Wey Wen Lim
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View article: Investigating setting-specific superspreading potential and generation intervals of COVID-19 in Hong Kong
Investigating setting-specific superspreading potential and generation intervals of COVID-19 in Hong Kong Open
Superspreading is an important feature of COVID-19 transmission dynamics, but few studies have investigated this feature stratified by transmission setting. Using detailed clustering data comprising 8647 COVID-19 cases confirmed in Hong Ko…
View article: Assessment of neutralizing antibody response as a correlate of protection against symptomatic SARS-CoV-2 infections after administration of two doses of the CoronaVac inactivated COVID-19 vaccine: A phase III randomized controlled trial
Assessment of neutralizing antibody response as a correlate of protection against symptomatic SARS-CoV-2 infections after administration of two doses of the CoronaVac inactivated COVID-19 vaccine: A phase III randomized controlled trial Open
The results highlight the value of neutralizing antibody response as a correlate of protection, which can be used to inform future vaccine development and implementation. Further studies of immune correlates of protection for other vaccine…
View article: Non-pharmaceutical interventions to reduce influenza transmission in households: a systematic review and meta-analysis
Non-pharmaceutical interventions to reduce influenza transmission in households: a systematic review and meta-analysis Open
Background Influenza pandemic plans often recommend non-pharmaceutical interventions (NPIs) in household settings, including hand hygiene and face masks. We reviewed the evidence supporting the recommendations of these measures to prevent …
View article: Insights into COVID-19 epidemiology and control from temporal changes in serial interval distributions in Hong Kong
Insights into COVID-19 epidemiology and control from temporal changes in serial interval distributions in Hong Kong Open
The serial interval (SI) distribution of an epidemic is used to approximate the generation time distribution, an essential parameter for inferring the transmissibility (${R}_t$) of an infectious disease. However, SI distributions may chang…
View article: Predicting Efficacies of Fractional Doses of Vaccines by Using Neutralizing Antibody Levels: Systematic Review and Meta-Analysis
Predicting Efficacies of Fractional Doses of Vaccines by Using Neutralizing Antibody Levels: Systematic Review and Meta-Analysis Open
Background With the emergence of SARS-CoV-2 variants that have eluded immunity from vaccines and prior infections, vaccine shortages and vaccine effectiveness pose unprecedented challenges for governments in expanding booster vaccination p…
View article: Investigating setting-specific superspreading potential and generation intervals of COVID-19 in Hong Kong
Investigating setting-specific superspreading potential and generation intervals of COVID-19 in Hong Kong Open
Superspreading is an important feature of SARS-CoV-2, though few studies have investigated quantitatively how transmission characteristics can vary by setting. Using detailed clustering data comprising 8635 SARS-CoV-2 cases confirmed in Ho…
View article: An observational study on imported COVID-19 cases in Hong Kong during mandatory on-arrival hotel quarantine
An observational study on imported COVID-19 cases in Hong Kong during mandatory on-arrival hotel quarantine Open
Testing inbound travellers at arrival and during quarantine can detect imported cases early, but may not prevent all COVID-19 introductions into the community. Public health measures should be adapted in response to the emergence of SARS-C…
View article: Hemagglutination Inhibition Antibody Titers as Mediators of Influenza Vaccine Efficacy Against Symptomatic Influenza A(H1N1), A(H3N2), and B/Victoria Virus Infections
Hemagglutination Inhibition Antibody Titers as Mediators of Influenza Vaccine Efficacy Against Symptomatic Influenza A(H1N1), A(H3N2), and B/Victoria Virus Infections Open
Background The hemagglutination inhibition antibody (HAI) titer contributes only a part of vaccine-induced protection against influenza virus infections. Using causal mediation analysis, we quantified the proportion of vaccine efficacy med…
View article: Effectiveness of social distancing measures and lockdowns for reducing transmission of COVID-19 in non-healthcare, community-based settings
Effectiveness of social distancing measures and lockdowns for reducing transmission of COVID-19 in non-healthcare, community-based settings Open
Social distancing measures (SDMs) are community-level interventions that aim to reduce person-to-person contacts in the community. SDMs were a major part of the responses first to contain, then to mitigate, the spread of SARS-CoV-2 in the …
