W. Giang
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View article: Cadherin Regulation of Endoplasmic Reticulum-Plasma Membrane Contact Sites
Cadherin Regulation of Endoplasmic Reticulum-Plasma Membrane Contact Sites Open
The spatial organization and dynamics of the endoplasmic reticulum (ER) govern when and where ER tubules engage with other organelles and the plasma membrane. We previously found that ER tubules are closely associated with desmosomes, but …
View article: Visualizing dynamics of charges and strings in (2 + 1)D lattice gauge theories
Visualizing dynamics of charges and strings in (2 + 1)D lattice gauge theories Open
Lattice gauge theories (LGTs)1-4 can be used to understand a wide range of phenomena, from elementary particle scattering in high-energy physics to effective descriptions of many-body interactions in materials5-7. Studying dynamical proper…
View article: Blocking autophagosome closure manifests the roles of mammalian Atg8-family proteins in phagophore formation and expansion during nutrient starvation
Blocking autophagosome closure manifests the roles of mammalian Atg8-family proteins in phagophore formation and expansion during nutrient starvation Open
Macroautophagy/autophagy, an evolutionarily conserved cellular degradation pathway, involves phagophores that sequester cytoplasmic constituents and mature into autophagosomes for subsequent lysosomal delivery. The ATG8 gene family, compri…
View article: Scaling and logic in the color code on a superconducting quantum processor
Scaling and logic in the color code on a superconducting quantum processor Open
Quantum error correction is essential for bridging the gap between the error rates of physical devices and the extremely low logical error rates required for quantum algorithms. Recent error-correction demonstrations on superconducting pro…
View article: The transmembrane domain of the desmosomal cadherin desmoglein-1 governs lipid raft association to promote desmosome adhesive strength
The transmembrane domain of the desmosomal cadherin desmoglein-1 governs lipid raft association to promote desmosome adhesive strength Open
Cholesterol- and sphingolipid-enriched domains called lipid rafts are hypothesized to selectively coordinate protein complex assembly within the plasma membrane to regulate cellular functions. Desmosomes are mechanically resilient adhesive…
View article: YAP/TAZ signaling in allantois-derived cells is required for placental vascularization
YAP/TAZ signaling in allantois-derived cells is required for placental vascularization Open
Normal placental development and angiogenesis are crucial for fetal growth and maternal health during pregnancy. However, molecular regulation of placental angiogenesis has been difficult to study due to a lack of specific genetic tools th…
View article: Pemphigus vulgaris autoantibodies induce an ER stress response
Pemphigus vulgaris autoantibodies induce an ER stress response Open
Desmosomes are intercellular junctions that mediate cell-cell adhesion and are essential for maintaining tissue integrity. Pemphigus vulgaris (PV) is an autoimmune epidermal blistering disease caused by autoantibodies (IgG) targeting desmo…
View article: MARCH family E3 ubiquitin ligases selectively target and degrade cadherin family proteins
MARCH family E3 ubiquitin ligases selectively target and degrade cadherin family proteins Open
Cadherin family proteins play a central role in epithelial and endothelial cell-cell adhesion. The dynamic regulation of cell adhesion is achieved in part through endocytic membrane trafficking pathways that modulate cadherin cell surface …
View article: The transmembrane domain of the desmosomal cadherin desmoglein-1 governs lipid raft association to promote desmosome adhesive strength
The transmembrane domain of the desmosomal cadherin desmoglein-1 governs lipid raft association to promote desmosome adhesive strength Open
Cholesterol- and sphingolipid-enriched domains called lipid rafts are hypothesized to selectively coordinate protein complex assembly within the plasma membrane to regulate cellular functions. Desmosomes are mechanically resilient adhesive…
View article: Overcoming leakage in quantum error correction
Overcoming leakage in quantum error correction Open
The leakage of quantum information out of the two computational states of a qubit into other energy states represents a major challenge for quantum error correction. During the operation of an error-corrected algorithm, leakage builds over…
View article: MARCH family E3 ubiquitin ligases selectively target and degrade cadherin family proteins
MARCH family E3 ubiquitin ligases selectively target and degrade cadherin family proteins Open
Cadherin family proteins play a central role in epithelial and endothelial cell-cell adhesion. The dynamic regulation of cell adhesion is achieved in part through endocytic membrane trafficking pathways that modulate cadherin cell surface …
