Explanipedia

Viability of Self-Taken Vaginal Swab Samples for RNA-Based Biomarker Analysis in Cervical Disease Open

Harry Scott, Andrew Stevenson, Daniel Mair, William D. Rooney, Hugh McMahon , et al. · 2025

MRI patterns of thigh muscle involvement in immune-mediated necrotizing myopathy and dermatomyositis Open

Anson W. Wilks, Kiana M Vakil-Gilani, William D. Rooney, Dongseok Choi, Daniela Ghetie , et al. · 2025

DM and IMNM affect disparate thigh muscles on MRI. DM preferentially affects the anterior thigh, semitendinosus and BF-SH in the posterior thigh, and gracilis in the medial thigh, whereas IMNM preferentially affects the posterior thigh (se…

A model‐informed clinical trial simulation tool with a graphical user interface for Duchenne muscular dystrophy Open

Jongjin Kim, Juan Francisco Morales, Sanghoon Kang, Marian Klose, Rebecca J. Willcocks , et al. · 2024

Quantitative model‐based clinical trial simulation tools play a critical role in informing study designs through simulation before actual execution. These tools help drug developers explore various trial scenarios in silico to select a cli…

ω-3 PUFA for Secondary Prevention of White Matter Lesions and Neuronal Integrity Breakdown in Older Adults Open

Lynne Shinto, Charles Murchison, Lisa C. Silbert, Hiroko H. Dodge, David Lahna , et al. · 2024

Importance Older adults with lower intake and tissue levels of long-chain ω-3 polyunsaturated fatty acids (PUFAs) eicosapentaenoic acid (EPA; 20:5) and docosahexaenoic acid (DHA; 22:6) have more brain white matter lesions (WMLs), an associ…

Impact of stalling events on microcirculatory hemodynamics in the aged brain Open

Mohammad Jamshidi, Thomas Ventimiglia, Patrice Sudres, Cong Zhang, Frédéric Lesage , et al. · 2024

Objective The role of cerebral microvasculature in cognitive dysfunction can be investigated by identifying the impact of blood flow on cortical tissue oxygenation. In this paper, the impact of capillary stalls on microcirculatory characte…

Imaging chronic active lesions in multiple sclerosis: a consensus statement Open

Francesca Bagnato, Pascal Sati, Christopher C. Hemond, Colm Elliott, Susan A. Gauthier , et al. · 2024

Chronic active lesions (CAL) are an important manifestation of chronic inflammation in multiple sclerosis and have implications for non-relapsing biological progression. In recent years, the discovery of innovative MRI and PET-derived biom…

Vascular synthesis based on hemodynamic efficiency principle recapitulates measured cerebral circulation properties in the human brain Open

Andreas A. Linninger, Thomas Ventimiglia, Mohammad Jamshidi, Mathieu Pascal Suisse, Ali Alaraj , et al. · 2023

Quantifying anatomical and hemodynamical properties of the brain vasculature in vivo is difficult due to limited spatiotemporal resolution neuroimaging, variability between subjects, and bias between acquisition techniques. This work intro…

Clinical importance of changes in magnetic resonance biomarkers for Duchenne muscular dystrophy Open

Rebecca J. Willcocks, Alison M. Barnard, Michael J. Daniels, Sean C. Forbes, William Triplett , et al. · 2023

Objective Magnetic resonance (MR) measures of muscle quality are highly sensitive to disease progression and predictive of meaningful functional milestones in Duchenne muscular dystrophy (DMD). This investigation aimed to establish the rep…

Multivariate modeling of magnetic resonance biomarkers and clinical outcome measures for Duchenne muscular dystrophy clinical trials Open

Sarah Kim, Rebecca J. Willcocks, Michael J. Daniels, Juan Francisco Morales, Deok Yong Yoon , et al. · 2023

Although regulatory agencies encourage inclusion of imaging biomarkers in clinical trials for Duchenne muscular dystrophy (DMD), industry receives minimal guidance on how to use these biomarkers most beneficially in trials. This study aims…

Processing speed and memory test performance are associated with different brain region volumes in Veterans and others with progressive multiple sclerosis Open

Rebecca Spain, Andrea Hildebrand, Carin S. Waslo, William D. Rooney, Joshua Emmons , et al. · 2023

