Willemke Stilma
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View article: Consensus Statements on Airway Clearance Interventions in Intubated Critically Ill Patients—Protocol for a Delphi Study
Consensus Statements on Airway Clearance Interventions in Intubated Critically Ill Patients—Protocol for a Delphi Study Open
Intubated critically ill patients are susceptible to secretion accumulation because of compromised airway clearance. Various airway clearance interventions are employed to prevent complications arising from mucus retention. This Delphi stu…
View article: Practice of nebulization in Intensive Care Unit Patients Receiving Invasive Ventilation – a nationwide survey
Practice of nebulization in Intensive Care Unit Patients Receiving Invasive Ventilation – a nationwide survey Open
View article: Pulmonary herpes simplex virus and cytomegalovirus in patients with acute respiratory distress syndrome related to COVID-19
Pulmonary herpes simplex virus and cytomegalovirus in patients with acute respiratory distress syndrome related to COVID-19 Open
In mechanically ventilated COVID-19 patients, HSV reactivations are common, while CMV reactivations were rare. HSV viral load dynamics prior to or without antiviral treatment are associated with mortality. Alveolar inflammation is elevated…
View article: The effect of immunosuppressive therapies on the endothelial host response in critically ill COVID-19 patients
The effect of immunosuppressive therapies on the endothelial host response in critically ill COVID-19 patients Open
While several effective therapies for critically ill patients with COVID-19 have been identified in large, well-conducted trials, the mechanisms underlying these therapies have not been investigated in depth. Our aim is to investigate the …
View article: European federation of Critical Care Nursing associations (<scp>EfCCNa</scp>) position statement: Towards sustainable intensive care
European federation of Critical Care Nursing associations (<span>EfCCNa</span>) position statement: Towards sustainable intensive care Open
The earth's climate is changing as a result of human-induced excessive resource usage and carbon dioxide (CO2) emissions.1 The healthcare sector accounts for approximately 4.4% of annual worldwide greenhouse emissions, and European Union (…
View article: Nursing Practice of Airway Care Interventions and Prone Positioning in ICU Patients with COVID-19—A Dutch National Survey
Nursing Practice of Airway Care Interventions and Prone Positioning in ICU Patients with COVID-19—A Dutch National Survey Open
Background: Airway care interventions and prone positioning are used in critically ill patients with coronavirus disease 2019 (COVID-19) admitted to the intensive care unit (ICU) to improve oxygenation and facilitate mucus removal. At the …
View article: Biomarker Analysis Provides Evidence for Host Response Homogeneity in Patients With COVID-19
Biomarker Analysis Provides Evidence for Host Response Homogeneity in Patients With COVID-19 Open
View article: Host Response Changes and Their Association with Mortality in COVID-19 Patients with Lymphopenia
Host Response Changes and Their Association with Mortality in COVID-19 Patients with Lymphopenia Open
Rationale: Lymphopenia in coronavirus disease (COVID-19) is associated with increased mortality. Objectives: To explore the association between lymphopenia, host response aberrations, and mortality in patients with lymphopeni…
View article: Open Versus Closed Suctioning in Invasively Ventilated Critically Ill Patients for Sustainability of ICU Care: A Life-Cycle Assessment Comparison
Open Versus Closed Suctioning in Invasively Ventilated Critically Ill Patients for Sustainability of ICU Care: A Life-Cycle Assessment Comparison Open
Contains fulltext : 307432.pdf (Publisher’s version ) (Open Access)
View article: Platelets of COVID-19 patients display mitochondrial dysfunction, oxidative stress, and energy metabolism failure compatible with cell death
Platelets of COVID-19 patients display mitochondrial dysfunction, oxidative stress, and energy metabolism failure compatible with cell death Open
View article: Prolonged indoleamine 2,3-dioxygenase-2 activity and associated cellular stress in post-acute sequelae of SARS-CoV-2 infection
Prolonged indoleamine 2,3-dioxygenase-2 activity and associated cellular stress in post-acute sequelae of SARS-CoV-2 infection Open
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View article: Broadening the Berlin definition of ARDS to patients receiving high-flow nasal oxygen: an observational study in patients with acute hypoxemic respiratory failure due to COVID-19
Broadening the Berlin definition of ARDS to patients receiving high-flow nasal oxygen: an observational study in patients with acute hypoxemic respiratory failure due to COVID-19 Open
Background High-flow nasal oxygen (HFNO) is increasingly used in patients with acute hypoxemic respiratory failure. It is uncertain whether a broadened Berlin definition of acute respiratory distress syndrome (ARDS), in which ARDS can be d…
View article: Endothelial Permeability and the Angiopoietin/Tie2 System Following Mild and Severe COVID-19
Endothelial Permeability and the Angiopoietin/Tie2 System Following Mild and Severe COVID-19 Open
Endotheliopathy plays a role in the development of acute kidney and lung injury in COVID-19, probably due to inflammation, endothelial permeability, vascular leakage and edema formation. This study examined alterations in the circulation o…
View article: Age-related changes in plasma biomarkers and their association with mortality in COVID-19
Age-related changes in plasma biomarkers and their association with mortality in COVID-19 Open
Background Coronavirus disease 2019 (COVID-19)-induced mortality occurs predominantly in older patients. Several immunomodulating therapies seem less beneficial in these patients. The biological substrate behind these observations is unkno…
View article: Airway Mucus in Invasively Ventilated Critically Ill Patients
Airway Mucus in Invasively Ventilated Critically Ill Patients Open
