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View article: Characterizing population-wide genomic risk distribution for development of a novel clinical-genomic risk system for prognostication in patients with clinically localized prostate cancer
Characterizing population-wide genomic risk distribution for development of a novel clinical-genomic risk system for prognostication in patients with clinically localized prostate cancer Open
Purpose Genomic classifiers are endorsed by guidelines and commonly used to inform prognosis in prostate cancer. We aimed to understand the distribution of genomic risk within the validated staging collaboration for cancer of the prostate …
View article: Postprostatectomy prostate cancer treated with radiation therapy: adverse features and androgen deprivation therapy use in a statewide consortium
Postprostatectomy prostate cancer treated with radiation therapy: adverse features and androgen deprivation therapy use in a statewide consortium Open
Background The 2024 American Urological Association, American Society for Radiation Oncology, and Society of Urologic Oncology practice guidelines recommend early salvage radiation therapy (RT) for biochemical recurrence after radical pros…
View article: Vascular smooth muscle cell atherosclerosis trajectories characterized at single cell resolution identify causal transcriptomic and epigenomic mechanisms of disease risk
Vascular smooth muscle cell atherosclerosis trajectories characterized at single cell resolution identify causal transcriptomic and epigenomic mechanisms of disease risk Open
Vascular smooth muscle cells (SMC) contribute to heritable coronary artery disease (CAD) risk and undergo complex cell state transitions to multiple disease related phenotypes. To investigate the genetic basis of SMC state trajectories tha…
View article: Shift work schedules alter immune cell regulation and accelerate cognitive impairment during aging
Shift work schedules alter immune cell regulation and accelerate cognitive impairment during aging Open
Background Disturbances of the sleep-wake cycle and other circadian rhythms typically precede the age-related deficits in learning and memory, suggesting that these alterations in circadian timekeeping may contribute to the progressive cog…
View article: Rates of PSMA PET Staging and Positivity in Newly Diagnosed Prostate Cancer in a National Health Care System
Rates of PSMA PET Staging and Positivity in Newly Diagnosed Prostate Cancer in a National Health Care System Open
Prostate-specific membrane antigen (PSMA) PET was approved by the U.S. Food and Drug Administration in 2020 for the staging of newly diagnosed prostate cancer, yet rates of adoption and real-world positivity rates are unknown. We character…
View article: Shift Work Schedules Alter Immune Cell Regulation and Accelerate Cognitive Impairment during Aging
Shift Work Schedules Alter Immune Cell Regulation and Accelerate Cognitive Impairment during Aging Open
Background: Disturbances of the sleep-wake cycle and other circadian rhythms typically precede the age-related deficits in learning and memory, suggesting that these alterations in circadian timekeeping may contribute to the progressive co…
View article: INTERIM ANALYSIS: VALIDATION OF THE AGITATION IN ALZHEIMER’S SCREENER FOR CAREGIVERS (AASC®)
INTERIM ANALYSIS: VALIDATION OF THE AGITATION IN ALZHEIMER’S SCREENER FOR CAREGIVERS (AASC®) Open
Agitation in Alzheimer’s dementia often goes unrecognized or underreported, contributing to delayed diagnosis and treatment. The International Psychogeriatric Association (IPA) set a standard for defining agitation in cognitive disorders. …
View article: Study Protocol: Quantitative evaluation of The Agitation in Alzheimer’s Screener for Caregivers AASC™, a novel tool for improving recognition of agitation in Alzheimer’s dementia
Study Protocol: Quantitative evaluation of The Agitation in Alzheimer’s Screener for Caregivers AASC™, a novel tool for improving recognition of agitation in Alzheimer’s dementia Open
Background Agitation, manifesting as aggressive and non‐aggressive behaviors, is one of the most common neuropsychiatric symptoms in Alzheimer’s dementia, presenting in approximately half of all patients. Despite the high prevalence, recog…
View article: Indications for lateral unicompartmental knee arthroplasty – A systematic review
Indications for lateral unicompartmental knee arthroplasty – A systematic review Open
While the literature suggests that some agreement does exist regarding indications for lateral UKA, a strong consensus was not found, indicating that well-defined and consensus-based indications for lateral UKA do not yet exist.
