William C. Ray
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T cell responses and clinical symptoms among infants with congenital cytomegalovirus infection Open
BACKGROUNDCongenital cytomegalovirus (cCMV) infection can cause developmental impairment and sensorineural hearing loss (SNHL). To determine the relationship between immune responses to cCMV infection and neurologic sequelae, T cell respon…
Invasive or More Direct Measurements Can Provide an Objective Early-Stopping Ceiling for Training Deep Neural Networks on Non-invasive or Less-Direct Biomedical Data Open
Early stopping is an extremely common tool to minimize overfitting, which would otherwise be a cause of poor generalization of the model to novel data. However, early stopping is a heuristic that, while effective, primarily relies on ad ho…
Chromatin structure in cancer Open
In the past decade, we have seen the emergence of sequence-based methods to understand chromosome organization. With the confluence of in situ approaches to capture information on looping, topological domains, and larger chromatin compartm…
Improvement of automated analysis of coronary Doppler echocardiograms Open
Coronary artery disease is the leading cause of heart disease, and while it can be assessed through transthoracic Doppler echocardiography (TTDE) by observing changes in coronary flow, manual analysis of TTDE is time consuming and subject …
The Importance of Weakly Co-Evolving Residue Networks in Proteins is Revealed by Visual Analytics Open
Small changes in a protein’s core packing produce changes in function, and even small changes in function bias species fitness and survival. Therefore individually deleterious mutations should be evolutionarily coupled with compensating mu…
View article: A 1% TBSA Chart Reduces Math Errors While Retaining Acceptable First-Estimate Accuracy
A 1% TBSA Chart Reduces Math Errors While Retaining Acceptable First-Estimate Accuracy Open
Life-threatening and treatment-altering errors occur in estimates of the percentage of total body surface area burned (%TBSA burned) with unacceptable frequency. In response, numerous attempts have been made to improve the charts commonly …
Forming Big Datasets through Latent Class Concatenation of Imperfectly Matched Databases Features Open
Informatics researchers often need to combine data from many different sources to increase statistical power and study subtle or complicated effects. Perfect overlap of measurements across academic studies is rare since virtually every dat…
Public Health and the Incident Command System: A Shift From Disasters To Every Day Management Open
The organizational structure of a public health agency can directly affect the success or failure of its programs. Currently within public health, quality improvement initiatives are being undertaken in order to improve the provision of se…
View article: <i>In Silico</i> Modeling of Biofilm Formation by Nontypeable Haemophilus influenzae <i>In Vivo</i>
<i>In Silico</i> Modeling of Biofilm Formation by Nontypeable Haemophilus influenzae <i>In Vivo</i> Open
Multiple respiratory illnesses are associated with formation of biofilms within the human airway by NTHI. However, a substantial amount of our understanding of the mechanisms that underlie NTHI biofilm formation is obtained from in vitro s…
Five Residues in the Apical Loop of the Respiratory Syncytial Virus Fusion Protein F <sub>2</sub> Subunit Are Critical for Its Fusion Activity Open
RSV infects virtually every child by the age of 3 years, causing nearly 33 million acute lower respiratory tract infections (ALRI) worldwide each year in children younger than 5 years of age (H. Nair et al., Lancet 375:1545–1555, 2010). RS…
Extracellular DNA and Type IV Pilus Expression Regulate the Structure and Kinetics of Biofilm Formation by Nontypeable <i>Haemophilus influenzae</i> Open
Biofilms formed in the middle ear by nontypeable Haemophilus influenzae (NTHI) are central to the chronicity, recurrence, and refractive nature of otitis media (OM). However, mechanisms that underlie the emergence of specific NTHI biofilm …
View article: Comparison of the Lund and Browder table to computed tomography scan three-dimensional surface area measurement for a pediatric cohort
Comparison of the Lund and Browder table to computed tomography scan three-dimensional surface area measurement for a pediatric cohort Open
While today's population is more obese than those studied by L&B, their body region proportions scale surprisingly well. The primary error in %TBSA estimation is not due to changing physical proportions of today's children and may instead …
View article: In silico modeling identifies CD45 as a regulator of IL-2 synergy in the NKG2D-mediated activation of immature human NK cells
In silico modeling identifies CD45 as a regulator of IL-2 synergy in the NKG2D-mediated activation of immature human NK cells Open
The basis for how the cytokine IL-2 boosts the activation of natural killer cells in response to NKG2D stimulation is uncovered.
View article: Investigating skin-to-skin care patterns with extremely preterm infants in the NICU and their effect on early cognitive and communication performance: a retrospective cohort study
Investigating skin-to-skin care patterns with extremely preterm infants in the NICU and their effect on early cognitive and communication performance: a retrospective cohort study Open
Objectives The primary objective of the study was to investigate how patterns of skin-to-skin care might impact infant early cognitive and communication performance. Design This was a retrospective cohort study. Setting This study took pla…
The separation of pygopagus conjoined twins with fused spinal cords and imperforate anus Open
Each set of conjoined twins has specific anatomic features dictating unique challenges to separation. Overcoming these challenges requires creative solutions that necessitate interdisciplinary collaboration. We present a unique case of pyg…