Patients who are critically ill and receiving invasivemechanical ventilation are at increased risk for accumula-tion of secretions in the lower airways. Such accumula-tion of airway mucus can induce atelectasis and contributeto ventilator-…
View article: Anti-C5a antibody vilobelimab treatment and the effect on biomarkers of inflammation and coagulation in patients with severe COVID-19: a substudy of the phase 2 PANAMO trial
Anti-C5a antibody vilobelimab treatment and the effect on biomarkers of inflammation and coagulation in patients with severe COVID-19: a substudy of the phase 2 PANAMO trial Open
View article: Mechanical insufflation‐exsufflation for invasively ventilated critically ill patients—A focus group study
Mechanical insufflation‐exsufflation for invasively ventilated critically ill patients—A focus group study Open
Introduction Mechanical Insufflation‐Exsufflation (MI‐E) is used as an airway clearance intervention in primary care (home ventilation), long‐term care (prolonged rehabilitation after intensive care, neuromuscular diseases, and spinal cord…
View article: Practice of Awake Prone Positioning in Critically Ill COVID-19 Patients—Insights from the PRoAcT–COVID Study
Practice of Awake Prone Positioning in Critically Ill COVID-19 Patients—Insights from the PRoAcT–COVID Study Open
We describe the incidence, practice and associations with outcomes of awake prone positioning in patients with acute hypoxemic respiratory failure due to coronavirus disease 2019 (COVID-19) in a national multicenter observational cohort st…
View article: Neurofilament light increases over time in severe COVID-19 and is associated with delirium
Neurofilament light increases over time in severe COVID-19 and is associated with delirium Open
Neurological monitoring in sedated Intensive Care Unit patients is constrained by the lack of reliable blood-based biomarkers. Neurofilament light is a cross-disease biomarker for neuronal damage with potential clinical applicability for m…
View article: Association between early cumulative fluid balance and successful liberation from invasive ventilation in COVID-19 ARDS patients — insights from the PRoVENT-COVID study: a national, multicenter, observational cohort analysis
Association between early cumulative fluid balance and successful liberation from invasive ventilation in COVID-19 ARDS patients — insights from the PRoVENT-COVID study: a national, multicenter, observational cohort analysis Open
View article: Lung Microbiota of Critically Ill Patients with COVID-19 Are Associated with Nonresolving Acute Respiratory Distress Syndrome
Lung Microbiota of Critically Ill Patients with COVID-19 Are Associated with Nonresolving Acute Respiratory Distress Syndrome Open
Rationale: Bacterial lung microbiota are correlated with lung inflammation and acute respiratory distress syndrome (ARDS) and altered in severe coronavirus disease (COVID-19). However, the association between lung microbiota (includ…
View article: The Use of Mechanical Insufflation-Exsufflation in Invasively Ventilated Critically Ill Adults
The Use of Mechanical Insufflation-Exsufflation in Invasively Ventilated Critically Ill Adults Open
Mechanical insufflation-exsufflation (MI-E) is traditionally used in the neuromuscular population. There is growing interest of MI-E use in invasively ventilated critically ill adults. We aimed to map current evidence on MI-E use in invasi…
View article: Prognostication using SpO2/FiO2 in invasively ventilated ICU patients with ARDS due to COVID-19 – Insights from the PRoVENT-COVID study
Prognostication using SpO2/FiO2 in invasively ventilated ICU patients with ARDS due to COVID-19 – Insights from the PRoVENT-COVID study Open
View article: Incidence and Practice of Early Prone Positioning in Invasively Ventilated COVID-19 Patients—Insights from the PRoVENT-COVID Observational Study
Incidence and Practice of Early Prone Positioning in Invasively Ventilated COVID-19 Patients—Insights from the PRoVENT-COVID Observational Study Open
We describe the incidence and practice of prone positioning and determined the association of use of prone positioning with outcomes in invasively ventilated patients with acute respiratory distress syndrome (ARDS) due to coronavirus disea…
View article: Association of intensity of ventilation with 28-day mortality in COVID-19 patients with acute respiratory failure: insights from the PRoVENT-COVID study
Association of intensity of ventilation with 28-day mortality in COVID-19 patients with acute respiratory failure: insights from the PRoVENT-COVID study Open
View article: Airway Care Interventions for Invasively Ventilated Critically Ill Adults—A Dutch National Survey
Airway Care Interventions for Invasively Ventilated Critically Ill Adults—A Dutch National Survey Open
Airway care interventions may prevent accumulation of airway secretions and promote their evacuation, but evidence is scarce. Interventions include heated humidification, nebulization of mucolytics and/or bronchodilators, manual hyperinfla…
View article: Mortality associated with early changes in ARDS severity in COVID–19 patients – Insights from the PRoVENT–COVID study
Mortality associated with early changes in ARDS severity in COVID–19 patients – Insights from the PRoVENT–COVID study Open
View article: Clinical features and prognostic factors in Covid-19: A prospective cohort study
Clinical features and prognostic factors in Covid-19: A prospective cohort study Open
View article: Practice of adjunctive treatments in critically ill COVID–19 patients—rational for the multicenter observational PRoAcT-COVID study in The Netherlands
Practice of adjunctive treatments in critically ill COVID–19 patients—rational for the multicenter observational PRoAcT-COVID study in The Netherlands Open
The PRoAcT-COVID study is registered at clinicaltrials.gov (study identifier NCT04719182).
View article: Head-to-head validation of six immunoassays for SARS-CoV-2 in hospitalized patients
Head-to-head validation of six immunoassays for SARS-CoV-2 in hospitalized patients Open