William E. Lutz
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View article: The role of Tyr34 in proton-coupled electron transfer of human manganese superoxide dismutase
The role of Tyr34 in proton-coupled electron transfer of human manganese superoxide dismutase Open
Human manganese superoxide dismutase (MnSOD) plays a crucial role in controlling levels of reactive oxygen species (ROS) by converting superoxide (O 2 •− ) to molecular oxygen (O 2 ) and hydrogen peroxide (H 2 O 2 ) with proton-coupled ele…
View article: Perfect Crystals: Microgravity capillary counterdiffusion crystallization of human manganese superoxide dismutase for neutron crystallography
Perfect Crystals: Microgravity capillary counterdiffusion crystallization of human manganese superoxide dismutase for neutron crystallography Open
The NASA mission Perfect Crystals used the microgravity environment on the International Space Station (ISS) to grow crystals of human manganese superoxide dismutase (MnSOD) - an oxidoreductase critical for mitochondrial vitality and human…
View article: Insect cell expression and purification of recombinant <scp>SARS‐COV</scp>‐2 spike proteins that demonstrate <scp>ACE2</scp> binding
Insect cell expression and purification of recombinant <span>SARS‐COV</span>‐2 spike proteins that demonstrate <span>ACE2</span> binding Open
The COVID‐19 pandemic caused by SARS‐CoV‐2 infection has led to socio‐economic shutdowns and the loss of over 5 million lives worldwide. There is a need for the identification of therapeutic targets to treat COVID‐19. SARS‐CoV‐2 spike is a…
View article: <scp>CyDisCo</scp> production of functional recombinant <scp>SARS‐CoV</scp>‐2 spike receptor binding domain
<span>CyDisCo</span> production of functional recombinant <span>SARS‐CoV</span>‐2 spike receptor binding domain Open
The COVID‐19 pandemic caused by SARS‐CoV‐2 has applied significant pressure on overtaxed healthcare around the world, underscoring the urgent need for rapid diagnosis and treatment. We have developed a bacterial strategy for the expression…
View article: Bromelain inhibits SARS‐CoV‐2 infection via targeting ACE‐2, TMPRSS2, and spike protein
Bromelain inhibits SARS‐CoV‐2 infection via targeting ACE‐2, TMPRSS2, and spike protein Open
The new coronavirus, SARS-CoV-2, transmits rapidly from human-to-human resulting in the ongoing pandemic. SARS-CoV-2 infects angiotensin-converting enzyme 2 (ACE-2) expressing lung, heart, kidney, intestine, gall bladder, and testicular ti…
View article: Direct detection of coupled proton and electron transfers in human manganese superoxide dismutase
Direct detection of coupled proton and electron transfers in human manganese superoxide dismutase Open
Human manganese superoxide dismutase (MnSOD) is a critical oxidoreductase found in the mitochondrial matrix. Concerted proton and electron transfers (CPETs) are used by the enzyme to rid the mitochondria of O2•−, a precursor to other harmf…
View article: Direct detection of coupled proton and electron transfers in human manganese superoxide dismutase
Direct detection of coupled proton and electron transfers in human manganese superoxide dismutase Open
Human manganese superoxide dismutase (MnSOD) is a critical oxidoreductase found in the mitochondrial matrix. Concerted proton and electron transfers (CPETs) are used by the enzyme to rid the mitochondria of O 2 •− , a precursor to other ha…
View article: Bromelain Inhibits SARS-CoV-2 Infection in VeroE6 Cells
Bromelain Inhibits SARS-CoV-2 Infection in VeroE6 Cells Open
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The initial interaction between Transmembrane Serine Protease 2 (TMPRSS2) primed SARS-CoV-2 spike (S) protein and host cell rece…
View article: Redox manipulation of the manganese metal in human manganese superoxide dismutase for neutron diffraction
Redox manipulation of the manganese metal in human manganese superoxide dismutase for neutron diffraction Open
Human manganese superoxide dismutase (MnSOD) is one of the most significant enzymes in preventing mitochondrial dysfunction and related diseases by combating reactive oxygen species (ROS) in the mitochondrial matrix. Mitochondria are the s…