View article: Predictive efficacies of vaccine dose fractionation using neutralizing antibody levels
Predictive efficacies of vaccine dose fractionation using neutralizing antibody levels Open
Background With the emergence of SARS-CoV-2 variants that eluded immunity from vaccines and prior infections, vaccine shortages and their effectiveness pose unprecedented challenges for governments to expand booster vaccination programs. F…
View article: The impact of repeated vaccination on relative influenza vaccine effectiveness among vaccinated adults in the United Kingdom
The impact of repeated vaccination on relative influenza vaccine effectiveness among vaccinated adults in the United Kingdom Open
Annual seasonal influenza vaccination is recommended for individuals at high risk of developing post-infection complications in many locations. However, reduced vaccine immunogenicity and effectiveness have been observed among repeat vacci…
View article: Insights into COVID-19 epidemiology and control from temporal changes in serial interval distributions in Hong Kong
Insights into COVID-19 epidemiology and control from temporal changes in serial interval distributions in Hong Kong Open
The serial interval distribution is used to approximate the generation time distribution, an essential parameter to predict the effective reproductive number “ R t ”, a measure of transmissibility. However, serial interval distributions ma…
View article: An observational study on imported COVID-19 cases in Hong Kong during mandatory on-arrival hotel quarantine
An observational study on imported COVID-19 cases in Hong Kong during mandatory on-arrival hotel quarantine Open
Background Hong Kong has enforced stringent travel restrictions particularly for inbound travellers since the emergence of SARS-CoV-2. Understanding the characteristics of imported COVID-19 cases is important for establishing evidence-base…
View article: Time-varying transmission heterogeneity of SARS and COVID-19 in Hong Kong
Time-varying transmission heterogeneity of SARS and COVID-19 in Hong Kong Open
Transmission heterogeneity is a notable feature of the severe acute respiratory syndrome (SARS) and coronavirus disease 2019 (COVID-19) epidemics, though previous efforts to estimate how heterogeneity changes over time are limited. Using c…
View article: Sepsis-associated hospitalizations and antimicrobial use in Hong Kong
Sepsis-associated hospitalizations and antimicrobial use in Hong Kong Open
Our study was conducted to assess the sepsis-associated hospitalisations and antimicrobials prescribed for sepsis inpatients in Hong Kong. Demographic, diagnostic and antimicrobial prescription data were analysed for patients admitted to p…
View article: Comparative cost-effectiveness of SARS-CoV-2 vaccine dose fractionation in India: a modelling study
Comparative cost-effectiveness of SARS-CoV-2 vaccine dose fractionation in India: a modelling study Open
Given constrained vaccine supplies globally, fractionation of vaccine doses may be an effective strategy for reducing disease and healthcare burdens, even with the emergence of COVID-19 variants. Using a multi-scale model that incorporates…
View article: Suppressing COVID-19 transmission in Hong Kong: an observational study of the first four months
Suppressing COVID-19 transmission in Hong Kong: an observational study of the first four months Open
Background: Hong Kong was one of the first locations outside of mainland China to identify COVID-19 cases in January 2020. We assessed the impact of various public health measures on transmission. Methods: We analysed data on all COVID-19 …
View article: Distinguishing Causation from Correlation in the Use of Correlates of Protection to Evaluate and Develop Influenza Vaccines
Distinguishing Causation from Correlation in the Use of Correlates of Protection to Evaluate and Develop Influenza Vaccines Open
There is increasing attention to the need to identify new immune markers for the evaluation of existing and new influenza vaccines. Immune markers that could predict individual protection against infection and disease, commonly called corr…
View article: Influenza Hemagglutination-inhibition Antibody Titer as a Mediator of Vaccine-induced Protection for Influenza B
Influenza Hemagglutination-inhibition Antibody Titer as a Mediator of Vaccine-induced Protection for Influenza B Open
The majority of the effect of inactivated influenza vaccination in children is mediated by the increased HAI titer after vaccination; however, other components of the immune response to vaccination may also play a role in protection and sh…