William Gump
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Initial Endoscopic Ventricular Failure to Relieve Hydrocephalus in Patients With Obstructing Brain Tumors Predicts a Histone 3K27M Mutation Open
Background Diffuse midline gliomas (DMG) are a subset of malignant gliomas that could be linked to an H3K27M mutation. Hydrocephalus may be the initial presenting condition because of its frequent pontine location. This study evaluated the…
SURG-27. TREATING HYDROCEPHALUS IN DIFFUSE MIDLINE GLIOMAS WITH AN H3 K27M MUTATION Open
BACKGROUND Diffuse midline gliomas (DMG) are a subset of malignant gliomas that share a characteristic Histone H3K27M mutation. These tumors are centrally located and may cause hydrocephalus on initial presentation. DMG lack characteristic…
S2-10 SESSION 2: POSTERIOR VAULT DISTRACTION 3D VOLUMETRIC CHANGES AND RADIOGRAPHIC MARKERS OF OPTIMAL POSTERIOR VAULT EXPANSION WITH DISTRACTION OSTEOGENESIS Open
Introduction: Distraction osteogenesis (DO) represents a paradigm shift in craniosynostosis treatment allowing for maximal volumetric expansion in the posterior vault (PV) by overcoming viscoelastic forces of overlying soft tissues. Submax…
P05.55 Tumor location may be more predictive than histology for postoperative cerebellar mutism: case series Open
Assessment of complications from posterior fossa tumor surgery in children have been confounded by nonstandard definitions and nomenclature regarding speech, cognitive, and coordination deficits. Recently, a new definition of postoperative…
CRAN-24. LANGERHANS CELL HISTIOCYTOSIS OF THE ORBIT AND SKULL BASE IN A 2 YEAR OLD: CASE REPORT Open
INTRODUCTION: Langerhans cell histiocytosis (LCH) results from clonal proliferation of cells which resemble Langerhans cells found normally in skin and lymph nodes. We present an unusual LCH case with significant bony erosion of the latera…
View article: Prospective feasibility and safety assessment of surgical biopsy for patients with newly diagnosed diffuse intrinsic pontine glioma
Prospective feasibility and safety assessment of surgical biopsy for patients with newly diagnosed diffuse intrinsic pontine glioma Open
Background Diagnosis of diffuse intrinsic pontine glioma (DIPG) has relied on imaging studies, since the appearance is pathognomonic, and surgical risk was felt to be high and unlikely to affect therapy. The DIPG Biology and Treatment Stud…
PDCT-20. FEASIBILITY AND SAFETY OF SURGICAL BIOPSY FOR PATIENTS WITH DIPG: PRELIMINARY RESULTS FROM DIPG-BATS Open
INTRODUCTION: The DIPG Biology and Treatment Study (DIPG-BATS) incorporated a surgical biopsy at presentation and stratified patients to receive FDA-approved agents chosen on the basis of specific biologic targets. METHODS: Subjects were e…
DIPG-29. GENOMIC LANDSCAPE OF DIFFUSE INTRINSIC PONTINE GLIOMA: AN ANALYSIS OF THE DIPG-BATS COHORT Open
INTRODUCTION: Diffuse intrinsic pontine glioma (DIPG) remains a devastating and incurable disease. The DIPG-BATs clinical trial incorporates diagnostic biopsy with molecularly determined treatment stratification. Here we present the initia…
TRTH-23. FEASIBILITY AND SAFETY OF SURGICAL BIOPSY FOR PATIENTS WITH DIPG: PRELIMINARY RESULTS FROM DIPG-BATS Open
INTRODUCTION: The DIPG Biology and Treatment Study (DIPG-BATS) incorporated a surgical biopsy at presentation and stratified patients to receive FDA-approved agents chosen on the basis of specific biologic targets. METHODS: Subjects were e…