View article: Role of epidural disease in local control of spinal metastases treated with stereotactic body radiation therapy
Role of epidural disease in local control of spinal metastases treated with stereotactic body radiation therapy Open
Spinal metastases can be contained in the bone or have epidural spread. Whether the extent of epidural involvement changes tumor response to therapy is unknown. The decision of when to treat disease progression with focal radiation therapy…
View article: Anteromedial knee osteoarthritis (AMOA) evaluated with magnetic resonance imaging (MRI): a cohort study of 100 patients
Anteromedial knee osteoarthritis (AMOA) evaluated with magnetic resonance imaging (MRI): a cohort study of 100 patients Open
Introduction Magnetic resonance imaging (MRI) scans are increasingly used for knee osteoarthritis evaluation and preoperative planning before unicompartmental knee arthroplasty (UKA), and often patients already have MRI scans before their …
View article: Stereotactic body radiotherapy for treatment of spinal metastasis: A systematic review of the literature
Stereotactic body radiotherapy for treatment of spinal metastasis: A systematic review of the literature Open
Background Advances in local and systemic therapies continue to improve overall survival for patients with cancer, increasing the incidence of spine metastases. Up to 15% of patients with solid tumors develop spinal metastases. Spinal meta…
View article: ONE MINUTE TO RECOGNITION: THE AGITATION IN ALZHEIMER’S SCREENER FOR CAREGIVERS (AASC™)
ONE MINUTE TO RECOGNITION: THE AGITATION IN ALZHEIMER’S SCREENER FOR CAREGIVERS (AASC™) Open
Agitation is a common neuropsychiatric symptom of Alzheimer’s dementia (AD) and both a complex and burdensome aspect of patient care. Caregivers are often first to encounter agitation-associated behaviors and play a pivotal role in communi…
View article: Patients with progression of spinal metastases who present to the clinic have better outcomes compared to those who present to the emergency department
Patients with progression of spinal metastases who present to the clinic have better outcomes compared to those who present to the emergency department Open
Background As cancer therapies have improved, spinal metastases are increasingly common. Resulting complications have a significant impact on patient's quality of life. Optimal methods of surveillance and avoidance of neurologic deficits a…
View article: Abstracts From the NCCN 2023 Annual Conference
Abstracts From the NCCN 2023 Annual Conference Open
Background: KRAS is the most commonly mutated oncogene in Lung adenocarcinoma (LUAD).Co-occurring mutations in tumor suppressors and a master kinase LKB1/ STK11 or TP53 define the major subgroups of KRASmutant LUAD with distinct biology an…
View article: Screening for Bipolar I Disorder and the Rapid Mood Screener
Screening for Bipolar I Disorder and the Rapid Mood Screener Open
Discussion: In our survey, the RMS was favorably evaluated by HCPs. A large percentage of respondents preferred the RMS over the MDQ and indicated that it would likely have a positive impact on clinicians' screening behavior.
View article: Considerations when selecting an antidepressant: a narrative review for primary care providers treating adults with depression
Considerations when selecting an antidepressant: a narrative review for primary care providers treating adults with depression Open
Major depressive disorder (MDD) is a debilitating mental disorder that can be treated with a number of different antidepressant therapies, each with its own unique prescribing considerations. Complicating the selection of an appropriate an…
View article: DISP-04. PATIENTS WITH PROGRESSION OF SPINE METASTASES WHO PRESENT TO CLINIC HAVE BETTER OUTCOMES COMPARED TO THOSE WHO PRESENT TO THE EMERGENCY DEPARTMENT
DISP-04. PATIENTS WITH PROGRESSION OF SPINE METASTASES WHO PRESENT TO CLINIC HAVE BETTER OUTCOMES COMPARED TO THOSE WHO PRESENT TO THE EMERGENCY DEPARTMENT Open
As cancer therapies have improved, survival has increased. Spine metastases are becoming more common in the course of oncologic disease. Complications arising from these metastases have a significant impact on patient quality of life and t…
View article: Biochemical Failure Is Not a Surrogate End Point for Overall Survival in Recurrent Prostate Cancer: Analysis of NRG Oncology/RTOG 9601
Biochemical Failure Is Not a Surrogate End Point for Overall Survival in Recurrent Prostate Cancer: Analysis of NRG Oncology/RTOG 9601 Open
PURPOSE Metastasis-free survival (MFS), but not event-free survival, is a validated surrogate end point for overall survival (OS) in men treated for localized prostate cancer. It remains unknown if this holds true in biochemically recurren…
View article: Patient reported outcomes for quality of life (QOL) by Expanded Prostate Cancer Index (EPIC) on average 15 years post treatment
Patient reported outcomes for quality of life (QOL) by Expanded Prostate Cancer Index (EPIC) on average 15 years post treatment Open
As the EPIC patient reported outcomes with the longest follow-up, these data uniquely reveal temporal trends from 2 to 15 years post treatment. However, the treatment modalities of open RP, 3D CRT without image guidance or intensity modula…
View article: Development and validation of a life expectancy calculator for US patients with prostate cancer
Development and validation of a life expectancy calculator for US patients with prostate cancer Open
Objective To develop and validate an accurate, usable prediction model for other‐cause mortality (OCM) in patients with prostate cancer diagnosed in the United States. Materials and Methods Model training was performed using the National H…
View article: Comparison of Response to Definitive Radiotherapy for Localized Prostate Cancer in Black and White Men
Comparison of Response to Definitive Radiotherapy for Localized Prostate Cancer in Black and White Men Open
The findings of this meta-analysis suggest that Black men enrolled in randomized clinical trials present with more aggressive disease but have better BCR, DM, and PCSM with definitive RT compared with White men, suggesting that other deter…