William L. Berry
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BRG1 (SMARCA4) Status Dictates the Response to EGFR Inhibitors in Wild-Type EGFR Non-Small Cell Lung Cancer Open
Background: Epidermal growth factor receptor (EGFR)-targeted tyrosine kinase inhibitors (TKIs) have exhibited efficacy in EGFR-mutant non-small cell lung cancer (NSCLC) patients. However, the response is modest in patients with wild-type (…
Genomic copy number burden distinguishes the diagnosis and prognosis of primary dermal melanoma Open
Background Primary dermal melanoma (PDM) is a subtype of melanoma with histological features indiscernible from non-epidermal metastatic cutaneous melanoma deposits, although patients with PDMs have more favourable outcomes compared to pat…
Mouse scalp development requires Rac1 and SRF for the maintenance of mechanoresponsive mesenchyme Open
Rac1 is a small GTPase that regulates cell proliferation, migration and differentiation processes crucial for development. Mutations in specific guanine nucleotide exchange factors and GTPases that regulate Rac1 are associated with Adams-O…
Mouse scalp development requires Rac1 and SRF for the maintenance of mechanosensing mesenchyme Open
Regulation of essential cellular responses like proliferation, migration, and differentiation is crucial for normal development. Rac1, a ubiquitously expressed small GTPase, executes these responses under the regulation of guanine nucleoti…
FGF1 supports glycolytic metabolism through the estrogen receptor in endocrine-resistant and obesity-associated breast cancer Open
Background Obesity increases breast cancer risk and breast cancer-specific mortality, particularly for people with estrogen receptor (ER)-positive tumors. Body mass index (BMI) is used to define obesity, but it may not be the best predicto…
Data from DCLK1-Isoform2 Alternative Splice Variant Promotes Pancreatic Tumor Immunosuppressive M2-Macrophage Polarization Open
Tumor-associated M2-macrophages are one of the most abundant immunosuppressive cell types in the pancreatic ductal adenocarcinoma (PDAC) tumor microenvironment (TME). However, the molecular mechanisms responsible for the generation of M2-m…
Supplementrary Figure 2 from DCLK1-Isoform2 Alternative Splice Variant Promotes Pancreatic Tumor Immunosuppressive M2-Macrophage Polarization Open
DCLK1-isoform2 expression increased in PDAC. A) TSVdb webtool were utilized to analyze TCGA-PAAD dataset to identify the expression of different isoforms of DCLK1 in human pancreatic adenocarcinoma. B) DCLK1-isoform2 mRNA is highly express…
Data from DCLK1-Isoform2 Alternative Splice Variant Promotes Pancreatic Tumor Immunosuppressive M2-Macrophage Polarization Open
Tumor-associated M2-macrophages are one of the most abundant immunosuppressive cell types in the pancreatic ductal adenocarcinoma (PDAC) tumor microenvironment (TME). However, the molecular mechanisms responsible for the generation of M2-m…
Supplementary Figure 3 from DCLK1-Isoform2 Alternative Splice Variant Promotes Pancreatic Tumor Immunosuppressive M2-Macrophage Polarization Open
Dclk1+ tumor cells and myeloid cells increased in the PDAC tissue samples compared to pre-neoplastic pancreatic tissues, while the CD8+ T-cell showed a mere change in their population. Fixed pancreatic tissues from 5 weeks and 20-week old …
Supplementrary Figure 2 from DCLK1-Isoform2 Alternative Splice Variant Promotes Pancreatic Tumor Immunosuppressive M2-Macrophage Polarization Open
DCLK1-isoform2 expression increased in PDAC. A) TSVdb webtool were utilized to analyze TCGA-PAAD dataset to identify the expression of different isoforms of DCLK1 in human pancreatic adenocarcinoma. B) DCLK1-isoform2 mRNA is highly express…
Supplementary Figure 4 from DCLK1-Isoform2 Alternative Splice Variant Promotes Pancreatic Tumor Immunosuppressive M2-Macrophage Polarization Open
