William E. Gibbons
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View article: <i>Dystrophin</i>interacts with<i>Msp300</i>to Regulate Myonuclear Positioning and Microtubule Organization
<i>Dystrophin</i>interacts with<i>Msp300</i>to Regulate Myonuclear Positioning and Microtubule Organization Open
During Drosophila myognesis, myonuclei are actively moved during embryogenesis, and their spacing is maintained through an anchoring mechanism in the fully differentiated myofiber. While we have identified microtubule associated proteins, …
View article: Evaluation of <scp>TrpM</scp> and <scp>PsiD</scp> substrate promiscuity reveals new biocatalytic capabilities
Evaluation of <span>TrpM</span> and <span>PsiD</span> substrate promiscuity reveals new biocatalytic capabilities Open
N ‐methylated tryptamines, such as the hallucinogenic natural products, psilocybin and N,N ‐dimethyltryptamine (DMT), are gaining interest from the medical community due to their potential as next generation treatments for mental health di…
View article: Pharmacological and behavioural effects of tryptamines present in psilocybin‐containing mushrooms
Pharmacological and behavioural effects of tryptamines present in psilocybin‐containing mushrooms Open
Background and Purpose Demand for new antidepressants has resulted in a re‐evaluation of the therapeutic potential of psychedelic drugs. Several tryptamines found in psilocybin‐containing “magic” mushrooms share chemical similarities with …
View article: Pharmacological and behavioral effects of tryptamines present in psilocybin-containing mushrooms
Pharmacological and behavioral effects of tryptamines present in psilocybin-containing mushrooms Open
Demand for more efficacious antidepressants, particularly those with a rapid onset of action, has resulted in a reevaluation of psychedelic drugs for their therapeutic potential. Several tryptamines found in psilocybin-containing ‘magic’ m…
View article: “Biosynthesis of psilocybin and its nonnatural derivatives by a promiscuous psilocybin synthesis pathway in <i>Escherichia coli</i>”
“Biosynthesis of psilocybin and its nonnatural derivatives by a promiscuous psilocybin synthesis pathway in <i>Escherichia coli</i>” Open
Traditional psychedelics are undergoing a transformation from recreational drugs, to promising pharmaceutical drug candidates with the potential to provide an alternative treatment option for individuals struggling with mental illness. Sus…
View article: Genetic carrier screening in donors: a challenging frontier
Genetic carrier screening in donors: a challenging frontier Open
The article by Chang et al. (1Chang C. Gupta A.O. Orchard P.J. Nascene D.R. Kierstein J. Tyon R.K. et al.A case series of adrenoleukodystrophy in children conceived through in vitro fertilization with an egg donor.F S Rep. 2023; 4: 24-28Ab…
View article: Decidualization of human endometrial stromal cells requires steroid receptor coactivator-3
Decidualization of human endometrial stromal cells requires steroid receptor coactivator-3 Open
Steroid receptor coactivator-3 (SRC-3; also known as NCOA3 or AIB1) is a member of the multifunctional p160/SRC family of coactivators, which also includes SRC-1 and SRC-2. Clinical and cell-based studies as well as investigations on mice …
View article: Oleuropein suppresses endometriosis progression and improves the fertility of mice with endometriosis
Oleuropein suppresses endometriosis progression and improves the fertility of mice with endometriosis Open
Background Endometriosis is an estrogen-dependent inflammatory reproductive disease. Therefore, systematic estrogen depletion and anti-inflammatory drugs are the current treatment for endometriosis. However, current endometriosis treatment…
View article: Evaluation of steam supply performance: Steamer vs. bubbler
Evaluation of steam supply performance: Steamer vs. bubbler Open
Water/steam electrolysis is a key enabling technology for clean, low-carbon and sustainable production of hydrogen and will play a crucial role in future hydrogen economy. For high temperature solid oxide electrolytic cells, steam is the c…
View article: Progesterone receptor isoform B regulates the<i>Oxtr</i>-<i>Plcl2</i>-<i>Trpc3</i>pathway to suppress uterine contractility
Progesterone receptor isoform B regulates the<i>Oxtr</i>-<i>Plcl2</i>-<i>Trpc3</i>pathway to suppress uterine contractility Open
Significance Preterm birth affects 10 to 12% of all pregnancies and is the primary cause of neonatal morbidity and mortality worldwide, while prolonged labor increases the risks of infection, uterine rupture, and neonatal distress. Progest…
View article: Homebrewed psilocybin: can new routes for pharmaceutical psilocybin production enable recreational use?
