William C. Mathews
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View article: Brief Report: Differences in Types of Myocardial Infarctions Among People Aging With HIV.
Brief Report: Differences in Types of Myocardial Infarctions Among People Aging With HIV. Open
BACKGROUND: Type 1 myocardial infarctions (T1MIs) result from atherosclerotic plaque instability, rupture, and/or erosion. Type 2 MIs (T2MIs) are secondary to causes such as sepsis and cocaine-induced vasospasm resulting in an oxygen deman…
View article: Brief Report: Weight Gain Following ART Initiation in ART-Naïve People Living With HIV in the Current Treatment Era.
Brief Report: Weight Gain Following ART Initiation in ART-Naïve People Living With HIV in the Current Treatment Era. Open
OBJECTIVES: Evaluate differences in weight change by regimen among people living with HIV (PLWH) initiating antiretroviral therapy (ART) in the current era. METHODS: Between 2012 and 2019, 3232 ART-naïve PLWH initiated ≥3-drug ART regimens…
View article: Insomnia and Risk of Myocardial Infarction Among People With HIV
Insomnia and Risk of Myocardial Infarction Among People With HIV Open
BACKGROUND: Insomnia is common among people with HIV (PWH) and may be associated with increased risk of myocardial infarction (MI). This study examines the association between insomnia and MI by MI type among PWH. SETTING: Longitudinal coh…
View article: Tobacco smoking and binge alcohol use are associated with incident venous thromboembolism in an HIV cohort
Tobacco smoking and binge alcohol use are associated with incident venous thromboembolism in an HIV cohort Open
BACKGROUND: People with HIV (PWH) are at increased risk of cardiovascular comorbidities and substance use is a potential predisposing factor. We evaluated associations of tobacco smoking and alcohol use with venous thromboembolism (VTE) in…
View article: Development of Frail RISC-HIV: a Risk Score for Predicting Frailty Risk in the Short-term for Care of People with HIV
Development of Frail RISC-HIV: a Risk Score for Predicting Frailty Risk in the Short-term for Care of People with HIV Open
OBJECTIVE: Frailty is common among people with HIV (PWH), so we developed frail risk in the short-term for care (RISC)-HIV, a frailty prediction risk score for HIV clinical decision-making. DESIGN: We followed PWH for up to 2 years to iden…
View article: Correction to: Genetic architecture of cardiometabolic risks in people living with HIV
Correction to: Genetic architecture of cardiometabolic risks in people living with HIV Open
View article: Genetic architecture of cardiometabolic risks in people living with HIV
Genetic architecture of cardiometabolic risks in people living with HIV Open
View article: Correlates of psychological intimate partner violence with HIV care outcomes on patients in HIV care
Correlates of psychological intimate partner violence with HIV care outcomes on patients in HIV care Open
Background: Among people living with HIV (PLWH), physical intimate partner violence (IPV) is associated with poor virologic, psychiatric, and behavioral outcomes. We examined non-physical, psychological intimate partner violence (psy-IPV) …
View article: Drug and alcohol use among people living with HIV in care in the United States by geographic region
Drug and alcohol use among people living with HIV in care in the United States by geographic region Open
Substance use in the U.S. varies by geographic region. Opioid prescribing practices and marijuana, heroin, and methamphetamine availability are evolving differently across regions. We examined self-reported substance use among people livin…
View article: Changing Patterns of Alcohol Use and Probability of Unsuppressed Viral Load Among Treated Patients with HIV Engaged in Routine Care in the United States
Changing Patterns of Alcohol Use and Probability of Unsuppressed Viral Load Among Treated Patients with HIV Engaged in Routine Care in the United States Open
View article: Predictors of Longitudinal Trajectories of Alcohol Consumption in People with HIV
Predictors of Longitudinal Trajectories of Alcohol Consumption in People with HIV Open
Background: Our aim was to describe alcohol consumption trajectories in a cohort of people living with HIV and determine clinical and sociodemographic predictors of each trajectory. Methods: This is a prospective cohort study of 7,906 pati…
