Charles W. Goss
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View article: The evolution of supportive supervision in low- and middle-income countries
The evolution of supportive supervision in low- and middle-income countries Open
Supportive supervision has shifted in low- and middle-income countries (LMICs) from hierarchical, inspection-based oversight toward collaborative, mentorship-driven approaches that emphasize two-way communication, joint problem-solving, an…
View article: Strategies to improve healthcare team communication structure and quality in resource-variable childhood cancer hospitals (TeamTalk): a study protocol
Strategies to improve healthcare team communication structure and quality in resource-variable childhood cancer hospitals (TeamTalk): a study protocol Open
Background Healthcare team communication is essential to high-quality childhood cancer care, especially during high-acuity events such as clinical deterioration and in resource-variable settings, where supportive interventions to resolve d…
View article: Heart failure with reduced ejection fraction polypill implementation strategy in Sri Lanka: design and protocol of a pilot type I hybrid randomised clinical trial
Heart failure with reduced ejection fraction polypill implementation strategy in Sri Lanka: design and protocol of a pilot type I hybrid randomised clinical trial Open
Introduction Guideline-directed medical therapy (GDMT) for patients with heart failure with reduced ejection fraction (HFrEF) reduces morbidity and mortality and remains widely underused. An HFrEF polypill containing all four pillars of GD…
View article: Multicenter Validation of a Machine Learning Model for Surgical Transfusion Risk at 45 US Hospitals
Multicenter Validation of a Machine Learning Model for Surgical Transfusion Risk at 45 US Hospitals Open
Importance Accurate estimation of surgical transfusion risk is important for perioperative planning and effective resource allocation. Most machine learning models in health care are not validated or perform poorly in external settings. Ob…
View article: NutriConnect: Enhancing Health and Food Security through Sustainable Solutions and Partnerships: Design and Protocol of a Pragmatic Comparative Effectiveness Trial
NutriConnect: Enhancing Health and Food Security through Sustainable Solutions and Partnerships: Design and Protocol of a Pragmatic Comparative Effectiveness Trial Open
Background Food insecurity and poor dietary intake contribute to health disparities, particularly among socioeconomically disadvantaged populations. Produce prescription programs aim to improve access to fruits and vegetables (F&V) for tho…
View article: A Customizable Data Quality Tool for Global Observational Research Networks
A Customizable Data Quality Tool for Global Observational Research Networks Open
Evaluating data quality is essential when combining multi-site observational clinical data for analysis. We collaborated with five research networks, representing various data approaches and workflows, to generalize an established data qua…
View article: When the parts are greater than the whole: how understanding mechanisms can advance implementation research
When the parts are greater than the whole: how understanding mechanisms can advance implementation research Open
Background Does the importance of context in implementation imply that generalizing about the effects of strategies is ultimately limited? Conceptual approaches for generalizing in the presence of significant contextual heterogeneity could…
View article: Impact of mass drug administration with ivermectin, diethylcarbamazine, and albendazole for lymphatic filariasis on hookworm and Strongyloides stercoralis infections in Papua New Guinea
Impact of mass drug administration with ivermectin, diethylcarbamazine, and albendazole for lymphatic filariasis on hookworm and Strongyloides stercoralis infections in Papua New Guinea Open
Background Persons with lymphatic filariasis (LF) are often co-infected with soil-transmitted helminths. A single co-administered dose of ivermectin/diethylcarbamazine/albendazole (IDA) is recommended by WHO for mass drug administration (M…
View article: Development of a metabolome-based respiratory infection prognostic during COVID-19 arrival.
