William G. McMaster
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Prioritizing heart transplantation during the COVID‐19 pandemic Open
We demonstrate that a single, large-volume transplant program was able to grow volume with little difference in donor variables and clinical outcomes following transplant. While multiple reasons are possible, most likely the reduction of v…
Prioritizing Heart Transplantation During the COVID-19 Pandemic Open
BACKGROUND: COVID-19 has significantly impacted the healthcare landscape in the United States in a variety of ways including a nation-wide reduction in operative volume. The impact of COVID-19 on the availability of donor organs and the im…
LNK deficiency promotes acute aortic dissection and rupture Open
Aortic dissection (AD) is a life-threatening vascular disease with limited treatment strategies. Here, we show that loss of the GWAS-identified SH2B3 gene, encoding lymphocyte adaptor protein LNK, markedly increases susceptibility to acute…
Sirt3 Impairment and SOD2 Hyperacetylation in Vascular Oxidative Stress and Hypertension Open
Rationale: Clinical studies have shown that Sirt3 (Sirtuin 3) expression declines by 40% by 65 years of age paralleling the increased incidence of hypertension and metabolic conditions further inactivate Sirt3 because of increased NADH (ni…
Gastrointestinal Bleed from a Left Ventricle to Colonic Interposition Graft Fistula following an Esophagectomy Open
Colonic interposition grafts are commonly used as an esophageal conduit following esophageal resection. Significant morbidity is associated with this reconstruction due to the nature of the operation. Many of the complications associated w…
BMP Antagonist Gremlin 2 Limits Inflammation After Myocardial Infarction Open
Rationale: We have recently shown that the bone morphogenetic protein (BMP) antagonist Gremlin 2 (Grem2) is required for early cardiac development and cardiomyocyte differentiation. Our initial studies discovered that Grem2 is strongly ind…
Activation of Human T Cells in Hypertension Open
Emerging evidence supports an important role for T cells in the genesis of hypertension. Because this work has predominantly been performed in experimental animals, we sought to determine whether human T cells are activated in hypertension…
Mitochondrial Cyclophilin D in Vascular Oxidative Stress and Hypertension Open
Vascular superoxide (O˙ 2 - ) and inflammation contribute to hypertension. The mitochondria are an important source of O˙ 2 - ; however, the regulation of mitochondrial O˙ 2 - and the antihypertensive potential of targeting the mitochondri…