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View article: Cross-species evidence for the refinement of intrinsic neural timescales supporting executive system maturation through adolescence
Cross-species evidence for the refinement of intrinsic neural timescales supporting executive system maturation through adolescence Open
Brain functional, structural, and neurochemical maturation has been found to support the specialization of executive systems through adolescence that will lead to adult level processing. Importantly, animal models and initial EEG studies i…
Developmental variation in dopamine neurobiology, neurocognitive functioning, and impulsivity shape substance use trajectories in youth Open
Theoretical neurodevelopmental models implicate increases in dopamine (DA) function and limitations in neurocognitive control in risk-taking behavior, including substance use, during the transition from adolescence to adulthood. However, d…
View article: Human amygdala nuclei show distinct developmental trajectories from adolescence to adulthood in functional integration with prefrontal circuitry
Human amygdala nuclei show distinct developmental trajectories from adolescence to adulthood in functional integration with prefrontal circuitry Open
Adolescent neurodevelopment of affective and cognitive control, crucial for healthy functioning and impaired transdiagnostically, is supported by refinements between the amygdala and prefrontal cortex (PFC). Due to technical limitations, f…
Developmental decorrelation of local cortical activity through adolescence supports high-dimensional encoding and working memory Open
Adolescence is a key period for the maturation of cognitive control during which cortical circuitry is refined through processes such as synaptic pruning, but how these refinements modulate local functional dynamics to support cognition re…
View article: Heterochronous laminar maturation in the human prefrontal cortex
Heterochronous laminar maturation in the human prefrontal cortex Open
The human prefrontal cortex (PFC) exhibits markedly protracted developmental plasticity, yet whether reductions in plasticity occur synchronously across prefrontal cortical layers is unclear. Animal studies have shown that intracortical my…
View article: Maturation of striatal dopamine supports the development of habitual behavior through adolescence
Maturation of striatal dopamine supports the development of habitual behavior through adolescence Open
Developmental trajectories during the transition from adolescence to adulthood contribute to the establishment of stable, adult forms of operation. Understanding the neural mechanisms underlying this transition is crucial for identifying v…
Prefrontal excitation/inhibition balance supports adolescent enhancements in circuit signal to noise ratio Open
The development and refinement of neuronal circuitry allow for stabilized and efficient neural recruitment, supporting adult-like behavioral performance. During adolescence, the maturation of PFC is proposed to be a critical period (CP) fo…
Prefrontal Excitation/Inhibition Balance Supports Adolescent Enhancements in Circuit Signal to Noise Ratio Open
The development and refinement of neuronal circuitry allow for stabilized and efficient neural recruitment, supporting adult-like behavioral performance. During adolescence, the maturation of PFC is proposed to be a critical period (CP) fo…
Aperiodic EEG and 7T MRSI evidence for maturation of E/I balance supporting the development of working memory through adolescence Open
Adolescence has been hypothesized to be a critical period for the development of human association cortex and higher-order cognition. A defining feature of critical period development is a shift in the excitation: inhibition (E/I) balance …
Multivariate and regional age-related change in basal ganglia iron in neonates Open
In the perinatal period, reward and cognitive systems begin trajectories, influencing later psychiatric risk. The basal ganglia is important for reward and cognitive processing but early development has not been fully characterized. To ass…
Aperiodic EEG and 7T MRSI evidence for maturation of E/I balance supporting the development of working memory through adolescence Open
Postmortem animal and human models suggest changes through adolescence in aspects of excitatory glutamatergic and inhibitory GABAergic function (E/I) in prefrontal cortex (PFC) suggestive of critical period plasticity at a time of signific…
Gestational and postnatal age associations for striatal tissue iron deposition in early infancy Open
Striatal development is crucial for later motor, cognitive, and reward behavior, but age-related change in striatal physiology during the neonatal period remains understudied. An MRI-based measure of tissue iron deposition, T2*, is a non-i…
Age-related differences in transient gamma band activity during working memory maintenance through adolescence Open
Adolescence is a stage of development characterized by neurodevelopmental specialization of cognitive processes. In particular, working memory continues to improve through adolescence, with increases in response accuracy and decreases in r…
Age-related change in transient gamma band activity during working memory maintenance through adolescence Open
Adolescence is a stage of development characterized by neurodevelopmental specialization of cognitive processes. In particular, working memory continues to improve through adolescence, with increases in response accuracy and decreases in r…
Puberty contributes to adolescent development of fronto-striatal functional connectivity supporting inhibitory control Open
Adolescence is defined by puberty and represents a period characterized by neural circuitry maturation (e.g., fronto-striatal systems) facilitating cognitive improvements. Though studies have characterized age-related changes, the extent t…
Changes in prefrontal GABA and glutamate through adolescence supports excitation/inhibition balance Open
Animal and human postmortem studies provide evidence for changes in gamma-aminobutyric acid (GABA) and glutamate in prefrontal cortex (PFC) during adolescence, suggesting shifts in excitation and inhibition balance consistent with critical…
Contributions of dopamine-related basal ganglia neurophysiology to the developmental effects of incentives on inhibitory control Open
Inhibitory control can be less reliable in adolescence, however, in the presence of rewards, adolescents' performance often improves to adult levels. Dopamine is known to play a role in signaling rewards and supporting cognition, but its r…
Hippocampal-Prefrontal Connectivity Prior to the COVID-19 Pandemic Predicts Stress Reactivity Open
Taken together, our results indicate that increases in stress reactivity to the COVID-19 pandemic across the transition to adulthood are driven by maturation of posterior HPC-ventromedial prefrontal cortex coupling, which integrates stress…
View article: QSIPrep: An integrative platform for preprocessing and reconstructing diffusion MRI
QSIPrep: An integrative platform for preprocessing and reconstructing diffusion MRI Open
Diffusion-weighted magnetic resonance imaging (dMRI) has become the primary method for non-invasively studying the organization of white matter in the human brain. While many dMRI acquisition sequences have been developed, they all sample …
Dopamine-related striatal neurophysiology is associated with specialization of frontostriatal reward circuitry through adolescence Open
Summary Characterizing developmental changes in frontostriatal circuitry is critical to our understanding of adolescent development and can clarify neurobiological mechanisms underlying increased reward sensitivity and sensation seeking, a…