as a Novel Cause of Common Variable Immunodeficiency Open
B cell maturation antigen (BCMA) is a TNF superfamily protein expressed predominantly on plasmablasts and plasma cells. BCMA, along with TACI and BAFF-R, has been implicated for proper B cell maturation, differentiation, and survival. Pati…
View article: PTBP1 controls intestinal epithelial regeneration through post-transcriptional regulation of gene expression
PTBP1 controls intestinal epithelial regeneration through post-transcriptional regulation of gene expression Open
The intestinal epithelial regeneration is driven by intestinal stem cells under homeostatic conditions. Differentiated intestinal epithelial cells, such as Paneth cells, are capable of acquiring multipotency and contributing to regeneratio…
View article: PTBP1/HNRNP I controls intestinal epithelial cell regeneration by maintaining stem cell survival and stemness
PTBP1/HNRNP I controls intestinal epithelial cell regeneration by maintaining stem cell survival and stemness Open
Properly controlled intestinal epithelial cell regeneration is not only vital for protection against insults from environmental hazards but also crucial for preventing intestinal cancer. Intestinal stem cells located in the crypt region pr…
View article: Inborn errors of TLR3- or MDA5-dependent type I IFN immunity in children with enterovirus rhombencephalitis
Inborn errors of TLR3- or MDA5-dependent type I IFN immunity in children with enterovirus rhombencephalitis Open
Enterovirus (EV) infection rarely results in life-threatening infection of the central nervous system. We report two unrelated children with EV30 and EV71 rhombencephalitis. One patient carries compound heterozygous TLR3 variants (loss-of-…
View article: IFIH1 loss-of-function variants contribute to very early-onset inflammatory bowel disease
IFIH1 loss-of-function variants contribute to very early-onset inflammatory bowel disease Open
View article: IMMU-25. SEVERE AND MULTIFACETED SYSTEMIC IMMUNOSUPPRESSION CAUSED BY EXPERIMENTAL CANCERS OF THE CENTRAL NERVOUS SYSTEM REQUIRES RELEASE OF NON-STEROID SOLUBLE MEDIATORS
IMMU-25. SEVERE AND MULTIFACETED SYSTEMIC IMMUNOSUPPRESSION CAUSED BY EXPERIMENTAL CANCERS OF THE CENTRAL NERVOUS SYSTEM REQUIRES RELEASE OF NON-STEROID SOLUBLE MEDIATORS Open
Immunosuppression of unknown etiology is a hallmark feature of glioblastoma (GBM) and is characterized by decreased CD4 T cell counts and down regulation of MHC class II expression on peripheral blood monocytes in patients. This immunosupp…
View article: Brain cancer induces systemic immunosuppression through release of non-steroid soluble mediators
Brain cancer induces systemic immunosuppression through release of non-steroid soluble mediators Open
Immunosuppression of unknown aetiology is a hallmark feature of glioblastoma and is characterized by decreased CD4 T-cell counts and downregulation of major histocompatibility complex class II expression on peripheral blood monocytes in pa…
View article: Severe and multifaceted systemic immunosuppression caused by experimental cancers of the central nervous system requires release of non-steroid soluble mediators
Severe and multifaceted systemic immunosuppression caused by experimental cancers of the central nervous system requires release of non-steroid soluble mediators Open
Immunosuppression of unknown etiology is a hallmark feature of glioblastoma (GBM) and is characterized by decreased CD4 T cell counts and down regulation of MHC class II expression on peripheral blood monocytes in patients. This immunosupp…
View article: Adipocyte β-arrestin-2 is essential for maintaining whole body glucose and energy homeostasis
Adipocyte β-arrestin-2 is essential for maintaining whole body glucose and energy homeostasis Open