William E. Schwarzmann
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View article: HIV‐1 drug resistance among individuals who seroconverted in the ASPIRE dapivirine ring trial
HIV‐1 drug resistance among individuals who seroconverted in the ASPIRE dapivirine ring trial Open
Introduction A potential concern with the use of dapivirine (DPV) for HIV prevention is the selection of a drug‐resistant virus that could spread and reduce the effectiveness of non‐nucleoside reverse transcriptase (NNRTI)‐based first‐line…
View article: Intractable Coronavirus Disease 2019 (COVID-19) and Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Replication in a Chimeric Antigen Receptor-Modified T-Cell Therapy Recipient: A Case Study
Intractable Coronavirus Disease 2019 (COVID-19) and Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Replication in a Chimeric Antigen Receptor-Modified T-Cell Therapy Recipient: A Case Study Open
A chimeric antigen receptor-modified T-cell therapy recipient developed severe coronavirus disease 2019, intractable RNAemia, and viral replication lasting >2 months. Premortem endotracheal aspirate contained >2 × 1010 severe acute r…
View article: The impact of physical frailty on the response to inactivated influenza vaccine in older adults
The impact of physical frailty on the response to inactivated influenza vaccine in older adults Open
Physical frailty's impact on hemagglutination inhibition antibody titers (HAI) and peripheral blood mononuclear cell (PBMC) transcriptional responses after influenza vaccination is unclear. Physical frailty was assessed using the 5-item Fr…
View article: Differential gene expression in peripheral blood mononuclear cells from children immunized with inactivated influenza vaccine
Differential gene expression in peripheral blood mononuclear cells from children immunized with inactivated influenza vaccine Open
The human immune response to inactivated influenza vaccine is dynamic and impacted by age and preexisting immunity. Our goal was to identify postvaccination transcriptomic changes in peripheral blood mononuclear cells from children. Blood …