Background Cognitive dysfunction and brain atrophy are both common in progressive multiple sclerosis (MS) but are seldom examined comprehensively in clinical trials. Antioxidant treatment may affect the neurodegeneration characteristic of …

Vascular disease risk factors in multiple sclerosis: Effect on metabolism and brain volumes Open

Manoj K Sammi, Allison Fryman, Eric Baker, Brendan Moloney, Katherine Powers , et al. · 2023

We found significantly lower brain ATP and higher inorganic phosphate (Pi) in those PwMS with VDRFs compared to those without. ATP depletion may reflect mitochondrial dysfunction. Ongoing longitudinal data analysis from this study, not pre…

Brain volumetrics across the lifespan of the rhesus macaque Open

Steven Dash, Byung Park, Christopher D. Kroenke, William D. Rooney, Henryk F. Urbanski , et al. · 2023

Protocol for an exploratory, randomised, single-blind clinical trial of aerobic exercise to promote remyelination in multiple sclerosis Open

Lindsey Wooliscroft, Sharon L. McCoy, Andrea Hildebrand, William D. Rooney, Barry Oken , et al. · 2023

Introduction There is an urgent need for remyelinating therapies that restore function in people with multiple sclerosis (pwMS). Aerobic exercise is a promising remyelinating strategy because it promotes remyelination in animal models both…

Postmortem 7T MRI for guided histopathology and evaluation of cerebrovascular disease Open

David Lahna, Natalie Roese, Randy Woltjer, Erin L. Boespflug, Daniel L. Schwartz , et al. · 2022

Postmortem (PM) magnetic resonance imaging (MRI) can serve as a bridge between in vivo imaging and histology by connecting MRI observed macrostructural findings to histological staining and microstructural changes. Data were acquired from …

Evaluating Genetic Modifiers of Duchenne Muscular Dystrophy Disease Progression Using Modeling and MRI Open

Alison M. Barnard, David W. Hammers, William Triplett, Sarah Kim, Sean C. Forbes , et al. · 2022

The results of this study link the historically mild phenotypes seen in individuals amenable to exon 8 skipping and with certain nonsense variations with alterations in trajectories of lower extremity muscle replacement by fat.

Immediate impact of yogic breathing on pulsatile cerebrospinal fluid dynamics Open

Selda Yıldız, John Grinstead, Andrea Hildebrand, John N. Oshinski, William D. Rooney , et al. · 2022

Step Activity Monitoring in Boys with Duchenne Muscular Dystrophy and its Correlation with Magnetic Resonance Measures and Functional Performance Open

Kavya S Nair, Donovan J. Lott, Sean C. Forbes, Alison M. Barnard, Rebecca J. Willcocks , et al. · 2022

Background: Muscles of boys with Duchenne muscular dystrophy (DMD) are progressively replaced by fatty fibrous tissues, and weakness leads to loss of ambulation (LoA). Step activity (SA) monitoring is a quantitative measure of real-world a…

Changes in Visceral and Ectopic Adipose Tissue Stores Across Pregnancy and Their Relationship to Gestational Weight Gain Open

Kimberly K. Vesco, Nicole Marshall, Eric Baetscher, Michael C. Leo, William D. Rooney , et al. · 2022

Sleep Dependent Changes of Lactate Concentration in Human Brain Open

Selda Yıldız, Miranda M. Lim, Manoj K. Sammi, Katherine Powers, Charles Murchison , et al. · 2021

Lactate is an important cellular metabolite that is present at high concentrations in the brain, both within cells and in the extracellular space between cells. Small animal studies demonstrated high extracellular concentrations of lactate…

Pregnancy and weaning regulate human maternal liver size and function Open

Alexandra Q. Bartlett, Kimberly K. Vesco, Jonathan Q. Purnell, Melanie Francisco, Erica T. Goddard , et al. · 2021

Significance These human data are consistent with reproductive control of liver size and function in women and concur with recent observations in rodents, suggesting a conserved liver biology. The question of whether this described liver b…

DCE-MRI of Brain Fluid Barriers: <i>In Vivo</i> Water Cycling at the Human Choroid Plexus Open

