William E. Ackerman
YOU?
Author Swipe
View article: Rapid clearance of bacteria from maternal bloodstream after delivery in pregnancies complicated by preterm pre-labor rupture of the membranes
Rapid clearance of bacteria from maternal bloodstream after delivery in pregnancies complicated by preterm pre-labor rupture of the membranes Open
Preterm pre-labor rupture of membranes (PPROM) increases maternal and neonatal sepsis risk, yet its association with maternal microbial translocation and systemic inflammation remains unclear. We investigated whether PPROM is linked to mic…
View article: Concordant and discordant gene expression signatures of twin placentas in the setting of preeclampsia
Concordant and discordant gene expression signatures of twin placentas in the setting of preeclampsia Open
Background Multifetal pregnancies are associated with increased risk for preeclampsia (PreE), but the underlying pathogenesis may differ from singleton gestations. It remains unclear whether both placentas in twin pregnancies complicated b…
View article: Epigenetic Changes Regulating Epithelial–Mesenchymal Plasticity in Human Trophoblast Differentiation
Epigenetic Changes Regulating Epithelial–Mesenchymal Plasticity in Human Trophoblast Differentiation Open
The phenotype of human placental extravillous trophoblast (EVT) at the end of pregnancy reflects both differentiation from villous cytotrophoblast (CTB) and later gestational changes, including loss of proliferative and invasive capacity. …
View article: Epigenetic changes regulating the epithelial-mesenchymal transition in human trophoblast differentiation
Epigenetic changes regulating the epithelial-mesenchymal transition in human trophoblast differentiation Open
The phenotype of human placental extravillous trophoblast (EVT) at the end of pregnancy reflects both first trimester differentiation from villous cytotrophoblast (CTB) and later gestational changes, including loss of proliferative and inv…
View article: Transcriptomics-Based Subphenotyping of the Human Placenta Enabled by Weighted Correlation Network Analysis in Early-Onset Preeclampsia With and Without Fetal Growth Restriction
Transcriptomics-Based Subphenotyping of the Human Placenta Enabled by Weighted Correlation Network Analysis in Early-Onset Preeclampsia With and Without Fetal Growth Restriction Open
Background: Placental disorders contribute to pregnancy complications, including preeclampsia and fetal growth restriction (FGR), but debate regarding their specific pathobiology persists. Our objective was to apply transcriptomics with we…
View article: Transcriptomics-based subphenotyping of the human placenta enabled by weighted correlation network analysis in early-onset preeclampsia with and without fetal growth restriction
Transcriptomics-based subphenotyping of the human placenta enabled by weighted correlation network analysis in early-onset preeclampsia with and without fetal growth restriction Open
Background: Placental disorders contribute to pregnancy complications, including preeclampsia (PE) and fetal growth restriction (FGR), but debate regarding their specific pathobiology persists. Our objective was to apply transcriptomics wi…
View article: Knockout of MAPK Phosphatase-1 Exaggerates Type I IFN Response during Systemic <i>Escherichia coli</i> Infection
Knockout of MAPK Phosphatase-1 Exaggerates Type I IFN Response during Systemic <i>Escherichia coli</i> Infection Open
We have previously shown that Mkp-1–deficient mice produce elevated TNF-α, IL-6, and IL-10 following systemic Escherichia coli infection, and they exhibited increased mortality, elevated bacterial burden, and profound metabolic alterations…
View article: Molecular signatures of labor and non-labor myometrium with parsimonious classification from two calcium transporter genes
Molecular signatures of labor and non-labor myometrium with parsimonious classification from two calcium transporter genes Open
Clinical phenotyping of term and preterm labor is imprecise, and disagreement persists on categorization relative to underlying pathobiology, which remains poorly understood. We performed RNA sequencing (RNA-seq) of 31 specimens of human u…
View article: Severity of Maternal HIV-1 Disease Is Associated With Adverse Birth Outcomes in Malawian Women: A Cohort Study
Severity of Maternal HIV-1 Disease Is Associated With Adverse Birth Outcomes in Malawian Women: A Cohort Study Open
Compared to HIV-negative women, HIV-infected women have increased risk of low birth weight (LBW) and preterm delivery (PTD). We assessed whether severity of maternal HIV-1 disease was associated with LBW or PTD.
View article: Unique transcriptomic landscapes identified in idiopathic spontaneous and infection related preterm births compared to normal term births
Unique transcriptomic landscapes identified in idiopathic spontaneous and infection related preterm births compared to normal term births Open
The study compared placental villous transcriptomes from carefully phenotyped cohorts of PTB due to infection or isPTB (idiopathic spontaneous preterm birth) between 28–36 weeks gestation and healthy term placentas. Transcriptomic analyses…
View article: Dysregulation of Lipid Metabolism in Mkp-1 Deficient Mice during Gram-Negative Sepsis
Dysregulation of Lipid Metabolism in Mkp-1 Deficient Mice during Gram-Negative Sepsis Open
Mitogen-activated protein kinase phosphatase (Mkp)-1 exerts its anti-inflammatory activities during Gram-negative sepsis by deactivating p38 and c-Jun N-terminal kinase (JNK). We have previously shown that Mkp-1+/+ mice, but not Mkp-1−/− m…
View article: Unique transcriptomic landscapes identified in idiopathic spontaneous and infection related preterm births compared to normal term births
Unique transcriptomic landscapes identified in idiopathic spontaneous and infection related preterm births compared to normal term births Open
Preterm birth (PTB) is leading contributor to infant death in the United States and globally, yet the underlying mechanistic causes are not well understood. Histopathological studies of preterm birth suggest advanced villous maturity may h…
View article: Skin Microbiota in Obese Women at Risk for Surgical Site Infection After Cesarean Delivery
Skin Microbiota in Obese Women at Risk for Surgical Site Infection After Cesarean Delivery Open
The obesity pandemic in the obstetrical population plus increased frequency of Cesarean delivery (CD) has increased vulnerability to surgical site infection (SSI). Here we characterized the microbiome at the site of skin incision before an…
View article: Integrated microRNA and mRNA network analysis of the human myometrial transcriptome in the transition from quiescence to labor†,‡
Integrated microRNA and mRNA network analysis of the human myometrial transcriptome in the transition from quiescence to labor†,‡ Open
We conducted integrated transcriptomics network analyses of miRNA and mRNA interactions in human myometrium to identify novel molecular candidates potentially involved in human parturition. Myometrial biopsies were collected from women und…