DCLK1-isoform2 staining is positively and negatively correlated with CD8 T cell staining. Fixed tumor tissues with CD8+ T-cell high ("T-cell high",) CD8+ T-cell mild ("T-cell mild") and CD8+ T-cell low ("T-cell low") from an autochthonous …
Supplementary Figure 4 from DCLK1-Isoform2 Alternative Splice Variant Promotes Pancreatic Tumor Immunosuppressive M2-Macrophage Polarization Open
DCLK1-isoform2 staining is positively and negatively correlated with CD8 T cell staining. Fixed tumor tissues with CD8+ T-cell high ("T-cell high",) CD8+ T-cell mild ("T-cell mild") and CD8+ T-cell low ("T-cell low") from an autochthonous …
Supplementary Figure 5 from DCLK1-Isoform2 Alternative Splice Variant Promotes Pancreatic Tumor Immunosuppressive M2-Macrophage Polarization Open
Correlation between the average number of Dclk1+ cells and M2 macrophages in the Dclk1 high and low PDAC. A. Fixed tumor tissues with CD8+ T-cell high (Dclk1 low) and CD8+ T-cell low (Dclk1 high) from an autochthonous mouse model of pancre…
Supplementary Figure 5 from DCLK1-Isoform2 Alternative Splice Variant Promotes Pancreatic Tumor Immunosuppressive M2-Macrophage Polarization Open
Correlation between the average number of Dclk1+ cells and M2 macrophages in the Dclk1 high and low PDAC. A. Fixed tumor tissues with CD8+ T-cell high (Dclk1 low) and CD8+ T-cell low (Dclk1 high) from an autochthonous mouse model of pancre…
Supplementary Figure 3 from DCLK1-Isoform2 Alternative Splice Variant Promotes Pancreatic Tumor Immunosuppressive M2-Macrophage Polarization Open
Dclk1+ tumor cells and myeloid cells increased in the PDAC tissue samples compared to pre-neoplastic pancreatic tissues, while the CD8+ T-cell showed a mere change in their population. Fixed pancreatic tissues from 5 weeks and 20-week old …
Supplementary Figure 1 from DCLK1-Isoform2 Alternative Splice Variant Promotes Pancreatic Tumor Immunosuppressive M2-Macrophage Polarization Open
DCLK1-isoforms. Graphical illustration demonstrating the length of each isoforms and shared protein kinase domain between DCLK1 isoforms referenced in UniProt; www.uniprot.org/uniprot/O15075. DCX1=Doublecortin1; DCX2=Doublecortin2; P/S=Pro…
Supplementary Figure 1 from DCLK1-Isoform2 Alternative Splice Variant Promotes Pancreatic Tumor Immunosuppressive M2-Macrophage Polarization Open
DCLK1-isoforms. Graphical illustration demonstrating the length of each isoforms and shared protein kinase domain between DCLK1 isoforms referenced in UniProt; www.uniprot.org/uniprot/O15075. DCX1=Doublecortin1; DCX2=Doublecortin2; P/S=Pro…
View article: Data from Survival of Patients with Gastrointestinal Cancers Can Be Predicted by a Surrogate microRNA Signature for Cancer Stem–like Cells Marked by DCLK1 Kinase
Data from Survival of Patients with Gastrointestinal Cancers Can Be Predicted by a Surrogate microRNA Signature for Cancer Stem–like Cells Marked by DCLK1 Kinase Open
Doublecortin-like kinase 1 (DCLK1) is a gastrointestinal (GI) tuft cell kinase that has been investigated as a biomarker of cancer stem–like cells in colon and pancreatic cancers. However, its utility as a biomarker may be limited in princ…
Supplementary Data from Targeted Transcriptome and <i>KRAS</i> Mutation Analysis Improve the Diagnostic Performance of EUS-FNA Biopsies in Pancreatic Cancer Open
Supplementary tables and figure
View article: Supplemental Figures and Table from Survival of Patients with Gastrointestinal Cancers Can Be Predicted by a Surrogate microRNA Signature for Cancer Stem–like Cells Marked by DCLK1 Kinase
Supplemental Figures and Table from Survival of Patients with Gastrointestinal Cancers Can Be Predicted by a Surrogate microRNA Signature for Cancer Stem–like Cells Marked by DCLK1 Kinase Open
Supplemental material containing a flowchart for how the 15-miRNA signature was generated, a table of pertinent patient clinical data, and a forest plot of hazard ratios of high-risk colon, pancreatic, and stomach cancer patients with high…
