William E. Funk
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View article: Investigating psychosocial factors and systemic inflammation using dried blood spots: a scoping review
Investigating psychosocial factors and systemic inflammation using dried blood spots: a scoping review Open
View article: Correction to: A state-of-the-science review and guide for measuring environmental exposure biomarkers in dried blood spots
Correction to: A state-of-the-science review and guide for measuring environmental exposure biomarkers in dried blood spots Open
View article: A state-of-the-science review and guide for measuring environmental exposure biomarkers in dried blood spots
A state-of-the-science review and guide for measuring environmental exposure biomarkers in dried blood spots Open
View article: Exposome-wide associations and polyexposure risks of workplace chemical exposures on adult asthma: The Personalized Environment and Genes Study (PEGS)
Exposome-wide associations and polyexposure risks of workplace chemical exposures on adult asthma: The Personalized Environment and Genes Study (PEGS) Open
Background Many potential occupational asthmagens and their co-exposure risks are underestimated. We conducted an exposome-wide association study (ExWAS) to systematically explore occupational chemical exposures and estimate their joint as…
View article: Dried Blood Spots to Assess Cardiovascular‐Kidney‐Metabolic Health
Dried Blood Spots to Assess Cardiovascular‐Kidney‐Metabolic Health Open
Dried blood spot sampling offers a scalable strategy to close diagnostic gaps and improve global surveillance for cardiovascular‐kidney‐metabolic syndrome. However, assay performance and the extent of validity vary widely between biomarker…
View article: Opportunities for evaluating chemical exposures and child health in the United States: the Environmental influences on Child Health Outcomes (ECHO) Program
Opportunities for evaluating chemical exposures and child health in the United States: the Environmental influences on Child Health Outcomes (ECHO) Program Open
View article: Cord Blood Adductomics Reveals Oxidative Stress Exposure Pathways of Bronchopulmonary Dysplasia
Cord Blood Adductomics Reveals Oxidative Stress Exposure Pathways of Bronchopulmonary Dysplasia Open
Fetal and neonatal exposures to perinatal oxidative stress (OS) are key mediators of bronchopulmonary dysplasia (BPD). To characterize these exposures, adductomics is an exposure science approach that captures electrophilic addition produc…
View article: Advancing Global Health Surveillance of Mycotoxin Exposures using Minimally Invasive Sampling Techniques: A State-of-the-Science Review
Advancing Global Health Surveillance of Mycotoxin Exposures using Minimally Invasive Sampling Techniques: A State-of-the-Science Review Open
Mycotoxins are a heterogeneous group of toxins produced by fungi that can grow in staple crops (e.g., maize, cereals), resulting in health risks due to widespread exposure from human consumption and inhalation. Dried blood spot (DBS), drie…
View article: Urinary fluoride levels and metal co-exposures among pregnant women in Los Angeles, California
Urinary fluoride levels and metal co-exposures among pregnant women in Los Angeles, California Open
View article: Correction to: A state-of-the-science review and guide for measuring environmental exposure biomarkers in dried blood spots
Correction to: A state-of-the-science review and guide for measuring environmental exposure biomarkers in dried blood spots Open
View article: A state-of-the-science review and guide for measuring environmental exposure biomarkers in dried blood spots
A state-of-the-science review and guide for measuring environmental exposure biomarkers in dried blood spots Open
View article: An Ovarian Steroid Metabolomic Pathway Analysis in Basal and Polycystic Ovary Syndrome (PCOS)-like Gonadotropin Conditions Reveals a Hyperandrogenic Phenotype Measured by Mass Spectrometry
An Ovarian Steroid Metabolomic Pathway Analysis in Basal and Polycystic Ovary Syndrome (PCOS)-like Gonadotropin Conditions Reveals a Hyperandrogenic Phenotype Measured by Mass Spectrometry Open
Prior work has demonstrated that murine ovarian explants and isolated ovarian follicles can recapitulate human-like 28-day cycles in vitro with normal patterns of estradiol and progesterone secretion in response to gonadotropin stimulation…
View article: Human Serum Albumin Cys34 Adducts in Newborn Dried Blood Spots: Associations With Air Pollution Exposure During Pregnancy
Human Serum Albumin Cys34 Adducts in Newborn Dried Blood Spots: Associations With Air Pollution Exposure During Pregnancy Open
Background: Increasing evidence suggests that exposure to air pollution during pregnancy is associated with adverse pregnancy outcomes. However, biomarkers associated with air pollution exposure are widely lacking and often transient. In a…
View article: Profiling Cys 34 Adducts of Human Serum Albumin by Fixed-Step Selected Reaction Monitoring
Profiling Cys 34 Adducts of Human Serum Albumin by Fixed-Step Selected Reaction Monitoring Open
A method is described for profiling putative adducts (or other unknown covalent modifications) at the Cys34 locus of human serum albumin (HSA), which represents the preferred reaction site for small electrophilic species in human serum. By…
View article: Indoor Air Pollutants and Health in the United Arab Emirates
Indoor Air Pollutants and Health in the United Arab Emirates Open
Background: Comprehensive global data on the health effects of indoor air pollutants are lacking. There are few large population-based multi–air pollutant health assessments. Further, little is known about indoor air health risks in the Mi…
