Weston J. Smith
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View article: Inability of <scp>GSTT1</scp> to activate iodinated halomethanes to mutagens in <i>Salmonella</i>
Inability of <span>GSTT1</span> to activate iodinated halomethanes to mutagens in <i>Salmonella</i> Open
Drinking water disinfection by‐products (DBPs), including the ubiquitous trihalomethanes (THMs), are formed during the treatment of water with disinfectants (e.g., chlorine, chloramines) to produce and distribute potable water. Brominated …
View article: Optogenetic Apoptosis: Light-Triggered Cell Death
Optogenetic Apoptosis: Light-Triggered Cell Death Open
An optogenetic Bax has been designed that facilitates light-induced apoptosis. We demonstrate that mitochondrial recruitment of a genetically encoded light-responsive Bax results in the release of mitochondrial proteins, downstream caspase…
View article: Cell-Mediated Assembly of Phototherapeutics
Cell-Mediated Assembly of Phototherapeutics Open
Light-activatable drugs offer the promise of controlled release with exquisite temporal and spatial resolution. However, light sensitive pro-drugs are typically converted to their active forms using short wavelengths, which display poor ti…
View article: Phototriggered Secretion of Membrane Compartmentalized Bioactive Agents
Phototriggered Secretion of Membrane Compartmentalized Bioactive Agents Open
A strategy for the light-activated release of bioactive compounds (BODIPY, colchicine, paclitaxel, and methotrexate) from membrane-enclosed depots is described. We have found that membrane-permeable bioagents can be rendered membrane imper…
View article: Evaluation of Targeting Efficiency of Joints with Anticollagen II Antibodies
Evaluation of Targeting Efficiency of Joints with Anticollagen II Antibodies Open
Diseases of the joints affect over 10% of the world's population, resulting in significant morbidity. There is an unmet need in strategies for specific delivery of therapeutics to the joints. Collagen type II is synthesized by chondrocytes…
View article: Phototriggered Secretion of Membrane Compartmentalized Bioactive Agents
Phototriggered Secretion of Membrane Compartmentalized Bioactive Agents Open
A strategy for the light‐activated release of bioactive compounds (BODIPY, colchicine, paclitaxel, and methotrexate) from membrane‐enclosed depots is described. We have found that membrane‐permeable bioagents can be rendered membrane imper…