View article: Supplemental Figure Legends from Survival of Patients with Gastrointestinal Cancers Can Be Predicted by a Surrogate microRNA Signature for Cancer Stem–like Cells Marked by DCLK1 Kinase
Supplemental Figure Legends from Survival of Patients with Gastrointestinal Cancers Can Be Predicted by a Surrogate microRNA Signature for Cancer Stem–like Cells Marked by DCLK1 Kinase Open
A separate file containging supplemental figure legends as requested by the editorial office
View article: Supplemental Figure Legends from Survival of Patients with Gastrointestinal Cancers Can Be Predicted by a Surrogate microRNA Signature for Cancer Stem–like Cells Marked by DCLK1 Kinase
Supplemental Figure Legends from Survival of Patients with Gastrointestinal Cancers Can Be Predicted by a Surrogate microRNA Signature for Cancer Stem–like Cells Marked by DCLK1 Kinase Open
A separate file containging supplemental figure legends as requested by the editorial office
Supplementary Table and Figure from Phase I Study of Seviteronel, a Selective CYP17 Lyase and Androgen Receptor Inhibitor, in Men with Castration-Resistant Prostate Cancer Open
Supplemental Table 1: Overview of Treatment Duration, Discontinuations and Dose Modifications Supplemental Figure 1: Seviteronel Plasma Concentrations over Time - Single Dose.
View article: Supplementary Data from Circulating Tumor Cell Chromosomal Instability and Neuroendocrine Phenotype by Immunomorphology and Poor Outcomes in Men with mCRPC Treated with Abiraterone or Enzalutamide
Supplementary Data from Circulating Tumor Cell Chromosomal Instability and Neuroendocrine Phenotype by Immunomorphology and Poor Outcomes in Men with mCRPC Treated with Abiraterone or Enzalutamide Open
Supplemental methods, figures, tables
View article: Supplementary Data from Circulating Tumor Cell Chromosomal Instability and Neuroendocrine Phenotype by Immunomorphology and Poor Outcomes in Men with mCRPC Treated with Abiraterone or Enzalutamide
Supplementary Data from Circulating Tumor Cell Chromosomal Instability and Neuroendocrine Phenotype by Immunomorphology and Poor Outcomes in Men with mCRPC Treated with Abiraterone or Enzalutamide Open
Supplemental methods, figures, tables
Data from Phase I Study of Seviteronel, a Selective CYP17 Lyase and Androgen Receptor Inhibitor, in Men with Castration-Resistant Prostate Cancer Open
Purpose: Seviteronel (INO-464) is a selective cytochrome P450c17a (CYP17) 17,20-lyase (lyase) and androgen receptor (AR) inhibitor with antitumor activity in vitro and in vivo. This open-label phase I clinical study evaluated the safety, t…
View article: Data from Circulating Tumor Cell Chromosomal Instability and Neuroendocrine Phenotype by Immunomorphology and Poor Outcomes in Men with mCRPC Treated with Abiraterone or Enzalutamide
Data from Circulating Tumor Cell Chromosomal Instability and Neuroendocrine Phenotype by Immunomorphology and Poor Outcomes in Men with mCRPC Treated with Abiraterone or Enzalutamide Open
Purpose:While the detection of AR-V7 in circulating tumor cells (CTC) is associated with resistance to abiraterone or enzalutamide in men with metastatic castration-resistant prostate cancer (mCRPC), it only accounts for a minority of this…
View article: Data from Survival of Patients with Gastrointestinal Cancers Can Be Predicted by a Surrogate microRNA Signature for Cancer Stem–like Cells Marked by DCLK1 Kinase
Data from Survival of Patients with Gastrointestinal Cancers Can Be Predicted by a Surrogate microRNA Signature for Cancer Stem–like Cells Marked by DCLK1 Kinase Open
Doublecortin-like kinase 1 (DCLK1) is a gastrointestinal (GI) tuft cell kinase that has been investigated as a biomarker of cancer stem–like cells in colon and pancreatic cancers. However, its utility as a biomarker may be limited in princ…