Homebrewed psilocybin: can new routes for pharmaceutical psilocybin production enable recreational use? Open
Psilocybin, a drug most commonly recognized as a recreational psychedelic, is quickly gaining attention as a promising therapy for an expanding range of neurological conditions, including depression, anxiety, and addiction. This growing in…
View article: Hyperandrogenemia alters mitochondrial structure and function in the oocytes of obese mouse with polycystic ovary syndrome
Hyperandrogenemia alters mitochondrial structure and function in the oocytes of obese mouse with polycystic ovary syndrome Open
The obese PCOS mouse model shows a decreased oocyte quality related to impaired mitochondrial function.
View article: Embryos from polycystic ovary syndrome patients with hyperandrogenemia reach morula stage faster than controls
Embryos from polycystic ovary syndrome patients with hyperandrogenemia reach morula stage faster than controls Open
Embryos from women with PCOS grew faster until 9-cell stage and women with hyperandrogenic PCOS until morula. Patients with PCOS also showed a higher miscarriage rate. The alterations in early embryo development are consistent with altered…
View article: Prenatal androgen induced lean PCOS impairs mitochondria and mRNA profiles in oocytes
Prenatal androgen induced lean PCOS impairs mitochondria and mRNA profiles in oocytes Open
Polycystic ovary syndrome (PCOS) is the most common ovulatory defect in women. Although most PCOS patients are obese, a subset of PCOS women are lean but show similar risks for adverse fertility outcomes. A lean PCOS mouse model was create…
View article: Gpr63 is a modifier of microcephaly in Ttc21b mouse mutants
Gpr63 is a modifier of microcephaly in Ttc21b mouse mutants Open
The primary cilium is a signaling center critical for proper embryonic development. Previous studies have demonstrated that mice lacking Ttc21b have impaired retrograde trafficking within the cilium and multiple organogenesis phenotypes, i…
View article: Heart Disease in a Mutant Mouse Model of Spontaneous Eosinophilic Myocarditis Maps to Three Loci
Heart Disease in a Mutant Mouse Model of Spontaneous Eosinophilic Myocarditis Maps to Three Loci Open
Background: Heart disease (HD) is the major cause of morbidity and mortality in patients with hypereosinophilic diseases. Due to a lack of adequate animal models, our understanding of the pathophysiology of eosinophil-mediated diseases wit…
View article: Heart Disease in a Mutant Mouse Model of Spontaneous Eosinophilic Myocarditis Maps to Three Loci
Heart Disease in a Mutant Mouse Model of Spontaneous Eosinophilic Myocarditis Maps to Three Loci Open
Background: Heart disease (HD) is the major cause of morbidity and mortality in patients with hypereosinophilic diseases. Due to a lack of adequate animal models, our understanding of the pathophysiology of eosinophil-mediated diseases wit…
View article: Heart Disease in a Mutant Mouse Model of Spontaneous Eosinophilic Myocarditis Maps to Three Loci
Heart Disease in a Mutant Mouse Model of Spontaneous Eosinophilic Myocarditis Maps to Three Loci Open
Background Heart disease (HD) is the major cause of morbidity and mortality in patients with hypereosinophilic diseases. Due to a lack of adequate animal models, our understanding of the pathophysiology of eosinophil-mediated diseases with…