William E. Lawson
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View article: Respiratory Health Associated With Systemic Metal Exposure in Post-9/11 Veterans in the Department of Veterans Affairs Toxic Embedded Fragment Registry
Respiratory Health Associated With Systemic Metal Exposure in Post-9/11 Veterans in the Department of Veterans Affairs Toxic Embedded Fragment Registry Open
Objective Adverse respiratory outcomes in post-9/11 veterans with elevated urinary metal measures and enrolled in the VA's Toxic Embedded Fragment registry were compared to those without elevated urinary metals. Methods Veterans completed …
View article: Hypoxia-inducible factor-2 (HIF2) regulates alveolar regeneration after repetitive injury
Hypoxia-inducible factor-2 (HIF2) regulates alveolar regeneration after repetitive injury Open
Idiopathic Pulmonary Fibrosis (IPF) is a progressive and often fatal chronic respiratory disease thought to result from repetitive injury and failed repair of the lung alveoli, and recent studies have identified a number of disease-emergen…
View article: C-23 | Association of Single Versus Dual Antiplatelet Therapy With Clinical Outcomes in Patients With Peripheral Artery Disease
C-23 | Association of Single Versus Dual Antiplatelet Therapy With Clinical Outcomes in Patients With Peripheral Artery Disease Open
The benefits of dual anti-platelet therapy (DAPT) in coronary artery disease are well established. However, less is known about the effects of DAPT in patients with peripheral artery disease (PAD). The aim of this meta-analysis is to compa…
View article: A-30 | Timing of Coronary Angiography for Patients Without ST-Segment Elevation After Cardiac Arrest
A-30 | Timing of Coronary Angiography for Patients Without ST-Segment Elevation After Cardiac Arrest Open
Early coronary angiography (CAG) is recommended in patients with out of hospital cardiac arrest (OHCA) with ST segment elevation (STE) on electrocardiogram (ECG), but less is known about early CAG in OHCA patients without STE. This meta-an…
View article: C-24 | Association of Anticoagulation and Antiplatelet Therapy With Clinical Outcomes in Patients With Peripheral Artery Disease.
C-24 | Association of Anticoagulation and Antiplatelet Therapy With Clinical Outcomes in Patients With Peripheral Artery Disease. Open
Anti-platelet therapy reduces the risk of adverse cardiovascular events in patients with peripheral artery disease (PAD). However, the effects of combining anti-platelet with anticoagulation (AC) therapy are less clear. The purpose of this…
View article: Low levels of tissue factor lead to alveolar hemorrhage, potentiating murine acute lung injury and oxidative stress
Low levels of tissue factor lead to alveolar hemorrhage, potentiating murine acute lung injury and oxidative stress Open
Systemic blockade of Tissue Factor (TF) attenuates acute lung injury (ALI) in animal models of sepsis but the effects of global TF deficiency are unknown.
View article: Bronchial Secretory Immunoglobulin A Deficiency Correlates With Airway Inflammation and Progression of Chronic Obstructive Pulmonary Disease
Bronchial Secretory Immunoglobulin A Deficiency Correlates With Airway Inflammation and Progression of Chronic Obstructive Pulmonary Disease Open
Rationale: Although airway inflammation can persist for years after smoking cessation in patients with chronic obstructive pulmonary disease (COPD), the mechanisms of persistent inflammation are largely unknown.
View article: Regulation of Alveolar Procoagulant Activity and Permeability in Direct Acute Lung Injury by Lung Epithelial Tissue Factor
Regulation of Alveolar Procoagulant Activity and Permeability in Direct Acute Lung Injury by Lung Epithelial Tissue Factor Open
Tissue factor (TF) initiates the extrinsic coagulation cascade in response to tissue injury, leading to local fibrin deposition. Low levels of TF in mice are associated with increased severity of acute lung injury (ALI) after intratracheal…
View article: Localized hypoxia links ER stress to lung fibrosis through induction of C/EBP homologous protein
Localized hypoxia links ER stress to lung fibrosis through induction of C/EBP homologous protein Open
ER stress in type II alveolar epithelial cells (AECs) is common in idiopathic pulmonary fibrosis (IPF), but the contribution of ER stress to lung fibrosis is poorly understood. We found that mice deficient in C/EBP homologous protein (CHOP…
View article: Secretory IgA Deficiency in Individual Small Airways Is Associated with Persistent Inflammation and Remodeling
Secretory IgA Deficiency in Individual Small Airways Is Associated with Persistent Inflammation and Remodeling Open
Our findings support the concept that localized, acquired SIgA deficiency in individual small airways of patients with COPD allows colonizing bacteria to cross the epithelial barrier and drive persistent inflammation and airway wall remode…
View article: Clinical Characteristics and Angiographic Findings of Acute Myocardial Infarction Associated With Marijuana Use: Consecutive Case Series.
Clinical Characteristics and Angiographic Findings of Acute Myocardial Infarction Associated With Marijuana Use: Consecutive Case Series. Open
In our study, marijuana use is associated with ST-elevation MI in largely minority population, occurring at a relatively younger age with half of the cases either low risk or CVD risk free. Additional studies are needed to further characte…
View article: Clinical Characteristics and Angiographic Findings of Myocardial Infarction among Marijuana Users and Non-Users.
Clinical Characteristics and Angiographic Findings of Myocardial Infarction among Marijuana Users and Non-Users. Open
In our study, marijuana use is associated with ST-elevation MI in largely minority population, occurring at a relatively younger age with half of the cases CVD risk free. Additional studies are needed to further characterize this populatio…
View article: Epithelial-macrophage interactions determine pulmonary fibrosis susceptibility in Hermansky-Pudlak syndrome
Epithelial-macrophage interactions determine pulmonary fibrosis susceptibility in Hermansky-Pudlak syndrome Open
Alveolar epithelial cell (AEC) dysfunction underlies the pathogenesis of pulmonary fibrosis in Hermansky-Pudlak syndrome (HPS) and other genetic syndromes associated with interstitial lung disease; however, mechanisms linking AEC dysfuncti…