View article: Secular Trends in Breast Cancer Risk Among Women With HIV Initiating ART in North America
Secular Trends in Breast Cancer Risk Among Women With HIV Initiating ART in North America Open
Background: Studies suggest lower risk of breast cancer in women with HIV versus without HIV. These estimates may be biased by lower life expectancy and younger age distribution of women with HIV. Our analysis evaluated this bias and chara…
View article: Development and Validation of a Multivariable Prediction Model for Missed HIV Health Care Provider Visits in a Large US Clinical Cohort
Development and Validation of a Multivariable Prediction Model for Missed HIV Health Care Provider Visits in a Large US Clinical Cohort Open
Identifying individuals at high risk of missing HIV care provider visits could support proactive intervention. Previous prediction models for missed visits have not incorporated data beyond the individual level. Methods: We developed predi…
View article: Associations between alcohol and cigarette use and type 1 and 2 myocardial infarction among people with HIV
Associations between alcohol and cigarette use and type 1 and 2 myocardial infarction among people with HIV Open
Objectives: People with HIV have a higher risk of myocardial infarction (MI) than the general population, with a greater proportion of type 2 MI (T2MI) due to oxygen demand–supply mismatch compared with type 1 (T1MI) resulting from atherot…
View article: Substance use and HIV stage at entry into care among people with HIV
Substance use and HIV stage at entry into care among people with HIV Open
Background: Information regarding the impact of substance use on the timing of entry into HIV care is lacking. Better understanding of this relationship can help guide approaches and policies to improve HIV testing and linkage. Methods: We…
View article: CD4/CD8 Ratio and Cancer Risk among Adults with HIV
CD4/CD8 Ratio and Cancer Risk among Adults with HIV Open
Background: Independent of CD4 cell count, a low CD4/CD8 ratio in people with HIV (PWH) is associated with deleterious immune senescence, activation, and inflammation, which may contribute to carcinogenesis and excess cancer risk. We exami…
View article: Estimating HIV transmissions in a large U.S. clinic-based sample: effects of time and syndemic conditions
Estimating HIV transmissions in a large U.S. clinic-based sample: effects of time and syndemic conditions Open
Introduction: Little is known about onward HIV transmissions from people living with HIV (PLWH) in care. Antiretroviral therapy (ART) has increased in potency, and treatment as prevention (TasP) is an important component of ending the epid…
View article: Longitudinal Associations of Syndemic Conditions with Antiretroviral Therapy Adherence and HIV Viral Suppression among HIV-Infected Patients in Primary Care
Longitudinal Associations of Syndemic Conditions with Antiretroviral Therapy Adherence and HIV Viral Suppression among HIV-Infected Patients in Primary Care Open
Psychosocial syndemic conditions have received more attention regarding their deleterious effects on HIV acquisition risk than for their potential impact on HIV treatment and viral suppression. To examine syndemic conditions' impact on the…
View article: Alcohol Use Patterns and Subsequent Sexual Behaviors Among Women, Men who have Sex with Men and Men who have Sex with Women Engaged in Routine HIV Care in the United States
Alcohol Use Patterns and Subsequent Sexual Behaviors Among Women, Men who have Sex with Men and Men who have Sex with Women Engaged in Routine HIV Care in the United States Open
View article: Types of Stroke among People Living with HIV in the United States
Types of Stroke among People Living with HIV in the United States Open
Background: Most studies of stroke in people living with HIV (PLWH) do not use verified stroke diagnoses, are small, and/or do not differentiate stroke types and subtypes.Setting: CNICS, a U.S. multisite clinical cohort of PLWH in care.Met…
View article: Internalized HIV Stigma Predicts Suboptimal Retention in Care among People Living with HIV in the United States
Internalized HIV Stigma Predicts Suboptimal Retention in Care among People Living with HIV in the United States Open
HIV-related stigma is a known barrier to retention in care. However, no large-scale, multi-site studies have prospectively evaluated the effect of internalized stigma on retention in care. The Centers for AIDS Research Network of Integrate…