Valerie C. Anderson, Ian Tagge, Aaron Doud, Xin Li, Charles S. Springer , et al. · 2021

Metabolic deficits at brain-fluid barriers are an increasingly recognized feature of cognitive decline in older adults. At the blood-cerebrospinal fluid barrier, water is transported across the choroid plexus (CP) epithelium against large …

Characterizing Expiratory Respiratory Muscle Degeneration in Duchenne Muscular Dystrophy Using MRI Open

Alison M. Barnard, Donovan J. Lott, Abhinandan Batra, William Triplett, Rebecca J. Willcocks , et al. · 2021

Immediate Impact of Yogic Breathing on Pulsatile Cerebrospinal Fluid Dynamics Open

Selda Yıldız, John Grinstead, Andrea Hildebrand, John N. Oshinski, William D. Rooney , et al. · 2021

Cerebrospinal fluid (CSF), a clear fluid bathing the central nervous system (CNS), undergoes pulsatile movements, and plays a critical role for the removal of waste products from the brain including amyloid beta, a protein associated with …

Gray matter blood‐brain barrier water exchange dynamics are reduced in progressive multiple sclerosis Open

Ian Tagge, Valerie C. Anderson, Charles S. Springer, Manoj K. Sammi, Dennis Bourdette , et al. · 2021

Background and Purpose To compare transcapillary wall water exchange, a putative marker of cerebral metabolic health, in brain T 2 white matter (WM) lesions and normal appearing white and gray matter (NAWM and NAGM, respectively) in indivi…

The Effect of High Fat Diet on Cerebrovascular Health and Pathology: A Species Comparative Review Open

Benjamin Zimmerman, Payel Kundu, William D. Rooney, Jacob Raber · 2021

In both humans and animal models, consumption of a high-saturated-fat diet has been linked to vascular dysfunction and cognitive impairments. Laboratory animals provide excellent models for more invasive high-fat-diet-related research. How…

252 Non-Invasive Quantification of Human Brain Lactate Concentrations Across Sleep-Wake Cycles Open

Selda Yıldız, Miranda M. Lim, Manoj K. Sammi, Katherine Powers, Charles Murchison , et al. · 2021

Introduction Cellular mechanisms underlying changes in small animal brain lactate concentrations have been investigated for more than 70 years and report sharp reductions in lactate (12-35%) during sleep or anesthesia relative to wakefulne…

MRI characteristics of Japanese macaque encephalomyelitis: Comparison to human diseases Open

Ian Tagge, Steven G. Kohama, Larry S. Sherman, Dennis Bourdette, Randall L. Woltjer , et al. · 2021

Background and Purpose To describe MRI findings in Japanese macaque encephalomyelitis (JME) with emphasis on lesion characteristics, lesion evolution, normal‐appearing brain tissue, and similarities to human demyelinating disease. Methods …

Deep grey matter injury in multiple sclerosis: a NAIMS consensus statement Open

Daniel Ontaneda, Praneeta Raza, Kedar Mahajan, Douglas L. Arnold, Michael G. Dwyer , et al. · 2021

Although multiple sclerosis has traditionally been considered a white matter disease, extensive research documents the presence and importance of grey matter injury including cortical and deep regions. The deep grey matter exhibits a broad…

Pregnancy and weaning regulate human maternal liver size and function Open

Alexandra Q. Bartlett, Kimberly K. Vesco, Jonathan Q. Purnell, Melanie Francisco, Erica T. Goddard , et al. · 2021

BACKGROUND During pregnancy, the rodent liver undergoes hepatocyte proliferation and increases in size, followed by weaning-induced involution via hepatocyte cell death and stromal remodeling, creating a pro-metastatic niche. These data su…

Disease-modifying effects of edasalonexent, an NF-κB inhibitor, in young boys with Duchenne muscular dystrophy: Results of the MoveDMD phase 2 and open label extension trial Open

Richard S. Finkel, Erika Finanger, Krista Vandenborne, H. Lee Sweeney, Gihan Tennekoon , et al. · 2021

Chronic activation of NF-κB is a key driver of muscle degeneration and suppression of muscle regeneration in Duchenne muscular dystrophy. Edasalonexent (CAT-1004) is an orally-administered novel small molecule that covalently links two bio…

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