William S. Dalton
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View article: Multicellular immune ecotypes within solid tumors predict real-world therapeutic benefits with immune checkpoint inhibitors
Multicellular immune ecotypes within solid tumors predict real-world therapeutic benefits with immune checkpoint inhibitors Open
Background Cancer initiation, progression, and immune evasion depend on the tumor microenvironment (TME). Thus, understanding the TME immune architecture is essential for understanding tumor metastasis and therapy response. This study aime…
View article: Jagged2 targeting in lung cancer activates anti-tumor immunity via Notch-induced functional reprogramming of tumor-associated macrophages
Jagged2 targeting in lung cancer activates anti-tumor immunity via Notch-induced functional reprogramming of tumor-associated macrophages Open
View article: 898 Demonstration of the utility of real-world progression-free survival (rwPFS) by application of an IFN-γ-related signature in a real-world cohort of patients with melanoma
898 Demonstration of the utility of real-world progression-free survival (rwPFS) by application of an IFN-γ-related signature in a real-world cohort of patients with melanoma Open
Background The rapid advancement of immunotherapies in oncology precipitates the need for clinicogenomic databases to verify published findings and to augment related discoveries. Growing bodies of real-world data (RWD) present such opport…
View article: 151 Genetic heterogeneity between paired primary and metastatic solid tumors and implications for neoantigen-based personalized cancer vaccines
151 Genetic heterogeneity between paired primary and metastatic solid tumors and implications for neoantigen-based personalized cancer vaccines Open
Background Neoantigen-based personalized cancer vaccines carry significant promise in treating solid malignancies. However, there are still uncertainties regarding the choice between the primary and metastatic tumor for neoantigen predicti…
View article: 185 Global and local copy number aberration signatures as prognostic and immunotherapeutic predictors
185 Global and local copy number aberration signatures as prognostic and immunotherapeutic predictors Open
Background Copy number aberrations (CNAs), involving the amplification or deletion of DNA segments, are prevalent in cancer and hold great promise as an alternative approach for predicting responses to immune checkpoint inhibitors (ICIs), …
View article: Data from An <i>Ex Vivo</i> Platform for the Prediction of Clinical Response in Multiple Myeloma
Data from An <i>Ex Vivo</i> Platform for the Prediction of Clinical Response in Multiple Myeloma Open
Multiple myeloma remains treatable but incurable. Despite a growing armamentarium of effective agents, choice of therapy, especially in relapse, still relies almost exclusively on clinical acumen. We have developed a system, Ex vivo…
View article: Data from HYD1-induced increase in reactive oxygen species leads to autophagy and necrotic cell death in multiple myeloma cells
Data from HYD1-induced increase in reactive oxygen species leads to autophagy and necrotic cell death in multiple myeloma cells Open
HYD1 is a D–amino acid peptide that was previously shown to inhibit adhesion of prostate cancer cells to the extracellular matrix. In this study, we show that in addition to inhibiting adhesion of multiple myeloma (MM) cells to fibronectin…
View article: Supplemental Figures and Tables from An <i>Ex Vivo</i> Platform for the Prediction of Clinical Response in Multiple Myeloma
Supplemental Figures and Tables from An <i>Ex Vivo</i> Platform for the Prediction of Clinical Response in Multiple Myeloma Open
Supplemental Figures and Tables to augment (1) the mathematical modeling (providing details on specific therapeutics); (2) patient characteristics (treatment history, clinical and predicted response), (3) synergistic activities identified …
View article: Data from Stemness of B-cell Progenitors in Multiple Myeloma Bone Marrow
Data from Stemness of B-cell Progenitors in Multiple Myeloma Bone Marrow Open
Purpose: In myeloma, B cells and plasma cells show a clonal relationship. Clonotypic B cells may represent a tumor-initiating compartment or cancer stem cell responsible for minimal residual disease in myeloma.Experimental Design…
View article: Supplemental Figure 6 from An <i>Ex Vivo</i> Platform for the Prediction of Clinical Response in Multiple Myeloma
Supplemental Figure 6 from An <i>Ex Vivo</i> Platform for the Prediction of Clinical Response in Multiple Myeloma Open
Individual patient EMMA predicitons of actual responses to therapy (companion to Figure 3i).
