Wiley A. Schell
YOU?
Author Swipe
View article: Efficacy of Liposomal Nystatin in a Rabbit Model of Cryptococcal Meningitis
Efficacy of Liposomal Nystatin in a Rabbit Model of Cryptococcal Meningitis Open
Cryptococcal meningitis (CM) causes significant global morbidity and mortality. Current therapeutic strategies rely on deoxycholated or liposomal forms of the polyene amphotericin B. Nystatin is also a polyene with broad-spectrum antimicro…
View article: A ketogenic diet enhances fluconazole efficacy in murine models of systemic fungal infection
A ketogenic diet enhances fluconazole efficacy in murine models of systemic fungal infection Open
Invasive fungal infections are a significant public health concern, with mortality rates ranging from 20% to 85% despite current treatments. Therefore, we examined whether a ketogenic diet could serve as a successful treatment intervention…
View article: Pharmacodynamics of ATI-2307 in a rabbit model of cryptococcal meningoencephalitis
Pharmacodynamics of ATI-2307 in a rabbit model of cryptococcal meningoencephalitis Open
Cryptococcal meningoencephalitis (CM) is a devastating fungal disease with high morbidity and mortality. The current regimen that is standard-of-care involves a combination of three different drugs administered for up to one year. There is…
View article: Susceptibility to Cryptococcus neoformans Infection with Bruton’s Tyrosine Kinase Inhibition
Susceptibility to Cryptococcus neoformans Infection with Bruton’s Tyrosine Kinase Inhibition Open
Patients receiving the Bruton’s tyrosine kinase (BTK) inhibitor ibrutinib have an increased likelihood of fungal infections. The objectives of this study were to determine if Cryptococcus neoformans infection severity was isolate dependent…
View article: Efficacy of APX2039 in a Rabbit Model of Cryptococcal Meningitis
Efficacy of APX2039 in a Rabbit Model of Cryptococcal Meningitis Open
Cryptococcal meningitis (CM) is a fungal disease with significant global morbidity and mortality. The gepix Gwt1 inhibitors are a new class of antifungal drugs.
View article: <i>Curvularia alcornii</i> Aortic Pseudoaneurysm Following Aortic Valve Replacement: Case Report and Review of the Literature
<i>Curvularia alcornii</i> Aortic Pseudoaneurysm Following Aortic Valve Replacement: Case Report and Review of the Literature Open
We report the first case of Curvularia alcornii aortic pseudoaneurysm following bioprosthetic aortic valve replacement in an immunocompetent host. Infection was complicated by septic emboli to multiple organs. Despite aggressive surgical i…
View article: 717. Susceptibility to Cryptococcosis in Bruton's Tyrosine Kinase Knockout Model
717. Susceptibility to Cryptococcosis in Bruton's Tyrosine Kinase Knockout Model Open
Background Patients receiving the Bruton’s tyrosine kinase (BTK) inhibitor ibrutinib have an increased likelihood of systemic and central nervous system (CNS) fungal infections. Previous work has shown that BTK knockout (KO) mice have more…
View article: Structure-In Vitro Activity Relationships of Pentamidine Analogues and Dication-Substituted Bis-Benzimidazoles as New Antifungal Agents
Structure-In Vitro Activity Relationships of Pentamidine Analogues and Dication-Substituted Bis-Benzimidazoles as New Antifungal Agents Open
Twenty analogues of pentamidine, 7 primary metabolites of pentamidine, and 30 dicationic substituted bis-benzimidazoles were screened for their inhibitory and fungicidal activities against Candida albicans and Cryptococcus neoformans. A ma…
View article: In Vitro Antifungal Activities of a Series of Dication-Substituted Carbazoles, Furans, and Benzimidazoles
In Vitro Antifungal Activities of a Series of Dication-Substituted Carbazoles, Furans, and Benzimidazoles Open
Aromatic dicationic compounds possess antimicrobial activity against a wide range of eucaryotic pathogens, and in the present study an examination of the structures-functions of a series of compounds against fungi was performed. Sixty-seve…
View article: Effect of fluconazole prophylaxis on Candida fluconazole susceptibility in premature infants
