William A. Farinelli
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View article: An Antimicrobial Blue Light Prototype Device Controls Infected Wounds in a Preclinical Porcine Model
An Antimicrobial Blue Light Prototype Device Controls Infected Wounds in a Preclinical Porcine Model Open
We developed a translational prototype antimicrobial blue light (ABL) device for treating skin wounds with ABL. Partial-thickness surgical wounds were created in live swine (an animal whose skin is considered the most like human skin), the…
View article: Structural and molecular characteristics of weight‐bearing volar skin can be reconstituted by micro skin tissue column grafting
Structural and molecular characteristics of weight‐bearing volar skin can be reconstituted by micro skin tissue column grafting Open
For patients with lower limb amputations, prostheses are immensely helpful for mobility and the ability to perform job‐related or recreational activities. However, the skin covering the amputation stump is typically transposed from adjacen…
View article: Laser Ablation Facilitates Implantation of Dynamic Self-Regenerating Cartilage for Articular Cartilage Regeneration
Laser Ablation Facilitates Implantation of Dynamic Self-Regenerating Cartilage for Articular Cartilage Regeneration Open
Objectives: This study investigated a novel strategy for improving regenerative cartilage outcomes. It combines fractional laser treatment with the implantation of neocartilage generated from autologous dynamic Self-Regenerating Cartilage …
View article: An antimicrobial blue light device to manage infection at the skin-implant interface of percutaneous osseointegrated implants
An antimicrobial blue light device to manage infection at the skin-implant interface of percutaneous osseointegrated implants Open
Antimicrobial blue light (aBL) is an attractive option for managing biofilm burden at the skin-implant interface of percutaneous osseointegrated (OI) implants. However, marketed aBL devices have both structural and optical limitations that…
View article: Vitamin K3 (Menadione) is a multifunctional microbicide acting as a photosensitizer and synergizing with blue light to kill drug-resistant bacteria in biofilms
Vitamin K3 (Menadione) is a multifunctional microbicide acting as a photosensitizer and synergizing with blue light to kill drug-resistant bacteria in biofilms Open
Cutaneous bacterial wound infections typically involve gram-positive cocci such as Staphylococcus aureus (SA) and usually become biofilm infections. Bacteria in biofilms may be 100-1000-fold more resistant to an antibiotic than the clinica…
View article: Optical, flow, and thermal analysis of a phototherapy extracorporeal membrane oxygenator for treating carbon monoxide poisoning
Optical, flow, and thermal analysis of a phototherapy extracorporeal membrane oxygenator for treating carbon monoxide poisoning Open
Background Extracorporeal membrane oxygenators (ECMO) are currently utilized to mechanically ventilate blood when lung or lung and heart function are impaired, like in cases of acute respiratory distress syndrome (ARDS). ARDS can be caused…
View article: Safety and feasibility of selective tongue fat reduction with injected ice‐slurry
Safety and feasibility of selective tongue fat reduction with injected ice‐slurry Open
Objectives There is growing evidence that excess adipose tissue within the head and neck contributes to obstructive sleep apnea (OSA), particularly in obese patients. This subset of the population is often difficult to treat with surgical …
View article: Total ice content and lipid saturation determine adipose tissue cryolipolysis by injection of ice‐slurry
Total ice content and lipid saturation determine adipose tissue cryolipolysis by injection of ice‐slurry Open
Objectives Cryolipolysis uses tissue cooling to solidify lipids, preferentially damaging lipid‐rich cells. Topical cooling is popular for the reduction of local subcutaneous fat. Injection of biocompatible ice‐slurry is a recently introduc…
View article: Local vasoregulative interventions impact drug concentrations in the skin after topical laser‐assisted delivery
Local vasoregulative interventions impact drug concentrations in the skin after topical laser‐assisted delivery Open
Introduction The ability of ablative fractional lasers (AFL) to enhance topical drug uptake is well established. After AFL delivery, however, drug clearance by local vasculature is poorly understood. Modifications in vascular clearance may…
View article: MagneTEskin—Reconstructing skin by magnetically induced assembly of autologous microtissue cores
MagneTEskin—Reconstructing skin by magnetically induced assembly of autologous microtissue cores Open
Replicating the structure and orientation of full-thickness skin by magnetically-induced assembling of micro tissue cores.
View article: Veno‐venous extracorporeal blood phototherapy increases the rate of carbon monoxide (CO) elimination in CO‐poisoned pigs
Veno‐venous extracorporeal blood phototherapy increases the rate of carbon monoxide (CO) elimination in CO‐poisoned pigs Open
Background and objectives Carbon monoxide (CO) inhalation is the leading cause of poison‐related deaths in the United States. CO binds to hemoglobin (Hb), displaces oxygen, and reduces oxygen delivery to tissues. The optimal treatment for …
View article: Supplementary document for Construction and validation of UV-C decontamination cabinets for filtering facepiece respirators - 4720876.pdf
Supplementary document for Construction and validation of UV-C decontamination cabinets for filtering facepiece respirators - 4720876.pdf Open
Expanded design and fabrication details
View article: Abstract 16: Tissue-Engineered Articular Cartilage Construct in Hand Surgery for Sub-mm Fractional Repair
Abstract 16: Tissue-Engineered Articular Cartilage Construct in Hand Surgery for Sub-mm Fractional Repair Open
PURPOSE: Articular cartilage lesions in large joints have been successfully treated with autologous chondrocyte implantation (ACI) with or without a matrix scaffold (e.g., MACI). However, lesions in small joints of the hand and wrist canno…
View article: Apparatus for Harvesting Tissue Microcolumns
Apparatus for Harvesting Tissue Microcolumns Open
This manuscript describes the production process for a laboratory apparatus, made from off-the-shelf components, that can be used to collect microcolumns of full-thickness skin tissue. The small size of the microcolumns allows donor sites …
View article: Reconstitution of full-thickness skin by microcolumn grafting
Reconstitution of full-thickness skin by microcolumn grafting Open
In addition to providing a physical barrier, skin also serves a diverse range of physiological functions through different specialized resident cell types/structures, including melanocytes (pigmentation and protection against ultraviolet r…