William A. Ducker
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View article: Effect of Salt on Synthetic Cationic Antimicrobial Polymer–Cell Interactions
Effect of Salt on Synthetic Cationic Antimicrobial Polymer–Cell Interactions Open
Cationic antiseptics are deployed in a variety of settings, where salinity ranges from almost pure water to hypertonic salt. Here, we examine how dissolved NaCl affects the antimicrobial action of a model antimicrobial, polydiallyldimethyl…
View article: Equine bone marrow-derived mesenchymal stromal cells reduce established S. aureus and E. coli biofilm matrix in vitro
Equine bone marrow-derived mesenchymal stromal cells reduce established S. aureus and E. coli biofilm matrix in vitro Open
Biofilms reduce antibiotic efficacy and lead to complications and mortality in human and equine patients with orthopedic infections. Equine bone marrow-derived mesenchymal stromal cells (MSC) kill planktonic bacteria and prevent biofilm fo…
View article: Data–driven modelling makes quantitative predictions regarding bacteria surface motility
Data–driven modelling makes quantitative predictions regarding bacteria surface motility Open
In this work, we quantitatively compare computer simulations and existing cell tracking data of P. aeruginosa surface motility in order to analyse the underlying motility mechanism. We present a three dimensional twitching motility model, …
View article: Time-Resolved Killing of Individual Bacterial Cells by a Polycationic Antimicrobial Polymer
Time-Resolved Killing of Individual Bacterial Cells by a Polycationic Antimicrobial Polymer Open
Polycationic polymers are widely studied antiseptics, and their efficacy is usually quantified by the solution concentration required to kill a fraction of a population of cells (e.g., by Minimum Bactericidal Concentration (MBC)). Here we …
View article: Robust and Transparent Silver Oxide Coating Fabricated at Room Temperature Kills Clostridioides difficile Spores, MRSA, and Pseudomonas aeruginosa
Robust and Transparent Silver Oxide Coating Fabricated at Room Temperature Kills Clostridioides difficile Spores, MRSA, and Pseudomonas aeruginosa Open
Antimicrobial coatings can inhibit the transmission of infectious diseases when they provide a quick kill that is achieved long after the coating application. Here, we describe the fabrication and testing of a glass coating containing Ag2O…
View article: Facile Implementation of Antimicrobial Coatings through Adhesive Films (Wraps) Demonstrated with Cuprous Oxide Coatings
Facile Implementation of Antimicrobial Coatings through Adhesive Films (Wraps) Demonstrated with Cuprous Oxide Coatings Open
Antimicrobial coatings have a finite lifetime because of wear, depletion of the active ingredient, or surface contamination that produces a barrier between the pathogen and the active ingredient. The limited lifetime means that facile repl…
View article: Decreasing the Energy of Evaporation Using Interfacial Water: Is This Useful for Solar Evaporation Efficiency?
Decreasing the Energy of Evaporation Using Interfacial Water: Is This Useful for Solar Evaporation Efficiency? Open
Evaporation of water using solar power is an economical and environmentally friendly method for purification of aqueous solutions. It has been suggested that intermediate states can be used to lower the enthalpy of evaporation of water and…
View article: Mechanism and Efficacy of Cu2O-Treated Fabric
Mechanism and Efficacy of Cu2O-Treated Fabric Open
Pathogenic bacteria can remain viable on fabrics for several days and therefore are a source of infection. Antimicrobial fabrics are a potential method of reducing such infections, and advances in antimicrobial fabrics can be enhanced by k…
View article: Proximity-induced surfactant aggregation
Proximity-induced surfactant aggregation Open
We describe surfactant aggregation (micellization) that is induced by the proximity between two interfaces. Under conditions where surface aggregation does not occur for a single interface, we observe surfactant aggregation between two gla…
View article: Effect of Surface Porosity on SARS-CoV-2 Fomite Infectivity
Effect of Surface Porosity on SARS-CoV-2 Fomite Infectivity Open
Previous reports indicated the low stability of severe actute respiratory syndrome coronovirus 2 (SARS-CoV-2) on various porous surfaces, but the role of porosity was unclear because there was no direct comparison between porous and nonpor…
View article: Transparent Anti-SARS-CoV-2 and Antibacterial Silver Oxide Coatings
Transparent Anti-SARS-CoV-2 and Antibacterial Silver Oxide Coatings Open
Transparent antimicrobial coatings can maintain the aesthetic appeal of surfaces and the functionality of a touch-screen while adding the benefit of reducing disease transmission. We fabricated an antimicrobial coating of silver oxide part…
View article: Transparent and Sprayable Surface Coatings that Kill Drug-Resistant Bacteria Within Minutes and Inactivate SARS-CoV-2 Virus
Transparent and Sprayable Surface Coatings that Kill Drug-Resistant Bacteria Within Minutes and Inactivate SARS-CoV-2 Virus Open
Antimicrobial coatings are one method to reduce the spread of microbial diseases. Transparent coatings preserve the visual properties of surfaces and are strictly necessary for applications such as antimicrobial cell phone screens. This wo…
View article: SARS-CoV-2 virus transfers to skin through contact with contaminated solids
SARS-CoV-2 virus transfers to skin through contact with contaminated solids Open
Transfer of SARS-CoV-2 from solids to fingers is one step in infection via contaminated solids, and the possibility of infection from this route has driven calls for increased frequency of handwashing during the COVID-19 pandemic. To analy…
View article: Cupric Oxide Coating That Rapidly Reduces Infection by SARS-CoV-2 via Solids
Cupric Oxide Coating That Rapidly Reduces Infection by SARS-CoV-2 via Solids Open
The ongoing COVID-19 pandemic has created a need for coatings that reduce infection from SARS-CoV-2 via surfaces. Such a coating could be used on common touch surfaces (e.g., door handles and railings) to reduce both disease transmission a…
View article: A Surface Coating that Rapidly Inactivates SARS-CoV-2
A Surface Coating that Rapidly Inactivates SARS-CoV-2 Open
SARS-CoV-2, the virus that causes the disease COVID-19, remains viable on solids for periods of up to 1 week, so one potential route for human infection is via exposure to an infectious dose from a solid. We have fabricated and tested a co…
View article: Impact of surface topography on biofilm formation by Candida albicans
Impact of surface topography on biofilm formation by Candida albicans Open
Candida albicans is a fungal pathogen that causes serious biofilm-based infections. Here we have asked whether surface topography may affect C. albicans biofilm formation. We tested biofilm growth of the prototypical wild-type strain SC531…