View article: Supplementary Figure 2 from Stemness of B-cell Progenitors in Multiple Myeloma Bone Marrow
Supplementary Figure 2 from Stemness of B-cell Progenitors in Multiple Myeloma Bone Marrow Open
PDF file - 31K, DNA sequence analysis of sorted marrow sub-populations
View article: Data from An <i>Ex Vivo</i> Platform for the Prediction of Clinical Response in Multiple Myeloma
Data from An <i>Ex Vivo</i> Platform for the Prediction of Clinical Response in Multiple Myeloma Open
Multiple myeloma remains treatable but incurable. Despite a growing armamentarium of effective agents, choice of therapy, especially in relapse, still relies almost exclusively on clinical acumen. We have developed a system, Ex vivo…
View article: Supplemental Figures and Tables from An <i>Ex Vivo</i> Platform for the Prediction of Clinical Response in Multiple Myeloma
Supplemental Figures and Tables from An <i>Ex Vivo</i> Platform for the Prediction of Clinical Response in Multiple Myeloma Open
Supplemental Figures and Tables to augment (1) the mathematical modeling (providing details on specific therapeutics); (2) patient characteristics (treatment history, clinical and predicted response), (3) synergistic activities identified …
View article: Supplementary Figure 1 from Stemness of B-cell Progenitors in Multiple Myeloma Bone Marrow
Supplementary Figure 1 from Stemness of B-cell Progenitors in Multiple Myeloma Bone Marrow Open
PDF file - 90K, Contour plots describing our gating strategy to exclude contamination with monocytes
View article: Supplementary Figure 3 from Stemness of B-cell Progenitors in Multiple Myeloma Bone Marrow
Supplementary Figure 3 from Stemness of B-cell Progenitors in Multiple Myeloma Bone Marrow Open
PDF file - 87K, Contour plots describing sorting gating strategy and purity of bone marrow populations obtained
View article: Data from HYD1-induced increase in reactive oxygen species leads to autophagy and necrotic cell death in multiple myeloma cells
Data from HYD1-induced increase in reactive oxygen species leads to autophagy and necrotic cell death in multiple myeloma cells Open
HYD1 is a D–amino acid peptide that was previously shown to inhibit adhesion of prostate cancer cells to the extracellular matrix. In this study, we show that in addition to inhibiting adhesion of multiple myeloma (MM) cells to fibronectin…
View article: Supplementary Figure 3 from Stemness of B-cell Progenitors in Multiple Myeloma Bone Marrow
Supplementary Figure 3 from Stemness of B-cell Progenitors in Multiple Myeloma Bone Marrow Open
PDF file - 87K, Contour plots describing sorting gating strategy and purity of bone marrow populations obtained
View article: Supplementary Figure Legend from Stemness of B-cell Progenitors in Multiple Myeloma Bone Marrow
Supplementary Figure Legend from Stemness of B-cell Progenitors in Multiple Myeloma Bone Marrow Open
PDF file - 65K
View article: Supplemental Figure 6 from An <i>Ex Vivo</i> Platform for the Prediction of Clinical Response in Multiple Myeloma
Supplemental Figure 6 from An <i>Ex Vivo</i> Platform for the Prediction of Clinical Response in Multiple Myeloma Open
Individual patient EMMA predicitons of actual responses to therapy (companion to Figure 3i).
