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View article: Fenoxycarb disrupts calcium homeostasis and impairs unfolded protein response and autophagy, leading to cell death in bovine mammary epithelial cells
Fenoxycarb disrupts calcium homeostasis and impairs unfolded protein response and autophagy, leading to cell death in bovine mammary epithelial cells Open
View article: Latest trends and future prospects in gene editing, omics, and AI-based approaches for enhancing swine reproductive productivity in response to climate change
Latest trends and future prospects in gene editing, omics, and AI-based approaches for enhancing swine reproductive productivity in response to climate change Open
View article: Upregulation of 15-Hydroxyprostaglandin Dehydrogenase by Celecoxib to Reduce Pain After Laparoendoscopic Single-Site Surgery (POPCORN Trial): A Randomized Controlled Trial
Upregulation of 15-Hydroxyprostaglandin Dehydrogenase by Celecoxib to Reduce Pain After Laparoendoscopic Single-Site Surgery (POPCORN Trial): A Randomized Controlled Trial Open
Background: Peritoneal stretching from CO2 insufflation is a primary mechanism of pain associated with laparoscopy. Cyclooxygenase-2 inhibitors are promising anti-inflammatory and analgesic agents. This study aimed to evaluate the effect o…
View article: Heated wood-based ethylene scavenger for active packaging to prevent browning of Lentinula edodes
Heated wood-based ethylene scavenger for active packaging to prevent browning of Lentinula edodes Open
Most mushrooms are sensitive to ethylene, and exposure leads to degradation in mushroom quality, particularly in appearance and organoleptic properties. This study investigated the feasibility of using heated wood for ethylene removal. The…
View article: Overview of the hazardous impacts of metabolism-disrupting chemicals on the progression of fatty liver diseases
Overview of the hazardous impacts of metabolism-disrupting chemicals on the progression of fatty liver diseases Open
View article: Female reproductive disease, endometriosis: From inflammation to infertility
Female reproductive disease, endometriosis: From inflammation to infertility Open
View article: Brief guidelines for zebrafish embryotoxicity tests
Brief guidelines for zebrafish embryotoxicity tests Open
View article: Guide for generating single-cell–derived knockout clones in mammalian cell lines using the CRISPR/Cas9 system
Guide for generating single-cell–derived knockout clones in mammalian cell lines using the CRISPR/Cas9 system Open
Genome editing has developed rapidly in various research fields for targeted genome modifications in many organisms, including cells, plants, viruses, and animals. The clustered regularly interspaced short palindromic repeats-associated pr…
View article: Osthole Suppresses Cell Growth of Prostate Cancer by Disrupting Redox Homeostasis, Mitochondrial Function, and Regulation of tiRNAHisGTG
Osthole Suppresses Cell Growth of Prostate Cancer by Disrupting Redox Homeostasis, Mitochondrial Function, and Regulation of tiRNAHisGTG Open
Prostate cancer remains a significant global health concern, posing a substantial threat to men’s well-being. Despite advancements in treatment modalities, the progression of prostate cancer still presents challenges, warranting further ex…
View article: Specific expression of CC chemokine CCL17 regulates ovarian development and cell cycle in response to female reproductive hormones on in female black rockfish, Sebastes schlegelii
Specific expression of CC chemokine CCL17 regulates ovarian development and cell cycle in response to female reproductive hormones on in female black rockfish, Sebastes schlegelii Open
CC chemokine ligand 17 (CCL17) is a CC chemokine present in various species, including fish and mammals. CCL17 plays an important role in various organs, including innate immune defense in mammals, but its role and histological expression …
View article: Autophagy regulation and redox perturbation by transcrocetin suppress the growth of endometriosis
Autophagy regulation and redox perturbation by transcrocetin suppress the growth of endometriosis Open