Effect of fluconazole prophylaxis on Candida fluconazole susceptibility in premature infants Open
Objectives Extremely premature infants are at high risk of developing invasive candidiasis; fluconazole prophylaxis is safe and effective for reducing invasive candidiasis in this population but further study is needed. We sought to better…
View article: <i>In Vitro</i> and <i>In Vivo</i> Evaluation of APX001A/APX001 and Other Gwt1 Inhibitors against Cryptococcus
<i>In Vitro</i> and <i>In Vivo</i> Evaluation of APX001A/APX001 and Other Gwt1 Inhibitors against Cryptococcus Open
Cryptococcal meningitis (CM), caused primarily by Cryptococcus neoformans , is uniformly fatal if not treated. Treatment options are limited, especially in resource-poor geographical regions, and mortality rates remain high despite current…
View article: Genomic characterization of recurrent mold infections in thoracic transplant recipients
Genomic characterization of recurrent mold infections in thoracic transplant recipients Open
Invasive mold disease in thoracic organ transplant recipients is a well‐recognized complication, but the long‐term persistence of molds within the human body and evasion of host defenses has not been well‐described. We present 2 cases of i…
View article: Antifungal Activity of SCY-078 and Standard Antifungal Agents against 178 Clinical Isolates of Resistant and Susceptible Candida Species
Antifungal Activity of SCY-078 and Standard Antifungal Agents against 178 Clinical Isolates of Resistant and Susceptible Candida Species Open
SCY-078 in vitro activity was determined for 178 isolates of resistant or susceptible Candida albicans , Candida dubliniensis , Candida glabrata , Candida krusei , Candida lusitaniae , and Candida parapsilosis , including 44 Candida isolat…
View article: Efficacy of Oral APX001 in a Murine Model of Cryptococcal Meningitis
Efficacy of Oral APX001 in a Murine Model of Cryptococcal Meningitis Open
APX001 is a first-in-class intravenous and orally available broad spectrum antifungal inhibitor of Gwt1, a protein involved in glycosylphosphatidylinositol anchor biosynthesis. This study evaluated efficacy of APX001, alone and in combinat…
View article: Fungal CYP51 Inhibitors VT-1161 and VT-1129 Exhibit Strong <i>In Vitro</i> Activity against Candida glabrata and C. krusei Isolates Clinically Resistant to Azole and Echinocandin Antifungal Compounds
Fungal CYP51 Inhibitors VT-1161 and VT-1129 Exhibit Strong <i>In Vitro</i> Activity against Candida glabrata and C. krusei Isolates Clinically Resistant to Azole and Echinocandin Antifungal Compounds Open
The in vitro activities of fungal CYP51 inhibitors VT-1161 and VT-1129 were determined for Candida glabrata ( n = 34) and C. krusei ( n = 50). C. glabrata isolates were screened for FKS gene mutations. All isolates were resistant clinicall…
View article: Diagnostic difficulty identifying Apophysomyces trapeziformis septic arthritis in a patient with multiple myeloma
Diagnostic difficulty identifying Apophysomyces trapeziformis septic arthritis in a patient with multiple myeloma Open
Introduction: Mucormycosis is a rare fungal infection, but can cause substantial morbidity and mortality in both immunocompromised and immunocompetent patients. Apophysomyces is a mucormycetes species ubiquitous in nature, particularly in …
View article: Simple Strategy for Taming Membrane-Disrupting Antibiotics
Simple Strategy for Taming Membrane-Disrupting Antibiotics Open
A strategy has been devised for increasing the cellular selectivity of membrane-disrupting antibiotics based on the attachment of a facially amphiphilic sterol. Using Amphotericin B (AmB) as a prototype, covalent attachment of cholic acid …
View article: Investigational CYP51 Inhibitors VT-1161 and VT-1129 Show Strong Activity In Vitro Against Candida krusei
Investigational CYP51 Inhibitors VT-1161 and VT-1129 Show Strong Activity In Vitro Against Candida krusei Open
Background.Candida krusei is the fifth most common Candida species recovered from clinical specimens in the United States and worldwide.At Duke University Hospital it was responsible for ∼4 % (96/2560) of blood stream infections between 19…