View article: Conducting Environmental Health Research in the Arabian Middle East: Lessons Learned and Opportunities
Conducting Environmental Health Research in the Arabian Middle East: Lessons Learned and Opportunities Open
Background: The Arabian Gulf nations are undergoing rapid economic development, leading to major shifts in both the traditional lifestyle and the environment. Although the pace of change is brisk, there is a dearth of environmental health …
View article: Quantification of arsenic, lead, mercury and cadmium in newborn dried blood spots
Quantification of arsenic, lead, mercury and cadmium in newborn dried blood spots Open
Exposures to heavy metals during fetal and perinatal development are of particular concern. Yet, the health impacts of exposures to toxic metals during these early stages of human development are not well understood due to the paucity of i…
View article: Enrichment of cysteinyl adducts of human serum albumin
Enrichment of cysteinyl adducts of human serum albumin Open
We report a method to enrich cysteinyl adducts of human serum albumin (HSA)2, representing biomarkers of exposure to systemic electrophiles. Because the major site of HSA adduction is the single free sulfhydryl group at Cys34, we used thio…
View article: Arsenic and birth outcomes in a predominately lower income Hispanic pregnancy cohort in Los Angeles
Arsenic and birth outcomes in a predominately lower income Hispanic pregnancy cohort in Los Angeles Open
View article: Opportunities for evaluating chemical exposures and child health in the United States: the Environmental influences on Child Health Outcomes (ECHO) Program
Opportunities for evaluating chemical exposures and child health in the United States: the Environmental influences on Child Health Outcomes (ECHO) Program Open
View article: Metabolomics and adductomics of newborn bloodspots to retrospectively assess the early-life exposome
Metabolomics and adductomics of newborn bloodspots to retrospectively assess the early-life exposome Open
Purpose of review Exposomics studies can measure health-relevant chemical exposures during a lifetime and estimate the ‘internal’ environment. However, sampling limitations make these features difficult to capture directly during the criti…
View article: Gestational diabetes mellitus, prenatal air pollution exposure, and autism spectrum disorder
Gestational diabetes mellitus, prenatal air pollution exposure, and autism spectrum disorder Open
GDM onset early in pregnancy may increase children's susceptibility to prenatal O3-associated ASD risk. These novel findings merit further investigation.
View article: Protein adducts as measures of exposure in epidemiological research
Protein adducts as measures of exposure in epidemiological research Open
Protein adducts can serve as biomarkers of exposure to variety of xenobiotic toxicants and reactive endogenous species. However, despite their utility as exposure biomarkers, protein adducts have rarely been used in epidemiology. One reaso…
View article: Sex-specific associations of autism spectrum disorder with residential air pollution exposure in a large Southern California pregnancy cohort
Sex-specific associations of autism spectrum disorder with residential air pollution exposure in a large Southern California pregnancy cohort Open
View article: Associations of gestational diabetes mellitus with residential air pollution exposure in a large Southern California pregnancy cohort
Associations of gestational diabetes mellitus with residential air pollution exposure in a large Southern California pregnancy cohort Open
View article: Expression and Characterization of Human Fragile X Mental Retardation Protein Isoforms and Interacting Proteins in Human Cells
Expression and Characterization of Human Fragile X Mental Retardation Protein Isoforms and Interacting Proteins in Human Cells Open
Fragile X mental retardation protein is an mRNA-binding protein associated with phenotypic manifestations of fragile X syndrome, an X-linked disorder caused by mutation in the FMR1 gene that is the most common inherited cause of intellectu…
View article: Human biomarker interpretation: the importance of intra-class correlation coefficients (ICC) and their calculations based on mixed models, ANOVA, and variance estimates
Human biomarker interpretation: the importance of intra-class correlation coefficients (ICC) and their calculations based on mixed models, ANOVA, and variance estimates Open
Human biomonitoring is the foundation of environmental toxicology, community public health evaluation, preclinical health effects assessments, pharmacological drug development and testing, and medical diagnostics. Within this framework, th…
View article: Cosmetics and Cancer: Adverse Event Reports Submitted to the Food and Drug Administration
Cosmetics and Cancer: Adverse Event Reports Submitted to the Food and Drug Administration Open
There have been numerous controversies surrounding cosmetic products and increased cancer risk. Such controversies include associations between parabens and breast cancer, hair dyes and hematologic malignancies, and talc powders and ovaria…
View article: Use of Dried Blood Spots for Estimating Children?s Exposures to Heavy Metals in Epidemiological Research
Use of Dried Blood Spots for Estimating Children?s Exposures to Heavy Metals in Epidemiological Research Open
Background: Children's exposures to arsenic (As), lead (Pb), mercury (Hg), and cadmium (Cd) are of particular concern in early-life.Exposures to heavy metals are traditionally measured in whole venous blood, which is costly and invasive.As…