Until non-hormonal therapeutic targets for endometriosis are suggested, we focused on mitochondrial function and autophagy regulation in the disease. Transcrocetin is a carotenoid and retinoic acid with high antioxidant potency and antipro…
View article: Relevance of the endoplasmic reticulum-mitochondria axis in cancer diagnosis and therapy
Relevance of the endoplasmic reticulum-mitochondria axis in cancer diagnosis and therapy Open
View article: EP014/#682 Effect of decitabine combined with belotecan on T-cell mediated immunity in ovarian cancer
EP014/#682 Effect of decitabine combined with belotecan on T-cell mediated immunity in ovarian cancer Open
Introduction We evaluated the effect of decitabine on T-cell mediated immunity in ovarian cancer cell lines when combined with topoisomerase I inhibitors Methods We selected five human (ES2, OV90, SKOV3, TOV21G, TOV112D) and one mouse ovar…
View article: Alpinumisoflavone Activates Disruption of Calcium Homeostasis, Mitochondria and Autophagosome to Suppress Development of Endometriosis
Alpinumisoflavone Activates Disruption of Calcium Homeostasis, Mitochondria and Autophagosome to Suppress Development of Endometriosis Open
Alpinumisoflavone is an isoflavonoid extracted from the Cudrania tricuspidate fruit and Genista pichisermolliana. It has various physiological functions, such as anti-inflammation, anti-proliferation, and apoptosis, in malignant tumors. Ho…
View article: Developmental Defects Induced by Thiabendazole are Mediated Via Apoptosis, Oxidative Stress and Alteration in Pi3k/Akt and Mapk Pathways in Zebrafish
Developmental Defects Induced by Thiabendazole are Mediated Via Apoptosis, Oxidative Stress and Alteration in Pi3k/Akt and Mapk Pathways in Zebrafish Open
View article: Palmitic acid induces inflammatory cytokines and regulates tRNA-derived stress-induced RNAs in human trophoblasts
Palmitic acid induces inflammatory cytokines and regulates tRNA-derived stress-induced RNAs in human trophoblasts Open
High levels of proinflammatory cytokines have been observed in obese pregnancies. Obesity during pregnancy may increase the risk of various pregnancyrelated complications, with pathogenesis resulting from excessive inflammation. Palmitic a…
View article: Oryzalin impairs maternal-fetal interaction during early pregnancy via ROS-mediated mitochondrial dysfunction leading to a decrease in ATP
Oryzalin impairs maternal-fetal interaction during early pregnancy via ROS-mediated mitochondrial dysfunction leading to a decrease in ATP Open
Oryzalin is a dinitroaniline pesticide for the control of weed growth via suppression of microtubule synthesis. There are studies about the deleterious effects of dinitroaniline pesticides on the reproductive system. Therefore, we attempte…
View article: Targeting Thymidylate Synthase and tRNA-Derived Non-Coding RNAs Improves Therapeutic Sensitivity in Colorectal Cancer
Targeting Thymidylate Synthase and tRNA-Derived Non-Coding RNAs Improves Therapeutic Sensitivity in Colorectal Cancer Open
Some colorectal cancer (CRC) patients are resistant to 5-fluorouracil (5-FU), and high expression levels of thymidylate synthase (TS) contribute to this resistance. This study investigated whether quercetin, a representative polyphenol com…
View article: Norflurazon causes developmental defects including cardiovascular abnormalities in early-stage zebrafish (<i>Danio rerio</i>)
Norflurazon causes developmental defects including cardiovascular abnormalities in early-stage zebrafish (<i>Danio rerio</i>) Open
Norflurazon is widely used on agricultural lands and has a high potential to pollute water sources. However, its effects on fish have not been fully elucidated. The purpose of our study was to determine whether norflurazon adversely affect…
View article: Mecoprop-p interrupts the development of zebrafish via apoptosis and vascular damage
Mecoprop-p interrupts the development of zebrafish via apoptosis and vascular damage Open
Mecoprop-p, a chlorophenoxy herbicide, has been widely used since the 1980s. Due to its high water solubility, it could be detected in the aquatic environment, as it has already been detected in the surface water or groundwater in several …