View article: Measurement-induced entanglement and teleportation on a noisy quantum processor
Measurement-induced entanglement and teleportation on a noisy quantum processor Open
Measurement has a special role in quantum theory: by collapsing the wavefunction it can enable phenomena such as teleportation and thereby alter the "arrow of time" that constrains unitary evolution. When integrated in many-body dynamics, …
View article: Suppressing quantum errors by scaling a surface code logical qubit
Suppressing quantum errors by scaling a surface code logical qubit Open
Practical quantum computing will require error rates well below those achievable with physical qubits. Quantum error correction 1,2 offers a path to algorithmically relevant error rates by encoding logical qubits within many physical qubit…
View article: Overcoming leakage in scalable quantum error correction
Overcoming leakage in scalable quantum error correction Open
Leakage of quantum information out of computational states into higher energy states represents a major challenge in the pursuit of quantum error correction (QEC). In a QEC circuit, leakage builds over time and spreads through multi-qubit …
View article: Non-Abelian braiding of graph vertices in a superconducting processor
Non-Abelian braiding of graph vertices in a superconducting processor Open
Indistinguishability of particles is a fundamental principle of quantum mechanics. For all elementary and quasiparticles observed to date - including fermions, bosons, and Abelian anyons - this principle guarantees that the braiding of ide…
View article: Readout of a quantum processor with high dynamic range Josephson parametric amplifiers
Readout of a quantum processor with high dynamic range Josephson parametric amplifiers Open
We demonstrate a high dynamic range Josephson parametric amplifier (JPA) in which the active nonlinear element is implemented using an array of rf-SQUIDs. The device is matched to the 50 $Ω$ environment with a Klopfenstein-taper impedance …
View article: Formation of robust bound states of interacting photons
Formation of robust bound states of interacting photons Open
Data and analysis scripts for the manuscript https://arxiv.org/abs/2206.05254
View article: Suppressing quantum errors by scaling a surface code logical qubit
Suppressing quantum errors by scaling a surface code logical qubit Open
Practical quantum computing will require error rates that are well below what is achievable with physical qubits. Quantum error correction offers a path to algorithmically-relevant error rates by encoding logical qubits within many physica…
View article: Architecture and dynamics of a novel desmosome-endoplasmic reticulum organelle
Architecture and dynamics of a novel desmosome-endoplasmic reticulum organelle Open
The endoplasmic reticulum (ER) forms a dynamic network that contacts other cellular membranes to regulate stress responses, calcium signaling, and lipid transfer. Using high-resolution volume electron microscopy, we find that the ER forms …
View article: Noise-resilient Edge Modes on a Chain of Superconducting Qubits
Noise-resilient Edge Modes on a Chain of Superconducting Qubits Open
Inherent symmetry of a quantum system may protect its otherwise fragile states. Leveraging such protection requires testing its robustness against uncontrolled environmental interactions. Using 47 superconducting qubits, we implement the o…
View article: The level of oncogenic Ras controls the malignant transformation of Lkb1 mutant tissue in vivo
The level of oncogenic Ras controls the malignant transformation of Lkb1 mutant tissue in vivo Open
The genetic and metabolic heterogeneity of RAS-driven cancers has confounded therapeutic strategies in the clinic. To address this, rapid and genetically tractable animal models are needed that recapitulate the heterogeneity of RAS-driven …
View article: VE-cadherin endocytosis controls vascular integrity and patterning during development
VE-cadherin endocytosis controls vascular integrity and patterning during development Open
Tissue morphogenesis requires dynamic intercellular contacts that are subsequently stabilized as tissues mature. The mechanisms governing these competing adhesive properties are not fully understood. Using gain- and loss-of-function approa…
View article: Detection of the Temporal Variation of the Sun's Cosmic Ray Shadow with the IceCube Detector
Detection of the Temporal Variation of the Sun's Cosmic Ray Shadow with the IceCube Detector Open
We report on the observation of a deficit in the cosmic ray flux from the directions of the Moon and Sun with five years of data taken by the IceCube Neutrino Observatory. Between 2010 May and 2011 May the IceCube detector operated with 79…