Wiebke Gandhi
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View article: Temporal dynamics of hippocampal activity predict stable patterns of sensitization or habituation to noxious stimulation across sessions
Temporal dynamics of hippocampal activity predict stable patterns of sensitization or habituation to noxious stimulation across sessions Open
Acute pain serves to warn an organism of potential damage. When nociceptive stimulation persists, two possible responses emerge: If no risk of harm is anticipated, habituation may occur. If harm is considered possible, pain sensitization i…
View article: Conditioned pain modulation is associated with heightened connectivity between the periaqueductal grey and cortical regions
Conditioned pain modulation is associated with heightened connectivity between the periaqueductal grey and cortical regions Open
Introduction: Conditioned pain modulation (CPM) is a psychophysical assessment used to estimate the efficiency of an individual's endogenous modulatory mechanisms. Conditioned pain modulation has been used as a predictive assessment for th…
View article: Do “central sensitization” questionnaires reflect measures of nociceptive sensitization or psychological constructs? Protocol for a systematic review
Do “central sensitization” questionnaires reflect measures of nociceptive sensitization or psychological constructs? Protocol for a systematic review Open
Introduction: Central sensitization (CS) was first defined in animal studies to be increased nociceptive responsiveness due to sensitization of neurons in the central nervous system, usually the result of prolonged nociceptive input or a d…
View article: Neural and behavioral correlates of human pain avoidance in participants with and without episodic migraine
Neural and behavioral correlates of human pain avoidance in participants with and without episodic migraine Open
The innate motivation to avoid pain can be disrupted when individuals experience uncontrollable stress, such as pain. This can lead to maladaptive behaviors, including passivity, and negative affect. Despite its importance, motivational as…
View article: Intrinsic attention to pain is associated with a pronociceptive phenotype
Intrinsic attention to pain is associated with a pronociceptive phenotype Open
Introduction: Evidence suggests that attention to pain is a product of both incoming sensory signals and cognitive evaluation of a stimulus. Intrinsic attention to pain (IAP) is a measure that captures an individual's natural tendency to a…
View article: Endogenous opioids contribute to the feeling of pain relief in humans
Endogenous opioids contribute to the feeling of pain relief in humans Open
Endogenous opioids mediate the pleasurable responses to positively reinforcing stimuli such as palatable food. Yet, the reduction or omission of a negative experience can also be rewarding (negative reinforcement). As such, pain relief lea…
View article: Neuropathic pain after thoracotomy: Tracking signs and symptoms before and at monthly intervals following surgery
Neuropathic pain after thoracotomy: Tracking signs and symptoms before and at monthly intervals following surgery Open
Background As the development of neuropathic symptoms contributes to pain severity and chronification after surgery, their early prediction is important to allow targeted treatment. Objectives We longitudinally investigated trajectories of…
View article: Induced oscillatory signaling in the beta frequency of top-down pain modulation
Induced oscillatory signaling in the beta frequency of top-down pain modulation Open
Background: Induced synchronized brain activity, particularly in the beta-frequency range, has rarely been investigated in human electrophysiological studies of attentional modulation of the perception of nociceptive stimuli. Methods: We m…
View article: Male-Specific Conditioned Pain Hypersensitivity in Mice and Humans
Male-Specific Conditioned Pain Hypersensitivity in Mice and Humans Open
View article: Multicenter assessment of quantitative sensory testing (QST) for the detection of neuropathic-like pain responses using the topical capsaicin model
Multicenter assessment of quantitative sensory testing (QST) for the detection of neuropathic-like pain responses using the topical capsaicin model Open
These results provide further support for the application of QST in multicenter studies examining normal and pathological pain responses.
View article: Subjective utility moderates bidirectional effects of conflicting motivations on pain perception
Subjective utility moderates bidirectional effects of conflicting motivations on pain perception Open
View article: How Accurate Appraisal of Behavioral Costs and Benefits Guides Adaptive Pain Coping
How Accurate Appraisal of Behavioral Costs and Benefits Guides Adaptive Pain Coping Open
Coping with pain is a complex phenomenon encompassing a variety of behavioral responses and a large network of underlying neural circuits. Whether pain coping is adaptive or maladaptive depends on the type of pain (e.g., escapable or inesc…
View article: Orbitofrontal cortex mediates pain inhibition by monetary reward
Orbitofrontal cortex mediates pain inhibition by monetary reward Open
Pleasurable stimuli, including reward, inhibit pain, but the level of the neuraxis at which they do so and the cerebral processes involved are unknown. Here, we characterized a brain circuitry mediating pain inhibition by reward. Twenty-fo…
View article: The influence of pain on reward processing
The influence of pain on reward processing Open
Avoiding pain and seeking reward are motivational states crucial for survival. When activated simultaneously, they are likely to interact (Becker et al., 2012; Navratilova and Porreca 2014). Chronic pain, for example, has been associated w…
View article: Doubling Your Payoff: Winning Pain Relief Engages Endogenous Pain Inhibition
Doubling Your Payoff: Winning Pain Relief Engages Endogenous Pain Inhibition Open
When in pain, pain relief is much sought after, particularly for individuals with chronic pain. In analogy to augmentation of the hedonic experience (“liking”) of a reward by the motivation to obtain a reward (“wanting”), the seeking of pa…