View article: Factors Associated with Severity of COVID-19 Disease in a Multicenter Cohort of People with HIV in the United States, March-December 2020
Factors Associated with Severity of COVID-19 Disease in a Multicenter Cohort of People with HIV in the United States, March-December 2020 Open
Background: Understanding the spectrum of COVID-19 in people with HIV (PWH) is critical to provide clinical guidance and risk reduction strategies.Setting:Centers for AIDS Research Network of Integrated Clinic System, a US multisite clinic…
View article: Detecting Disengagement from HIV Care before It Is Too Late: Development and Preliminary Validation of a Novel Index of Engagement in HIV Care
Detecting Disengagement from HIV Care before It Is Too Late: Development and Preliminary Validation of a Novel Index of Engagement in HIV Care Open
Background:Engagement in care is critical to achieving and sustaining optimal benefits of efficacious antiretroviral therapies for HIV infection. Current metrics of engagement in care, including problematic patterns of retention in care, a…
View article: Measuring engagement in HIV care: Measurement invariance in three racial/ethnic patient groups
Measuring engagement in HIV care: Measurement invariance in three racial/ethnic patient groups Open
Objective: The objective of the study was to evaluate a novel measure of HIV care engagement in a large sample of non-Latino White, Latino, and African American patients. The Index of Engagement in HIV care (the Index) measures the degree …
View article: Brief report: The association of chronic pain and long-term opioid therapy with HIV treatment outcomes
Brief report: The association of chronic pain and long-term opioid therapy with HIV treatment outcomes Open
Background: Chronic pain occurs in up to 85% of persons living with HIV and is commonly treated with long-term opioid therapy (LTOT). We investigated the impact of chronic pain and LTOT on HIV outcomes. Methods: This was prospective cohort…
View article: Associations between drug and alcohol use, smoking, and frailty among people with HIV across the United States in the current era of antiretroviral treatment
Associations between drug and alcohol use, smoking, and frailty among people with HIV across the United States in the current era of antiretroviral treatment Open
View article: Risk factors for atrial fibrillation in a multicenter United States clinical cohort of people with HIV infection
Risk factors for atrial fibrillation in a multicenter United States clinical cohort of people with HIV infection Open
To assess atrial fibrillation risk factors in people with HIV, we identified incident atrial fibrillation in a large clinical cohort of people receiving care. Compared with 970 controls without atrial fibrillation, the 97 with adjudicated …
View article: Chronic obstructive pulmonary disease and the risk for myocardial infarction by type in people with HIV
Chronic obstructive pulmonary disease and the risk for myocardial infarction by type in people with HIV Open
Objectives:The relationship between chronic obstructive pulmonary disease (COPD) and cardiovascular disease in people with HIV (PWH) is incompletely understood. We determined whether COPD is associated with risk of myocardial infarction (M…
View article: Internalized HIV stigma predicts subsequent viremia in US HIV patients through depressive symptoms and antiretroviral therapy adherence
Internalized HIV stigma predicts subsequent viremia in US HIV patients through depressive symptoms and antiretroviral therapy adherence Open
Objective:We sought to examine the prospective association between internalized HIV stigma and unsuppressed viral load and to investigate whether this relationship was sequentially mediated by depressive symptoms and antiretroviral therapy…
View article: Marijuana Use Is Not Associated with Changes in Opioid Prescriptions or Pain Severity among People Living with HIV and Chronic Pain
Marijuana Use Is Not Associated with Changes in Opioid Prescriptions or Pain Severity among People Living with HIV and Chronic Pain Open
Background:People living with HIV (PLWH) commonly report marijuana use for chronic pain, although there is limited empirical evidence to support its use. There is hope that marijuana may reduce prescription opioid use. Our objective was to…