View article: Supplementary Data from HYD1-induced increase in reactive oxygen species leads to autophagy and necrotic cell death in multiple myeloma cells
Supplementary Data from HYD1-induced increase in reactive oxygen species leads to autophagy and necrotic cell death in multiple myeloma cells Open
Supplementary Data from HYD1-induced increase in reactive oxygen species leads to autophagy and necrotic cell death in multiple myeloma cells
View article: Supplementary Figure 2 from Stemness of B-cell Progenitors in Multiple Myeloma Bone Marrow
Supplementary Figure 2 from Stemness of B-cell Progenitors in Multiple Myeloma Bone Marrow Open
PDF file - 31K, DNA sequence analysis of sorted marrow sub-populations
View article: Supplementary Data from HYD1-induced increase in reactive oxygen species leads to autophagy and necrotic cell death in multiple myeloma cells
Supplementary Data from HYD1-induced increase in reactive oxygen species leads to autophagy and necrotic cell death in multiple myeloma cells Open
Supplementary Data from HYD1-induced increase in reactive oxygen species leads to autophagy and necrotic cell death in multiple myeloma cells
View article: Supplementary Figure 1 from Stemness of B-cell Progenitors in Multiple Myeloma Bone Marrow
Supplementary Figure 1 from Stemness of B-cell Progenitors in Multiple Myeloma Bone Marrow Open
PDF file - 90K, Contour plots describing our gating strategy to exclude contamination with monocytes
View article: Data from Stemness of B-cell Progenitors in Multiple Myeloma Bone Marrow
Data from Stemness of B-cell Progenitors in Multiple Myeloma Bone Marrow Open
Purpose: In myeloma, B cells and plasma cells show a clonal relationship. Clonotypic B cells may represent a tumor-initiating compartment or cancer stem cell responsible for minimal residual disease in myeloma.Experimental Design…
View article: Supplementary Figure Legend from Stemness of B-cell Progenitors in Multiple Myeloma Bone Marrow
Supplementary Figure Legend from Stemness of B-cell Progenitors in Multiple Myeloma Bone Marrow Open
PDF file - 65K
View article: Data from Targeting the Fanconi Anemia/BRCA Pathway Circumvents Drug Resistance in Multiple Myeloma
Data from Targeting the Fanconi Anemia/BRCA Pathway Circumvents Drug Resistance in Multiple Myeloma Open
The Fanconi anemia/BRCA (FA/BRCA) DNA damage repair pathway plays a pivotal role in the cellular response to replicative stress induced by DNA alkylating agents and greatly influences drug response in cancer treatment. We recently reported…
View article: Supplementary Methods and Materials from Targeting the Fanconi Anemia/BRCA Pathway Circumvents Drug Resistance in Multiple Myeloma
Supplementary Methods and Materials from Targeting the Fanconi Anemia/BRCA Pathway Circumvents Drug Resistance in Multiple Myeloma Open
Supplementary Methods and Materials from Targeting the Fanconi Anemia/BRCA Pathway Circumvents Drug Resistance in Multiple Myeloma
View article: Supplementary Figures 1-14 from Targeting the Fanconi Anemia/BRCA Pathway Circumvents Drug Resistance in Multiple Myeloma
Supplementary Figures 1-14 from Targeting the Fanconi Anemia/BRCA Pathway Circumvents Drug Resistance in Multiple Myeloma Open
Supplementary Figures 1-14 from Targeting the Fanconi Anemia/BRCA Pathway Circumvents Drug Resistance in Multiple Myeloma
View article: Supplementary Methods and Materials from Targeting the Fanconi Anemia/BRCA Pathway Circumvents Drug Resistance in Multiple Myeloma
Supplementary Methods and Materials from Targeting the Fanconi Anemia/BRCA Pathway Circumvents Drug Resistance in Multiple Myeloma Open
Supplementary Methods and Materials from Targeting the Fanconi Anemia/BRCA Pathway Circumvents Drug Resistance in Multiple Myeloma
View article: Supplementary Figures 1-14 from Targeting the Fanconi Anemia/BRCA Pathway Circumvents Drug Resistance in Multiple Myeloma
Supplementary Figures 1-14 from Targeting the Fanconi Anemia/BRCA Pathway Circumvents Drug Resistance in Multiple Myeloma Open
Supplementary Figures 1-14 from Targeting the Fanconi Anemia/BRCA Pathway Circumvents Drug Resistance in Multiple Myeloma