Development of a metabolome-based respiratory infection prognostic during COVID-19 arrival. Open
In a new respiratory virus pandemic, optimizing allocation of scarce medical resources becomes an urgent challenge. Infection prognosis takes on particular importance when allocating scarce antiviral antibodies and drugs, which are most ef…
View article: Development of a metabolome-based respiratory infection prognostic during COVID-19 arrival
Development of a metabolome-based respiratory infection prognostic during COVID-19 arrival Open
In a new respiratory virus pandemic, optimizing allocation of scarce medical resources becomes an urgent challenge. Infection prognosis takes on particular importance when allocating scarce antiviral antibodies and drugs, which are most ef…
View article: The Post-transplant Lymphoproliferative Disorders—Metagenomic Shotgun Microbial Sequencing (PTLD-MSMS) Study Methods and Protocol
The Post-transplant Lymphoproliferative Disorders—Metagenomic Shotgun Microbial Sequencing (PTLD-MSMS) Study Methods and Protocol Open
Post-transplant lymphoproliferative disorders (PTLDs) remain a feared complication of transplantation, with significant morbidity and mortality. The oncogenic Epstein-Barr virus (EBV) is a key pathogenic driver in 50%–80% of cases. Numerou…
View article: Increased Muc5AC and Decreased Ciliated Cells in Severe Asthma Partially Restored by Inhibition of IL-4Rα Receptor
Increased Muc5AC and Decreased Ciliated Cells in Severe Asthma Partially Restored by Inhibition of IL-4Rα Receptor Open
Rationale: The role of IL-13 on the airway epithelium in severe asthma leading to airway remodeling remains poorly understood. Objectives: To study IL-13-induced airway remodeling on goblet cells and cilia in the airway epithelium in sever…
View article: Factors associated with never treatment and acceptability of mass drug administration for the elimination of lymphatic filariasis in Guyana, 2021
Factors associated with never treatment and acceptability of mass drug administration for the elimination of lymphatic filariasis in Guyana, 2021 Open
Guyana remains one of four countries in the Americas endemic for lymphatic filariasis (LF). Elimination of LF requires repeated annual mass drug administration (MDA) with sufficient levels of coverage for success. This study assesses the a…
View article: Intravenous Levothyroxine for Unstable Brain-Dead Heart Donors
Intravenous Levothyroxine for Unstable Brain-Dead Heart Donors Open
In hemodynamically unstable brain-dead potential heart donors, intravenous levothyroxine infusion did not result in significantly more hearts being transplanted than saline infusion. (Funded by Mid-America Transplant and others; ClinicalTr…
View article: Planning for the End at the Beginning: A Lesson in Sharing Research Findings of a Community-based COVID-19 Seroprevalence Survey
Planning for the End at the Beginning: A Lesson in Sharing Research Findings of a Community-based COVID-19 Seroprevalence Survey Open
Introduction Sharing research findings with participants is important but challenging. We evaluated a plan to share findings with participants of a COVID-19 seroprevalence project. Methods An electronic survey was distributed to participan…
View article: Behavioral Mechanisms That Mediate Mental and Physical Health Improvements in People With Chronic Pain Who Receive a Digital Health Intervention: Prospective Cohort Pilot Study
Behavioral Mechanisms That Mediate Mental and Physical Health Improvements in People With Chronic Pain Who Receive a Digital Health Intervention: Prospective Cohort Pilot Study Open
Background Preliminary evidence suggests that digital mental health intervention (Wysa for Chronic Pain) can improve mental and physical health in people with chronic musculoskeletal pain and coexisting symptoms of depression or anxiety. H…
View article: Impact of Integrase Strand Transfer Inhibitors on Cognition in the HAILO Cohort
Impact of Integrase Strand Transfer Inhibitors on Cognition in the HAILO Cohort Open
Background: Integrase inhibitors (INSTIs) have been associated with poorer cognition in people with HIV (PWH). We examined the impact of switching to INSTIs on neuropsychological (NP) outcomes in PWH 40 years of age and older. Methods: Fro…
View article: Safety and tolerability of moxidectin and ivermectin combination treatments for lymphatic filariasis in Côte d’Ivoire: A randomized controlled superiority study
Safety and tolerability of moxidectin and ivermectin combination treatments for lymphatic filariasis in Côte d’Ivoire: A randomized controlled superiority study Open
Background Moxidectin is a macrocyclic lactone registered for the treatment of human onchocerciasis. The drug has a good safety profile, large volume of distribution and a long elimination half-life. This paper reports tolerability data fr…