View article: Alpinumisoflavone Impairs Mitochondrial Respiration via Oxidative Stress and MAPK/PI3K Regulation in Hepatocellular Carcinoma Cells
Alpinumisoflavone Impairs Mitochondrial Respiration via Oxidative Stress and MAPK/PI3K Regulation in Hepatocellular Carcinoma Cells Open
Alpinumisoflavone is a natural prenylated isoflavonoid extracted from the raw fruit of Cudrania tricuspidata. Several studies have reported the beneficial characteristics of alpinumisoflavone, such as its antioxidant, anti-inflammation, an…
View article: Hesperidin Suppresses the Proliferation of Prostate Cancer Cells by Inducing Oxidative Stress and Disrupting Ca2+ Homeostasis
Hesperidin Suppresses the Proliferation of Prostate Cancer Cells by Inducing Oxidative Stress and Disrupting Ca2+ Homeostasis Open
Although androgen deprivation therapy is mainly used for its treatment, the mortality rate of prostate cancer remains high due to drug resistance. Hence, there is a need to discover new compounds that exhibit therapeutic effects against pr…
View article: Establishment of a piglet model for peritoneal metastasis of ovarian cancer
Establishment of a piglet model for peritoneal metastasis of ovarian cancer Open
Background A piglet model for peritoneal metastasis (PM) of ovarian cancer was developed. It will contribute to establishing innovative chemotherapeutical and surgical strategies without any limitation on rodent models. Methods A total of …
View article: Alpinumisoflavone Disrupts Endoplasmic Reticulum and Mitochondria Leading to Apoptosis in Human Ovarian Cancer
Alpinumisoflavone Disrupts Endoplasmic Reticulum and Mitochondria Leading to Apoptosis in Human Ovarian Cancer Open
Alpinumisoflavone is a prenylated isoflavonoid derived from the Cudrania tricuspidate fruit and Genista pichisermolliana. Alpinumisoflavone has anticancer properties in a variety of cancer cells, including colorectal, esophageal, renal and…
View article: Inhibitory Effects of 6,8-Diprenylorobol on Endometriosis Progression in Humans by Disrupting Calcium Homeostasis and Mitochondrial Function
Inhibitory Effects of 6,8-Diprenylorobol on Endometriosis Progression in Humans by Disrupting Calcium Homeostasis and Mitochondrial Function Open
6,8-Diprenylorobol is a flavonoid compound extracted from Cudrania tricuspidata. It has various biological functions, such as inhibiting melanin synthesis and inducting cell death in cancerous cells. In addition, Cudrania tricuspidata is k…
View article: Thiobencarb Induces Cardiovascular Toxicity in Zebrafish Embryos Through Oxidative Stress and Inflammation
Thiobencarb Induces Cardiovascular Toxicity in Zebrafish Embryos Through Oxidative Stress and Inflammation Open
View article: Ethalfluralin Impairs Implantation by Aggravation of Mitochondrial Viability and Function During Early Pregnancy
Ethalfluralin Impairs Implantation by Aggravation of Mitochondrial Viability and Function During Early Pregnancy Open
View article: Rotational intraperitoneal pressurized aerosol chemotherapy with paclitaxel and cisplatin: pharmacokinetics, tissue concentrations, and toxicities in a pig model
Rotational intraperitoneal pressurized aerosol chemotherapy with paclitaxel and cisplatin: pharmacokinetics, tissue concentrations, and toxicities in a pig model Open
Delayed absorption of paclitaxel sprayed by RIPAC into the peritoneum to the bloodstream may lead to higher tissue concentrations at different regions and lower serum concentrations than cisplatin.
View article: Dinitramine Induces Implantation Failure by Cell Cycle Arrest and Mitochondrial Dysfunction in Porcine Trophectoderm and Luminal Epithelial Cells
Dinitramine Induces Implantation Failure by Cell Cycle Arrest and Mitochondrial Dysfunction in Porcine Trophectoderm and Luminal Epithelial Cells Open
View article: Pendimethalin Exposure Induces Bovine Mammary Epithelial Cell Death Through Excessive ROS Production and Alterations in the Pi3k and Mapk Signaling Pathways
Pendimethalin Exposure Induces Bovine Mammary Epithelial Cell Death Through Excessive ROS Production and Alterations in the Pi3k and Mapk Signaling Pathways Open